{"id":1013,"date":"2018-12-31T00:00:00","date_gmt":"2018-12-31T00:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cancer5\/"},"modified":"2025-02-07T13:50:34","modified_gmt":"2025-02-07T04:50:34","slug":"cancer5","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cancer5\/","title":{"rendered":"\u3010\u3044\u307e\u3055\u3089\u805e\u3051\u306a\u3044\u304c\u3093\u306e\u57fa\u790e 5\u3011Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3 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\/>\nWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u306f\u3001\u816b\u760d\u5f62\u6210\u306b\u304a\u3051\u308b\u5341\u5206\u306b\u78ba\u7acb\u3055\u308c\u305fWnt\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u6d3b\u52d5\u7684\u306a\u7814\u7a76\u9818\u57df\u3067\u3059\u3002\u3053\u306e\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2>\u6982\u8981\uff1aWnt\u7d4c\u8def<\/h2>\n<h4>\u5065\u5e38\u304a\u3088\u3073\u75be\u60a3\u306b\u304a\u3051\u308bWnt \u306e\u6a5f\u80fd<\/h4>\n<p>Drosophila\uff08\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\uff09\u907a\u4f1d\u5b50wingless(wg)\u306f\u3001\u54fa\u4e73\u985e\u306eint1\u907a\u4f1d\u5b50\u306e\u30aa\u30eb\u30bd\u30ed\u30b0\u3067\u3001\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u4e73\u304c\u3093\u3092\u8a98\u767a\u3059\u308b\u767a\u304c\u3093\u6027\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308b\u30de\u30a6\u30b9\u4e73\u817a\u816b\u760d\u30a6\u30a4\u30eb\u30b9\uff08MMTV\uff09\u306e\u633f\u5165\u90e8\u4f4d\u3068\u3057\u3066\u6700\u521d\u306b\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u304c\u3093\u539f\u907a\u4f1d\u5b50\u306ewg\u304a\u3088\u3073int1\u306f\u3001\u9032\u5316\u7684\u306b\u4fdd\u5b58\u3055\u308c\u305f\u3001\u7121\u810a\u690e\u52d5\u7269\u304a\u3088\u3073\u810a\u690e\u52d5\u7269\u306e\u521d\u671f\u80da\u767a\u751f\u306b\u5fc5\u8981\u3068\u3055\u308c\u308bWnt\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30bf\u30f3\u30d1\u30af\u8cea\u30e1\u30f3\u30d0\u30fc\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\uff08\u56f35.1\uff09\u00a0<sup>*1\u20133<\/sup> \u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3001\u795e\u7d4c\u5824\u3001\u304a\u3088\u3073\u56db\u80a2\u306e\u767a\u751f\u306fWnt\u7d4c\u8def\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u6b63\u5e38\u306a\u30d7\u30ed\u30bb\u30b9\u306e\u4f8b\u3067\u3042\u308a\u3001Wnt\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3092\u5909\u5316\u3055\u305b\u308b\u5909\u7570\u306f\u5148\u5929\u6027\u7570\u5e38\u306b\u95a2\u9023\u3057\u307e\u3059 *<sup>3\u20135<\/sup> \u3002\u5206\u6ccc\u6027\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u306eWnt\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u306f\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30a4\u30d9\u30f3\u30c8\u306e\u5f15\u304d\u91d1\u3068\u306a\u308a\u3001\u6210\u4eba\u7d44\u7e54\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u3067\u3001\u7d30\u80de\u306e\u5897\u6b96\u3001\u5206\u5316\u3001\u304a\u3088\u3073\u904a\u8d70\u306b\u95a2\u9023\u3057\u307e\u3059\u00a0<sup>*6,7<\/sup>\u3002<br \/>\nWnt\u907a\u4f1d\u5b50\u306f\u3001\u30de\u30a6\u30b9\u304a\u3088\u3073\u30d2\u30c8\u306b\u304a\u3044\u306619\u7a2e\u985e\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3044\u304f\u3064\u304b\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306e\u6a5f\u80fd\u3092\u5909\u5316\u3055\u305b\u308b\u907a\u4f1d\u5b50\u5909\u7570\u306b\u95a2\u9023\u3059\u308b\u533b\u5b66\u7684\u75c5\u72b6\u3092\u88685.1\u306b\u793a\u3057\u307e\u3059 <sup>*8 <\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-97.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3109 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-97.jpg\" alt=\"Wingless\u306e\u8868\u73fe\u578b\" width=\"411\" height=\"262\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-27.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3110 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-27.jpg\" alt=\"Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u4e0d\u5168\u306b\u95a2\u9023\u3059\u308b\u533b\u5b66\u7684\u75c7\u72b6\" width=\"813\" height=\"566\" \/><\/a><\/p>\n<h2>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def<\/h2>\n<h4>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9<\/h4>\n<p>Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u306f\u3001\u53e4\u5178\u7684\u7d4c\u8def\u3068\u975e\u53e4\u5178\u7684\u7d4c\u8def\u304c\u5b58\u5728\u3057\u307e\u3059\uff08\u56f35.2\uff09<sup>*7<\/sup>\u3002 \u305d\u308c\u305e\u308c\u306eWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u306f\u3001\u7d30\u80de\u5916Wnt\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30ac\u30f3\u30c9\u0336\u304a\u3088\u3073\u95a2\u9023\u5171\u5f79\u53d7\u5bb9\u4f53\uff08LPR5,6\uff09\u0336\u304c\u7d30\u80de\u819c\u4e0a\u306e7\u56de\u819c\u8cab\u901a\u578bFrizzled\uff08FZD\uff09\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u3068\u958b\u59cb\u3055\u308c\u307e\u3059\uff08\u56f35.3\uff09\u3002\u305d\u308c\u306b\u7d9a\u304d\u3001\u819c\u8fd1\u508d\u306e\u7d30\u80de\u8cea\u30bf\u30f3\u30d1\u30af\u8ceaDishevelled\uff08Dvl\/Dsh\uff09\u3092\u4ecb\u3057\u3066\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u4e0b\u6d41\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306b\u30b7\u30b0\u30ca\u30eb\u304c\u4f1d\u9054\u3055\u308c\u307e\u3059\u00a0<sup>*9<\/sup>\u3002<br \/>\nDvl\u30b7\u30b0\u30ca\u30eb\u306f\u3001RhoA\u304a\u3088\u3073ROCK\u306a\u3069\u306e\u7d30\u80de\u8cea\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4ecb\u3057\u3066\u3001\u5e73\u9762\u5185\u7d30\u80de\u6975\u6027\uff08PCP\uff09\u306b\u4f1d\u64ad\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u7d44\u7e54\u306e\u5e73\u9762\u306b\u304a\u3051\u308b\u7d30\u80de\u306e\u7a7a\u9593\u7684\u69cb\u6210\u3092\u751f\u3058\u3055\u305b\u308b\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u3002PCP\u306b\u304a\u3051\u308b\u6df7\u4e71\u306f\u3001\u79e9\u5e8f\u304c\u4e71\u308c\u305f\u7d44\u7e54\u69cb\u9020\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u810a\u690e\u52d5\u7269\u3067\u306f\u3001\u795e\u7d4c\u7ba1\u6b20\u640d\u304a\u3088\u3073\u591a\u767a\u6027\u56a2\u80de\u814e\u75be\u60a3\u306e\u767a\u75c7\u306a\u3069\u306e\u5e45\u5e83\u3044\u7570\u5e38\u72b6\u614b\u306b\u95a2\u9023\u3057\u307e\u3059\u00a0<sup>*5<\/sup> \u3002Dvl\u3082\u307e\u305f\u3001\u7d30\u80de\u904a\u8d70\u306e\u6b63\u306e\u5236\u5fa1\u56e0\u5b50\u3067\u3059\u3002Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u5236\u5fa1\u306f\u8907\u96d1\u3067\u3001\u8907\u6570\u306e\u30b5\u30a4\u30c8\u30be\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308bDvl\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002<br \/>\n\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u6b63\u304a\u3088\u3073\u8ca0\u306e\u5236\u5fa1\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3001\u8907\u6570\u306e\u6a19\u7684\u907a\u4f1d\u5b50\uff08\u305d\u306e\u4e00\u90e8\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3084\u7d30\u80de\u5897\u6b96\u306b\u95a2\u4e0e\uff09\u306e\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308b\u591a\u6a5f\u80fd\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u00a0<sup>*10<\/sup>\u3002 Dvl\u306f\u3001\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u4ed6\u306b\u3001\u7d30\u80de\u819c\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u3084\u30ab\u30eb\u30b7\u30cb\u30e5\u30fc\u30ea\u30f3\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3068\u3082\u306b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30a4\u30d9\u30f3\u30c8\u306b\u95a2\u308f\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u904b\u547d\u306e\u6c7a\u5b9a\u304a\u3088\u3073\u904a\u8d70\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u6d3b\u52d5\u3082\u4fc3\u9032\u3057\u307e\u3059\u00a0<sup>*7<\/sup>\u3002<br \/>\n\u6b74\u53f2\u7684\u306b\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306f\u3001\u53e4\u5178\u7684Wnt\u7d4c\u8def\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u6df7\u4e71\u306f\u304c\u3093\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306e\u767a\u75c7\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u975e\u53e4\u5178\u7684Wnt\u7d4c\u8def\u0336 PCP\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u304a\u3088\u3073Wnt\/Ca2+\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u0336\u306f\u3001\u751f\u7269\u5b66\u7684\u72b6\u6cc1\u306b\u3088\u3063\u3066\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u975e\u4f9d\u5b58\u7684\u3042\u308b\u3044\u306fWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u62ee\u6297\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002Wnt\u7d4c\u8def\u3068\u3001\u5897\u6b96\u56e0\u5b50\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u8abf\u7bc0\u3059\u308b\u3088\u3046\u306a\u4ed6\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ce\u30fc\u30c9\u9593\u3067\u9ad8\u30ec\u30d9\u30eb\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u306b\u3064\u3044\u3066\u306f\u8907\u6570\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u500b\u3005\u306eWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6d3b\u6027\u5316\u3059\u308b\u306e\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u7279\u5225\u306a\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u00a0<sup>*7,11<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-98.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3111 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-98.jpg\" alt=\"Wnt\u7d4c\u8def\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u591a\u69d8\u6027\" width=\"817\" height=\"506\" \/><\/a><\/p>\n<h4>Frizzled\u53d7\u5bb9\u4f53<\/h4>\n<p>\u30af\u30e9\u30b9FZD\u53d7\u5bb9\u4f53\u306f\u3001G\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53\u306e\u53e4\u5178\u7684\u30af\u30e9\u30b9A,B, C\u30d5\u30a1\u30df\u30ea\u30fc\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002FZD\u53d7\u5bb9\u4f53\u306fWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001Wnt\u2013FZD\u6d3b\u6027\u5316\u306e\u57fa\u672c\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u30ea\u30ac\u30f3\u30c9\u306e\u9078\u629e\u6027\u306b\u3064\u3044\u3066\u306f\u60c5\u5831\u304c\u4e0d\u8db3\u3057\u3066\u304a\u308a\u3001\u3069\u306e\u3088\u3046\u306aWnt\u2013FZD\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u69d8\u5f0f\u3067\u7279\u7570\u7684\u304b\u3064\u5354\u8abf\u7684\u306bWnt\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u5206\u5c90\u7d4c\u8def\u306b\u304a\u3051\u308b\u4e0b\u6d41\u30a4\u30d9\u30f3\u30c8\u306b\u50cd\u3044\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u3088\u304f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u00a0<sup>*14<\/sup>\u3002<br \/>\n<a href=\"http:\/\/www.thermofisher.com\/fzd?