{"id":14750,"date":"2023-07-14T11:55:25","date_gmt":"2023-07-14T02:55:25","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/?p=14750"},"modified":"2024-09-18T14:09:02","modified_gmt":"2024-09-18T05:09:02","slug":"crispr-cas9_basic_bid_ts_1","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/","title":{"rendered":"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f"},"content":{"rendered":"<h2>\u306f\u3058\u3081\u306b<\/h2>\n<p>2020\u5e74\u306b\u30b2\u30ce\u30e0\u7de8\u96c6\u306eCRISPR\/Cas9\uff08\u30af\u30ea\u30b9\u30d1\u30fc\u30fb\u30ad\u30e3\u30b99\uff09\u3092\u958b\u767a\u3057\u305f\u5973\u6027\u7814\u7a76\u80052\u540d\u304c\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u305f\u306e\u306f\u8a18\u61b6\u306b\u65b0\u3057\u3044\u3068\u3053\u308d\u3067\u3059\u3002\u5b9f\u306f\u3053\u306e\u53d7\u8cde\u3001\u7814\u7a76\u8005\u305f\u3061\u306e\u9593\u3067\u306f\u78ba\u5b9f\u8996\u3055\u308c\u3066\u3044\u305f\u6804\u8a89\u3067\u30012012\u5e74\u306b\u8a66\u9a13\u7ba1\u5185\u3067\u30012013\u5e74\u306b\u751f\u4f53\u5185\u3067CRISPR\/Cas9\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u521d\u3081\u3066\u6210\u529f\u3057\u3066\u4ee5\u6765\u3001\u3042\u307e\u308a\u306e\u7c21\u6613\u3055\u306b\u3001\u307e\u305f\u305f\u304f\u9593\u306b\u7814\u7a76\u8005\u306e\u9593\u306b\u6d78\u900f\u3057\u3066\u3044\u3063\u305f\u6280\u8853\u306a\u306e\u3067\u3059\u3002<\/p>\n<p>\u3067\u306f\u3001\u306a\u305cCRISPR\/Cas9\u306f\u3053\u3093\u306a\u306b\u3082\u753b\u671f\u7684\u3060\u3063\u305f\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u305d\u3082\u305d\u3082\u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u306f\u3069\u3046\u3044\u3046\u539f\u7406\u3067\u3001\u3069\u3046\u3044\u3046\u6280\u8853\u3067\u3001\u3053\u308c\u304b\u3089\u5b9f\u9a13\u3092\u59cb\u3081\u308b\u4eba\u306f\u4f55\u3092\u5b66\u3093\u3067\u304a\u304d\u3001\u4f55\u3092\u7528\u610f\u3059\u308c\u3070\u3088\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u3053\u306e\u30d6\u30ed\u30b0\u3067\u306f\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u3053\u308c\u304b\u3089\u59cb\u3081\u308b\u7814\u7a76\u8005\u3084\u5206\u5b50\u751f\u7269\u5b66\u3092\u5b66\u3076\u4eba\u5411\u3051\u306b\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<h2>\u6642\u4ee3\u304c\u6c42\u3081\u3066\u3044\u305f\u6280\u8853\u30fb\u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u305d\u306e\u6b74\u53f2<\/h2>\n<p>\u3055\u3066\u3001\u6700\u521d\u306b\u300c\u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u306f\u4f55\u304b\u300d\u3092\u78ba\u8a8d\u3057\u3066\u304a\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u306f\u3001\u6587\u5b57\u901a\u308a\u30b2\u30ce\u30e0\u3092\u7de8\u96c6\u3059\u308b\u6280\u8853\u3002\u3088\u304f\u3001\u30a4\u30e9\u30b9\u30c8\u3067\u306f\u3001\u30cf\u30b5\u30df\u304c\u30b2\u30ce\u30e0\u3092\u5207\u3063\u3066\u3044\u308b\u69d8\u5b50\u304c\u63cf\u304b\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u307e\u3055\u306b\u3053\u306e\u30a4\u30e1\u30fc\u30b8\u901a\u308a\u3067\u3059\u3002\u30cf\u30b5\u30df\u3067\u30b2\u30ce\u30e0\u306e\u597d\u304d\u306a\u3068\u3053\u308d\u3092\u5207\u3063\u305f\u308a\u3001\u5207\u3063\u305f\u5834\u6240\u306b\u9055\u3046\u914d\u5217\u3092\u5165\u308c\u8fbc\u3093\u3060\u308a\u3067\u304d\u307e\u3059\u3002\u30b2\u30ce\u30e0\u306e\u7279\u5b9a\u90e8\u4f4d\u306b\u30e9\u30f3\u30c0\u30e0\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u65b9\u6cd5\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u6cd5\u3001\u5207\u308a\u53d6\u3063\u305f\u5834\u6240\u306b\u5225\u306e\u914d\u5217\u3092\u5165\u308c\u308b\u65b9\u6cd5\u3092\u30ce\u30c3\u30af\u30a4\u30f3\u6cd5\u3068\u547c\u3073\u307e\u3059\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-14752\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-01.jpg\" alt=\"\" width=\"1000\" height=\"508\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-01.jpg 1000w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-01-300x152.