{"id":11278,"date":"2022-03-18T11:16:19","date_gmt":"2022-03-18T02:16:19","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/?p=11278"},"modified":"2024-12-13T15:34:24","modified_gmt":"2024-12-13T06:34:24","slug":"prs_genotyping_ma_gsd_ts_1","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/prs_genotyping_ma_gsd_ts_1\/","title":{"rendered":"\u5927\u898f\u6a21\u306a\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u7d50\u679c\u306f\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u306e\u9032\u6b69\u306b\u3064\u306a\u304c\u308b"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-11280 size-medium\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2022\/03\/1bb1ed5c860ff9764c6c59e5a82987d3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" 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href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/jp-contact.html?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u5f53\u793e<\/a>\u306b\u9023\u7d61\u3057\u3066\u3044\u305f\u3060\u304f\u304b\u3001\u5f53\u793e\u306e<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/microarray-analysis.html?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u4e88\u6e2c\u30b2\u30ce\u30df\u30af\u30b9\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3<\/a>\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u306b\u57fa\u3065\u3044\u3066\u500b\u4eba\u306e\u75be\u60a3\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306f\u3001\u30b2\u30ce\u30e0\u533b\u5b66\u306e\u3082\u3063\u3068\u3082\u9b45\u529b\u7684\u306a\u6210\u679c\u306e1\u3064\u3067\u3059\u3002\u7279\u5b9a\u306e\u75be\u60a3\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u5224\u5b9a\u3055\u308c\u305f\u4eba\u306b\u306f\u3001\u81e8\u5e8a\u8a3a\u65ad\u3001\u6295\u85ac\u624b\u9806\u3001\u3042\u308b\u3044\u306f\u751f\u6d3b\u69d8\u5f0f\u306e\u5909\u66f4\u3092\u542b\u3093\u3060\u3001\u3088\u308a\u7684\u78ba\u306a\u6cbb\u7642\u6cd5\u304c\u63d0\u4f9b\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u8a3a\u65ad\u3001\u4e88\u5f8c\u3001\u6cbb\u7642\u306e\u6539\u5584\u306b\u3088\u308a\u3001\u3088\u308a\u826f\u3044\u6210\u679c\u304c\u5f97\u3089\u308c\u3001\u5168\u822c\u7684\u306b\u60a3\u8005\u306e\u533b\u7642\u8cbb\u8ca0\u62c5\u304c\u4e0b\u304c\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306e10\u5e74\u9593\u306e\u907a\u4f1d\u5b50\u7814\u7a76\u306b\u3088\u308a\u3001\u5fc3\u81d3\u75c5\u3001\u304c\u3093\u3001\u7cd6\u5c3f\u75c5\u3001\u8133\u969c\u5bb3\u306e\u3088\u3046\u306a\u591a\u304f\u306e\u4e00\u822c\u7684\u306a\u8907\u96d1\u306a\u75be\u60a3\u3067\u306f\u3001\u307e\u308c\u306a\u5358\u4e00\u907a\u4f1d\u5b50\u5909\u7570\u3088\u308a\u3082\u30011\u3064\u3060\u3051\u3067\u306f\u5f71\u97ff\u304c\u5c0f\u3055\u3044\u907a\u4f1d\u7684\u5909\u7570\u304c\u8907\u6570\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u3001\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u308f\u305f\u3063\u3066\u5b58\u5728\u3059\u308b\u4f55\u5343\u3082\u306e\u5909\u7570\u304c1\u3064\u306e\u5f62\u8cea\u3068\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u6570\u5343\u3042\u308b\u4e2d\u306e1\u3064\u306e\u5909\u7570\u306f\u3001\u8907\u96d1\u306a\u5f62\u8cea\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306b\u306f\u305d\u308c\u307b\u3069\u6709\u76ca\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u3042\u308b1\u3064\u306e\u6307\u6a19\u3084\