{"id":1072,"date":"2018-12-19T00:00:00","date_gmt":"2018-12-19T00:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/"},"modified":"2023-12-27T17:47:15","modified_gmt":"2023-12-27T08:47:15","slug":"neuro_disease1","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/","title":{"rendered":"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b"},"content":{"rendered":"\n<h2>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6982\u8ad6<\/h2>\n<p>\u795e\u7d4c\u5909\u6027\u3068\u306f\u3001\u7d30\u80de\u306e\u69cb\u9020\u304a\u3088\u3073\u6a5f\u80fd\u306e\u640d\u5931\u3092\u304d\u305f\u3057\u3066\u3044\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u6307\u3059\u4e00\u822c\u7684\u7528\u8a9e\u3067\u3059\u00a0<sup>*1<\/sup> \u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u4f8b\u3068\u3057\u3066\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff08PD\uff09\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u3001\u304a\u3088\u3073\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\uff08ND\uff09\u306f\u6d88\u8017\u6027\u75be\u60a3\u3067\u3001\u5168\u4e16\u754c\u306e\u7f79\u60a3\u8005\u6570\u306f\u6025\u5897\u3057\u7d9a\u3051\u3066\u3044\u307e\u3059\u00a0<sup>*2,3<\/sup> \u3002\u6700\u65b0\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u75be\u60a3\u306e\u521d\u671f\u6bb5\u968e\u306b\u7834\u58ca\u3055\u308c\u308b\u7279\u5b9a\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u304a\u3088\u3073\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4f8b\u3068\u3057\u3066\u3001AD\u306b\u304a\u3044\u3066\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3059\u308b\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u306b\u5bfe\u3059\u308b\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\u3084\u3001PD\u306b\u5bfe\u3059\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u4f5c\u52d5\u85ac\u304c\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u3088\u304f\u3066\u3082\u75c7\u72b6\u3092\u8efd\u6e1b\u3059\u308b\u3060\u3051\u3067\u3001\u6839\u672c\u7684\u306a\u75c5\u72b6\u306b\u5bfe\u51e6\u3057\u305f\u308a\u3001\u75be\u60a3\u7d4c\u904e\u3092\u6709\u610f\u306b\u7de9\u548c\u3042\u308b\u3044\u306f\u9045\u5ef6\u3055\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u795e\u7d4c\u306e\u4fdd\u8b77\u304a\u3088\u3073\u518d\u751f\u306b\u3064\u306a\u304c\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u6025\u52d9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30d2\u30c8\u80da\u6027\u5e79\u7d30\u80de\uff08ESC\uff09\u3084\u4eba\u5de5\u591a\u80fd\u6027\u7d30\u80de\uff08iPSC\uff09\u3092\u30d9\u30fc\u30b9\u3068\u3059\u308b\u3088\u3046\u306a\u7d30\u80de\u7f6e\u63db\u7642\u6cd5\u304c\u3001\u69d8\u3005\u306aND\u306e\u6cbb\u7642\u3092\u6210\u529f\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u795e\u7d4c\u708e\u75c7\u306f\u795e\u7d4c\u5909\u6027\u969c\u5bb3\u306e\u751f\u7406\u75c5\u7406\u5b66\u306b\u57fa\u672c\u7684\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u795e\u7d4c\u708e\u75c7\u53cd\u5fdc\u3092\u8abf\u7bc0\u3059\u308b\u6226\u7565\u304c\u65b0\u3057\u3044\u6cbb\u7642\u306e\u9078\u629e\u80a2\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u00a0<sup>*3,4\u00a0<\/sup>\u3002<br \/>\n\u672c\u8a18\u4e8b\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6982\u8ad6\u3092\u63d0\u4f9b\u3057\u3001\u65b0\u898f\u304a\u3088\u3073\u65b0\u8208\u306e\u6280\u8853\u306a\u3089\u3073\u306b\u3055\u3089\u306a\u308b\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u3092\u53ef\u80fd\u3068\u3059\u308b\u6297\u4f53\u30d9\u30fc\u30b9\u306e\u30c4\u30fc\u30eb\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u7d39\u4ecb\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u203b<span style=\"text-decoration: underline\">\u672c\u8a18\u4e8b\u306e\u672b\u5c3e\u306b\u304a\u3044\u3066\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u3064\u3044\u3066\u4f53\u7cfb\u7684\u306b\u5b66\u3079\u308b\u7121\u6599\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h4>\u4e00\u822c\u7d71\u8a08<\/h4>\n<p>\u5168\u4e16\u754c\u3067\u6570\u767e\u4e07\u4eba\u304c\u4f55\u3089\u304b\u306eND\u306b\u7f79\u60a3\u3057\u3066\u3044\u307e\u3059\u30025 AD\u304a\u3088\u3073PD\u306e\u7f79\u60a3\u7387\u304c\u6700\u3082\u9ad8\u304f\u3001\u7c73\u56fd\u3067\u306f\u305d\u308c\u305e\u308c500\u4e07\u4eba\u4ee5\u4e0a\u304a\u3088\u3073\u6700\u5927100\u4e07\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u307e\u3059\uff08\u88681.1\uff09\u3002\u4f55\u3089\u304b\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3092\u6301\u3064\u60a3\u8005\u306e\u6570\u306f\u4e0a\u6607\u3057\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u300165\u6b73\u4ee5\u4e0a\u306eAD\u7f79\u60a3\u8005\u306f\u30012050\u5e74\u307e\u3067\u306b3\u500d\u306b\u306a\u308b\u3053\u3068\u304c\u4e88\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u00a0<sup>*6-16\u00a0<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-122.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3204 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-122.jpg\" alt=\"2015\u5e74\u306e\u4e16\u754c\u304a\u3088\u3073\u7c73\u56fd\u5185\u306b\u304a\u3051\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3 \u306e\u7f79\u60a3\u8005\u6570\" width=\"402\" height=\"273\" \/><\/a><\/p>\n<h4>\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc<\/h4>\n<p>\u907a\u4f1d\u56e0\u5b50\u306f\u3001\u65e9\u671f\u767a\u75c7\u578b\u3001\u5bb6\u65cf\u578b\u304a\u3088\u3073\u5b64\u767a\u578b\u306e\u795e\u7d4c\u7cfb\u3092\u4fb5\u3059\u5909\u6027\u75be\u60a3\u306b\u8d77\u56e0\u3057\u307e\u3059\u3002\u7d99\u627f\u3055\u308c\u305f\u5358\u4e00\u907a\u4f1d\u5b50\u5909\u7570\u306f\u512a\u6027\u307e\u305f\u306f\u52a3\u6027\u5f62\u5f0f\u3067\u767a\u73fe\u3057\u3001\u5bb6\u65cf\u6027ND\u306e\u75be\u60a3\u767a\u75c7\u306e\u4e88\u6e2c\u306f\u53ef\u80fd\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001\u4ed6\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3067\u306f\u5b64\u767a\u6027\u75be\u60a3\u304c\u767a\u73fe\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30b7\u30cc\u30af\u30ec\u30a4\u30f3,\u03b1\uff08\u30a2\u30df\u30ed\u30a4\u30c9\u524d\u99c6\u4f53\u306e\u975eA4\u6210\u5206\uff09\uff08SNCA\uff09\u306b\u304a\u3051\u308b\u5909\u7570\u306fPD\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u4e00\u65b9\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\uff08A4\uff09\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff08APP\uff09\u907a\u4f1d\u5b50\u306b\u304a\u3051\u308b\u591a\u69d8\u306a\u969c\u5bb3\u306fAD\u306e\u69d8\u3005\u306a\u5f62\u614b\u3068\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u69d8\u3005\u306aND\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u306e\u4ee3\u8868\u4f8b\u3092\u88681.2\u306b\u793a\u3057\u307e\u3059\u3002\u8907\u6570\u306e\u69d8\u3005\u306a\u907a\u4f1d\u7684\u304a\u3088\u3073\u74b0\u5883\u7684\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u304cND\u306e\u767a\u75c7\u306b\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\uff08\u56f31.1\uff09\u3002\u3055\u3089\u306b\u3001\u52a0\u9f62\u3082\u591a\u304f\u306eND\u306e\u767a\u75c7\u306b\u95a2\u4fc2\u3059\u308b\u5225\u306e\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u3067\u3042\u308a\u3001\u6050\u3089\u304f\u74b0\u5883\u56e0\u5b50\u3078\u306e\u66dd\u9732\u306e\u84c4\u7a4d\u3084\u7d30\u80de\u4fee\u5fa9\u6a5f\u69cb\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u982d\u90e8\u5916\u50b7\u306b\u3088\u308b\u795e\u7d4c\u640d\u50b7\u306a\u3069\u306e\u75c7\u72b6\u3082\u3001AD\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\u3002\u4e00\u65b9\u3001\u55ab\u7159\u304a\u3088\u3073\u7279\u5b9a\u306e\u611f\u67d3\u6027\u75c5\u539f\u4f53\u306fMS\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\u00a0<sup>*17-20<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-123.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3205 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-123.jpg\" alt=\"\u591a\u304f\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u304c\u5171\u6709\u3059\u308b\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u304a\u3088\u3073\u75be\u60a3\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5171\u901a\u6027\" width=\"792\" height=\"382\" \/><\/a><\/p>\n<h4>\u6297\u4f53\uff1a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u306e\u305f\u3081\u306e\u5f37\u529b\u306a\u30c4\u30fc\u30eb<\/h4>\n<p>\u6297\u4f53\u306f\u3001\u514d\u75ab\u86cd\u5149\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3001\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u3001\u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c6\u30a3\u30f3\u30b0\u3001ELISA\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3001\u304a\u3088\u3073\u4ed6\u306e\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u3092\u542b\u3080\u8907\u6570\u306e\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u793e\u306e\u6297\u4f53\u304c\u512a\u308c\u305f\u5b9f\u9a13\u7d50\u679c\u306e\u9054\u6210\u3092\u53ef\u80fd\u3068\u3059\u308b\u3053\u3068\u306f\u4e16\u754c\u4e2d\u306e\u591a\u304f\u306e\u6587\u732e\u3067\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\u3002<a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies\/primary-antibodies\/research-area-antibodies\/neurobiology-antibodies.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u6297\u4f53\u691c\u7d22\u30c4\u30fc\u30eb\u306b\u30a2\u30af\u30bb\u30b9\u3057\u3001\u76ee\u7684\u306e\u7814\u7a76\u306b\u9069\u3057\u305f\u6297\u4f53\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306b\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p><span style=\"font-size: 8pt\">\u53c2\u8003\u6587\u732e\uff1a<br \/>\n1. Przedborski S, Vila M, Jackson-Lewis V (2003) Neurodegeneration: what is it and\u00a0where are we? J Clin Invest 111(1):3\u201310.<br \/>\n2. Davis M, Stroud C, eds (2013) Neurodegeneration: Exploring Commonalities Across\u00a0Diseases: Workshop Summary USA: National Academy of Sciences. p4-15. http:\/\/www.nap.edu\/catalog.php?record_id=18341. Accessed September 2015.<br \/>\n3. Aoun S, McConigley R, Abernethy A Currow DC et al. (2010) Caregivers of people\u00a0with neurodegenerative diseases: profile and unmet needs from a population-based\u00a0survey in South Australia. J Palliat Med 13(6):653\u2013661.<br \/>\n4. Amor S, Puentes F, Baker D et al. (2010) Inflammation in neurodegenerative\u00a0diseases. Immunology 129(2):154\u2013169.<br \/>\n5. Neurodegenerative Diseases. National Institute of Environmental Health Sciences.\u00a0https:\/\/www.niehs.nih.gov\/research\/supported\/diseases\/neurodegenerative\/index.cfm. Accessed July 2015.<br \/>\n6. Alzheimers.net 2015 Alzheimer\u2019s Statistics. http:\/\/www.alzheimers.net\/resources\/alzheimers-statistics\/. Accessed July 2015.