{"id":13745,"date":"2023-04-06T09:43:19","date_gmt":"2023-04-06T00:43:19","guid":{"rendered":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/?p=13745"},"modified":"2023-08-15T15:45:13","modified_gmt":"2023-08-15T06:45:13","slug":"metabolomics-ic-cmd-mkt","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/metabolomics-ic-cmd-mkt\/","title":{"rendered":"\u7db2\u7f85\u89e3\u6790\u306b\u3088\u308b\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\uff08\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\uff09\u306e\u9032\u5316"},"content":{"rendered":"

\u4ee3\u8b1d\u7269\u8cea\u306e\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\u3092\u7db2\u7f85\u89e3\u6790\u3067\u884c\u3046\u65b0\u624b\u6cd5<\/h2>\n

\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\uff08\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\uff09\u306f\u3001\u751f\u4f53\u5185\u306e\u4ee3\u8b1d\u7269\u3092\u7db2\u7f85\u7684\u306b\u628a\u63e1\u30fb\u5b9a\u91cf\uff08\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\uff09\u3057\u3001\u751f\u5316\u5b66\u7684\u306a\u72b6\u614b\u3084\u6a5f\u80fd\u306e\u5909\u5316\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u7db2\u7f85\u7684\u306a\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\u306f\u3001\u5b9f\u9a13\u30b5\u30f3\u30d7\u30eb\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u3067\u304d\u308b\u3060\u3051\u591a\u304f\u306e\u4ee3\u8b1d\u7269\u306e\u30b0\u30ed\u30fc\u30d0\u30eb\u306a\u6bd4\u8f03\u3092\u5f97\u308b\u3053\u3068\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u8907\u96d1\u306a\u751f\u7269\u5b66\u7684\u62bd\u51fa\u7269\u4e2d\u306b\u5b58\u5728\u3059\u308b\u4f55\u5343\u3082\u306e\u5316\u5b66\u7684\u306b\u591a\u69d8\u306a\u4ee3\u8b1d\u7269\u3092\u5805\u7262\u304b\u3064\u5305\u62ec\u7684\u306b\u30a2\u30f3\u30bf\u30fc\u30b2\u30c3\u30c8\u89e3\u6790\u3059\u308b\u3053\u3068\u306f\u3001\u6280\u8853\u7684\u306b\u56f0\u96e3\u3067\u3057\u305f\u3002
\n\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\uff08\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\uff09\u306b\u304a\u3044\u3066\u3001\u9577\u3044\u9593\u8ab2\u984c\u3068\u3055\u308c\u3066\u304d\u305f\u4ee3\u8b1d\u7269\u540c\u5b9a\u306b\u304a\u3051\u308b\u7db2\u7f85\u7684\u306a\u5206\u6790\u306b\u3064\u3044\u3066\u82f1\u56fd\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u5316\u5b66\u90e8\uff08Department of Chemistry, University of Oxford\uff09\u306e\u30b0\u30eb\u30fc\u30d7\u304c\u884c\u3063\u3066\u3044\u308b\u624b\u6cd5\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n

\u7db2\u7f85\u89e3\u6790\u306e\u554f\u984c\uff1a\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u30a2\u30ce\u30c6\u30fc\u30b7\u30e7\u30f3\u306e\u56f0\u96e3\u3055<\/h2>\n

\u305d\u3082\u305d\u3082\u3001\u306a\u305c\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\uff08\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\uff09\u3092\u884c\u3046\u4e0a\u3067\u3001\u4f55\u304c\u7db2\u7f85\u7684\u306a\u89e3\u6790\uff08\u4ee3\u8b1d\u7269\u540c\u5b9a\uff09\u3092\u96e3\u3057\u304f\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002
\n\u5927\u304d\u304f\u5206\u3051\u30663\u3064\u306e\u8ab2\u984c\u304c\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u8907\u6570\u306e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u624b\u6cd5\u306e\u4f75\u7528<\/h3>\n

\u7b2c\u4e00\u306b\u3001\u4e00\u822c\u7684\u306a\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\uff08\u30e1\u30bf\u30dc\u30ed\u30fc\u30e0\u89e3\u6790\uff09\u306b\u304a\u3044\u3066\u306f\u3001\u8907\u6570\u306e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5fc5\u9808\u3068\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u8907\u6570\u306e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u624b\u6cd5\u3092\u9069\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5305\u62ec\u7684\u306a\u5206\u6790\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u4e00\u65b9\u3067\u5404\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u30e1\u30bd\u30c3\u30c9\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u7269\u7406\u7684\u6027\u8cea\u3001\u5316\u5b66\u7684\u6027\u8cea\u306b\u9078\u629e\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u4ee3\u8b1d\u7269\u3092\u5358\u4e00\u624b\u6cd5\u3067\u7db2\u7f85\u7684\u306b\u5206\u6790\u3059\u308b\u3053\u3068\u306f\u56f0\u96e3\u3068\u306a\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n