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab10_Social_LAB\" target=\"_blank\" rel=\"noopener\">Frizzled\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u53d7\u5bb9\u4f53\u304a\u3088\u3073\u4ed6\u306eWnt\u7d4c\u8def\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u4e00\u6b21\u6297\u4f53\u304a\u3088\u3073\u4e8c\u6b21\u6297\u4f53\u306a\u3089\u3073\u306b\u30a4\u30e0\u30ce\u30a2\u30c3\u30bb\u30a4\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-99.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3112 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-99.jpg\" alt=\"Frizzled\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a21\u5f0f\u56f3\" width=\"400\" height=\"378\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-28.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3113 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-28.jpg\" alt=\"FZD1\/Fr izzl ed 1 Rabbit Polyclonal Antibody\u3000\" width=\"401\" height=\"654\" \/><\/a><\/p>\n<p><strong>Dishevelled<\/strong><br \/>\nDrosophila\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3001Dvl\u306e\u30db\u30e2\u30ed\u30b0\u3067\u3042\u308bDsh\u306f\u3001\u4f53\u304a\u3088\u3073\u7fc5\u6bdb\u306e\u65b9\u5411\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u304a\u3088\u3073\u30d2\u30c8\u306b\u304a\u3044\u3066\u306f\u3001Dvl\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c3\u7a2e\u985e (DVL1\u30012\u304a\u3088\u30733\uff09\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002Dvl\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7d04750\u30a2\u30df\u30ce\u9178\u304b\u3089\u69cb\u6210\u3055\u308c\u30013\u5206\u306e1\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30c9\u30e1\u30a4\u30f3\u2015N\u672b\u7aef\u306eDvl\u2013AXIN\uff08DIX\uff09\u30c9\u30e1\u30a4\u30f3\u3001\u4e2d\u592e\u306ePDZ\u30c9\u30e1\u30a4\u30f3\u3001\u304a\u3088\u3073C\u672b\u7aef\u306eDvl\u2013Egl-10\u2013\u30d7\u30ec\u30af\u30b9\u30c8\u30ea\u30f3\uff08DEP\uff09\u30c9\u30e1\u30a4\u30f3\u2015\u304c\u4fdd\u5b58\u3055\u308c\u3066\u304a\u308a\u3001\u5e83\u7bc4\u306a\u7d30\u80de\u8cea\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u307e\u3059\u3002Dvl\u306f\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6b63\u306e\u5236\u5fa1\u56e0\u5b50\u304a\u3088\u3073\u8ca0\u306e\u5236\u5fa1\u56e0\u5b50\u306b\u7d50\u5408\u3059\u308b\u4ed6\u306b\u591a\u69d8\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u30a2\u30ec\u30a4\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u307e\u3059\uff08\u88685.2\uff09<sup>*9<\/sup>\u3002<br \/>\nWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u304a\u3044\u3066\u3001Dvl\u306f\u91cd\u5408\u3057\u3001Wnt\/FZD\/LRP5\/6\u30b7\u30b0\u30ca\u30ed\u30bd\u30fc\u30e0\u306e\u30de\u30eb\u30c1\u30e6\u30cb\u30c3\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u30af\u30e9\u30b9\u30bf\u30fc\u3068\u9023\u643a\u3057\u3066\u4e0b\u6d41\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u3078\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u819c\u8fd1\u4f4d\u306e\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u306e\u5f79\u5272\u306b\u52a0\u3048\u3001Dsh\/Dvl\u306b\u306f\u6838\u8f38\u9001\u914d\u5217\u304a\u3088\u3073\u6838\u79fb\u884c\u914d\u5217\u304c\u542b\u307e\u308c\u3001\u6838\u306b\u304a\u3051\u308b\u8ee2\u5199\u6a5f\u80fd\u3092\u5a92\u4ecb\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u306b\u304a\u3044\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u00a0<sup>*9<\/sup>\u3002<br \/>\n<a href=\"http:\/\/www.thermofisher.com\/dvl?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab10_Social_LAB\" target=\"_blank\" rel=\"noopener\">DVL\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u4e00\u6b21\u6297\u4f53\u304a\u3088\u3073\u4e8c\u6b21\u6297\u4f53\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-100.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3114 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-100.jpg\" alt=\"\u4ee3\u8868\u7684\u306aDvl-\u76f8\u4e92\u4f5c\u7528\u30bf\u30f3\u30d1\u30af\u8cea\" width=\"401\" height=\"320\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-29.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3115 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-29.jpg\" alt=\"DVL1 Rabbit Pol yclonal Antibody\" width=\"402\" height=\"609\" \/><\/a><\/p>\n<h4>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u6d3b\u6027\u5316\u6a5f\u69cb<\/h4>\n<p>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306e\u5236\u5fa1\u6a5f\u69cb\u306f\u975e\u5e38\u306b\u8907\u96d1\u3067\u3059\u3002\u03b2-\u30ab\u30c6\u30cb\u30f3\u306f\u3001Drosophila\uff08\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\uff09\u5c5e\u3067\u6700\u521d\u306b\u767a\u898b\u3055\u308c\u305f\u3001\u4e00\u9023\u306e\u6838\u3068\u306a\u308b\u767a\u751f\u95a2\u9023\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u90e8\u3067\u3059\u00a0<sup>*15,16<\/sup> \u3002\u30ab\u30c6\u30cb\u30f3\uff08\u03b1\u3001\u03b2\u3001\u304a\u3088\u3073\u03b3\uff09\u306f\u3001Ca2+-\u4f9d\u5b58\u6027\u7d30\u80de\u9593\u63a5\u7740\u3092\u5a92\u4ecb\u3059\u308bE-\u30ab\u30c9\u30d8\u30ea\u30f3\u304c\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u8cea\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u904d\u5728\u7684\u306b\u767a\u73fe\u3057\u307e\u3059\u3002\u30ab\u30c9\u30d8\u30ea\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7d30\u80de\u5897\u6b96\u304a\u3088\u3073\u7d30\u80de\u9593\u63a5\u7740\u306e\u5236\u5fa1\u306b\u3088\u308b\u4e0a\u76ae\u7d30\u80de\u5c64\u306e\u5f62\u6210\u304a\u3088\u3073\u7dad\u6301\u306b\u5fc5\u8981\u306a\u63a5\u7740\u7d50\u5408\u306e\u5f62\u6210\u306b\u90e8\u5206\u7684\u306b\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\u3002\u03b2-\u30ab\u30c6\u30cb\u30f3\u0336Drosophila \u30a2\u30eb\u30de\u30b8\u30ed\u306e\u54fa\u4e73\u985e\u30db\u30e2\u30ed\u30b0\u0336\u306f\u307e\u305f\u3001\u30a2\u30af\u30c1\u30f3\u9aa8\u683c\u3092\u7e4b\u7559\u3057\u3001\u4e0a\u76ae\u30b7\u30fc\u30c8\u304c\u5b8c\u6210\u3057\u305f\u969b\u306b\u7d30\u80de\u306e\u5206\u5316\u3092\u505c\u6b62\u3055\u305b\u308b\u63a5\u89e6\u963b\u6b62\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u9054\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u03b2-\u30ab\u30c6\u30cb\u30f3\u306f\u3001E-\u30ab\u30c9\u30d8\u30ea\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u4ed6\u306b\u3001N-\u30ab\u30c9\u30d8\u30ea\u30f3\u3001\u03b1-\u30ab\u30c6\u30cb\u30f3\u304a\u3088\u3073\u816b\u760d\u6291\u5236\u56e0\u5b50\u907a\u4f1d\u5b50\u7523\u7269APC\uff08\u5927\u8178\u817a\u816b\u75c7\uff09\u306a\u3069\u306e\u3044\u304f\u3064\u304b\u306e\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u00a0<sup>*17<\/sup> \u3002\u53e4\u5178\u7684Wnt\/\u03b2- \u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u304c\u30aa\u30f3\u72b6\u614b\u306b\u304a\u3044\u3066\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306f\u3001\u8907\u6570\u306e\u30b5\u30a4\u30c8\u30be\u30eb\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u307e\u3059\uff08\u56f35.4\uff09\u00a0<sup>*15<\/sup>\u3002<\/p>\n<p>\u30aa\u30d5\u72b6\u614b\u3067\u306f\u3001\u7d30\u80de\u8cea\u304a\u3088\u3073\u6838\u306e\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u30ec\u30d9\u30eb\u306f\u4f4e\u304f\u3001\u7d30\u80de\u5916Wnt\u306e\u5206\u6ccc\u578bFrizzled\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\uff08sFRP\uff09\u304a\u3088\u3073Dickkopf\uff08DKK\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u3078\u306e\u7d50\u5408\u306b\u3088\u3063\u3066\u3001\u3053\u306e\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u304c\u59a8\u3052\u3089\u308c\u307e\u3059\u3002Wnt\u30ea\u30ac\u30f3\u30c9\u306e\u5b58\u5728\u6bd4\u304cFRP\u3084DKK\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u306e\u963b\u5bb3\u5264\u306e\u5b58\u5728\u6bd4\u3092\u4e0a\u56de\u308b\u3068\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u6d3b\u6027\u5316\u304c\u751f\u3058\u307e\u3059\u3002Wnt\u304cLRP5\/6\u306b\u7d50\u5408\u3059\u308b\u3068\u3068\u3082\u306b\u3001FZD\u53d7\u5bb9\u4f53\u3092\u5360\u62e0\u3059\u308b\u3068\u3001Dvl\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u52d5\u54e1\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30a4\u30d9\u30f3\u30c8\u306b\u7d9a\u3044\u3066\u3001AXIN\u304a\u3088\u3073\u5206\u89e3\u8907\u5408\u4f53\u304c\u7d30\u80de\u819c\u306b\u52d5\u54e1\u3055\u308c\u3001\u305d\u3053\u3067\u3001AXIN\u306e\u5206\u89e3\u304a\u3088\u3073GSK-3\u03b2\u306e\u963b\u5bb3\u304c\u3068\u3082\u306b\u30b5\u30a4\u30c8\u30be\u30eb\u03b2-\u30ab\u30c6\u30cb\u30f3\u6fc3\u5ea6\u306e\u4e0a\u6607\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u84c4\u7a4d\u304a\u3088\u3073\u305d\u306e\u6838\u5185\u79fb\u884c\u306f\u3001\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u3001DNA\u306b\u7d50\u5408\u3059\u308bTCF\/LEF\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u4fc3\u9032\u3057\u307e\u3059\uff08\u56f35.5\uff09\u3002\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306f\u3001\u591a\u7a2e\u591a\u69d8\u306a\u7d30\u80de\u30bf\u30a4\u30d7\u304a\u3088\u3073\u7d44\u7e54\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002TCF\/LEF\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u4ee3\u8868\u4f8b\u3092\u8868 5.3\u306b\u793a\u3057\u307e\u3059\u00a0<sup>*15<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3116 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-101.jpg\" alt=\"Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u5236\u5fa1\u306b\u95a2\u9023\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\" width=\"405\" height=\"625\" \/>APC\u306f\u3001Wnt\u7d4c\u8def\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u91cd\u8981\u306a\u5236\u5fa1\u56e0\u5b50\u3067\u3001conductin\u3092\u542b\u3080\u69cb\u9020\u6210\u5206\u306e\u7d30\u80de\u9593\u7d50\u5408\u306b\u95a2\u4e0e\u3057\u3001\u03b2-\u304a\u3088\u3073\u03b3-\u30ab\u30c6\u30cb\u30f3\u306e\u7279\u5b9a\u306e\u5185\u90e8\u9818\u57df\u3078\u306e\u7d50\u5408\u306b\u304a\u3044\u3066E-\u30ab\u30c9\u30d8\u30ea\u30f3\u3068\u7af6\u5408\u3057\u307e\u3059\u3002APC\u306f\u3001\u6d3b\u6027\u578b\u03b2-\u30ab\u30c6\u30cb\u30f3\u2013TCF\u8907\u5408\u4f53\u306e\u5f62\u6210\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002APC\u306f\u3001\u660e\u78ba\u306b\u306a\u3063\u3066\u3044\u308b\u816b\u760d\u6291\u5236\u56e0\u5b50\u3067\u3001APC\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u55aa\u5931\u307e\u305f\u306f\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308b\u751f\u6b96\u7d30\u80de\u7cfb\u5217\u5909\u7570\u306f\u5927\u8178\u304a\u3088\u3073\u76f4\u8178\u306e\u304c\u3093\u306b\u95a2\u4e0e\u3059\u308b\u5bb6\u65cf\u6027\u5927\u8178\u817a\u816b\u75c7\uff08FAP\uff09\u306b\u95a2\u9023\u3057\u307e\u3059\u00a0<sup>*18<\/sup>\u3002 