<br \/>\n7. Statistics on Parkinson\u2019s. Parkinson\u2019s Diseae Foundation http:\/\/www.pdf.org\/en\/parkinson_statistics Accessed July 2015.<br \/>\n8. Bates GP, Dorsey R, Gusella J, et al. (2015) Huntington Disease. Nat Rev Dis Primers 1:1\u201321.<br \/>\n9. Kinsley L, Siddique (2001) T Amyotrophic Lateral Sclerosis Overview. [Updated\u00a02015 Feb 12]. In: GeneReviews\u2122 [Internet]. Pagon RA, Adam MP, Ardinger HH etal., editors. Seattle (WA): University of Washington, Seattle; 1993\u20132015.<br \/>\n10. Epidemiology of ALS and Suspected Clusters. ALS Association. http:\/\/www.alsa.org\/als-care\/resources\/publications-videos\/factsheets\/epidemiology.html. Accessed\u00a0July 2015.<br \/>\n11. Epidemiology of MS. MS International Federation. http:\/\/www.msif.org\/research\/epidemiology-of-ms\/. Accessed July 2015.<br \/>\n12. Tullman MJ (2013) Overview of the epidemiology, diagnosis, and disease\u00a0progression associated with multiple sclerosis. Am J Manag Care 2013;19(2 Suppl):S15\u2013S20.<br \/>\n13. Facts You Should Know. ALS Association. http:\/\/www.alsa.org\/about-als\/facts-youshould-know.html. Accessed July 2015.<br \/>\n14. What is ALS\/MND? International Alliance of ALS\/MND Associations. http:\/\/www.alsmndalliance.org\/what-is-alsmnd\/. Accessed July 2015.<br \/>\n15. Huntington\u2019s Disease. Remedy\u2019s Health Communities.com. http:\/\/www.healthcommunities.com\/huntingtons-disease\/overview-of-huntingtons.shtml. Accessed July 2015.<br \/>\n16. 2015 Alzheimer\u2019s Disease Facts and Figures. Alzheimer\u2019s Association. https:\/\/www.alz.org\/facts\/downloads\/facts_figures_2015.pdf. Accessed July 2015.<br \/>\n17. Hindle JV (2010) Ageing, neurodegeneration and Parkinson\u2019s disease. Age Ageing\u00a039(2):156\u2013161.<br \/>\n18. Risk Factors. Alz.org http:\/\/www.alz.org\/alzheimers_disease_causes_risk_factors.asp. Accessed July 2015.<br \/>\n19. Simon KC, Schmidt H, Loud S (2015) Risk factors for multiple sclerosis,neuromyelitis optica and transverse myelitis. Mult Scler 21(6):703\u2013709.<br \/>\n20. Van Deerlin VM (2012) The genetics and neuropathology of neurodegenerative\u00a0disorders: perspectives and implications for research and clinical practice. ActaNeuropathol 124(3):297\u2013303.<br \/>\n21. Klein C, Westenberger (2010) A Genetics of Parkinson\u2019s disease. Cold Spring Harb\u00a0Perspect Med 2(1):a008888.<br \/>\n<\/span><\/p>\n<h2>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u5171\u901a\u306e\u30c6\u30fc\u30de<\/h2>\n<p>\u3053\u308c\u307e\u3067\u3001\u305d\u308c\u305e\u308c\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\uff08ND\uff09\u306f\u3001\u75c5\u56e0\u3084\u75c5\u614b\u306e\u7570\u306a\u308b\u500b\u5225\u306e\u30a8\u30f3\u30c6\u30a3\u30c6\u30a3\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8fd1\u5e74\u3001\u7279\u5b9a\u306e\u5206\u5b50\u3001\u7d30\u80de\u3001\u304a\u3088\u3073\u907a\u4f1d\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u304cND\u306e\u591a\u69d8\u6027\u3092\u5e83\u3052\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8abf\u67fb\u7d50\u679c\u306f\u3001\u5171\u901a\u6027\u306b\u95a2\u3059\u308b\u8abf\u67fb\u304c\u57fa\u672c\u7684\u306a\u75c5\u614b\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u3059\u308b\u898b\u8b58\u3060\u3051\u3067\u306a\u304f\u3001\u5171\u901a\u306e\u8a3a\u65ad\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304a\u3088\u3073\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u95a2\u3059\u308b\u898b\u8b58\u3082\u63d0\u4f9b\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u00a0<sup>*1\u00a0<\/sup>\u3002<br \/>\n\u69d8\u3005\u306a\u8133\u9818\u57df\u306b\u308f\u305f\u308b\u985e\u4f3c\u3057\u305f\u795e\u7d4c\u6a5f\u80fd\u969c\u5bb3\u306e\u7279\u5fb4\u306b\u52a0\u3048\u3066\u3001ND\u306f\u7279\u5b9a\u306e\u75c5\u614b\u751f\u7406\u5b66\u30d7\u30ed\u30bb\u30b9\u3092\u5171\u6709\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u591a\u304f\u306f\u3001\u4e0d\u6eb6\u6027\u30d7\u30e9\u30fc\u30af\u306e\u51fa\u73fe\u3092\u5c0e\u304f\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7523\u751f\u3001\u84c4\u7a4d\u3001\u304a\u3088\u3073\u6392\u51fa\u306e\u6e1b\u5c11\u304c\u95a2\u4fc2\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u795e\u7d4c\u6a5f\u80fd\u969c\u5bb3\u304a\u3088\u3073\u7834\u58ca\u306e\u4e00\u822c\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u8907\u6570\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3044\u3066\u751f\u3058\u3066\u304a\u308a\u3001\u708e\u75c7\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3001\u304a\u3088\u3073\u8208\u596e\u6bd2\u6027\u5897\u5f37\u3068\u3057\u3066\u5146\u5019\u304c\u73fe\u308c\u307e\u3059\uff08\u88682.1\uff09\u00a0<sup>*2-12\u00a0<\/sup>\u3002<br \/>\n\u6570\u5341\u5e74\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u73fe\u5728\u306e\u6cbb\u7642\u6cd5\u304c\u3082\u305f\u3089\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u591a\u304f\u306e\u30b1\u30fc\u30b9\u3067\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u7d4c\u904e\u306b\u304a\u3044\u3066\u7834\u58ca\u3055\u308c\u308b\u7279\u5b9a\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u304a\u3088\u3073\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u304c\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7642\u6cd5\u306b\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306b\u304a\u3044\u3066\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3059\u308b\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u306b\u5bfe\u3059\u308b\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u30a8\u30b9\u30c6\u30e9\u30fc\u30bc\u963b\u5bb3\u5264\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff08PD\uff09\u306b\u5bfe\u3059\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u4f5c\u52d5\u85ac\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u65e2\u5b58\u306e\u7642\u6cd5\u306f\u3001\u3088\u304f\u3066\u3082\u75c7\u72b6\u3092\u8efd\u6e1b\u3042\u308b\u3044\u306f\u9045\u5ef6\u3055\u305b\u308b\u3060\u3051\u3067\u3001\u6839\u672c\u7684\u306a\u75c5\u72b6\u306b\u5bfe\u51e6\u3057\u305f\u308a\u3001\u75be\u60a3\u7d4c\u904e\u3092\u6709\u610f\u306b\u7de9\u548c\u3042\u308b\u3044\u306f\u9045\u5ef6\u3055\u305b\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u65e2\u5b58\u306e\u7642\u6cd5\u3067\u306f\u795e\u7d4c\u6a5f\u80fd\u3092\u4fdd\u5b58\u307e\u305f\u306f\u4fee\u5fa9\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001\u958b\u767a\u4e2d\u306e\u65b0\u3057\u3044\u7642\u6cd5\u306f\u795e\u7d4c\u7834\u58ca\u306b\u95a2\u4e0e\u3059\u308b\u7279\u5b9a\u306e\u75c5\u7406\u904e\u7a0b\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u3066\u304a\u308a\u3001\u795e\u7d4c\u3092\u4fdd\u8b77\u304a\u3088\u3073\u4fee\u5fa9\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u3084\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPSC\uff09\u7531\u6765\u7d30\u80de\u3092\u7528\u3044\u308b\u5e79\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u7642\u6cd5\u306f\u3001\u69d8\u3005\u306aND\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u6b21\u4e16\u4ee3\u306e\u6cbb\u7642\u6cd5\u3092\u30ea\u30fc\u30c9\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h4>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6982\u8ad6<\/h4>\n<p>\u305d\u308c\u305e\u308c\u306eND\u306b\u306f\u3001\u75be\u60a3\u3092\u6c7a\u5b9a\u4ed8\u3051\u308b\u69d8\u3005\u306a\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u305d\u308c\u305e\u308c\u306eND\u306e\u75c5\u614b\u5f62\u6210\u306b\u306f\u7570\u306a\u308b\u8133\u9818\u57df\u304c\u95a2\u4e0e\u3057\u3001\u7279\u6709\u306e\u7d30\u80de\u30bf\u30a4\u30d7\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001AD\u3067\u306f\u30b3\u30ea\u30f3\u4f5c\u52d5\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u95a2\u4e0e\u3057\u3001PD\u306b\u306f\u30c9\u30fc\u30d1\u30df\u30f3\u4f5c\u52d5\u6027\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5206\u89e3\u304c\u95a2\u4fc2\u3057\u3001\u305d\u3057\u3066MS\u3067\u306fCNS\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5468\u308a\u306b\u5b58\u5728\u3059\u308b\u30df\u30a8\u30ea\u30f3\u9798\u3092\u5f62\u6210\u3059\u308b\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u304c\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002ND\u306f\u3001\u75be\u60a3\u7279\u7570\u7684\u306a\u7279\u5fb4\u3092\u6301\u3064\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3001\u6162\u6027\u708e\u75c7\u3001\u304a\u3088\u3073\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u9ad8\u30ec\u30d9\u30eb\u306a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u306e\u591a\u304f\u306e\u5171\u901a\u3059\u308b\u75c5\u72b6\u3092\u5171\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u8907\u6570\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u7279\u5fb4\u306e\u6982\u8981\u3092\u88682.1\u306b\u793a\u3057\u307e\u3059\u00a0<sup>*13\u201320<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-125.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3216 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-125.jpg\" alt=\"\u69d8\u3005\u306a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u7279\u5fb4\" width=\"809\" height=\"487\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-37.