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\uff08PRS\uff09\u306b\u3088\u3063\u3066\u591a\u304f\u306e\u4e00\u9023\u3068\u306a\u308b\u5909\u7570\u306e\u7d2f\u7a4d\u52b9\u679c\u3092\u5b9a\u91cf\u5316\u3067\u304d\u308c\u3070\u3001\u3053\u306e\u8ab2\u984c\u3092\u514b\u670d\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>PRS\u306f\u3001\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u7814\u7a76\uff08GWAS\uff09\u304b\u3089\u8a08\u7b97\u3055\u308c\u307e\u3059\u304c\u3001\u305d\u308c\u306f\u500b\u4eba\u304c\u4fdd\u6709\u3059\u308b\u30ea\u30b9\u30af\u306b\u95a2\u9023\u3057\u305f\u5bfe\u7acb\u907a\u4f1d\u5b50\u6570\u3092\u5408\u8a08\u3057\u3001\u305d\u306e\u5f71\u97ff\u306e\u5927\u304d\u3055\u306b\u5f93\u3063\u3066\u91cd\u307f\u4ed8\u3051\u3057\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u8005\u305f\u3061\u306f\u3001GWAS\u306e\u521d\u671f\u304b\u3089PRS\u306e\u958b\u767a\u3092\u8a66\u307f\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u6700\u521d\u306e\u53d6\u308a\u7d44\u307f\u306f\u4ee5\u4e0b\u306e3\u3064\u306e\u8ab2\u984c\u306b\u3088\u3063\u3066\u59a8\u3052\u3089\u308c\u307e\u3057\u305f\u3002<br \/>\n1\uff09\u5c0f\u898f\u6a21\u306aGWAS\u3067\u306f\u3001\u500b\u3005\u306e\u5909\u7570\u3067\u30ea\u30b9\u30af\u3078\u306e\u5f71\u97ff\u3092\u63a8\u5b9a\u3059\u308b\u7cbe\u5ea6\u306b\u9650\u754c\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br \/>\n2\uff09\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0\u8a08\u7b97\u6cd5\u306b\u9650\u754c\u304c\u3042\u308a\u307e\u3057\u305f\u3002<br \/>\n3\uff09PRS\u3092\u691c\u8a3c\u304a\u3088\u3073\u30c6\u30b9\u30c8\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3068\u306a\u308b\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306b\u3082\u9650\u754c\u304c\u3042\u308a\u307e\u3057\u305f\uff3b1\uff3d\u3002<\/p>\n<h2>\u65b0\u305f\u306a\u7814\u7a76\u3067PRS\u3092\u691c\u8a3c<\/h2>\n<p>GWAS\u306e\u6a5f\u80fd\u306f\u3001\u305d\u306e\u521d\u671f\u304b\u3089\u5927\u304d\u306a\u9032\u6b69\u3092\u9042\u3052\u3066\u304a\u308a\u3001\u81e8\u5e8a\u7528\u30c4\u30fc\u30eb\u3068\u3057\u3066PRS\u3092\u4f7f\u7528\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u7814\u7a76\u3068\u671f\u5f85\u3092\u5c0e\u3044\u3066\u3044\u307e\u3059\u3002\u8868\u73fe\u578b\u3068\u907a\u4f1d\u5b50\u306b\u95a2\u3059\u308b\u8c4a\u5bcc\u306a\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3059\u308b\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u304c\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3001\u7814\u7a76\u8005\u305f\u3061\u306fPRS\u306e\u691c\u8a3c\u3068\u30c6\u30b9\u30c8\u306b\u5fc5\u8981\u306a\u975e\u5e38\u306b\u5927\u898f\u6a21\u3067\u9577\u671f\u7684\u306a\u30b3\u30db\u30fc\u30c8\u3092\u96c6\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u73fe\u5728\u3001\u7814\u7a76\u8005\u305f\u3061\u306f\u591a\u304f\u306eGWAS\u30c7\u30fc\u30bf\u3092\u5229\u7528\u3067\u304d\u3001\u3044\u304f\u3064\u304b\u306f100\u4e07\u4eba\u306e\u30c7\u30fc\u30bf\u304b\u3089\u306a\u308b\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002PRS\u3092\u8a08\u7b97\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u65b9\u6cd5\u3082\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u305f\u3068\u3048\u3070\u6700\u8fd1\u3001\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u7dcf\u5408\u75c5\u9662\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8\u3001\u304a\u3088\u3073\u30d6\u30ed\u30fc\u30c9\u