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\u75c5\u614b\u751f\u7406\u5b66<\/h4>\n

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\u5b9f\u9a13\u7684\u6cbb\u7642<\/h4>\n

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\"\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u65e2\u5b58\u306e\u6cbb\u7642\u6cd5\"<\/a>\u5f53\u793e\u306e\u6297\u4f53\u30d9\u30fc\u30b9\u30c4\u30fc\u30eb\u306e\u5e45\u5e83\u3044\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n

\u5f53\u8a18\u4e8b\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002
\n\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n

\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n

\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5<\/h2>\n

\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306e\u7279\u5fb4<\/h4>\n

\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\uff08HD)\u306f\u3001\u9032\u884c\u6027\u3067\u3001\u901a\u5e38\u907a\u4f1d\u6027\u306e\u3001\u5178\u578b\u7684\u306a\u4e09\u5927\u75c7\u72b6\u3092\u7279\u5fb4\u3068\u3059\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3059\uff08\u88684.4\uff09*23<\/sup> \u3002\u75c7\u72b6\u306e\u5e73\u5747\u767a\u75c7\u5e74\u9f62\u306f\u7d0435\uff5e44\u6b73\u3067\u3059\u304c\u300110\uff05\u306e\u75c7\u4f8b\u3067\u306f\u5e7c\u5150\u671f\u306b\u767a\u75c7\u3057\u307e\u3059\u00a0*24,25<\/sup> \u3002\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306e\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u4e00\u822c\u7684\u306b\u306f\u767a\u75c7\u5e74\u304b\u308915\uff5e18\u5e74\u3067\u3059\u00a0*27<\/sup> \u3002\u73fe\u5728\u3001HD\u306e\u9032\u884c\u3092\u9045\u5ef6\u307e\u305f\u306f\u505c\u6b62\u3055\u305b\u308b\u6cbb\u7642\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u00a0*28<\/sup> \u3002\u672c\u75be\u60a3\u306e\u81ea\u7136\u7d4c\u904e\u306b\u306f\u3001\u660e\u3089\u304b\u306a\u75be\u60a3\u306b\u5148\u884c\u3057\u3066\u5fae\u5999\u306a\u5909\u5316\u3092\u6765\u305f\u3059\u201c\u524d\u99c6\u201d\u6bb5\u968e\u3082\u5b58\u5728\u3057\u307e\u3059\u3002\uff08\u56f34.3\uff09\u00a0*25\u00a0<\/sup>\u3002<\/p>\n

\u7814\u7a76\u306e\u91cd\u8981\u306a\u65b0\u9818\u57df\u306e1\u3064\u306f\u3001\u524d\u99c6\u6bb5\u968e\u306b\u304a\u3051\u308b\u5fae\u5999\u306a\u5909\u5316\u3092\u691c\u51fa\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u540c\u5b9a\u3067\u3059\u3002\u65e9\u671f\u306e\u533b\u7642\u4ecb\u5165\u306b\u3064\u306a\u304c\u308a\u3001\u5275\u85ac\u52aa\u529b\u3092\u524d\u9032\u3055\u305b\u308b\u65e9\u671f\u767a\u898b\u3092\u53ef\u80fd\u3068\u3057\u3001\u3055\u3089\u306b\u75be\u60a3\u9032\u884c\u306e\u8ffd\u8de1\u3082\u53ef\u80fd\u3068\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a\u306f\u6025\u52d9\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u3001\u65e9\u671f\u533b\u7642\u4ecb\u5165\u306e\u305f\u3081\u306e\u6cbb\u7642\u6cd5\u306e\u63d0\u6848\u3092\u53ef\u80fd\u3068\u3057\u307e\u3059\u00a0*26\u00a0<\/sup>\u3002<\/p>\n

\"\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7528\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\"<\/a>\"\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306e\u4e09\u5927\u75c7\u72b6\/\u7279\u6027\/\u7279\u5fb4\"<\/a><\/p>\n

HD\u306e\u539f\u56e0<\/h4>\n

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\"HTT\u907a\u4f1d\u5b50\u4e2d\u306eCAG\u30ea\u30d4\u30fc\u30c8\"<\/a><\/p>\n