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3217 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-37.jpg\" alt=\"PSD95\u30de\u30a6\u30b9\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\uff086G6-1C9\uff09a\" width=\"333\" height=\"385\" \/><\/a><\/p>\n<h4>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u65b9\u6cd5\u306e\u9078\u629e<\/h4>\n<p>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u767a\u898b\u306f\u3001ND\u306e\u521d\u671f\u6bb5\u968e\u3067\u306e\u691c\u51fa\u3084\u3053\u308c\u3089\u306e\u6d88\u8017\u6027\u75c7\u72b6\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u7642\u6cd5\u306e\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u6226\u7565\u3092\u767a\u5c55\u3055\u305b\u308b\u306e\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u307e\u305f\u3001\u7d30\u80de\u5185\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c40\u5728\u6027\u304a\u3088\u3073\u5206\u5e03\u30d1\u30bf\u30fc\u30f3\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u75c5\u614b\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u898b\u8b58\u304c\u3082\u305f\u3089\u3055\u308c\u307e\u3059\u3002\u6570\u591a\u304f\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u304a\u3044\u3066\u3001\u7279\u5b9a\u306eND\u306b\u95a2\u9023\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d30\u80de\u5185\u5c40\u5728\u6027\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7269\u7406\u7684\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u3001\u8133\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6cd5\u306b\u5206\u985e\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u8840\u6db2\u304a\u3088\u3073\u8133\u810a\u9ac4\u6db2\uff08CSF\uff09\u306b\u5b58\u5728\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u540c\u5b9a\u304a\u3088\u3073\u5b9a\u91cf\u3059\u308b\u305f\u3081\u306e\u6280\u8853\u306e\u4f8b\u3068\u3057\u3066\u306f\u3001ELISA\u3084Luminex\u306a\u3069\u306e\u69d8\u3005\u306a\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u00a0<sup>*21<\/sup>\u3002<br \/>\n\u30cb\u30e5\u30fc\u30ed\u30f3\u96c6\u56e3\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306e\u65b9\u6cd5\u306e\u4f8b\u3068\u3057\u3066\u306f\u3001\u30a2\u30df\u30ce\u9178\u3001\u30da\u30d7\u30c1\u30c9\u3001\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u691c\u51fa\u3092\u53ef\u80fd\u3068\u3059\u308b\u514d\u75ab\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5\uff08immuno-EM\uff09\u306e\u4f7f\u7528\u304c\u5897\u52a0\u3057\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u624b\u6cd5\u306b\u306f\u3001\u7279\u5225\u306a\u7d44\u7e54\u8abf\u88fd\u30d7\u30ed\u30c8\u30b3\u30eb\u304a\u3088\u3073\u91d1\u30b3\u30ed\u30a4\u30c9\u7c92\u5b50\u306e\u3088\u3046\u306a\u9ad8\u96fb\u5b50\u5bc6\u5ea6\u30de\u30fc\u30ab\u30fc\u304c\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\uff08\u8868 2.2\u304a\u3088\u3073\u56f32.1\uff09\u3002<br \/>\n\u75c5\u5909\u3092\u76f4\u63a5\u53ef\u8996\u5316\u3059\u308b\u305f\u3081\u306b\u30d2\u30c8\u7531\u6765CNS\u7d44\u7e54\u30b5\u30f3\u30d7\u30eb\u3092\u53d6\u5f97\u3059\u308b\u3053\u3068\u306b\u306f\u5927\u304d\u306a\u5236\u9650\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001AD\u304a\u3088\u3073\u4ed6\u306eND\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7d44\u7e54\u5b66\u7684\u304a\u3088\u3073\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u5206\u6790\u3092\u7528\u3044\u308b\u6b7b\u5f8c\u7d44\u7e54\u5206\u6790\u306f\u8a3a\u65ad\u88dc\u52a9\u306b\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u521d\u4ee3\u795e\u7d4c\u7d30\u80de\u304a\u3088\u3073\u7d30\u80de\u682a\u3092\u4f7f\u7528\u3059\u308bin vitro\u7d30\u80de\u5b9f\u9a13\u306f\u6297\u4f53\u30d9\u30fc\u30b9\u306e\u30c4\u30fc\u30eb\u3092\u7528\u3044\u308b\u5b9f\u9a13\u306b\u3082\u3088\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059 *<sup>22<\/sup> \u3002\u3053\u308c\u3089\u306e\u30c4\u30fc\u30eb\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u3001CNS\u306a\u3069\u306e\u30b5\u30ed\u30b2\u30fc\u30c8\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u8a66\u9a13\u7528\u3001\u306a\u3089\u3073\u306b\u975e\u30d2\u30c8\u970a\u9577\u985e\u304a\u3088\u3073\u3052\u3063\u6b6f\u985e\u3092\u542b\u3080\u5e45\u5e83\u3044\u69d8\u3005\u306a\u751f\u7269\u7a2e\u306b\u767a\u73fe\u3055\u305b\u305f\u795e\u7d4c\u5909\u6027\u30e2\u30c7\u30eb\u306e\u7279\u6027\u6c7a\u5b9a\u3092\u884c\u3046\u305f\u3081\u306e\u5b9f\u9a13\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u3066\u983b\u7e41\u306b\u4f7f\u7528\u3055\u308c\u308b\u795e\u7d4c\u7d44\u7e54\u89e3\u6790\u7528\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u524d\u81e8\u5e8a\u8a66\u9a13\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3059\u308b\u969b\u306e\u5927\u304d\u306a\u8ab2\u984c\u306f\u3001\u30d2\u30c8ND\u306e\u8907\u96d1\u3055\u3092\u5b8c\u5168\u306b\u518d\u73fe\u3067\u304d\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5b9f\u9a13\u30e2\u30c7\u30eb\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u3001\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3092\u540c\u5b9a\u3057\u305f\u308a\u3001\u85ac\u5264\u3001\u304a\u3088\u3073\u795e\u7d4c\u5909\u6027\u72b6\u614b\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u6cbb\u7642\u6cd5\u306b\u3064\u3044\u3066\u30c6\u30b9\u30c8\u3059\u308b\u969b\u306e\u52a9\u3051\u3068\u306a\u308a\u3001ND\u306e\u767a\u75c5\u304a\u3088\u3073\u9032\u884c\u306b\u95a2\u4e0e\u3059\u308b\u7d30\u80de\u304a\u3088\u3073\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u898b\u8b58\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u00a0<sup>*23\u00a0<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-126.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3218 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-126.jpg\" alt=\"\u795e\u7d4c\u5909\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u75c7\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u65b9\u6cd5\u306e\u9078\u629e\" width=\"401\" height=\"292\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-38.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3219 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-38.jpg\" alt=\"Immuno-EM\u306f\u7d44\u7e54\u306b\u304a\u3051\u308b\u6297\u539f\u306e\u6297\u539f\u7279\u7570\u7684\u306a\u5c40\u5728\u5316\u304a\u3088\u3073 \u5206\u5e03\u3092\u540c\u5b9a\u53ef\u80fd\" width=\"400\" height=\"374\" \/><\/a><\/p>\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002<br \/>\n\u4e0b\u8a18\u306e\u5185\u5bb9\u3092\u542b\u3080PDF\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies\/antibodies-learning-center\/antibodies-resource-library\/antibody-neurodegeneration-guidebook.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<h2>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u304a\u3088\u3073\u795e\u7d4c\u5909\u6027<\/h2>\n<h4>\u30bf\u30f3\u30d1\u30af\u8cea\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h4>\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306f\u3001AD\u3001PD\u3001HD\u3001\u304a\u3088\u3073\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u3092\u542b\u3080\u591a\u304f\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u9855\u8457\u306a\u7279\u5fb4\u3067\u3059\u3002\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u4e00\u9023\u306e\u5c0f\u80de\u4f53\uff08ER\uff09\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u3092\u958b\u59cb\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u3092\u767a\u751f\u3057\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u975e\u6298\u308a\u7573\u307f\u30bf\u30f3\u30d1\u30af\u8cea\u5fdc\u7b54\uff08UPR\uff09\u3068\u7dcf\u79f0\u3055\u308c\u3001\u6709\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u304b\u3089\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u3088\u3046\u306b\u50cd\u304d\u307e\u3059\u00a0<sup>*12<\/sup>\u3002 \u591a\u304f\u306e\u91ce\u751f\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3057\u305f\u308a\u3001\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u80fd\u529b\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u907a\u4f1d\u5b50\u5909\u7570\u306e\u7d50\u679c\u3001\u30a2\u30df\u30ce\u9178\u914d\u5217\u304c\u5909\u5316\u3057\u3001\u6298\u308a\u7573\u307e\u308c\u3066\u51dd\u96c6\u3059\u308b\u50be\u5411\u306e\u9ad8\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u751f\u6210\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u4f8b\u3048\u3070\u3001AD\u3067\u306f\u3001\u8907\u6570\u306e\u69d8\u3005\u306aAPP\u5909\u7570\u306b\u3088\u3063\u3066\u30aa\u30ea\u30b4\u30de\u30fc\u306e\u5f62\u6210\u304a\u3088\u3073\u7dda\u7dad\u5f62\u6210\u306b\u5bc4\u4e0e\u3059\u308b\u7570\u5e38A\u03b2\u30da\u30d7\u30c1\u30c9\u306e\u751f\u6210\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\uff08\u56f32.2\uff09\u3002\u51dd\u96c6\u306e\u5897\u52a0\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u7523\u7269\u306e\u904e\u5270\u7523\u751f\u3001\u3042\u308b\u3044\u306f\u4ee3\u8b1d\u3001\u9178\u5316\u3001\u304a\u3088\u3073\u708e\u75c7\u6027\u306e\u30b9\u30c8\u30ec\u30b9\u30a4\u30d9\u30f3\u30c8\u306e\u5897\u52a0\u306b\u3082\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u5c0f\u80de\u4f53\uff08ER\uff09\u5185\u306b\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3001\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3001\u304a\u3088\u3073\u8f38\u9001\u306b\u304a\u3051\u308b\u54c1\u8cea\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u30a8\u30ec\u30ac\u30f3\u30c8\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u5b58\u5728\u3057\u3001\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u3092\u56de\u907f\u3057\u3066\u3044\u307e\u3059\u3002\u30d5\u30a9\u30fc\u30eb\u30c0\u30fc\u30bc\u304a\u3088\u3073\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306f\u3001\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3044\u3066\u5bc6\u63a5\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001ER\u5185\u306b\u4fdd\u6301\u3055\u308c\u308b\u304b\u3001\u3042\u308b\u3044\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u81ea\u98df\u4f5c\u7528\uff09\u307e\u305f\u306f\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u4f9d\u5b58\u6027ER\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u7d4c\u8def\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u307e\u3059\u00a0<sup>*24,25<\/sup>\u3002<\/p>\n<p>\u819c\u901a\u904e\u30b9\u30c8\u30ec\u30b9\u30bb\u30f3\u30b5\u30fc\u304a\u3088\u3073\u4e0b\u6d41\u306e\u8ee2\u5199\u56e0\u5b50\u306fUPR\u3092\u6709\u3057\u307e\u3059\u00a0<sup>*26<\/sup>\u3002 \u95a2\u9023\u3059\u308b\u30b9\u30c8\u30ec\u30b9\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308bER\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4f8b\u3068\u3057\u3066\u306f\u3001\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\u8981\u6c42\u6027\u30c8\u30e9\u30f3\u30b9\u30e1\u30f3\u30d6\u30ec\u30f3\u30ad\u30ca\u30fc\u30bc\/\u30a8\u30f3\u30c9\u30ea\u30dc\u30cc\u30af\u30ec\u30a2\u30fc\u30bc 1\uff08IRE1\uff09\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u69d8\u771f\u6838\u751f\u7269\u7ffb\u8a33\u958b\u59cb\u56e0\u5b502\u03b1\u30ad\u30ca\u30fc\u30bc\uff08PERK\uff09\u3001\u304a\u3088\u3073\u6d3b\u6027\u5316\u8ee2\u5199\u56e0\u5b50-6\uff08ATF6\uff09\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u00a0<sup>*25<\/sup> \u3002\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u6210\u901f\u5ea6\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3092\u52a9\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u306e\u9632\u6b62\u3001\u306a\u3089\u3073\u306bER\u3067\u7523\u751f\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9006\u8f38\u9001\u306e\u4fc3\u9032\u304a\u3088\u3073\u5206\u89e3\u3092\u542b\u3080\u8907\u6570\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u8abf\u7bc0\u3057\u307e\u3059\uff08\u88682.3\uff09<sup>*12<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-127-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3220 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-127-1.jpg\" alt=\"\u4ee3\u8868\u7684\u306aER\u819c\u30b9\u30c8\u30ec\u30b9\u30bb\u30f3\u30b5\u30fc\" width=\"399\" height=\"334\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-39-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3221 