APC\u306b\u304a\u3051\u308b\u4f53\u7d30\u80de\u5909\u7570\u306f\u3001\u80ba\u3001\u4e73\u623f\u3001\u7d50\u8178\u3001\u76f4\u8178\u3001\u304a\u3088\u3073\u4ed6\u306e\u5668\u5b98\u306e\u60aa\u6027\u816b\u760d\u306b\u3082\u95a2\u9023\u3057\u307e\u3059\u00a0<sup>*19,20<\/sup>\u3002<br \/>\n\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u5408\u6210\u9175\u7d20\u30ad\u30ca\u30fc\u30bc3\uff08GSK-3\uff09\u306f\u30012\u7a2e\u985e\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\uff08\u03b1\u304a\u3088\u3073\u03b2\uff09\u3092\u6709\u3059\u308b\u591a\u6a5f\u80fd\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u3001\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u4ee3\u8b1d\u306b\u304a\u3051\u308b\u9375\u3068\u306a\u308b\u9175\u7d20\u3068\u3057\u3066\u6700\u521d\u306b\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001GSK-3\u306f\u7d30\u80de\u5206\u88c2\u3001\u5897\u6b96\u3001\u904b\u52d5\u6027\u3001\u304a\u3088\u3073\u751f\u5b58\u306b\u304a\u3044\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002GSK-3\u306f\u3001\u304c\u3093\u3001\u7cd6\u5c3f\u75c5\u3001\u304a\u3088\u3073\u7279\u5b9a\u306e\u795e\u7d4c\u969c\u5bb3\u306a\u3069\u306e\u6570\u591a\u304f\u306e\u75c5\u614b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u304a\u3044\u3066\u3001APC\u304a\u3088\u3073GSK-3\u03b2\u306f\u3068\u3082\u306b\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8ceaAXIN\u306b\u52d5\u54e1\u3055\u308c\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u8ca0\u306e\u5236\u5fa1\u56e0\u5b50\u3068\u3057\u3066\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\u00a0<sup>*20,21<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-102.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3117 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-102.jpg\" alt=\"TCF\/LEF\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u4ee3\u8868\u4f8b\" width=\"807\" height=\"159\" \/><\/a><\/p>\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002<br \/>\n\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/antibody-cancer-guidebook-form.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab10_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<h2>\u304c\u3093\u306b\u304a\u3051\u308bWnt\u7d4c\u8def<\/h2>\n<h4>Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u8abf\u7bc0\u4e0d\u5168<\/h4>\n<p>\u304c\u3093\u306b\u304a\u3051\u308bWnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u8abf\u7bc0\u4e0d\u5168\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u306f\u5341\u5206\u306b\u7acb\u8a3c\u3055\u308c\u3066\u304a\u308a\u3001\u304c\u3093\u306b\u304a\u3051\u308bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u8abf\u7bc0\u4e0d\u5168\u306b\u3064\u306a\u304c\u308b\u3055\u307e\u3056\u307e\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u7814\u7a76\u8005\u306b\u3088\u3063\u3066\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002APC\u306b\u95a2\u4e0e\u3059\u308b\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\u306f\u3001\u5206\u89e3\u8907\u5408\u4f53\u306e\u5206\u89e3\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u6301\u7d9a\u7684\u306a\u84c4\u7a4d\u3001\u304a\u3088\u3073Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u308b\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u69cb\u6210\u7684\u767a\u73fe\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002\u03b2-\u30ab\u30c6\u30cb\u30f3\u306b\u304a\u3051\u308b\u5909\u7570\u306e\u6d3b\u6027\u5316\u306f\u3001\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3092\u4ecb\u3059\u308b\u03b2-\u30ab\u30c6\u30cb\u30f3\u5206\u89e3\u3092\u59a8\u3052\u3001FZD\u53d7\u5bb9\u4f53\u307e\u305f\u306fWnt\u30ea\u30ac\u30f3\u30c9\u306e\u904e\u5270\u767a\u73fe\u306e\u7d50\u679c\u3068\u3057\u3066\u3001\u7121\u5236\u5fa1\u306a\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6700\u7d42\u7684\u306b\u3001\u5206\u6ccc\u578bFZD-\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u304a\u3051\u308b\u6df7\u4e71\u306b\u95a2\u4e0e\u3059\u308bWnt\u30ea\u30ac\u30f3\u30c9\u963b\u5bb3\u306e\u6e1b\u5c11\u306f\u3001\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306e\u5897\u52a0\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u00a0<sup>*22<\/sup>\u3002<\/p>\n<p>Wnt\u7d4c\u8def\u306b\u95a2\u3059\u308b\u8907\u96d1\u3055\u306f\u3001\u60aa\u6027\u816b\u760d\u306e\u8a98\u767a\u306b\u3064\u3044\u3066\u6570\u591a\u304f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3001Wnt\u7d4c\u8def\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002Wnt\u7d4c\u8def\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e88\u60f3\u901a\u308a\u306b\u8abf\u7bc0\u3059\u308b\u80fd\u529b\u304c\u597d\u90fd\u5408\u3067\u3042\u308b\u3053\u3068\u306f\u5b9f\u8a3c\u53ef\u80fd\u306a\u3053\u3068\u3067\u3059\u304c\u3001\u7814\u7a76\u8005\u306f\u9650\u3089\u308c\u305f\u6210\u679c\u3057\u304b\u6319\u3052\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u306e\u4e00\u56e0\u3068\u3057\u3066\u3001\u7814\u7a76\u5bfe\u8c61\u306e\u7d4c\u8def\u3092\u52b9\u7387\u7684\u306b\u963b\u5bb3\u3059\u308b\u305f\u3081\u306e\u5229\u7528\u53ef\u80fd\u306a\u85ac\u5264\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u4ed6\u306b\u3082Wnt\u6a19\u7684\u7642\u6cd5\u306e\u958b\u767a\u3092\u56f0\u96e3\u306b\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u8981\u56e0\u304c\u5b58\u5728\u3057\u307e\u3059\u00a0<sup>*20,22\u201324<\/sup>\u3002<\/p>\n<ul>\n<li>\u00a0\u591a\u6570\u306eWnt\u30ea\u30ac\u30f3\u30c9\u304a\u3088\u3073\u7d4c\u8def-\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\uff08i.e., Wnt\u30ea\u30ac\u30f3\u30c9\u3001Dvl\u304a\u3088\u3073FZD\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3089\u3073\u306b\u4ed6\u306e\u7d4c\u8def\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\uff09\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u7d4c\u8def\u5185\u306b\u6a5f\u80fd\u7684\u5197\u9577\u6027\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u3067\u5b58\u5728\u3059\u308b<\/li>\n<li>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30ab\u30b9\u30b1\u30fc\u30c9 (\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u7d4c\u8def\u3068\u306e\u95a2\u9023\u6027\uff09\u306f\u904d\u5728\u3057\u3001\u6210\u4f53\u7d44\u7e54\u306b\u898b\u3089\u308c\u308b\u9020\u8840\u5e79\u7d30\u80de\u304a\u3088\u3073\u5e79\u7d30\u80de\u3092\u542b\u3080\u3001\u4f53\u5185\u306e\u6570\u591a\u304f\u306e\u7d30\u80de\u30bf\u30a4\u30d7\u304a\u3088\u3073\u7d44\u7e54\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3002<\/li>\n<li>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u8abf\u7bc0\u4e0d\u5168\u306f\u7d4c\u6642\u7684\u306b\u5909\u5316\u3057\u5f97\u308b\uff1a\u816b\u760d\u5f62\u6210\u521d\u671f\u306b\u751f\u3058\u308bWnt\u4f9d\u5b58\u7684\u306a\u30a4\u30d9\u30f3\u30c8\u306f\u3001\u816b\u760d\u9032\u884c\u304c\u9032\u3080\u306e\u306b\u5f93\u3044\u3001Wnt\u6a19\u7684\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u6b20\u5982\u3055\u305b\u308b\u65b9\u6cd5\u306b\u3088\u3063\u3066\u5909\u5316\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b<\/li>\n<li>\u304c\u3093\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306b\u95a2\u3059\u308b\u77e5\u8b58\u306e\u6b20\u5982\u3068\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u963b\u5bb3\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u5206\u5b50\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u95a2\u3059\u308b\u7406\u89e3\u306e\u6b20\u5982\u304c\u3001\u5275\u85ac\u52aa\u529b\u306e\u59a8\u3052\u3068\u306a\u308a\u5f97\u308b<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-103.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3118 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-103.jpg\" alt=\"APC\uff08Adenomatous Polyposis Coli\uff09Rabbit Polyclonal Antibody\" width=\"401\" height=\"757\" \/><\/a><\/p>\n<h4>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u7d4c\u8def\u304c\u95a2\u4e0e\u3059\u308b\u524d\u81e8\u5e8a\u5b9f\u9a13<\/h4>\n<p>\u5927\u591a\u6570\u306e\u524d\u81e8\u5e8a\u304c\u3093\u30e2\u30c7\u30eb\u3067\u306f\u3001\u6052\u5e38\u7684\u306aWnt\u6d3b\u6027\u5316\u3068\u816b\u760d\u7d30\u80de\u306e\u9032\u884c\u3068\u306e\u95a2\u4fc2\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u76f8\u53cd\u3059\u308b\u5831\u544a\u3082\u5b58\u5728\u3057\u307e\u3059\u3002\u30d2\u30c8\u816b\u760d\u30b5\u30f3\u30d7\u30eb\u3092\u89e3\u6790\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u8a66\u9a13\u3067\u306f\u3001Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6d3b\u6027\u5316\u304a\u3088\u3073\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u767a\u73fe\u5897\u52a0\u3068\u4e88\u5f8c\u6539\u5584\u3068\u306e\u76f8\u95a2\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002Wnt\u306f\u7d30\u80de\u5206\u5316\u304a\u3088\u3073\u7d30\u80de\u904b\u547d\u6c7a\u5b9a\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u4e00\u8aac\u3067\u306f\u3001\u3053\u306e\u9006\u8aac\u7684\u306a\u77e5\u898b\u306f\u3001\u60aa\u6027\u7d30\u80de\u306b\u304a\u3051\u308bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u6642\u9593\u7684\u30fb\u7a7a\u9593\u7684\u306a\u7d30\u80de\u72b6\u6cc1\u306f\u6a5f\u80fd\u7684\u5e30\u7d50\u306b\u5f71\u97ff\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u305f\u3081\u3001Wnt\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u72b6\u6cc1\u306f\u3053\u306e\u7d4c\u8def\u304c\u816b\u760d\u6291\u5236\u307e\u305f\u306f\u767a\u304c\u3093\u904e\u7a0b\u306e\u3044\u305a\u308c\u3092\u8a98\u5c0e\u3059\u308b\u304b\u3092\u6c7a\u5b9a\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u00a0<sup>*25<\/sup>\u3002<\/p>\n<p>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u5909\u7570\u3092\u6301\u3064\u816b\u760d\u3092\u7279\u7570\u7684\u306b\u6a19\u7684\u3068\u3059\u308b\u627f\u8a8d\u6e08\u307f\u306e\u6cbb\u7642\u85ac\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u304c\u3001\u3053\u306e\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u6a19\u7684\u3068\u3059\u308b\u5b9f\u73fe\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u691c\u8a0e\u3059\u308b\u305f\u3081\u306e\u521d\u671f\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u958b\u59cb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6297FZD7\u30d2\u30c8\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306e\u30d0\u30f3\u30c1\u30af\u30c4\u30de\u30d6\u306f\u3001\u9032\u884c\u6027\u56fa\u5f62\u816b\u760d\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5316\u5b66\u7642\u6cd5\u3068\u306e\u4f75\u7528\u306b\u3064\u3044\u3066\u7b2cI\u76f8\u8a66\u9a13\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u307e\u3059\u00a0<sup>*26<\/sup> \u3002\u540c\u69d8\u306b\u3001\u751f\u7269\u5b66\u7684Wnt\u963b\u5bb3\u5264\u0336FZD8-Fc\u878d\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u0336\u306b\u3064\u3044\u3066\u306f\u3001\u627