7814\u7a76\u6240\u306e\u30c1\u30fc\u30e0\u306f\u51a0\u52d5\u8108\u75be\u60a3\u3001\u5fc3\u623f\u7d30\u52d5\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u708e\u75c7\u6027\u8178\u75be\u60a3\u304a\u3088\u3073\u4e73\u304c\u3093\u306e5\u3064\u306e\u4e00\u822c\u7684\u306a\u75be\u60a3\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306aPRS\u3092\u958b\u767a\u3057\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f[1]\u3002UK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3067\u306f\u3001Applied Biosystems\u2122 UK BiLEVE Axiom\u2122 \u30a2\u30ec\u30a4\u3001\u3042\u308b\u3044\u306f<a href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/biobanks-phenotypes-and-population-variation-revolution-or-evolution-in-complex-trait-genetics\/?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">UK Biobank Axiom\u2122 \u30a2\u30ec\u30a4<\/a>\u306e\u3044\u305a\u308c\u304b\u3092\u4f7f\u7528\u3057\u306640\u4e07\u4eba\u4ee5\u4e0a\u3082\u306e\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3069\u3061\u3089\u306e\u30a2\u30ec\u30a4\u3068\u3082\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u6563\u5728\u3059\u308b80\u4e07\u3092\u8d85\u3048\u308b\u907a\u4f1d\u30de\u30fc\u30ab\u30fc\u304c\u642d\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8ffd\u52a0\u306e\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u30c7\u30fc\u30bf\u306f\u3001Haplotype Reference Consortium\u30ea\u30bd\u30fc\u30b9\u3001UK10K\u30d1\u30cd\u30eb\u3001\u304a\u3088\u30731000 Genomes Project\u30d1\u30cd\u30eb\u3092\u4f7f\u7528\u3057\u3066\u88dc\u5b8c\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u53d6\u308a\u7d44\u307f\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\u304c3\u500d\u4ee5\u4e0a\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u5272\u5408\u3067\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u30b9\u30b3\u30a2\u306fUK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u96c6\u56e3\u5185\u3067\u691c\u8a3c\u3001\u304a\u3088\u3073\u30c6\u30b9\u30c8\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>2\u3064\u76ee\u306e\u6700\u8fd1\u306e\u4e16\u754c\u7684\u306a\u53d6\u308a\u7d44\u307f\u306f\u3001\u4e73\u304c\u3093\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u5206\u985e\u3092\u53ef\u80fd\u306b\u3059\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3057\u3066\u4e73\u304c\u3093\u306e\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0\u3092\u3055\u3089\u306b\u6398\u308a\u4e0b\u3052\u308b\u305f\u3081\u306b\u300169\u306e\u7814\u7a76\u304b\u308917\u4e07\u4eba\u306e\u88ab\u9a13\u8005\u3092\u96c6\u3081\u307e\u3057\u305f\uff3b2\uff3d\u3002\u3053\u306e\u7814\u7a76\u3067\u958b\u767a\u3055\u308c\u305fPRS\u306f\u30012\u4e07\u4eba\u306e\u72ec\u7acb\u3057\u305f\u8a66\u9a13\u5bfe\u8c61\u8005\u3068UK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u306e19\u4e07\u4eba\u306e\u88ab\u9a13\u8005\u306e\u30b3\u30db\u30fc\u30c8\u306b\u3088\u308b10\u4ef6\u306e\u524d\u5411\u304d\u7814\u7a76\u3067\u7d4c\u9a13\u7684\u306b\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002UK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u30b5\u30f3\u30d7\u30eb\u306f\u3001UK BiLEVE Axiom\u30a2\u30ec\u30a4\u3068UK Biobank Axiom\u30a2\u30ec\u30a4\u3092\u4f7f\u7528\u3057\u3066\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u89e3\u6790\u3092\u884c\u306a\u3044\u30011000 Genomes