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-39-1.jpg\" alt=\"\u30bf\u30f3\u30d1\u30af\u8cea\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u304a\u3088\u3073\u795e\u7d4c\u5909\u6027\" width=\"811\" height=\"328\" \/><\/a><\/p>\n<h4>\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u4f9d\u5b58\u6027\u306e\u5c0f\u80de\u4f53\u95a2\u9023\u5206\u89e3\u304a\u3088\u3073\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc<\/h4>\n<p>\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9664\u53bb\u3059\u308b\u305f\u3081\u306e\u4e3b\u8981\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f2\u7a2e\u985e\u5b58\u5728\u3057\u307e\u3059\u30021\u3064\u306e\u7d4c\u8def\u3067\u306f\u3001ER\u304b\u3089\u30b5\u30a4\u30c8\u30be\u30eb\u3078\u9006\u8f38\u9001\u3055\u308c\u3001\u305d\u3053\u3067\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3055\u308c\u3001\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u5206\u89e3\u3092\u53d7\u3051\u307e\u3059\u3002\u3053\u308c\u306f\u5c0f\u80de\u4f53\u95a2\u9023\u5206\u89e3\uff08ERAD\uff09\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3082\u30461\u3064\u306eUPR\u306b\u3088\u308a\u523a\u6fc0\u3055\u308c\u308b\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u9664\u53bb\u3059\u308b\u305f\u3081\u306e\u7d4c\u8def\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u3067\u3001\u5927\u304d\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\u304a\u3088\u3073\u30ea\u30dd\u30bd\u30fc\u30e0\u5185\u90e8\u306e\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u305f\u30aa\u30eb\u30ac\u30cd\u30e9\u3092\u9664\u53bb\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3061\u307e\u3059\u00a0<sup>*26,27<\/sup> \u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3044\u3066\u3044\u304f\u3064\u304b\u306e\u5909\u5316\u304c\u751f\u3058\u308b\u3068\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306e\u6982\u8981\u3092\u88682.4\u306b\u793a\u3057\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-128-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3222 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-128-1.jpg\" alt=\"ND\u306b\u95a2\u9023\u3059\u308b\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u304a\u3088\u3073\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6a5f\u80fd\u4e0d\u5168\" width=\"399\" height=\"385\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-40-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3223 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-40-1.jpg\" alt=\"Invitrogen\u2122 BrainStain\u2122 Imaging Kit\u7531\u6765\u306e\u8a66\u85ac\u3067\u67d3\u8272\u3057\u305f\u30de\u30a6\u30b9 \u5c0f\u8133\u51cd\u7d50\u5207\u7247\" width=\"397\" height=\"926\" \/><\/a><\/p>\n<h4>\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u30b9\u30c6\u30c3\u30d7<\/h4>\n<p>\u30de\u30af\u30ed\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u4e3b\u8981\u306a\u7d4c\u8def\u306e1\u3064\u3067\u3059\u3002\u3053\u308c\u306f\u69d8\u3005\u306a\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u30a2\u30bb\u30f3\u30d6\u30ea\u304c\u95a2\u4e0e\u3059\u308b\u6bb5\u968e\u7684\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3001ATG\u3068\u547c\u3070\u308c\u308b\u4e00\u9023\u306e\u4e2d\u5fc3\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u52d5\u54e1\u3055\u308c\u307e\u3059\uff08\u56f32.3\uff09\u300228,29 ATG\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30aa\u30fc\u30c8\u30d5\u30a1\u30fc\u30b8\u2015\u306e\u958b\u59cb\u3001\u5c0f\u80de\u306e\u6838\u5f62\u6210\u3001\u304a\u3088\u3073\u30aa\u30fc\u30c8\u30d5\u30a1\u30b4\u30bd\u30fc\u30e0\u306e\u5ef6\u9577\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u4ed6\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u88682.5\u306b\u30ea\u30b9\u30c8\u8868\u793a\u3057\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u00a0\u8a98\u767a\u30fc\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u958b\u59cb\u3092\u6d3b\u6027\u5316\u3059\u308b\u305f\u3081\u306b\u306f\u3001mTOR\u3092\u4e0d\u6d3b\u6027\u5316\u3057\u3066ULK1\u306e\u30ea\u30f3\u9178\u5316\u3092\u4f4e\u4e0b\u3055\u305b\u308b \u3053\u3068\u304c\u5fc5\u8981\u3068\u3055\u308c\u307e\u3059\u3002<\/li>\n<li>\u5c0f\u80de\u306e\u6838\u5f62\u6210\u30fc\u30aa\u30fc\u30c8\u30d5\u30a1\u30b4\u30bd\u30fc\u30e0\u306e\u69cb\u7bc9\u306f\u3001PI3K\u6db2\u80de\u30bf\u30f3\u30d1\u30af\u8cea\u9078\u5225\u30bf\u30f3\u30d1\u30af\u8ceaVPS34 \u304a\u3088\u3073VPS15\u3092\u542b\u3080PI3K\u8907\u5408\u4f53\u306e\u6d3b\u6027\u5316\u306b\u95a2\u4e0e\u3057\u3001Beclin-1\uff08BECN1-\u8abf\u7bc0\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30bf\u30f3\u30d1\u30af\u8cea[AMBRA1]\u306b\u304a\u3051\u308b\u6d3b\u6027\u5316\u5206\u5b50\uff09\u3001UV\u7167\u5c04\u8010\u6027\u95a2\u9023\u907a\u4f1d\u5b50(UVRAG)\u3001\u304a\u3088\u3073Bax-\u76f8\u4e92\u4f5c\u7528\u56e0\u5b501\uff08BIF1\uff09\u3068\u306e\u30b3\u30e9\u30dc\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308a\u751f\u3058\u307e\u3059\u3002<\/li>\n<li>\u5c0f\u80de\u306e\u5ef6\u9577\u30fc\u30e6\u30d3\u30ad\u30ce\u30f3\u69d8\u62b1\u5408\u7cfb\u304c\u5c0f\u80de\u306e\u5ef6\u9577\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002<\/li>\n<li>\u5c0f\u80de\u306e\u56de\u5fa9\u30fc\u5c0f\u80de\u8907\u5408\u4f53\u5185\u306e\u5927\u90e8\u5206\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u5c0f\u80de\u3068\u7d50\u5408\u3057\u305f\u72b6\u614b\u3067\u7559\u307e\u3089\u305a\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u30d7\u30ed\u30bb\u30b9\u3092\u4ecb\u3057\u3066\u30ea\u30b5\u30a4\u30af\u30eb\u3055\u308c\u307e\u3059\u3002<\/li>\n<li>\u5b8c\u4e86\u30fcATG\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u653e\u51fa\u3055\u308c\u3001\u30ea\u30b5\u30a4\u30af\u30eb\u3055\u308c\u307e\u3059\u3002<\/li>\n<li>\u30c9\u30c3\u30ad\u30f3\u30b0\u304a\u3088\u3073\u878d\u5408\u30fc\u30aa\u30fc\u30c8\u30d5\u30a1\u30b4\u30bd\u30fc\u30e0\u306f\u30ea\u30bd\u30bd\u30fc\u30e0\u3068\u878d\u5408\u3057\u3001\u30aa\u30fc\u30c8\u30ea\u30bd\u30bd\u30fc\u30e0\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/li>\n<li>\u5c0f\u80de\u306e\u5d29\u58ca\u304a\u3088\u3073\u5206\u89e3\u30fc\u30ea\u30bd\u30bd\u30fc\u30e0\u9175\u7d20\u306b\u3088\u308a\u30ab\u30fc\u30b4\u304c\u5206\u89e3\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-129-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3224 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-129-1.jpg\" alt=\"\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\" width=\"399\" height=\"597\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-41-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3225 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-41-1.jpg\" alt=\"\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u30b9\u30c6\u30c3\u30d7\" width=\"399\" height=\"343\" \/><\/a><\/p>\n<h4>\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u30d7\u30e9\u30fc\u30af\u3001\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u5c01\u5165\u4f53<\/h4>\n<p>\u6700\u3082\u8513\u5ef6\u3057\u3066\u3044\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306f\u3001\u795e\u7d4c\u306e\u69cb\u9020\u304a\u3088\u3073\u6a5f\u80fd\u3092\u640d\u50b7\u3059\u308b\u30aa\u30ea\u30b4\u30de\u30fc\u304a\u3088\u3073\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e0d\u6eb6\u6027\u306e\u5927\u304d\u306a\u51dd\u96c6\u4f53\u304c\u84c4\u7a4d\u3059\u308b\u3068\u3044\u3046\u5171\u901a\u306e\u7279\u5fb4\u3092\u5171\u6709\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u51dd\u96c6\u4f53\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3001\u7d30\u80de\u5916\u3067\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\uff08A\u03b2\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u30d7\u30e9\u30fc\u30af\u3001\u7d30\u80de\u5185\u3067\u306f\u9ad8\u30ea\u30f3\u9178\u5316\u30bf\u30a6\u304c\u84c4\u7a4d\u3057\u305f\u795e\u7d4c\u539f\u7dda\u7dad\u3068\u3057\u3066\u3001\u305d\u3057\u3066\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u304c\u542b\u307e\u308c\u308b\u30ec\u30d3\u30fc\u5c0f\u4f53\u3068\u3057\u3066\uff08\u6700\u3082\u4ee3\u8868\u7684\u306a\u306e\u306f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3078\u306e\u95a2\u4e0e\uff09\u5f62\u6210\u3055\u308c\u5b58\u5728\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5404\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\u306f\u3001\u5f53\u521d\u306f\u969b\u7acb\u3063\u305fND\u306e\u7279\u5fb4\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u3067\u306f\u8003\u616e\u3059\u3079\u304d\u30af\u30ed\u30b9\u30aa\u30fc\u30d0\u30fc\u304c\u3042\u308b\u3068\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001A\u03b2\u30bf\u30f3\u30d1\u30af\u8cea\u30d7\u30e9\u30fc\u30af\u304a\u3088\u3073\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306f\u3068\u3082\u306b\u3001PD\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u306e\u8133\u306b\u304a\u3044\u3066\u9ad8\u983b\u5ea6\u3067\u540c\u5b9a\u3055\u308c\u307e\u3059\u3002\u30ea\u30f3\u9178\u5316\u30bf\u30a6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7570\u5e38\u306a\u51dd\u96c6\u4f53\u306f\u3001AD\u306b\u95a2\u9023\u3059\u308b\u795e\u7d4c\u6bd2\u6027\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u304c\u3001\u30bf\u30a6\u30aa\u30d1\u30c1\u30fc\u306b\u5206\u985e\u3055\u308c\u308b\u4ed6\u306e\u75be\u60a3\u4f8b\u3068\u3057\u3066\u306f\u3053\u308c\u3089\u306b\u9650\u5b9a\u3055\u308c\u307e\u305b\u3093\u304c\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u304a\u3088\u3073\u524d\u982d\u5074\u982d\u8a8d\u77e5\u75c7\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6210\u5206\u304a\u3088\u3073\u4ed6\u306e\u7279\u6027\u306b\u95a2\u3059\u308b\u6982\u8981\u3092\u88682.1\u306b\u793a\u3057\u307e\u3059\u00a0<sup>*30,31<\/sup>\u3002<\/p>\n<p>\u75c5\u7684\u5c01\u5165\u4f53\u306b\u304a\u3051\u308b\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u5b58\u5728\u306fPD\u306e\u7279\u5fb4\u3092\u5b9a\u7fa9\u4ed8\u3051\u308b\u3082\u306e\u3067\u3059\u304c\u3001\u84c4\u7a4d\u3059\u308b\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7dcf\u79f0\u3057\u3066\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u75c5\u3068\u547c\u3070\u308c\u308b\u5e45\u5e83\u3044\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u7279\u5fb4\u7684\u306a\u75c5\u5909\u306e\u4e3b\u8981\u306a\u975e\u30a2\u30df\u30ed\u30a4\u30c9\u6210\u5206\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u306f\u3001\u3053\u308c\u3089\u306b\u9650\u5b9a\u3055\u308c\u307e\u305b\u3093\u304c\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u578b\u8a8d\u77e5\u75c7\u3001\u306a\u3089\u3073\u306b\u5bb6\u65cf\u6027\u304a\u3088\u3073\u5b64\u767a\u6027\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u30c0\u30a6\u30f3\u75c7\u3001\u9032\u884c\u6027\u81ea\u5f8b\u795e\u7d4c\u4e0d\u5168\u75c7\u304c\u542b\u307e\u308c\u307e\u3059\u00a0<sup>*22<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-130-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3227 