f\u8a8d\u6e08\u307f\u306e\u6297\u304c\u3093\u6cbb\u7642\u85ac\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306b\u3088\u308b\u56fa\u5f62\u816b\u760d\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u7b2cI\u76f8\u7528\u91cf\u6f38\u5897\u8a66\u9a13\u306b\u304a\u3044\u3066\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306e\u8a55\u4fa1\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u00a0<sup>*27,28<\/sup>\u3002<\/p>\n<p>\u524d\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u9650\u5b9a\u3055\u308c\u305f\u5316\u5b66\u7684\u5316\u5408\u7269\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u304a\u3044\u3066\u3001\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308bWnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u963b\u5bb3\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3088\u308a\u6709\u52b9\u306a\u963b\u5bb3\u5264\u3092\u8abf\u67fb\u3059\u308b\u7814\u7a76\u8a66\u9a13\u304c\u7d99\u7d9a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u8907\u96d1\u306a\u7d4c\u8def\u306e\u5236\u5fa1\u6a5f\u69cb\u306e\u7406\u89e3\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u3001\u3053\u306e\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u304c\u51fa\u73fe\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u00a0<sup>*29,30<\/sup>\u3002<\/p>\n<p><a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab10_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u5f53\u793e\u306f\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\/Wnt\u7d4c\u8def\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5e45\u5e83\u3044\u4e00\u6b21\u6297\u4f53\u304a\u3088\u3073\u4e8c\u6b21\u6297\u4f53\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u5e83\u7bc4\u306a\u88fd\u54c1\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306b\u3064\u3044\u3066\u306f \u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p>\u03b2-\u30ab\u30c6\u30cb\u30f3\u306f\u3001\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u304a\u3088\u3073\u63a5\u7740\u3001\u306a\u3089\u3073\u306b\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u7d30\u80de\u5f62\u614b\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u6838\u306b\u304a\u3044\u3066\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306f\u3001\u7d30\u80de\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u30b5\u30a4\u30af\u30ea\u30f3D\u304a\u3088\u3073c-myc\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3092\u542b\u3080\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u4fc3\u9032\u3059\u308bLEF\/TCF\u8ee2\u5199\u56e0\u5b50\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u540c\u6642\u306b\u6d3b\u6027\u5316\u3059\u308b\u3088\u3046\u306b\u50cd\u304d\u307e\u3059\u3002\u5897\u6b96\u3078\u306e\u3053\u306e\u5f71\u97ff\u306f\u3001\u7279\u306b\u3001\u4e73\u623f\u3001\u7d50\u8178\u3001\u809d\u81d3\u3001\u80ba\u3001\u80c3\u3001\u524d\u7acb\u817a\u3001\u304a\u3088\u3073\u76ae\u819a\u306e\u56fa\u5f62\u816b\u760d\u306e\u816b\u760d\u5f62\u6210\u306b\u304a\u3051\u308b\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u5f79\u5272\u306e\u5206\u5b50\u57fa\u76e4\u3067\u3059\u00a0<sup>*31,32<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-104.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3119 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-104.jpg\" alt=\"NIH\/3T3\uff08\u4e0d\u6b7b\u5316\u30de\u30a6\u30b9\u80ce\u4ed4\u7dda\u7dad\u82bd\u7d30\u80de\uff09\u7d30\u80de\u306e\u514d\u75ab\u86cd\u5149\u5206\u6790\" width=\"403\" height=\"295\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-30.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3120 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-30.jpg\" alt=\"FZD8\/frizzled 8 Goat Polyclonal Antibody\" width=\"402\" height=\"206\" \/><\/a> <img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3121 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/3-6.jpg\" alt=\"\u03b2-catenin Mouse Monoclonal Antibody (15B8)\u3000\" width=\"404\" height=\"722\" \/><\/p>\n<h2>\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af<\/h2>\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002\u4e0b\u8a18\u306e\u5185\u5bb9\u3092\u542b\u3080PDF\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n<p>\uff5e\u4e3b\u306a\u5185\u5bb9\uff5e<\/p>\n<ol>\n<li>\u304c\u3093\u6982\u8ad6<\/li>\n<li>\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/li>\n<li>PI3K\/Akt\/mTOR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/li>\n<li>Ras\/Raf\/MEK\/ERK(MAPK)\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/li>\n<li>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3 \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/li>\n<li>\u6297\u4f53\uff1a\u304c\u3093\u7814\u7a76\u306e\u305f\u3081\u306e\u5354\u529b\u306a\u30c4\u30fc\u30eb<\/li>\n<\/ol>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/antibody-cancer-guidebook-form.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab10_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<h2>\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011\u304c\u3093\u7814\u7a76\u3092\u4fc3\u9032\u3055\u305b\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u30cf\u30f3\u30c9\u30d6\u30c3\u30af<\/h2>\n<p>\u307e\u305f\u3001\u8907\u6570\u306e\u304c\u3093\u7814\u7a76\u9818\u57df\u306b\u304a\u3051\u308b\u8208\u5473\u6df1\u3044\u6700\u65b0\u306e\u767a\u898b\u3092\u53ef\u80fd\u306b\u3059\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3092\u7d39\u4ecb\u3059\u308b\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3082\u914d\u5e03\u3057\u3066\u3044\u307e\u3059\u3002\u4f75\u305b\u3066\u3054\u3089\u3093\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/cancer-genetic-tech-ebook-download.