\u75c5\u614b\u751f\u7406\u5b66<\/h4>\n

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\"HD\u306e\u9032\u884c\u306b\u304a\u3051\u308b\u5909\u7570HTT\u306e\u5f79\u5272\"<\/a><\/p>\n

\u30bf\u30fc\u30b2\u30c3\u30c8\u304a\u3088\u3073\u6709\u671b\u306a\u6cbb\u7642\u85ac<\/h4>\n

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\u5e79\u7d30\u80de\u30d9\u30fc\u30b9\u306e\u6cbb\u7642<\/h4>\n

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\u7b2c1\u306e\u76ee\u6a19\u306e\u305f\u3081\u306e\u91cd\u8981\u8981\u4ef6\u306f\u3001\u88ab\u9a13\u8005\u306b\u79fb\u690d\u3059\u308b\u305f\u3081\u306b\u3001\u5e79\u7d30\u80de\u3092\u3001\u660e\u78ba\u306b\u5b9a\u7fa9\u3055\u308c\u3001\u9ad8\u5ea6\u306b\u7d14\u5316\u3055\u308c\u305f\u7cfb\u5217\u6c7a\u5b9a\u6e08\u307f\u7d30\u80de\u307e\u305f\u306f\u5206\u5316\u7d30\u80de\u306e\u96c6\u56e3\u306b\u5206\u5316\u3055\u305b\u308b\u80fd\u529b\u3067\u3059\u3002\u3053\u306e\u76ee\u6a19\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u30012\u3064\u306e\u88dc\u5b8c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u3063\u3066\u3001\u56fa\u6709\u306e\u907a\u4f1d\u5b50\u30b5\u30a4\u30f3\u3084\u907a\u4f1d\u5b50\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306b\u57fa\u3065\u3044\u3066\u3001\u5e79\u7d30\u80de\u3001\u524d\u99c6\u4f53\u3001\u304a\u3088\u3073\u5206\u5316\u3057\u305f\u795e\u7d4c\u7d30\u80de\u307e\u305f\u306f\u30b0\u30ea\u30a2\u7d30\u80de\u306e\u7279\u6027\u6c7a\u5b9a\u304a\u3088\u3073\u5206\u985e\u3092\u884c\u3044\u307e\u3059\u3002\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u30b5\u30a4\u30f3\u3092\u691c\u51fa\u3057\u307e\u3059\u304c\u3001\u7d30\u80de\u8868\u9762\u30de\u30fc\u30ab\u30fc\u304a\u3088\u3073\u6804\u990a\/\u5206\u5316\u56e0\u5b50\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3067\u304d\u308b\u70b9\u3067\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u30a2\u30d7\u30ed\u30fc\u30c1\u3088\u308a\u3082\u52b9\u7387\u7684\u3067\u3059\u00a0*35\u00a0<\/sup>\u3002<\/p>\n

\"\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u85ac\"\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u3092\u4fc3\u9032\u3059\u308b\u6297\u4f53\u30d9\u30fc\u30b9\u306e\u30c4\u30fc\u30eb\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n

\u5f53\u8a18\u4e8b\u306f\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002
\n\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n

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\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7<\/h2>\n