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-130-1.jpg\" alt=\"Amyloid-beta\/Amyloid A4 Polyclonal Antibody (PA5-32263)\" width=\"400\" height=\"686\" \/><\/a><a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">A\u03b2\u3001\u30bf\u30a6\u304a\u3088\u3073\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u691c\u51fa\u7528\u306e\u6297\u4f53\u3001ELISA\u304a\u3088\u3073Luminex\u30ad\u30c3\u30c8\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p>\u5f53\u793e\u3067\u306f\u3001Thermo Fisher Scientific\u30d6\u30e9\u30f3\u30c9\u306e\u795e\u7d4c\u7279\u7570\u7684\u30bf\u30fc\u30b2\u30c3\u30c8\u7814\u7a76\u7528\u306e\u6297\u4f53\u3001ELISA\u3001\u304a\u3088\u3073Luminex\u30a2\u30c3\u30bb\u30a4\u306e\u5e45\u5e83\u3044\u88fd\u54c1\u7fa4\u306b\u52a0\u3048\u3066\u3001\u7d30\u80de\u751f\u5b58\u7387\u304a\u3088\u3073\u5897\u6b96\u30a2\u30c3\u30bb\u30a4\u30ad\u30c3\u30c8\u3001\u795e\u7d4c\u89e3\u5256\u304a\u3088\u3073\u6a5f\u80fd\u5206\u6790\u7528\u86cd\u5149\u30d7\u30ed\u30fc\u30d6\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u30c8\u30ec\u30fc\u30b5\u30fc\u3001\u795e\u7d4c\u5909\u6027\u751f\u7269\u5b66\u7814\u7a76\u95a2\u9023\u4e00\u6b21\u6297\u4f53\u304a\u3088\u3073\u30ad\u30c3\u30c8\u306e\u5e45\u5e83\u3044\u30bb\u30ec\u30af\u30b7\u30e7\u30f3\u3001\u306a\u3089\u3073\u306b\u521d\u4ee3\u7d30\u80de\u304a\u3088\u3073\u5e79\u7d30\u80de\u7814\u7a76\u7528\u306e\u795e\u7d4c\u7d30\u80de\u57f9\u990a\u8a66\u85ac\u3092\u542b\u3080\u795e\u7d4c\u5909\u6027\u7814\u7a76\u306e\u305f\u3081\u306e\u591a\u69d8\u306a\u8a66\u85ac\u304a\u3088\u3073\u30ad\u30c3\u30c8\u306e\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\uff08\u88682.6\uff09\u3002<a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies\/primary-antibodies\/research-area-antibodies\/neurobiology-antibodies.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u5168\u88fd\u54c1\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-131-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3228 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-131-1.jpg\" alt=\"\u795e\u7d4c\u5909\u6027\u89e3\u6790\u306b\u4e00\u822c\u7684\u306b\u7528\u3044\u3089\u308c\u308b\u4ee3\u8868\u7684\u306a\u30c4\u30fc\u30eb\" width=\"759\" height=\"452\" \/><\/a><\/p>\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002<br \/>\n\u4e0b\u8a18\u306e\u5185\u5bb9\u3092\u542b\u3080PDF\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies\/antibodies-learning-center\/antibodies-resource-library\/antibody-neurodegeneration-guidebook.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<h2>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304a\u3088\u3073\u795e\u7d4c\u5909\u6027<\/h2>\n<h4>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168<\/h4>\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u304a\u3088\u3073\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u795e\u7d4c\u5909\u6027\u304a\u3088\u3073\u52a0\u9f62\u3068\u5bc6\u63a5\u306a\u95a2\u4fc2\u304c\u3042\u308a\u3001\u69d8\u3005\u306aND\u306b\u304a\u3044\u3066\u75be\u60a3\u7279\u7570\u7684\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u95a2\u9023\u306e\u5909\u5316\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059\uff08\u56f32.4\u304a\u3088\u3073\u88682.7\uff09<sup>*32-41<\/sup>\u00a0\u3002\u4f8b\u3048\u3070\u3001\u30cf\u30f3\u30c1\u30f3\u30c1\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073\u30dd\u30eaQ\u3092\u542b\u3080\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8f38\u9001\u969c\u5bb3\u304a\u3088\u3073\u7d30\u80de\u5185Ca2+\u6fc3\u5ea6\u4e0a\u6607\u3092\u8a98\u767a\u3057\u307e\u3059\u00a0<sup>*42\u00a0<\/sup>\u3002<br \/>\nPD\u3067\u306f\u96fb\u5b50\u4f1d\u9054\u304c\u4f4e\u4e0b\u3057\u3001AD\u3001PD\u304a\u3088\u3073ALS\u3067\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mtDNA\uff09\u306b\u304a\u3051\u308b\u5909\u7570\u304c\u691c\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u00a0<sup>*43<\/sup> \u3002\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u3092\u4fc3\u9032\u3057\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u88c2\u3068\u878d\u5408\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5065\u5168\u6027\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u751f\u7406\u7684\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306e\u64b9\u4e71\u306f\u3001\u304c\u3093\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u795e\u7d4c\u5909\u6027\u72b6\u614b\u3092\u542b\u3080\u6570\u591a\u304f\u306e\u30d2\u30c8\u75be\u60a3\u306b\u304a\u3044\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u00a0<sup>*44<\/sup> \u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304a\u3088\u3073ER\u6a5f\u80fd\u9593\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306e\u8907\u96d1\u3055\u306b\u3064\u3044\u3066\u306f\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3068\u5c0f\u80de\u4f53\u306e\u63a5\u89e6\u9818\u57df\uff08MAM\uff09\u304c2\u3064\u306e\u30aa\u30eb\u30ac\u30cd\u30e9\u9593\u306b\u304a\u3051\u308b\u8102\u8cea\u306e\u79fb\u52d5\u304a\u3088\u3073Ca2+\u306e\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u3092\u53ef\u80fd\u3068\u3057\u3066\u304a\u308a\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b4\u30bd\u30fc\u30e0\u5f62\u6210\u306e\u90e8\u4f4d\u3067\u3042\u308b\u3053\u3068\u304c\u7814\u7a76\u306b\u304a\u3044\u3066\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u8907\u5408\u4f53\u3082\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u306b\u95a2\u4e0e\u3057\u3001\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u767a\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u591a\u30bf\u30f3\u30d1\u30af\u8cea\u30aa\u30ea\u30b4\u30de\u30fc\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\uff081\u03b2\u304a\u3088\u307318\uff09\u306e\u7523\u751f\u3092\u8a98\u5c0e\u3057\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u306b\u95a2\u4e0e\u3059\u308b\u30ab\u30b9\u30d1\u30fc\u30bc\u3092\u6d3b\u6027\u5316\u3059\u308b\u75c5\u539f\u30b7\u30b0\u30ca\u30eb\u306b\u53cd\u5fdc\u3057\u3066\u5f62\u6210\u3055\u308c\u307e\u3059\u3002NOD-\u69d8\u53d7\u5bb9\u4f53\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308bNLRP1\u30013\u3001\u304a\u3088\u30734\u306f\u3001ROS\u306e\u751f\u6210\u3092\u5c0e\u304f\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u30ad\u30fc\u30b3\u30f3\u30dd\u30fc\u30cd\u30f3\u30c8\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4ee3\u8868\u4f8b\u3092\u88682.8\u306b\u793a\u3057\u307e\u3059\u00a0<sup>*32-42<\/sup>\u3002<\/p>\n<h4>\u795e\u7d4c\u5909\u6027\u306b\u304a\u3051\u308bCOX-2\u306e\u5f79\u5272<\/h4>\n<p>\u904e\u5270\u306aROS\u30ec\u30d9\u30eb\u306f\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u30da\u30d7\u30c1\u30c9\u3001\u304a\u3088\u3073\u75c5\u539f\u69cb\u9020\u306a\u3069\u306e\u8907\u6570\u306e\u708e\u75c7\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306e\u7523\u751f\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8981\u7d20\u306f\u8133\u640d\u50b7\u306b\u5bc4\u4e0e\u3057\u3001\u30b7\u30af\u30ed\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc-2\uff08COX-2\uff09\u306e\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306e\u4e00\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u306e\u751f\u6210\u306b\u5fc5\u8981\u3068\u3055\u308c\u308bCOX-2\u306f\u3001\u69d8\u3005\u306aND\u306b\u95a2\u9023\u3059\u308b\u708e\u75c7\u306b\u95a2\u4e0e\u3057\u307e\u3059\uff08\u56f32.5\uff09\u3002COX-2\u3084\u708e\u75c7\u3092\u963b\u5bb3\u3059\u308b\u85ac\u7406\u4f5c\u7528\u306e\u3042\u308b\u85ac\u5264\uff08\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u6027\u6297\u708e\u75c7\u85ac[NSAIDs]\u306a\u3069\uff09\u306f\u3001AD\u3001PD\u3001ALS\u3001\u304a\u3088\u3073MS\u306a\u3069\u306e\u75be\u60a3\u9032\u884c\u306e\u6291\u5236\u3042\u308b\u3044\u306f\u8efd\u6e1b\u306e\u76ee\u7684\u3067\u4f7f\u7528\u3059\u308b\u305f\u3081\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059<sup>*45<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-132-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3229 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-132-1.jpg\" alt=\"\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u53cd\u5fdc\" width=\"405\" height=\"346\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-42-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3230 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-42-1.jpg\" alt=\"NSAIDs\u306b\u3088\u308bCOX-2\u963b\u5bb3\u306b\u3088\u308b\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3\u751f\u6210\u306e\u6291\u5236\" width=\"397\" height=\"355\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-133-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3231 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-133-1.jpg\" alt=\"ND\u306b\u95a2\u9023\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\" width=\"811\" height=\"267\" \/><\/a> <img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3232 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-43-1.jpg\" alt=\"\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4e0d\u5168\u306b\u95a2\u4e0e\u3059\u308b\u4ee3\u8868\u7684\u306a\u30bf\u30f3\u30d1\u30af\u8cea\" width=\"812\" height=\"429\" \/><a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30bf\u30f3\u30d1\u30af\u8cea\u691c\u51fa\u7528\u6297\u4f53\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<h2>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u306e\u65b0\u898f\u5206\u91ce<\/h2>\n<h4>\u708e\u75c7<\/h4>\n<p>\u4e2d\u67a2\u795e\u7d4c\u7cfb\uff08CNS\uff09\u306f\u3001\u514d\u75ab\u5b66\u7684\u306b\u7279\u6709\u306e\u201c\u514d\u75ab\u7279\u6a29\u201d\u90e8\u4f4d\u3067\u3059\u3002\u30a4\u30f3\u30bf\u30af\u30c8\u306a\u8840\u6db2\u8133\u95a2\u9580\uff08BBB\uff09\u306f\u3001\u672b\u68a2\u514d\u75ab\u7d30\u80de\u304b\u3089CNS\u3078\u306e\u6d41\u5165\u3092\u5236\u9650\u3057\u307e\u3059\u3002\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u6d3b\u6027\u5316\u304a\u3088\u3073\u305d\u308c\u306b\u7d9a\u304f\u514d\u75ab\u5fdc\u7b54\u6027\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u6eb6\u6027\u56e0\u5b50\u3001\u306a\u3089\u3073\u306b\u795e\u7d4c\u6297\u539f\u306e\u30ea\u30f3\u30d1\u6392\u6db2\u306f\u3001\u514d\u75ab\u53cd\u5fdc\u3092\u8a98\u767a\u3059\u308b\u3088\u308a\u3082\u3080\u3057\u308d\u514d\u75ab\u5bdb\u5bb9 \uff08\u81ea\u5df1\u3068\u975e\u81ea\u5df1\u306e\u533a\u5225\u306e\u5b66\u7fd2\uff09\u3092\u4fc3\u9032\u3059\u308b\u3088\u3046\u306b\u4f5c\u7528\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u9632\u5fa1\u6a5f\u69cb\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u514d\u75ab\u7cfb\u306e\u81ea\u7136\u514d\u75ab\u304a\u3088\u3073\u9069\u5fdc\u514d\u75ab\u306f\u3068\u3082\u306b\u69d8\u3005\u306aND\u306b\u304a\u3051\u308b\u795e\u7d4c\u640d\u50b7\u306e\u958b\u59cb\u304a\u3088\u3073\u9032\u884c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u3068\u3055\u308c\u307e\u3059\uff08\u88682.9\uff09\u3002\u8133\u306b\u304a\u3051\u308b\u708e\u75c7\u8a98\u767a\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b\u305f\u3081\u306e\u6226\u7565\u306e\u958b\u767a\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6cbb\u7642\u306e\u65b0\u3057\u3044\u9078\u629e\u80a2\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u00a0<sup>*46<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-134-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3233 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-134-1.jpg\" alt=\"\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u514d\u75ab\u53cd\u5fdc \u75be\u60a3\u81ea\u7136\" width=\"811\" height=\"301\" \/><\/a><\/p>\n<p><a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies\/immunoassays.