{"id":8671,"date":"2016-11-01T11:00:36","date_gmt":"2016-11-01T11:00:36","guid":{"rendered":"http:\/\/admin.acceleratingscience.com\/biobanking\/?p=8671"},"modified":"2016-11-01T11:00:36","modified_gmt":"2016-11-01T11:00:36","slug":"innovation-from-disaster-the-tohoku-medical-megabank-project","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/biobanking\/innovation-from-disaster-the-tohoku-medical-megabank-project\/","title":{"rendered":"Innovation from Disaster: The Tohoku Medical Megabank Project"},"content":{"rendered":"<p><span class=\"thread\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.thermofisher.com\/blog\/biobanking\/wp-content\/uploads\/sites\/6\/2016\/11\/shutterstock_256600405.jpg\" style=\"float: left;margin: 5px\" alt=\"Reality of the tsunami disaster. The outbreak of the unprecedented Great East Japan Earthquake and tsunami. Image: mTaira\/Shutterstock.com.\" width=\"330\" height=\"219\" \/>Following<\/span>&nbsp;the&nbsp;Great East Japan Earthquake and its resulting tsunami in 2011,&nbsp;Tohoku University&rsquo;s Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University&rsquo;s Iwate&nbsp;Tohoku Medical Megabank Organization (IMM) launched the Tohoku Medical Megabank project. The aim of the project is to address the consequent issues that the T\u014dhoku region of Japan is still facing in the aftermath of the earthquake some five years later. Many survivors still face poor nutrition, a lack of medical care and psychological stress, which&nbsp;Kuriyama et al. (2016) argue accelerate the onset of or aggravate&nbsp;a variety of chronic, non-infectious diseases, such as&nbsp;peptic ulcers,&nbsp;ulcerative colitis,&nbsp;cardiovascular disorders,&nbsp;cerebrovascular disorders,&nbsp;diabetes and chronic&nbsp;obstructive pulmonary disease. The TMM will form part of&nbsp;an advanced medical system&nbsp;and practice to help restore medical services in tsunami-stricken areas.<\/p>\n<p>The Tohoku Medical Megabank&nbsp;started in 2012 and will introduce&nbsp;personalized health care and medicine into damaged&nbsp;areas. It currently has three initiatives:<\/p>\n<ol>\n<li>Conduct two&nbsp;prospective cohort studies and one cross-sectional study<\/li>\n<li>Construct an integrated biobank that stores&nbsp;biospecimens and information collected through the cohort&nbsp;studies<\/li>\n<li><span class=\"thread\"><\/span><span>Perform regular genome and &ndash;omics analyses with the collected biospecimens and store resulting data for distribution to the research community<\/span><\/li>\n<\/ol>\n<p>To conduct cohort studies, the Tohoku Medical Megabankrecovered damaged health care services where possible and&nbsp;established a rotation system for dispatching physicians to areas&nbsp;with a physician shortage. They cleverly deployed two fellowships, the ToMMo Clinical Fellowship and the IMM Medical Megabank&nbsp;Fellows System, to entice young physicians. In this way, they can provide medical care while offering&nbsp;clinical and research expertise to young&nbsp;physicians.<\/p>\n<p>The TMM recruits participants into the cohort studies during regular annual checkups. These participants<span class=\"thread\"> are<\/span>&nbsp;between&nbsp;40 and 74 years of age. In July 2013, they also started a birth and three-generation&nbsp;cohort study that now has approximately 50&nbsp;obstetric clinics&nbsp;and hospitals participating in the recruitment process.&nbsp;The data being<span class=\"thread\">&nbsp;collected<\/span>&nbsp;includes the following:<\/p>\n<ul>\n<li>Sociodemographic factors, lifestyle habits and medical&nbsp;history<\/li>\n<li>Biospecimens, such as blood,&nbsp;urine, saliva, dental plaque and breast milk<\/li>\n<li>Measurements, such as height, weight and blood pressure<\/li>\n<li>Magnetic&nbsp;resonance imaging (MRI)<\/li>\n<\/ul>\n<p>The TMM intends to&nbsp;transfer biospecimens and data to the researchers most&nbsp;suited to maximizing their potential and to adopt a materials and data transfer policy, which&nbsp;will contribute to the reconstruction of the affected areas.&nbsp;They are collecting data and biospecimens with the intention of sharing them with&nbsp;many researchers focused on the mechanisms of disease. They also intend to conduct in-house&nbsp;genomic and &ndash;<span class=\"thread\">omics<\/span> research. The purpose of this is as follows:<\/p>\n<ul>\n<li>Construct an integrated biobank<\/li>\n<li>Return genomic research results to participants in the&nbsp;cohort studies, leading to&nbsp;personalized health care in the near future<\/li>\n<li>Contribute to the development&nbsp;of personalized health care and medicine worldwide<\/li>\n<\/ul>\n<p>The Tohoku Medical Megabank&nbsp;has already created a Japanese reference panel of&nbsp;genomic variation, called the <a href=\"https:\/\/ijgvd.megabank.tohoku.ac.jp\/\" target=\"_blank\">Integrative Japanese Genome Variation&nbsp;Database<\/a>, which is publicly available online.<\/p>\n<p>Finally, the consent process uses continuing consent. The initial consent process explains&nbsp;the studies,&nbsp;biobanking and general research methods for genome&nbsp;analysis, &ndash;omics analysis and cell culture. During follow-up, participants receive additional information about the research through newsletters, Web pages and other channels, as researchers define new protocols.<\/p>\n<p>Kuriyama et al. note that the TMM currently has some limitations, such as controlling for the bias of males to females as well as their ages because of women&rsquo;s increased likelihood to seek specific health checkups. However, the TMM offers a unique opportunity to address health-related issues from the earthquake and improve future health using personalized medicine.<\/p>\n<p><strong>Reference<\/strong><span style=\"text-decoration: underline\"><br \/><\/span>1. Kuriyama, S., et al. (2016) &ldquo;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27374138\" target=\"_blank\">The Tohoku medical megabuck project: Design and mission<\/a>,&rdquo; Journal of Epidemiology, 26(9) (pp. 493&ndash;511), doi: 10.2188\/jea.JE20150268.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Following&nbsp;the&nbsp;Great East Japan Earthquake and its resulting tsunami in 2011,&nbsp;Tohoku University&rsquo;s Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University&rsquo;s Iwate&nbsp;Tohoku Medical Megabank Organization (IMM) launched the Tohoku Medical Megabank project. The aim of the project is to address the consequent issues that the T\u014dhoku region of Japan is still facing in the aftermath of<\/p>\n","protected":false},"author":7,"featured_media":8695,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[17],"tags":[131,32,184],"division":[],"class_list":{"0":"post-8671","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-case-studies","8":"tag-data-management","9":"tag-donors","10":"tag-personalized-medicine","11":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- 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