\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u306e\u7279\u5fb4<\/h4>\n

\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306f\u3001\u30eb\u30fc\u30fb\u30b2\u30fc\u30ea\u30c3\u30af\u75c5\u3068\u3082\u547c\u3070\u308c\u3001\u8133\u304a\u3088\u3073\u810a\u9ac4\u306e\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u4fb5\u3055\u308c\u307e\u3059\u3002ALS\u306f\u3001\u6210\u4eba\u5f8c\u306b\u767a\u75c7\u3059\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u75be\u60a3\u3067\u30013\u756a\u76ee\u306b\u4e00\u822c\u7684\u306a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3059\u00a0*36<\/sup> \u3002ALS\u306e\u75c7\u72b6\u306b\u306f\u3001\u53cd\u5c04\u306e\u5909\u5316\u3001\u7b4b\u529b\u4f4e\u4e0b\u3001\u7b4b\u8089\u306e\u840e\u7e2e\u3001\u6523\u7e2e\u3001\u304a\u3088\u3073\u75d9\u6523\u304c\u3042\u308a\u307e\u3059\u3002ALS\u306f\u3001\u4e00\u822c\u7684\u306b\u7d0460\u6b73\u3067\u767a\u75c7\u3057\u30011\u3064\u306e\u7b4b\u8089\u30b5\u30d6\u30bb\u30c3\u30c8\u306b\u304a\u3044\u3066\u5f90\u3005\u306b\u75c7\u72b6\u304c\u59cb\u307e\u308a\u3001\u4ed6\u306e\u7b4b\u8089\u30b0\u30eb\u30fc\u30d7\u306b\u6d3e\u751f\u3057\u3066\u3044\u304d\u307e\u3059\u00a0*37<\/sup> \u300280\uff05\u306e\u75c7\u4f8b\u306b\u304a\u3044\u3066\u810a\u9ac4\u306b\u767a\u75c7\u3057\u3001\u975e\u5bfe\u79f0\u6027\u3067\u7121\u75db\u306e\u56db\u80a2\u306e\u7b4b\u529b\u4f4e\u4e0b\u304c\u751f\u3058\u307e\u3059\u00a0*37<\/sup> \u3002\u307e\u305f\u300120\uff05\u306e\u75c7\u4f8b\u306b\u304a\u3044\u3066\u5480\u56bc\u3001\u56a5\u4e0b\u3001\u304a\u3088\u3073\u767a\u58f0\u3092\u53f8\u308b\u9854\u9762\u306e\u5ef6\u9ac4\u7b4b\u306b\u767a\u75c7\u3057\u307e\u3059\u3002ALS\u60a3\u8005\u306f\u3001\u75c7\u72b6\u306e\u767a\u75c7\u5f8c\u3001\u5e73\u57473\u5e74\u751f\u5b58\u3057\u307e\u3059\u304c\u3001\u751f\u5b58\u671f\u9593\u306b\u306f\u9855\u8457\u306a\u3070\u3089\u3064\u304d\u3082\u3042\u308a\u307e\u3059\u00a0*41<\/sup> \u3002\u6b7b\u4ea1\u539f\u56e0\u306f\u3001\u901a\u5e38\u3001\u547c\u5438\u56f0\u96e3\u304a\u3088\u3073\u547c\u5438\u306e\u904b\u52d5\u5236\u5fa1\u969c\u5bb3\u3067\u3059\u00a0*41\u3002<\/sup> ALS\u3067\u306f\u3001\u904b\u52d5\u7cfb\u306e\u969c\u5bb3\u306b\u52a0\u3048\u3066\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u524d\u982d\u5074\u982d\u8449\u306e\u6a5f\u80fd\u969c\u5bb3\u306f\u3001\u8efd\u5ea6\u306e\u7570\u5e38\u304b\u3089\u91cd\u7be4\u306a\u524d\u982d\u5074\u982d\u8449\u8a8d\u77e5\u75c7\uff08FTD\uff09\u306e\u7bc4\u56f2\u3067\u767a\u73fe\u3057\u307e\u3059\u3002ALS\u3068FTD\u306e\u4e21\u65b9\u3092\u767a\u73fe\u3057\u305f\u60a3\u8005\u306f\u3001\u3044\u305a\u308c\u304b\u3092\u5358\u72ec\u3067\u767a\u73fe\u3057\u305f\u60a3\u8005\u306b\u6bd4\u3079\u3066\u751f\u5b58\u7387\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u00a0*44\u00a0<\/sup>\u3002<\/p>\n