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab10_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/p>\n<p><span style=\"font-size: 8pt\">\u53c2\u8003\u6587\u732e\uff1a<br \/>\n1. Bejsovec A (2006) Flying at the head of the pack: Wnt biology in Drosophila. Oncogene 25(57):7442\u20137449.<br \/>\n2. Miller JR (2002) The Wnts. Genome Biol 3(1):REVIEWS3001.<br \/>\n3. Nusse R, Varmus HE (1992) Wnt genes. Cell 69(7):1073\u20131087.<br \/>\n4. Cadigan KM, Nusse R (1997) Wnt signaling: a common theme in animal development. Genes Dev\u00a011(24):3286\u20133305.<br \/>\n5. Simons M, Mlodzik M (2008) Planar cell polarity signaling: from fly development to human disease. Annu\u00a0Rev Genet 42:517\u2013540.<br \/>\n6. Clevers H (2006) Wnt\/beta-catenin signaling in development and disease. Cell 127(3):469\u2013480.<br \/>\n7. Niehrs C (2012) The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol 13(12):767\u2013779.<br \/>\n8. Nusse R (2014) The Wnt homepage: Human Wnt genes. http:\/\/web.stanford.edu\/group\/nusselab\/cgi-bin\/wnt\/human<br \/>\n9. Gao C, Chen YG (2010) Dishevelled: the hub of Wnt signaling. Cell Signal 22(5):717\u2013727.<br \/>\n10. Olmeda D, Castel S, Vilar\u00f3 S, Cano A (2003) Beta-catenin regulation during the cell cycle: implications in\u00a0G2\/M and apoptosis. Mol Biol Cell 14(7):2844\u20132860.<br \/>\n11. Thompson M, Nejak-Bowen K, Monga SPS (2011) Crosstalk of the Wnt Signaling Pathway. In: Gross KH,\u00a0Kahn M (editors), Targeting the Wnt Pathway in Cancer. New York (NY): Springer. pp 51\u201380.<br \/>\n12. Schulte G, Bryja V (2007) The Frizzled family of unconventional G protein-couple receptors. Trends\u00a0Pharmacol Sci 28(10):518\u2013525.<br \/>\n13. Macor JE, editor (2012) Annual Reports in Medicinal Chemistry, Volume 47. San Diego (CA): Academic\u00a0Press.<br \/>\n14. Dijksterhuis JP, Petersen J, Schulte G (2014) WNT\/Frizzled signalling: receptor-ligand selectivity with focus on\u00a0FZD-G protein signalling and its physiological relevance: IUPHAR Review 3. Br J Pharmacol 171(5):1195\u20131209.<br \/>\n15. Moon RT, Kohn AD, De Ferrari GV, Kaykas A (2004) WNT and beta-catenin signalling: diseases and\u00a0therapies. Nat Rev Genet 5(9):691\u2013701.<br \/>\n16. Clevers H, Nusse R (2012) Wnt\/ -catenin signaling and disease. Cell 149(6):1192\u20131205.<br \/>\n17. Thorstensen L, Lothe RA (2003) The WNT signaling pathway and its role in human solid tumors.\u00a0Atlas Genet Cytogenet Oncol Haematol 7(2):144\u2013159. http:\/\/atlasgeneticsoncology.org\/Deep\/WNTSignPathID20042.html<br \/>\n18. National Library of Medicine (US), Genetics Home Reference website (2012) Familial adenomatous\u00a0polyposis. http:\/\/ghr.nlm.nih.gov\/condition\/familial-adenomatous-polyposis<br \/>\n19. Virmani AK, Rathi A, Sathyanarayana UG, et al. (2001) Aberrant methylation of the adenomatous polyposis\u00a0coli (APC) gene promoter 1A in breast and lung carcinomas. Clin Cancer Res 7(7):1998\u20132004.<br \/>\n20. Polakis P (2012) Wnt signaling in cancer. Cold Spring Harb Perspect Biol 4(5).<br \/>\n21. Luo J (2009) Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy.\u00a0Cancer Lett 273(2):194\u2013200.<br \/>\n22. Voronkov A, Krauss S (2013) Wnt\/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des\u00a019(4):634\u2013664.<br \/>\n23. Gurney A, Axelrod F, Bond CJ, et al. (2012) Wnt pathway inhibition via the targeting of Frizzled\u00a0receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A\u00a0109(29):11717\u201311722.<br \/>\n24. Chien AJ, Dawson DW (2014) Wnt signaling pathways in cancer: a new hope. ASCO Daily News. May 31,\u00a02014. p 4C.<br \/>\n25. Lucero OM, Dawson DW, Moon RT, Chien AJ (2010) A re-evaluation of the \u201concogenic\u201d nature of Wnt\/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep 12(5):314\u2013318.<br \/>\n26. ClinicalTrials.gov website (2015) Vantictumab. https:\/\/clinicaltrials.gov\/ct2\/results?term=vantictumab&amp;Search=Search<br \/>\n27. National Cancer Institute (US) website (2015) NCI drug dictionary entry: Fzd8 fusion protein OMP-54F28.\u00a0http:\/\/www.cancer.gov\/drugdictionary?cdrid=734935<br \/>\n28. ClinicalTrials.gov website (2015) OMP-54F28. https:\/\/clinicaltrials.gov\/ct2\/results?term=OMP-54F28&amp;Search=Search<br \/>\n29. Liu J, Pan S, Hsieh MH, et al. (2013) Targeting Wnt-driven cancer through the inhibition of Porcupine by\u00a0LGK974. Proc Natl Acad Sci U S A 110(50):20224\u201320229.<br \/>\n30. Hitt E (2013) Wnt signaling inhibition: will decades of effort be fruitful at last? OncLive website. http:\/\/www.onclive.com\/publications\/oncology-live\/2012\/december-2012\/wnt-signaling-inhibition-will-decades-ofeffort-be-fruitful-at-last\/2<br \/>\n31. Sampson EM, Haque ZK, Ku MC, et al. (2001) Negative regulation of the Wnt-beta-catenin pathway by the\u00a0transcriptional repressor HBP1. EMBO J 20(16):4500\u20134511.<br \/>\n32. Polakis P (2007) The many ways of wnt in cancer. Curr Opin Genet Dev 17(1):45\u201351.<br 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