Project\u3068UK10K\u30ea\u30d5\u30a1\u30ec\u30f3\u30b9\u30d1\u30cd\u30eb\u3067\u30c7\u30fc\u30bf\u3092\u88dc\u5b8c\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u30b5\u30d6\u30bf\u30a4\u30d7\u7279\u7570\u7684\u75be\u60a3\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u306b\u3082\u81f3\u9069\u5316\u3055\u308c\u305fER\u7279\u7570\u7684\u4e73\u304c\u3093\u3092\u4e88\u6e2c\u3059\u308bPRS\u3092\u751f\u307f\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<h2>\u8003\u616e\u3059\u308b\u5fc5\u8981\u306e\u3042\u308b\u4e8b\u9805<\/h2>\n<p>PRS\u306f\u975e\u5e38\u306b\u671f\u5f85\u3059\u308b\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u305d\u306e\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u306b\u306f\u6ce8\u610f\u3057\u3001\u3044\u304f\u3064\u304b\u306e\u554f\u984c\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u30fb\u4ed6\u306e\u5185\u5728\u3059\u308b\u8981\u56e0\u304cPRS\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4e00\u90e8\u306e\u75be\u60a3\u3067\u306f\u3001\u907a\u4f1d\u7684\u8981\u7d20\u304c\u5f71\u97ff\u529b\u306e\u3042\u308b\u6700\u5927\u306e\u8981\u56e0\u3067\u306f\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u305f\u3068\u3048\u3070\u3001\u80a5\u6e80\u306e\u4eba\u306fPRS\u304c\u4f4e\u304f\u3066\u3082\u3001PRS\u306e\u9ad8\u3044\u75e9\u305b\u305f\u4eba\u3088\u308a\u3082\u7cd6\u5c3f\u75c5\u306e\u4e88\u9632\u306b\u53d6\u308a\u7d44\u3080\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5bb6\u65cf\u6b74\u3001\u793e\u4f1a\u7d4c\u6e08\u7684\u304a\u3088\u3073\u7269\u7406\u7684\u74b0\u5883\u3001\u305d\u3057\u3066\u751f\u6d3b\u69d8\u5f0f\u306a\u3069\u306e\u8981\u56e0\u304c\u75be\u60a3\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3082\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u75be\u60a3\u304c\u7570\u306a\u308c\u3070\u3001\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0\u8981\u56e0\u3082\u7570\u306a\u308a\u307e\u3059\u3002\u30ea\u30b9\u30af\u3092\u5c64\u5225\u5316\u3059\u308b\u305f\u3081\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306f\u3001\u3053\u308c\u3089\u306e\u30b9\u30b3\u30a2\u30ea\u30f3\u30b0\u8981\u56e0\u3084\u305d\u306e\u4ed6\u306e\u30ea\u30b9\u30af\u8981\u56e0\u3068\u3069\u306e\u3088\u3046\u306b\u7d71\u5408\u3057\u305f\u3089\u826f\u3044\u3067\u3057\u3087\u3046\u304b\uff1f\u5171\u901a\u3057\u305f\u7d4c\u9a13\u306e\u8981\u56e0\u3092\u6301\u3064\u500b\u4eba\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u306f\u3001\u3053\u308c\u3089\u306e\u8cea\u554f\u3078\u306e\u56de\u7b54\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u6771\u5317\u30e1\u30c7\u30a3\u30ab\u30eb\u30e1\u30ac\u30d0\u30f3\u30af\u6a5f\u69cb\uff08ToMMo\uff09\u306f\u30012011\u5e74\u306e\u885d\u6483\u7684\u306a\u5927\u5730\u9707\u306b\u3088\u308b\u5065\u5eb7\u3078\u306e\u5f71\u97ff\u3092\u7814\u7a76\u3059\u308b\u305f\u3081\u306b\u300115\u4e07\u4eba\u898f\u6a21\u306e\u65e5\u672c\u4eba\u4e00\u822c\u96c6\u56e3\u7531\u6765\u306e\u907a\u4f1d\u5b66\u7684\u306a\u751f\u7269\u691c\u4f53\u30c7\u30fc\u30bf\u3092\u53ce\u96c6\u3057\u3066\u3044\u307e\u3059\u3002\u30df\u30ea\u30aa\u30f3\u00b7\u3079\u30c6\u30e9\u30f3\u00b7\u30d7\u30ed\u30b0\u30e9\u30e0\uff08MVP\uff09\u306f\u3001\u7279\u306b\u8ecd\u4e8b\u306b\u95a2\u308f\u3063\u305f\u5f71\u97ff\u3084\u305d\u306e\u4ed6\u306e\u75be\u60a3\u306e\u7814\u7a76\u306e\u305f\u3081\u306b\u3001\u7c73\u8ecd\u306b\u52e4\u52d9\u3057\u305f\u4eba\u305f\u3061\u3060\u3051\u306e\