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u5f53\u793e\u3067\u306f\u3001\u6297\u4f53\u306b\u52a0\u3048\u3066\u3001\u795e\u7d4c\u514d\u75ab\u5b66\u306b\u95a2\u9023\u3059\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3064\u3044\u3066\u7814\u7a76\u3059\u308b\u305f\u3081\u306e\u9ad8\u5ea6\u306b\u691c\u8a3c\u3055\u308c\u305f\u5e45\u5e83\u3044ELISA\u304a\u3088\u3073Luminex\u30ad\u30c3\u30c8\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u8a73\u3057\u3044\u60c5\u5831\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<h4>\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u7642\u6cd5\u306e\u958b\u767a<\/h4>\n<p>\u5e79\u7d30\u80de\u751f\u7269\u5b66\u3001\u795e\u7d4c\u79d1\u5b66\u3001\u304a\u3088\u3073\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u6280\u8853\u306e\u9032\u6b69\u306f\u3001\u7814\u7a76\u306e\u65b0\u3057\u3044\u9053\u3092\u5207\u308a\u62d3\u304d\u307e\u3057\u305f\u3002\u5e79\u7d30\u80de\u306f\u81ea\u5df1\u8907\u88fd\u3057\u5206\u5316\u7d30\u80de\u3092\u7523\u751f\u3059\u308b\u305f\u3081\u3001\u4e2d\u67a2\u304a\u3088\u3073\u672b\u68a2\u795e\u7d4c\u7cfb\u306e\u969c\u5bb3\u304a\u3088\u3073\u640d\u50b7\u306e\u305f\u3081\u306e\u5e79\u7d30\u80de\u7f6e\u63db\u7642\u6cd5\u306f\u73fe\u5728\u4e0d\u6cbb\u306eND\u304a\u3088\u3073\u30cb\u30e5\u30fc\u30ed\u30f3\u640d\u50b7\u306e\u305f\u3081\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6b63\u5e38\u306a\u795e\u7d4c\u7cfb\u306e\u767a\u9054\u30d7\u30ed\u30bb\u30b9\u3092\u518d\u73fe\u3059\u308b\u305f\u3081\u306e\u6226\u7565\u3068\u3057\u3066\u306f\u3001\u5185\u5728\u6027\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u518d\u751f\u80fd\u529b\u306e\u6d3b\u6027\u5316\u3001\u3042\u308b\u3044\u306f\u80ce\u5150\u795e\u7d4c\u7d30\u80de\u307e\u305f\u306f\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPSCs\uff09\u7531\u6765\u7d30\u80de\u306e\u79fb\u690d\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u795e\u7d4c\u7cfb\u306b\u304a\u3051\u308b\u69d8\u3005\u306a\u6700\u7d42\u5206\u5316\u7d30\u80de\u96c6\u56e3\u3092\u751f\u3058\u3055\u305b\u308b\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08PSCs\uff09\u306e\u5206\u5316\u7d4c\u8def\u3092\u88682.6\u306b\u793a\u3057\u307e\u3059\u3002\u7279\u5b9a\u306e\u795e\u7d4c\u751f\u7269\u5b66\u7814\u7a76\u306e\u76ee\u7684\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u305f\u3081\u306b\u3001\u5f53\u793e\u3067\u306f\u8907\u6570\u306e\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u3067\u691c\u8a3c\u6e08\u307f\u306e\u9ad8\u7279\u7570\u7684\u6297\u4f53\u306e\u5e45\u5e83\u3044\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30c4\u30fc\u30eb\u306f\u3001\u30b0\u30ea\u30a2\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u8f38\u9001\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u65b0\u751f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u7814\u7a76\u3001\u304a\u3088\u3073\u4ed6\u306e\u795e\u7d4c\u751f\u7269\u5b66\u7814\u7a76\u5206\u91ce\u306b\u304a\u3051\u308b\u7814\u7a76\u3092\u5bb9\u6613\u306b\u3057\u307e\u3059\uff08\u88682.10\uff09<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-135-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3234 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-135-1.jpg\" alt=\"PSC\u306e\u795e\u7d4c\u7cfb\u7d71\u3078\u306e\u5206\u5316\u7d4c\u8def\" width=\"405\" height=\"806\" \/><\/a> <a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-44-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3235 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-44-1.jpg\" alt=\"B e t a - 3 T u b u l i n Monoclonal Antibody\" width=\"399\" height=\"404\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h2>\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u30ac\u30a4\u30c9\u30d6\u30c3\u30af<\/h2>\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u5185\u5bb9\u3092\u542b\u3080PDF\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n<p>\uff5e\u4e3b\u306a\u5185\u5bb9\uff5e<\/p>\n<ol>\n<li>\u30a4\u30f3\u30c8\u30ed\u30c0\u30af\u30b7\u30e7\u30f3<\/li>\n<li>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u5171\u901a\u306e\u30c6\u30fc\u30de<\/li>\n<li>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3078\u306e\u53d6\u308a\u7d44\u307f<\/li>\n<li>\u4ed6\u306e\u4e3b\u8981\u306a\u795e\u7d4c\u5909\u6027\u75be\u60a3<\/li>\n<li>\u6297\u4f53\uff1a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u306e\u305f\u3081\u306e\u5f37\u529b\u306a\u30c4\u30fc\u30eb<\/li>\n<\/ol>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies\/antibodies-learning-center\/antibodies-resource-library\/antibody-neurodegeneration-guidebook.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab3_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 8pt\">\u53c2\u8003\u6587\u732e\uff1a<br \/>\n1. Davis M, Stroud C, eds (2013) Neurodegeneration: Exploring Commonalities\u00a0Across Diseases: Workshop Summary USA: National Academy of Sciences. p4-15. http:\/\/www.nap.edu\/catalog.php?record_id=18341. Accessed September\u00a02015.<br \/>\n2. Prentice H, Pravinchandra JM, Wu JY (2015) Mechanisms of neuronal protection\u00a0against excitotoxicity, endoplasmic reticulum stress, and mitochondrial\u00a0dysfunction. Oxid Med Cell Longev Article ID 964518, in press.<br \/>\n3. Moussaud S, Jones DR, Moussaud-Lamodi\u00e8re, EL et al. (2014) et al. Alphasynuclein\u00a0and tau: teammates in neurodegeneration? Mol Neurodegen. 9:43.<br \/>\n4. Trippier PC, Jansen Labby K, Hawker DD et al. (2013) Target- and mechanismbased\u00a0therapeutics for neurodegenerative diseases: strength in numbers. J Med\u00a0Chem 56(8):3121\u20133147.<br \/>\n5. Jin H, Kanthasamy A, Ghosh A et al. (2014) Mitochondria-targeted antioxidants\u00a0for treatment of Parkinson\u2019s disease: preclinical and clinical outcomes. Biochim\u00a0Biophys Acta 1842(8):1282\u20131294.<br \/>\n6. Rao VK, Carlson EA, Yan SS et al. (2014) Mitochondrial permeability transition\u00a0pore is a potential drug target for neurodegeneration. Biochim Biophys Acta\u00a01842(8):1267\u20131272.<br \/>\n7. Swomley AM, F\u00f6rster S, Keeney JT et al. (2014) Abeta, oxidative stress in\u00a0Alzheimer disease: evidence based on proteomics studies. Biochim et Biophys\u00a0Acta. 2014; 1842(8):1248\u20131257.<br \/>\n8. Ciechanover A, Kwon YT (2015) Degradation of misfolded proteins in\u00a0neurodegenerative diseases: therapeutic targets and strategies. Exp Mol Med\u00a047:e147.<br \/>\n9. Peggion C, Sorgato MC, Bertoli A (2014) Prions and prion-like pathogens in\u00a0neurodegenerative disorders. Pathogens 3(1):149\u2013163.<br \/>\n10. Nah J, Yuan J, Jung YK et al. (2015) Autophagy in neurodegenerative diseases:\u00a0from mechanism to therapeutic approach. Mol Cells 38(5):381\u2013389.<br \/>\n11. Kesidou E, Lagoudaki R, Touloumi O et al. (2013) Autophagy and\u00a0neurodegenerative disorders. Neural Regen Res 8(24):2275\u20132283.<br \/>\n12. Rao RV, Bredesen DE (2004) Misfolded proteins, endoplasmic reticulum stress\u00a0and neurodegeneration. Curr Opin Cell Biol 16(6):653\u2013662.<br \/>\n13. Soto C (2003) Unfolding the role of protein misfolding in neurodegenerative\u00a0diseases. Nat Rev Neurosci 4(1):49\u201360.<br \/>\n14. Tullman MJ (2013) Overview of the epidemiology, diagnosis, and disease\u00a0progression associated with multiple sclerosis. Am J Manag Care 19(2 Suppl):S15\u201320.<br \/>\n15. Van der Walt A, Butzkeuven H, Kolbe S et al. (2010) Neuroprotection in\u00a0multiple sclerosis: a therapeutic challenge for the next decade. Pharmacol Ther\u00a0126(1):82\u201393.<br \/>\n16. Wilkins A, Scolding N (2008) Protecting axons in multiple sclerosis. Mult Scler\u00a014(8):1013\u20131025.<br \/>\n17. Querfurth HW, LaFerla FM (2010) Alzheimer\u2019s disease. N Engl J Med\u00a0362(4):329\u2013344.<br \/>\n18. Kumar A, Singh A, Ekavi AS (2015) A review on Alzheimer\u2019s disease\u00a0pathophysiology and its management: an update. Pharmacol Rep 67(2):195\u2013203.<br \/>\n19. Wu GF, Alvarez E (2011) The Immunopathophysiology of multiple sclerosis.\u00a0Neurol Clin 29(2):257\u2013278.<br \/>\n20. Miller BR, Bezprozvanny I (2010) Corticostriatal circuit dysfunction in\u00a0Huntington\u2019s disease: intersection of glutamate, dopamine and calcium. Future\u00a0Neurol 5(5):735\u2013756.<br \/>\n21. Persson S, Havton LA (2009) Retrogradely transported fluorogold accumulates in lysosomes of neurons and is detectable ultrastructurally using postembedding\u00a0immuno-gold methods. J Neurosci Methods 184(1):42\u201347.<br \/>\n22. Tarawneh R, Galvin JE (2009) Dementia With Lewy Bodies and Other\u00a0Synucleinopathies. In: Weiner MF, Lipton AM, eds. Textbook of Alzheimer\u00a0Disease and Other Dementias Washington DC: American Psychiatric Publishing,\u00a0Inc. pp 195\u2013217.<br \/>\n23. http:\/\/www.neurodegenerationresearch.eu\/uploads\/media\/JPND_Exp_Models_Final_report_Jan_2014_-_DM.pdf<br \/>\n24. Irwin DJ, Lee VM, Trojanowski JQ (2013) Parkinson\u2019s disease dementia:\u00a0convergence of -synuclein, tau and amyloid- pathologies. Nat Rev Neurosci\u00a014(9):626\u2013636.<br \/>\n25. Wang S, Kaufman RJ (2012) The impact of the unfolded protein response on\u00a0human disease. J Cell Biol. 2012 Jun 25;197(7):857\u2013867.<br \/>\n26. Hetz C, Mollereau B (2014) Disturbance of endoplasmic reticulum proteostasis\u00a0in neurodegenerative diseases. Nat Rev Neurosci 15(4):233\u2013249.