\"ALS\u306b\u4fb5\u3055\u308c\u308b\u8eab\u4f53\u90e8\u4f4d\"<\/a><\/p>\n

\u4e00\u822c\u7684\u539f\u56e0<\/h4>\n

ALS\u75c7\u4f8b\u306e\u3046\u3061\u3001\u7d0410\uff05\u304c\u5bb6\u65cf\u6027ALS\u3067\u3042\u308a\u3001\u5168\u90e8\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u5927\u90e8\u5206\u306e\u5bb6\u65cf\u6027ALS\u306f\u5358\u4e00\u907a\u4f1d\u5b50\u5909\u7570\u306e\u7d99\u627f\u306b\u3088\u3063\u3066\u767a\u75c7\u3057\u307e\u3059\u00a0*37<\/sup> \u3002\u907a\u4f1d\u7684\u539f\u56e0\u306b\u3064\u3044\u3066\u306f\u3001\u73fe\u5728\u3067\u306f\u7d043\u5206\u306e2\u306e\u5bb6\u65cf\u6027ALS\u75c7\u4f8b\u306810\uff05\u306e\u5b64\u767a\u6027ALS\u306b\u3064\u3044\u3066\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u3059\u00a0*36<\/sup> \u300260\uff05\u306eALS\u306e\u75c7\u4f8b\u306f\u3001SOD1\u3001TARDBP\/TDP-43\u3001FUS\u3001\u304a\u3088\u3073C9orf72\u306e\u308f\u305a\u304b4\u7a2e\u985e\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u767a\u75c7\u3057\u3066\u3044\u307e\u3059\u00a0*36<\/sup> \u3002\u7570\u306a\u308bALS\u5909\u7570\u304c\u540c\u3058\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u306b\u5f71\u97ff\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u3068\u3044\u3046\u65b0\u3057\u3044\u30c6\u30fc\u30de\u304c\u63d0\u8d77\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001SQSTM1\u304a\u3088\u3073TBK1\u907a\u4f1d\u5b50\u306f\u3068\u3082\u306b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u5fc5\u8981\u3068\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3001FUS\/TLS\uff08fused in sarcoma\uff09\u304a\u3088\u3073TARDBP\/TDP-43\u306f\u3068\u3082\u306bRNA\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u6a5f\u80fd\u3057\u307e\u3059\uff08\u88684.7\uff09\u00a0*36,45<\/sup> \u3002Als2\/Alsin\u907a\u4f1d\u5b50\u306f\u82e5\u5e74\u767a\u75c7\u3001\u5e38\u67d3\u8272\u4f53\u52a3\u6027\u578b\u306e\u5bb6\u65cf\u6027ALS\u306b\u95a2\u4e0e\u3057\u307e\u3059\uff08\u5e73\u5747\u5e74\u9f626.5\uff09*36,41,45<\/sup>\u3002<\/p>\n

\"\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u9078\u629e\u30bf\u30f3\u30d1\u30af\u8cea\"<\/a><\/p>\n

\u75c5\u614b\u751f\u7406\u5b66<\/h4>\n

ALS\u306e\u75c5\u614b\u306f\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u30b0\u30ea\u30aa\u30fc\u30b7\u30b9\uff08\u30cb\u30e5\u30fc\u30ed\u30f3\u6b7b\u306b\u53cd\u5fdc\u3057\u305f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u5897\u52a0\uff09\u3092\u4f34\u3046\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5909\u6027\u304a\u3088\u3073\u6b7b\u3092\u7279\u5fb4\u3068\u3057\u307e\u3059\u00a0*48<\/sup>\u00a0\u3002\u30e6\u30d3\u30ad\u30c1\u30f3\u967d\u6027\u3001TARDBP\u967d\u6027\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\uff08\u4e0d\u6eb6\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u4f53\uff09\u306f\u3001\u5b9f\u8cea\u7684\u306b\u3001SOD1\u307e\u305f\u306fFUS\u5909\u7570\u306b\u3088\u308bALS\u3092\u9664\u304f\u5168\u3066\u306eALS\u5f62\u614b\u306e\u9855\u8457\u306a\u7279\u5fb4\u3067\u3059\u00a0*36, 38,49-51<\/sup> \u3002\u3053\u306e\u305f\u3081\u3001\u75be\u60a3\u7279\u6709\u306e\u75c5\u614b\u751f\u7406\u5b66\u304a\u3088\u3073\/\u307e\u305f\u306f\u75be\u60a3\u7279\u6709\u306e\u907a\u4f1d\u5b50\u95a2\u9023\u6027\u306b\u57fa\u3065\u3044\u3066\u3001ALS\u306e\u69d8\u3005\u306a\u4e9c\u578b\u3092\u5b9a\u7fa9\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30cb\u30e5\u30fc\u30ed\u30f3\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\u306f\u3001\u305d\u308c\u81ea\u4f53\u304c\u7d30\u80de\u6b7b\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u304b\u306f\u672a\u77e5\u3067\u3059\u304c\u3001ALS\u306e\u8a3a\u65ad\u30de\u30fc\u30ab\u30fc\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u00a0*49,52<\/sup> \u3002ALS\u306b\u95a2\u9023\u3059\u308b\u7279\u6027\u306e\u6982\u8981\u3092\u88684.8\u306b\u793a\u3057\u307e\u3059\u3002<\/p>\n