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3067\u3059\u3002<\/p>\n<p>\u30fb\u81e8\u5e8a\u533b\u306f\u3001\u75c5\u7406\u5b66\u3001\u753b\u50cf\u8a3a\u65ad\u3001\u8840\u6db2\u691c\u67fb\u3001\u60a3\u8005\u306e\u6240\u898b\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u65b9\u6cd5\u3001\u30c4\u30fc\u30eb\u3001\u6307\u6a19\u3092\u4f7f\u7528\u3057\u3066\u75be\u60a3\u306e\u8a3a\u65ad\u3068\u4e88\u5f8c\u3092\u8a3a\u65ad\u3057\u307e\u3059\u3002\u907a\u4f1d\u60c5\u5831\u306f\u8a3a\u65ad\u30c4\u30fc\u30eb\u3068\u3057\u3066\u65b0\u3057\u304f\u8ffd\u52a0\u3055\u308c\u305f\u5f37\u529b\u306a\u60c5\u5831\u3067\u3059\u304c\u3001\u4ed6\u306e\u30c4\u30fc\u30eb\u306b\u7f6e\u304d\u63db\u308f\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002PRS\u306f\u4ed6\u306e\u81e8\u5e8a\u6307\u6a19\u3068\u3069\u306e\u3088\u3046\u306b\u7d71\u5408\u3067\u304d\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u30fb\u73fe\u6642\u70b9\u3067\u5229\u7528\u53ef\u80fd\u306a\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u30c7\u30fc\u30bf\u3001\u30b3\u30db\u30fc\u30c8\u3001\u30d0\u30ea\u30a2\u30f3\u30c8\u30d1\u30cd\u30eb\u306e\u307b\u3068\u3093\u3069\u306f\u3001\u4e3b\u306b\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u306e\u4eba\u3005\u3092\u5bfe\u8c61\u306b\u3057\u3066\u958b\u767a\u304a\u3088\u3073\u30c6\u30b9\u30c8\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u75be\u60a3\u306f\u7570\u306a\u308b\u96c6\u56e3\u3067\u306f\u5f71\u97ff\u3084\u6709\u75c5\u7387\u304c\u7570\u306a\u308a\u307e\u3059\u3002<br \/>\n\u305f\u3068\u3048\u3070\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u306f\u30e8\u30fc\u30ed\u30c3\u30d1\u7cfb\u306e\u4eba\u3005\u3088\u308a\u3082\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u751f\u7387\u304c\u9ad8\u3044\u3067\u3059\u3002\u3053\u306e\u5834\u5408\u3001\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u96c6\u56e3\u304b\u3089\u306e\u30b3\u30db\u30fc\u30c8\u304a\u3088\u3073\u30d0\u30ea\u30a2\u30f3\u30c8\u30d1\u30cd\u30eb\u3092\u4f7f\u7528\u3057\u3066\u958b\u767a\u3055\u308c\u305fPRS\u306f\u3001\u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u306b\u5bfe\u3057\u3066\u9069\u5408\u3057\u3066\u3044\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4e2d\u56fd\u306eKadoorie\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3084\u30d5\u30a3\u30f3\u30e9\u30f3\u30c9\u306e<a href=\"https:\/\/www.thermofisher.com\/blog\/behindthebench\/the-finngen-research-project-combining-genomics-and-health-record-data-to-understand-disease-mechanisms\/?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">FinnGen\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/a>\u306a\u3069\u306e\u7279\u5b9a\u96c6\u56e3\u306e\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3001\u304a\u3088\u3073<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/microarray-analysis\/human-genotyping-pharmacogenomic-microbiome-solutions-microarrays\/axiom-population-focused-arrays.html?