\u5206\u6790\u306e\u518d\u73fe\u6027<\/h3>\n

\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\u306e\u7db2\u7f85\u89e3\u6790\u3067\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u88ab\u9a13\u7fa4\u3092\u6bd4\u8f03\u3057\u3001\u305d\u306e\u4ee3\u8b1d\u7269\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u9055\u3044\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u5206\u6790\u518d\u73fe\u6027\u3068\u53b3\u5bc6\u306a\u30c7\u30fc\u30bf\u89e3\u6790\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002\u5206\u6790\u518d\u73fe\u6027\u304c\u9ad8\u3051\u308c\u3070\u3001\u30c7\u30fc\u30bf\u304c\u751f\u7269\u5b66\u7684\u306a\u5dee\u7570\u3092\u76f4\u63a5\u8868\u73fe\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4fe1\u983c\u6027\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u904e\u53bb\u306b\u6e2c\u5b9a\u3057\u305f\u5316\u5408\u7269\u306e\u540c\u5b9a\u306b\u306f\u3001\u4fdd\u6301\u6642\u9593\u306e\u5b89\u5b9a\u6027\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n

\u69cb\u9020\u7570\u6027\u4f53\u306e\u5224\u5225<\/h3>\n

\u5b9f\u9a13\u30b0\u30eb\u30fc\u30d7\u9593\u306e\u30c7\u30fc\u30bf\u6bd4\u8f03\u306e\u5f8c\u3001\u4f55\u5343\u3082\u306e\u672a\u77e5\u5316\u5408\u7269\u306e\u7279\u5fb4\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u304c\u8ab2\u984c\u3068\u3057\u3066\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6b63\u78ba\u306a\u8cea\u91cf\u3068\u540c\u4f4d\u4f53\u306e\u30d1\u30bf\u30fc\u30f3\u306f\u3001\u5206\u5b50\u5f0f\u306e\u4e88\u6e2c\u306b\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u751f\u7269\u5b66\u3067\u898b\u3089\u308c\u308b\u4f4e\u5206\u5b50\u306b\u591a\u304f\u542b\u307e\u308c\u308b\u69cb\u9020\u7570\u6027\u4f53\u306f\u3001\u8b58\u5225\u304c\u56f0\u96e3\u306a\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

IC-MS\u306b\u3088\u308b\u7db2\u7f85\u89e3\u6790\uff08\u30a2\u30f3\u30bf\u30fc\u30b2\u30c6\u30a3\u30f3\u30b0\u5206\u6790\uff09\u306b\u3088\u308b\u6210\u679c<\/h2>\n