\"\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u306e\u75c5\u614b\u751f\u7406\u5b66\"<\/a><\/p>\n

\u30bf\u30fc\u30b2\u30c3\u30c8\u304a\u3088\u3073\u6709\u671b\u306a\u6cbb\u7642\u85ac<\/h4>\n

\u65e2\u5b58\u306eALS\u306b\u5bfe\u3059\u308b\u85ac\u7269\u7642\u6cd5\u306f\u3001\u4e3b\u306b\u5bfe\u75c7\u7684\u3067\u3001\u75be\u60a3\u9032\u884c\u3092\u9045\u5ef6\u307e\u305f\u306f\u56de\u5fa9\u3055\u305b\u308b\u3088\u308a\u3082\u3001\u75d9\u6523\u3001\u75d9\u7e2e\u3001\u553e\u6db2\u5206\u6ccc\u904e\u591a\u3001\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u75c7\u72b6\u306e\u5f71\u97ff\u3092\u8efd\u6e1b\u3055\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u4eba\u5de5\u547c\u5438\u5668\u3082\u547c\u5438\u3092\u88dc\u52a9\u3059\u308b\u76ee\u7684\u3067\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 \u30cb\u30e5\u30fc\u30ed\u30f3\u6b7b\u304b\u3089\u306e\u4fdd\u8b77\u3084\u75be\u60a3\u9032\u884c\u306e\u7de9\u548c\u3092\u53ef\u80fd\u3068\u3059\u308b\u85ac\u5264\u3092\u767a\u898b\u3059\u308b\u305f\u3081\u306e\u52aa\u529b\u304c\u7d9a\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3044\u307e\u3060\u6210\u529f\u306b\u3044\u305f\u3063\u3066\u3044\u307e\u305b\u3093\u3002FDA\u627f\u8a8d\u85ac\u306e1\u3064\u3067\u3042\u308b\u30ea\u30eb\u30be\u30fc\u30eb\u306f\u3001\u308f\u305a\u304b\u306a\u751f\u5b58\u671f\u9593\u5ef6\u9577\u52b9\u679c\uff08\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u304c\u7d043\u30f6\u6708\u5ef6\u9577\uff09\u3092\u793a\u3057\u307e\u3059\u304c\u3001\u3053\u308c\u306fN-\u30e1\u30c1\u30eb-D-\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\uff08NMDA\uff09\u53d7\u5bb9\u4f53\u6d3b\u6027\u3068\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ca\u30c8\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u6d3b\u6027\u306e\u6291\u5236\u304a\u3088\u3073\/\u307e\u305f\u306f\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u8208\u596e\u6bd2\u6027\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u00a0*53\u00a0<\/sup>\u3002<\/p>\n