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">AppliedBiosystems\u2122 Axiom\u2122GenomeWide Population-Optimized Array<\/a>\u306a\u3069\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u306f\u3001\u7279\u5b9a\u96c6\u56e3\u306e\u591a\u69d8\u6027\u3092\u6c7a\u5b9a\u3057\u3001\u6c11\u65cf\u30b0\u30eb\u30fc\u30d7\u3084\u305d\u306e\u4ed6\u306e\u96c6\u56e3\u306b\u304a\u3044\u3066\u504f\u308a\u306a\u304f\u30ea\u30b9\u30af\u306e\u5c64\u5225\u5316\u3092\u78ba\u4fdd\u3059\u308b\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n<p>\u30fbPRS\u306e\u81e8\u5e8a\u7684\u5fdc\u7528\u306b\u306f\u3001\u975e\u5e38\u306b\u96e3\u89e3\u306a\u502b\u7406\u7684\u554f\u984c\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u4f55\u3089\u304b\u306e\u75c7\u72b6\u304c\u767a\u75c7\u3059\u308b\u304b\u306a\u308a\u524d\u306b\u500b\u4eba\u306ePRS\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u306f\u53ef\u80fd\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u305d\u306e\u4ed6\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u60a3\u8005\u3001\u3042\u308b\u3044\u306f\u81e8\u5e8a\u533b\u306f\u77e5\u3089\u306a\u3044\u65b9\u304c\u826f\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<br 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\/>\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-11279\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2022\/03\/39120527c1bd740289656719a553d940.jpg\" alt=\"\" width=\"906\" height=\"476\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2022\/03\/39120527c1bd740289656719a553d940.jpg 906w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2022\/03\/39120527c1bd740289656719a553d940-300x158.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2022\/03\/39120527c1bd740289656719a553d940-768x403.jpg 768w\" sizes=\"auto, (max-width: 906px) 100vw, 906px\" \/><\/p>\n<h2>\u6700\u5f8c\u306b<\/h2>\n<p>\u691c\u8a3c\u6e08\u307f\u306ePRS\u3092\u516c\u958b\u3057\u305f\u6700\u521d\u306e\u7814\u7a76\u304c\u767a\u8868\u3055\u308c\u308b\u3068\u3001\u9ad8\u7cbe\u5ea6\u533b\u7642\u306e\u6642\u4ee3\u306b\u304a\u3051\u308b\u75be\u60a3\u8a3a\u65ad\u3001\u4e88\u5f8c\u3001\u304a\u3088\u3073\u6cbb\u7642\u306b\u5bfe\u3059\u308bPRS\u306e\u6f5c\u5728\u7684\u306a\u8ca2\u732e\u306b\u671f\u5f85\u304c\u9ad8\u307e\u308a\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001\u4ed6\u306e\u75be\u60a3\u8981\u56e0\u3001\u8ffd\u52a0\u306e\u8a3a\u65ad\u3001\u30b5\u30f3\u30d7\u30eb\u306e\u504f\u308a\u3001\u305d\u3057\u3066\u502b\u7406\u7684\u306a\u554f\u984c\u3068\u3044\u3063\u305f\u691c\u8a0e\u4e8b\u9805\u304c\u3042\u308a\u307e\u3059\u3002GWAS\u3068\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u306e\u898f\u6a21\u304c\u7d99\u7d9a\u7684\u306b\u5e83\u304c\u3063\u3066\u3044\u304f\u3053\u3068\u306f\u3001\u8a08\u7b97\u624b\u6cd5\u306e\u9032\u6b69\u3068\u3068\u3082\u306b\u3001\u5c06\u6765\u7684\u306b\u6709\u671b\u306a\u30c4\u30fc\u30eb\u3068\u3057\u3066\u5f79\u7acb\u3064\u65b0\u305f\u306aPRS\u624b\u6cd5\u306e\u958b\u767a\u304c\u52a0\u901f\u3055\u308c\u3001\u7d71\u8a08\u7684\u691c\u8a3c\u304c\u5f37\u5316\u3055\u308c\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p>\u4ed6\u306e\u7814\u7a76\u8005\u304c\u63a1\u7528\u3057\u305f\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u6226\u7565\u306b\u3064\u3044\u3066\u306f\u3001<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/products-and-services\/promotions\/life-science\/predictive-genomics.html?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">thermofisher.com \/ scientistspotlight<\/a> \u306b\u30a2\u30af\u30bb\u30b9\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u76ee\u7684\u3067\u306f\u4f7f\u7528\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u6280\u8853\u7684\u306a\u3054\u8cea\u554f\u304c\u3042\u308a\u307e\u3057\u305f\u3089\u3001<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/jp-contact.html?