<br \/>\n27. Glick D, Barth S, Macleod KF (2010) Autophagy: cellular and molecular\u00a0mechanisms. J Pathol 22(1):3\u201312.<br \/>\n28. F\u00fcllgrabe J, Klionsky DJ, Joseph B (2014) The return of the nucleus:\u00a0transcriptional and epigenetic control of autophagy. Nat Rev Mol Cell Biol\u00a015(1):65\u201374.<br \/>\n29. Chen Y, Klionsky DJ (2011) The regulation of autophagy &#8211; unanswered\u00a0questions. J Cell Sci 124(Pt 2):161\u201370.<br \/>\n30. Bachhuber T, Katzmarski N, McCarter JF et al (2015) Inhibition of amyloidplaque\u00a0formation by -synuclein. Nat Med 21(7):802\u2013807.<br \/>\n31. Lee G, Leugers CJ (2012) Tau and tauopathies. Prog Mol Biol Transl Sci\u00a0107:263\u2013293.<br \/>\n32. Smirnova E, Griparic L, Shurland DL et al. (2001) Dynamin-related protein\u00a0Drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell\u00a012(8):2245\u20132256.36.<br \/>\n33. Lalier L, Cartron PF, Juin P et al. (2007) Bax activation and mitochondrial\u00a0insertion during apoptosis. Apoptosis 12(5):887\u2013896.<br \/>\n34. NCBI. FIS1 fission, mitochondrial 1 [ Homo sapiens (human) ]. http:\/\/www.ncbi.nlm.nih.gov\/gene\/51024. Accessed August, September 2015.<br \/>\n35. Coll RC, Robertson AA, Chae JJ et al. (2015) A small-molecule inhibitor of the\u00a0NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med.\u00a02015 Mar;21(3):248\u2013255.<br \/>\n36. Wakana Y, Takai S, Nakajima K et al. (2008) Bap31 Is an Itinerant protein that\u00a0moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear\u00a0compartment related to ER-associated degradation. Mol Biol Cell 19(5):1825\u20131836.<br \/>\n37. Phosphofurin Acidic Cluster Sorting Protein 2. GeneCards.org. Http:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=PACS2. Accessed August, September\u00a02015.<br \/>\n38. Liu Y, Liu W, Song XD et al. (2005) Effect of GRP75\/mthsp70\/PBP74\/mortalinoverexpression on intracellular ATP level, mitochondrial membrane potential\u00a0and ROS accumulation following glucose deprivation in PC12 cells. Mol Cell\u00a0Biochem 268(1\u20132):45\u201351.<br \/>\n39. MFN2 Gene. GeneCards.org. http:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=MFN2. Accessed August, September 2015.<br \/>\n40. Sebasti\u00e1n D, Hern\u00e1ndez-Alvarez MI, Segal\u00e9s J et al. (2012) Mitofusin 2 (Mfn2)\u00a0links mitochondrial and endoplasmic reticulum function with insulin signaling and\u00a0is essential for normal glucose homeostasis. PNAS 109(14):5523\u20135528.<br \/>\n41. Hong J, Sha S, Zhou L et al. (2015) Sigma-1 receptor deficiency reduces\u00a0MPTP-induced parkinsonism and death of dopaminergic neurons. Cell Death\u00a0Dis 23;6:e1832.<br \/>\n42. Li XJ, Orr AL, Li S (2010) Impaired mitochondrial trafficking in Huntington\u2019s\u00a0disease. Biochim Biophys Acta 1802(1):62\u201365.<br \/>\n43. Cha MY, Kim DK, Mook-Jung I et al. (2015) The role of mitochondrial DNA\u00a0mutation on neurodegenerative diseases. Exp Mol Med 47:e150.<br \/>\n44. Youle RJ, van der Bliek AM (2012) Mitochondrial fission, fusion, and stress\u00a0Science 337(6098):1062\u20131065.<br \/>\n45. Figueiredo-Pereira ME, Rockwell P, Schmidt-Glenewinkel T et al. (2015)\u00a0Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitinproteasome\u00a0pathway and mitochondria to neurodegeneration. Front Mol\u00a0Neurosci 13;7:104.<br \/>\n46. Amor S, Peferoen LA, Vogel DY et al. (2014) Inflammation in neurodegenerative\u00a0diseases&#8211;an update. Immunology 142(2):151\u201366<br \/>\n<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u76ee\u7684\u304a\u3088\u3073\u305d\u306e\u624b\u7d9a\u304d\u4e0a\u3067\u306e\u4f7f\u7528\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6982\u8ad6 \u795e\u7d4c\u5909\u6027\u3068\u306f\u3001\u7d30\u80de\u306e\u69cb\u9020\u304a\u3088\u3073\u6a5f\u80fd\u306e\u640d\u5931\u3092\u304d\u305f\u3057\u3066\u3044\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u6307\u3059\u4e00\u822c\u7684\u7528\u8a9e\u3067\u3059\u00a0*1 \u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u4f8b\u3068\u3057\u3066\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff08PD\uff09\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u3001\u304a\u3088<\/p>\n","protected":false},"author":988,"featured_media":4273,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[156],"tags":[32],"division":[],"class_list":{"0":"post-1072","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-mol-bio","8":"tag-antibody","9":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b - Learning at the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b\" \/>\n<meta property=\"og:description\" content=\"\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6982\u8ad6 \u795e\u7d4c\u5909\u6027\u3068\u306f\u3001\u7d30\u80de\u306e\u69cb\u9020\u304a\u3088\u3073\u6a5f\u80fd\u306e\u640d\u5931\u3092\u304d\u305f\u3057\u3066\u3044\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u6307\u3059\u4e00\u822c\u7684\u7528\u8a9e\u3067\u3059\u00a0*1 \u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u4f8b\u3068\u3057\u3066\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff08PD\uff09\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u3001\u304a\u3088\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/\" \/>\n<meta property=\"og:site_name\" content=\"Learning at the Bench\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ThermoFisherJapan\" \/>\n<meta property=\"article:published_time\" content=\"2018-12-19T00:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-12-27T08:47:15+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png\" \/>\n\t<meta property=\"og:image:width\" content=\"830\" \/>\n\t<meta property=\"og:image:height\" content=\"429\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"LATB Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ThermoFisherJP\" \/>\n<meta name=\"twitter:site\" content=\"@ThermoFisherJP\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"LATB Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"51\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/\"},\"author\":{\"name\":\"LATB Staff\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/00a095a01d54afcdf9457465feb04f7d\"},\"headline\":\"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b\",\"datePublished\":\"2018-12-19T00:00:00+00:00\",\"dateModified\":\"2023-12-27T08:47:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/\"},\"wordCount\":1444,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/neuron-modfied.png\",\"keywords\":[\"\u6297\u4f53\"],\"articleSection\":[\"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023\"],\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/\",\"name\":\"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b - Learning at the Bench\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/neuron-modfied.png\",\"datePublished\":\"2018-12-19T00:00:00+00:00\",\"dateModified\":\"2023-12-27T08:47:15+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/00a095a01d54afcdf9457465feb04f7d\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/neuron-modfied.png\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/neuron-modfied.png\",\"width\":830,\"height\":429,\"caption\":\"\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/neuro_disease1\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/\",\"name\":\"Learning at the Bench\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/00a095a01d54afcdf9457465feb04f7d\",\"name\":\"LATB Staff\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g\",\"caption\":\"LATB Staff\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/latbstaff\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b - Learning at the Bench","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/","og_locale":"ja_JP","og_type":"article","og_title":"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b","og_description":"\u795e\u7d4c\u5909\u6027\u75be\u60a3\u6982\u8ad6 \u795e\u7d4c\u5909\u6027\u3068\u306f\u3001\u7d30\u80de\u306e\u69cb\u9020\u304a\u3088\u3073\u6a5f\u80fd\u306e\u640d\u5931\u3092\u304d\u305f\u3057\u3066\u3044\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u6307\u3059\u4e00\u822c\u7684\u7528\u8a9e\u3067\u3059\u00a0*1 \u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u4f8b\u3068\u3057\u3066\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\uff08PD\uff09\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u3001\u304a\u3088","og_url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/","og_site_name":"Learning at the Bench","article_publisher":"https:\/\/www.facebook.com\/ThermoFisherJapan","article_published_time":"2018-12-19T00:00:00+00:00","article_modified_time":"2023-12-27T08:47:15+00:00","og_image":[{"width":830,"height":429,"url":"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png","type":"image\/png"}],"author":"LATB Staff","twitter_card":"summary_large_image","twitter_creator":"@ThermoFisherJP","twitter_site":"@ThermoFisherJP","twitter_misc":{"\u57f7\u7b46\u8005":"LATB Staff","\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"51\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#article","isPartOf":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/"},"author":{"name":"LATB Staff","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/00a095a01d54afcdf9457465feb04f7d"},"headline":"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b","datePublished":"2018-12-19T00:00:00+00:00","dateModified":"2023-12-27T08:47:15+00:00","mainEntityOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/"},"wordCount":1444,"commentCount":0,"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png","keywords":["\u6297\u4f53"],"articleSection":["\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023"],"inLanguage":"ja","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/","url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/","name":"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b - Learning at the Bench","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#primaryimage"},"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png","datePublished":"2018-12-19T00:00:00+00:00","dateModified":"2023-12-27T08:47:15+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/00a095a01d54afcdf9457465feb04f7d"},"breadcrumb":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/"]}]},{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png","contentUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png","width":830,"height":429,"caption":"\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76"},{"@type":"BreadcrumbList","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/neuro_disease1\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/"},{"@type":"ListItem","position":2,"name":"\u3010\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u5b66\u307c\u30461\u3011\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u305b\u307e\u308b"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#website","url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/","name":"Learning