ALS\u4e9c\u578b\u306b\u7279\u6709\u306e\u7279\u5fb4\u3092\u5229\u7528\u3059\u308b\u65b0\u3057\u3044\u6226\u7565\u304c\u3042\u308b\u4e00\u65b9\u3001\u4e00\u822c\u7684\u306a\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u3084\u795e\u7d4c\u5909\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\uff08\u88684.9\uff09\u00a0*54-62<\/sup> \u3002\u524d\u8005\u306e\u4f8b\u3068\u3057\u3066\u3001\u5bb6\u65cf\u6027SOD1\u306e\u75c5\u614b\u306f\u7279\u6709\u3067\u512a\u6027\u306aSOD1\u542b\u6709\u5c01\u5165\u4f53\u306e\u6bd2\u6027\u4f5c\u7528\u3092\u793a\u3059\u305f\u3081\u3001\u5909\u7570\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ec\u30d9\u30eb\u3092\u6e1b\u5c11\u3055\u305b\u308b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u6226\u7565\u306f\u6709\u76ca\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u5e79\u7d30\u80de\u7642\u6cd5\u306f\u3001\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u56de\u8def\u306e\u4fee\u5fa9\u3042\u308b\u3044\u306f\u795e\u7d4c\u6804\u990a\u56e0\u5b50\u306e\u4f9b\u7d66\u3001\u3055\u3089\u306b\u306fALS\/FTD\u95a2\u9023\u5909\u7570\u3092\u6709\u3059\u308bALS\u304a\u3088\u3073\u524d\u982d\u5074\u982d\u8449\u8a8d\u77e5\u75c7\uff08FTD\uff09\u306e\u30d2\u30c8\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u7528\u3044\u308bin vitro\u30e2\u30c7\u30eb\u306e\u958b\u767a\u306b\u6709\u671b\u306a\u65b0\u3057\u3044\u65b9\u6cd5\u3067\u3059\u3002\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u3053\u308c\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3001\u9020\u8840\u7d30\u80de\u3001\u307e\u305f\u306f\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\u7531\u6765\u795e\u7d4c\u524d\u99c6\u7d30\u80de\u306eCNS\u3078\u306e\u79fb\u690d\u304c\u60f3\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n

\"\u7b4b\u59d4\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u307e\u305f\u306f\u524d\u982d\u5074\u982d\u8449\u8a8d\u77e5\u75c7\u306b\u5bfe\u3059\u308b\u958b\u767a\u4e2d\u306e\u6cbb\u7642\u6cd5\"\u76ee\u7684\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u7279\u7570\u7684\u306a\u6297\u4f53\u304a\u3088\u3073\u514d\u75ab\u30a2\u30c3\u30bb\u30a4\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n

\u591a\u767a\u6027\u786c\u5316\u75c7<\/h2>\n

\u591a\u767a\u6027\u786c\u5316\u75c7\u306e\u7279\u5fb4<\/h4>\n

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\"\u591a\u767a\u6027\u786c\u5316\u75c7\u306e\u75c5\u5de3\u5f62\u6210\u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u8907\u6570\u306e\u5668\u5b98\u7cfb\"<\/a>\"HLA-DRB1<\/a><\/p>\n

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\u75c5\u614b\u751f\u7406\u5b66<\/h4>\n

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\"\u8131\u9ac4\u306e\u6a5f\u80fd\u7684\u7d50\u679c\"<\/a><\/p>\n

\u514d\u75ab\u75c5\u7406\u5b66<\/h4>\n

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\"\u591a\u767a\u6027\u786c\u5316\u75c7\u306e\u75c5\u614b\u751f\u7406\u5b66\"<\/a><\/p>\n

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\"MBP<\/a><\/p>\n

MS\u306b\u304a\u3051\u308bT\u7d30\u80de\u306e\u5f79\u5272<\/h4>\n

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\"\u30ca\u30a4\u30fc\u30d6CD4+T\u7d30\u80de\"<\/a><\/p>\n

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\n\u3053\u308c\u3089\u306e\u85ac\u5264\u306b\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u3001\u30b0\u30e9\u30c1\u30e9\u30de\u30fc\u9162\u9178\u5869\u3001\u751f\u7269\u88fd\u5264\u3001\u304a\u3088\u3073\u7d4c\u53e3\u5264\u304c\u542b\u307e\u308c\u307e\u3059\uff08\u88684.11\uff09\u00a0*93,96-107\u00a0<\/sup>\u3002<\/p>\n

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    \n
  1. \u30a4\u30f3\u30c8\u30ed\u30c0\u30af\u30b7\u30e7\u30f3<\/li>\n
  2. \u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3051\u308b\u5171\u901a\u306e\u30c6\u30fc\u30de<\/li>\n
  3. \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3078\u306e\u53d6\u308a\u7d44\u307f<\/li>\n
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  5. \u6297\u4f53\uff1a\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u306e\u305f\u3081\u306e\u5f37\u529b\u306a\u30c4\u30fc\u30eb<\/li>\n<\/ol>\n

    \u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong>
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