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">https:\/\/www.thermofisher.com\/jp\/ja\/home\/jp-contact.html<\/a> \u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2>\u3010\u7121\u6599\u30aa\u30f3\u30e9\u30a4\u30f3\u30bb\u30df\u30ca\u30fc\u3011\u4e88\u6e2c\u30b2\u30ce\u30df\u30af\u30b9\u306b\u95a2\u3059\u308b\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u304b\u3089\u306e\u65b0\u3057\u3044\u77e5\u898b<\/h2>\n<p>\u8fd1\u5e74\u3001\u5305\u62ec\u7684\u306a\u907a\u4f1d\u5b50\u578b\u5224\u5b9a\u60c5\u5831\u3092\u96c6\u7a4d\u3001\u968e\u5c64\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u500b\u5225\u5316\u533b\u7642\u3078\u5f79\u7acb\u3066\u3088\u3046\u3068\u3059\u308b\u7814\u7a76\u958b\u767a\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u4e2d\u3067\u3001\u5404\u5730\u57df\u6bce\u306e\u6c11\u65cf\u6027\u3084\u7279\u5b9a\u75be\u60a3\u3078\u306e\u306a\u308a\u3084\u3059\u3055\u3001\u85ac\u7406\u30b2\u30ce\u30df\u30af\u30b9\u7279\u6027\u306a\u3069\u304c\u7279\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u30aa\u30f3\u30e9\u30a4\u30f3\u30bb\u30df\u30ca\u30fc\u3067\u306f\u3001American Society on Human Genetics(ASHG) 2020\u3067\u516c\u958b\u3001\u8b70\u8ad6\u3055\u308c\u305f\u3055\u307e\u3056\u307e\u306a\u30c8\u30d4\u30c3\u30af\u3092\u9650\u5b9a\u516c\u958b\u3057\u307e\u3059\u3002<\/p>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/predictive-genomics-download.html?cid=gsd_mic_get_r04_jp_cp1424_pjt7219_gsd00000_0so_blg_op_awa_og_s00_ma20_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u8a73\u7d30\u3092\u898b\u308b<\/a><\/strong><\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><br \/>\n1. Khera, A.V., et al. \uff082018\uff09\u3000\u4e00\u822c\u7684\u306a\u75be\u60a3\u306b\u5bfe\u3059\u308b\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306a\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30b9\u30b3\u30a2\u306f\u3001\u5358\u4e00\u907a\u4f1d\u5b50\u5909\u7570\u3068\u540c\u7b49\u306e\u30ea\u30b9\u30af\u3092\u6301\u3064\u500b\u4eba\u3092\u7279\u5b9a\u3059\u308b\u3000Nat Genet 50: 1219\u20131224<br \/>\n2. Mavaddat\u3001N., et al.\uff082019\uff09\u3000\u4e73\u304c\u3093\u304a\u3088\u3073\u4e73\u304c\u3093\u30b5\u30d6\u30bf\u30a4\u30d7\u306e\u4e88\u6e2c\u306e\u305f\u3081\u306e\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3000Am J Hum Genet 104: 21\u201334<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e88\u6e2c\u30b2\u30ce\u30df\u30af\u30b9\u30d6\u30ed\u30b0\uff08\u82f1\u8a9e\uff09\u3067\u306f\u3001\u81e8\u5e8a\u7814\u7a76\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u85ac\u7406\u30b2\u30ce\u30df\u30af\u30b9\u306e\u5229\u7528\u3068\u52b9\u679c\u306b\u95a2\u3059\u308b\u5c55\u671b\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002 \u4e88\u6e2c\u30b2\u30ce\u30df\u30af\u30b9\u306f\u3001\u8ee2\u5e30\u6539\u5584\u3068\u30b3\u30b9\u30c8\u7ba1\u7406\u306b\u5065\u5eb7\u7ba1\u7406\u306e\u91cd\u70b9\u3092\u7f6e\u3044\u3066\u3001\u75c5\u6c17\u306b\u306a\u308b\u30ea\u30b9\u30af\u7814<\/p>\n","protected":false},"author":975,"featured_media":11280,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[156],"tags":[26],"division":[],"class_list":{"0":"post-11278","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-mol-bio","8":"tag-genotyping","9":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- 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