\u30a8\u30cd\u30eb\u30ae\u30fc\u5909\u63db\u3001\u6838\u9178\u4ee3\u8b1d\u3001\u7cd6\u8cea\u4ee3\u8b1d\u306a\u3069\u306e\u4e00\u6b21\u4ee3\u8b1d\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u9023\u3059\u308b\u4ee3\u8b1d\u7269\u306e\u591a\u304f\u306f\u3001\u9ad8\u6975\u6027\u307e\u305f\u306f\u8ca0\u306b\u5e2f\u96fb\u3057\u3066\u3044\u307e\u3059\u3002\u9ad8\u6975\u6027\u4ee3\u8b1d\u7269\u3084\u30a4\u30aa\u30f3\u6027\u4ee3\u8b1d\u7269\u306e\u5206\u6790\u306b\u306f\u3001\u89aa\u6c34\u6027\u76f8\u4e92\u4f5c\u7528\u6db2\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u8cea\u91cf\u5206\u6790\u6cd5\uff08HILIC-MS\uff09\u3001\u30a4\u30aa\u30f3\u30da\u30a2\u8a66\u85ac\u3092\u4f7f\u7528\u3057\u305f\u8cea\u91cf\u5206\u6790\u6cd5\uff08IP-MS\uff09\u3001\u8a98\u5c0e\u4f53\u5316\u3092\u5fc5\u8981\u3068\u3059\u308b\u30ac\u30b9\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u8cea\u91cf\u5206\u6790\u6cd5\uff08GC-MS\uff09\u306a\u3069\u304c\u4e3b\u306b\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u5805\u7262\u3067\u518d\u73fe\u6027\u306e\u9ad8\u3044\u30ab\u30d0\u30ec\u30c3\u30b8\u3092\u9054\u6210\u3059\u308b\u3053\u3068\u306f\u3001\u30e1\u30bd\u30c3\u30c9\u3084\u30b5\u30f3\u30d7\u30eb\u524d\u51e6\u7406\u306e\u8981\u4ef6\u306b\u3088\u308a\u56f0\u96e3\u306a\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u82f1\u56fd\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u5316\u5b66\u90e8\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u30a4\u30aa\u30f3\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u8cea\u91cf\u5206\u6790\u6cd5\uff08IC-MS\uff09\u3092\u6d3b\u7528\u3057\u3001\u3053\u306e\u3088\u3046\u306a\u4ee3\u8b1d\u7269\u306e\u5206\u6790\u306b\u304a\u3044\u3066\u3001\u5e83\u7bc4\u3067\u518d\u73fe\u6027\u306e\u9ad8\u3044\u5206\u6790\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002IC-MS\u306f\u3001\u5e45\u5e83\u3044\u7269\u8cea\u306e\u5206\u96e2\u3001\u540c\u5b9a\u3001\u5b9a\u91cf\u304c\u53ef\u80fd\u306b\u306a\u308b\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u308b\u624b\u6cd5\u3067\u30591<\/sup>\u3002<\/p>\n

IC-MS\u304c\u63d0\u4f9b\u3059\u308b\u4fdd\u6301\u6642\u9593\u306e\u5b89\u5b9a\u6027\u306f\u3001\u6a19\u6e96\u7269\u8cea\u306a\u3069\u306e\u5316\u5408\u7269\u3092\u4ee5\u524d\u306b\u6e2c\u5b9a\u3057\u305f\u3053\u3068\u304c\u3042\u308b\u5834\u5408\u306e\u540c\u5b9a\u306b\u6b20\u304b\u305b\u306a\u3044\u3082\u306e\u3067\u3059\u304c\u3001IC\u306e\u4fdd\u6301\u6642\u9593\u306f\u3001\u3053\u308c\u307e\u3067\u4f7f\u7528\u3057\u3066\u304d\u305f\u4ed6\u306e\u30bf\u30a4\u30d7\u306e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u3088\u308a\u3082\u518d\u73fe\u6027\u304c\u9ad8\u304f\u3001\u5316\u5408\u7269\u306e\u540c\u5b9a\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u305f\u3081\u306b\u4fe1\u983c\u3067\u304d\u308b\u7d50\u679c\u3092\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002
\n\u307e\u305f\u3001\u4ee5\u524d\u306b\u5206\u6790\u3057\u305f\u3053\u3068\u306e\u306a\u3044\u5316\u5408\u7269\u306e\u5834\u5408\u3067\u3082\u3001IC\u306e\u4fdd\u6301\u6642\u9593\u306f\u69cb\u9020\u306b\u5bfe\u3057\u3066\u9ad8\u3044\u9078\u629e\u6027\u3092\u6301\u3061\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u7279\u5b9a\u306e\u7570\u6027\u4f53\u3092\u78ba\u5b9f\u306b\u5206\u96e2\u3057\u3066\u540c\u5b9a\u3067\u304d\u308b\u305f\u3081\u3001\u6642\u9593\u306e\u304b\u304b\u308b\u8a66\u6599\u306e\u8a98\u5c0e\u4f53\u5316\u3001\u30ac\u30b9\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u3092\u884c\u3046\u5fc5\u8981\u3082\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u5b9f\u969b\u306e\u7814\u7a76\u30c7\u30fc\u30bf\u3084\u5206\u6790\u7d50\u679c\u3092\u898b\u305f\u3044\u65b9\u306f\u3053\u3061\u3089\u306e\u30ea\u30f3\u30af\u304b\u3089\u8cc7\u6599\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u8cc7\u6599\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><\/p>\n

\u53c2\u8003\u6587\u732e
\n1. Judith B. Ngere, Kourosh H. Ebrahimi, Rachel Williams, Elisabete Pires, John Walsby-Tickle, and James S. O. McCullagh, Ion-Exchange Chromatography Coupled to Mass Spectrometry in Life Science, Environmental, and Medical Research
\nhttps:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.analchem.2c04298<\/a> (accessed Mar. 3, 2023)<\/p>\n

 <\/p>\n

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