at the Bench","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/00a095a01d54afcdf9457465feb04f7d","name":"LATB Staff","image":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/secure.gravatar.com\/avatar\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g","caption":"LATB Staff"},"url":"https:\/\/admin.acceleratingscience.com\/author\/latbstaff\/"}]}},"taxonomy_info":{"category":[{"value":156,"label":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023"}],"post_tag":[{"value":32,"label":"\u6297\u4f53"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png",760,393,false],"author_info":{"display_name":"LATB Staff","author_link":"https:\/\/admin.acceleratingscience.com\/author\/latbstaff\/"},"comment_info":0,"category_info":[{"term_id":156,"name":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","slug":"mol-bio","term_group":0,"term_taxonomy_id":156,"taxonomy":"category","description":"","parent":0,"count":538,"filter":"raw","meta":[],"cat_ID":156,"category_count":538,"category_description":"","cat_name":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","category_nicename":"mol-bio","category_parent":0}],"tag_info":[{"term_id":32,"name":"\u6297\u4f53","slug":"antibody","term_group":0,"term_taxonomy_id":32,"taxonomy":"post_tag","description":"","parent":0,"count":31,"filter":"raw","meta":[]}],"jetpack-related-posts":[{"id":24108,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cell-culture-cell-count-bid-ts-mbr-25065-2\/","url_meta":{"origin":1072,"position":0},"title":"\u3010\u7b2c6\u56de\u3011 \u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c6\u30a3\u30f3\u30b0\u6cd5\u306b\u3088\u308b \u300e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u4e2d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\uff08Protein cargo\uff09\u300f\u306e\u89e3\u6790","author":"LatB Staff","date":"2026\u5e747\u670815\u65e5","format":false,"excerpt":"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff08\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\uff09\u306f\u3001\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u5c0f\u3055\u306a\u819c\u5c0f\u80de\u3067\u3001\u6838\u9178\uff08RNA\uff0fDNA\uff09\u3060\u3051\u3067\u306a\u304f\u3001\u2026","rel":"","context":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","block_context":{"text":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/mol-bio\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-culture-cell-count-bid-ts-mbr-25065_eyecatch.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-culture-cell-count-bid-ts-mbr-25065_eyecatch.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-culture-cell-count-bid-ts-mbr-25065_eyecatch.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-culture-cell-count-bid-ts-mbr-25065_eyecatch.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-culture-cell-count-bid-ts-mbr-25065_eyecatch.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-culture-cell-count-bid-ts-mbr-25065_eyecatch.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":25472,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/exosome-ts-r-25067\/","url_meta":{"origin":1072,"position":1},"title":"\u3010\u7b2c7\u56de\u3011 \u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u30b5\u30d6\u30bf\u30a4\u30d7\u306e\u5206\u753b\u306e\u6982\u8981","author":"LatB Staff","date":"2026\u5e748\u670813\u65e5","format":false,"excerpt":"\u7d30\u80de\u304c\u5206\u6ccc\u3059\u308b\u7d30\u80de\u5916\u5c0f\u80de\u306e\u4e2d\u3067\u3082\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u305d\u306e\u60c5\u5831\u4f1d\u9054\u6a5f\u80fd\u3084\u75be\u60a3\u3068\u306e\u95a2\u9023\u6027\u304b\u3089\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u2026","rel":"","context":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","block_context":{"text":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/mol-bio\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25019_eyecatch.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25019_eyecatch.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25019_eyecatch.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25019_eyecatch.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25019_eyecatch.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25019_eyecatch.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":24382,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cell-imaging-fluorescent-dye-bid-ts-mbr-25075\/","url_meta":{"origin":1072,"position":2},"title":"Cell Painting Assay\u3067\u7528\u3044\u3089\u308c\u308b\u8a66\u85ac\u306b\u3064\u3044\u3066 (Hoechst\u3092\u7528\u3044\u305f\u6838\u67d3\u8272\uff09","author":"LatB Staff","date":"2025\u5e7412\u670810\u65e5","format":false,"excerpt":"\u8fd1\u5e74\u3001\u30bb\u30eb\u30da\u30a4\u30f3\u30c6\u30a3\u30f3\u30b0\uff08Cell Painting\uff09\u3068\u3044\u3046\u30a2\u30c3\u30bb\u30a4\u65b9\u6cd5\u304c\u5e83\u307e\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u7d30\u80de\u306b\u2026","rel":"","context":"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0","block_context":{"text":"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/cell\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-imaging-fluorescent-dye-bid-ts-mbr-25075_eyecatch-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-imaging-fluorescent-dye-bid-ts-mbr-25075_eyecatch-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-imaging-fluorescent-dye-bid-ts-mbr-25075_eyecatch-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-imaging-fluorescent-dye-bid-ts-mbr-25075_eyecatch-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-imaging-fluorescent-dye-bid-ts-mbr-25075_eyecatch-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/cell-imaging-fluorescent-dye-bid-ts-mbr-25075_eyecatch-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":20124,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/exosome-gene-therapy-ts-r-25015\/","url_meta":{"origin":1072,"position":3},"title":"\u3010\u7b2c1\u56de\u3011Exosome\uff08\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff0f\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\uff09\u3068\u306f\uff1f","author":"LatB Staff","date":"2026\u5e744\u670815\u65e5","format":false,"excerpt":"Exosome\uff08\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff0f\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\uff09\u306e\u7814\u7a76\u304c\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u8208\u5473\u306f\u3042\u3063\u3066\u3082\u3001\u3069\u306e\u3088\u3046\u306b\u7814\u2026","rel":"","context":"\u305d\u306e\u4ed6","block_context":{"text":"\u305d\u306e\u4ed6","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/else\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":24416,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cell-imaging-fluorescent-dye-bid-ts-mbr-25076\/","url_meta":{"origin":1072,"position":4},"title":"Cell Painting Assay\u3067\u7528\u3044\u3089\u308c\u308b\u8a66\u85ac\u306b\u3064\u3044\u3066\uff08MitoTracker\u3092\u7528\u3044\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u67d3\u8272\uff09","author":"LatB Staff","date":"2025\u5e7412\u670819\u65e5","format":false,"excerpt":"\u8fd1\u5e74\u3001\u30bb\u30eb\u30da\u30a4\u30f3\u30c6\u30a3\u30f3\u30b0\uff08Cell Painting\uff09\u3068\u3044\u3046\u30a2\u30c3\u30bb\u30a4\u65b9\u6cd5\u304c\u5e83\u307e\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u2026","rel":"","context":"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0","block_context":{"text":"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/cell\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/12\/cell-imaging-fluorescent-dye-bid-ts-mbr-25076_eyecatch-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/12\/cell-imaging-fluorescent-dye-bid-ts-mbr-25076_eyecatch-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/12\/cell-imaging-fluorescent-dye-bid-ts-mbr-25076_eyecatch-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/12\/cell-imaging-fluorescent-dye-bid-ts-mbr-25076_eyecatch-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/12\/cell-imaging-fluorescent-dye-bid-ts-mbr-25076_eyecatch-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/12\/cell-imaging-fluorescent-dye-bid-ts-mbr-25076_eyecatch-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":23239,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/ngs-gene-expression-csd-ts-bfx-25060\/","url_meta":{"origin":1072,"position":5},"title":"\u98df\u54c1\u958b\u767a\u306b\u304a\u3051\u308b\u83cc\u53e2\u89e3\u6790\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u306e\u6d3b\u7528","author":"LatB Staff","date":"2025\u5e7410\u67088\u65e5","format":false,"excerpt":"\u907a\u4f1d\u5b50\u95a2\u9023\u306e\u89e3\u6790\u6280\u8853\u304c\u7814\u7a76\u306e\u307f\u306a\u3089\u305a\u7523\u696d\u5206\u91ce\u3067\u6d3b\u7528\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u5e74\u6708\u304c\u7d4c\u904e\u3059\u308b\u306b\u3064\u308c\u3066\u5fdc\u7528\u7bc4\u56f2\u3082\u2026","rel":"","context":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","block_context":{"text":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/mol-bio\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/09\/ngs-gene-expression-gsd-ts-tr-25060_eyecatch.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/09\/ngs-gene-expression-gsd-ts-tr-25060_eyecatch.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/09\/ngs-gene-expression-gsd-ts-tr-25060_eyecatch.jpg?resize=525%2C300&ssl=1 1.5x"},"classes":[]}],"jetpack_sharing_enabled":true,"amp_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/neuron-modfied.png","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts\/1072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/users\/988"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/comments?post=1072"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts\/1072\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/media\/4273"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/media?parent=1072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/categories?post=1072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/tags?post=1072"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/division?post=1072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}