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-01-768x390.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><br \/>\n\u307e\u305a\u306f\u3053\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u3068CRISPR\/Cas9\u304c\u3001\u306a\u305c\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u7372\u5f97\u3059\u308b\u307b\u3069\u9769\u65b0\u7684\u3060\u3063\u305f\u306e\u304b\u3001\u6b74\u53f2\u3092\u632f\u308a\u8fd4\u308a\u306a\u304c\u3089\u3054\u7d39\u4ecb\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>2003\u5e74\u306b\u30d2\u30c8\u30b2\u30ce\u30e0\u8a08\u753b\u304c\u5b8c\u4e86\u3057\u3066\u304b\u3089\u3001\u304a\u306e\u304a\u306e\u306e\u907a\u4f1d\u5b50\u306e\u5f79\u5272\u3084\u3001\u75c5\u6c17\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u89e3\u660e\u3001\u85ac\u5264\u3078\u306e\u5fdc\u7b54\u6027\u306a\u3069\u3001\u30b2\u30ce\u30e0\u306e\u7814\u7a76\u306f\u52a0\u901f\u5ea6\u7684\u306b\u9032\u3093\u3067\u304d\u307e\u3057\u305f\u3002\u305d\u308c\u3089\u306e\u7814\u7a76\u306b\u4eca\u307e\u3067\u5927\u304d\u306a\u8ca2\u732e\u3092\u3057\u3066\u304d\u305f\u6280\u8853\u306e\u3072\u3068\u3064\u304c\u3001\u30ce\u30fc\u30d9\u30eb\u533b\u5b66\u751f\u7406\u5b66\u8cde\u3092\u7372\u5f97\u3057\u305f<b>siRNA\u306b\u3088\u308bRNA\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0<\/b>\u3067\u3059\u3002\u5b9f\u9a13\u624b\u6cd5\u304c\u7c21\u5358\u3067\u30011\u9031\u9593\u7a0b\u5ea6\u3067\u7d50\u679c\u304c\u308f\u304b\u308a\u307e\u3059\u306e\u3067\u3001\u4eca\u3067\u3082\u591a\u304f\u306e\u7814\u7a76\u8005\u306b\u5e45\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001siRNA\u306f\u3042\u304f\u307e\u3067\u3082\u300c\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u300d\u3002\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u3092\u4e0b\u3052\u308b\u3082\u306e\u306e\u3001\u5b8c\u5168\u306b\u305d\u306e\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3092\u5931\u308f\u305b\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e00\u65b9\u3067\u3001\u300c\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u300d\u3068\u3044\u3046\u6280\u8853\u3082\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u73fe\u308c\u308b\u524d\u304b\u3089\u5b58\u5728\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306a\u3069\uff09\u304c\u3001\u304b\u306a\u308a\u306e\u52b4\u529b\u3068\u6708\u65e5\u3092\u6d88\u8cbb\u305b\u3056\u308b\u3092\u5f97\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u300c\u7c21\u5358\u306b\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u304c\u3067\u304d\u305f\u3089\u3044\u3044\u306e\u306b\u300d\u3068\u3044\u3046\u9858\u3044\u306f\u3001\u305a\u3063\u3068\u7814\u7a76\u8005\u306e\u4e2d\u306b\u304f\u3059\u3076\u308a\u7d9a\u3051\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u89e3\u660e\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30b2\u30ce\u30e0\u306e\u3046\u30611\u5869\u57fa\u3060\u3051\u304c\u7570\u306a\u308b\u3053\u3068\u3092SNP\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09\u3068\u547c\u3073\u307e\u3059\u304c\u3001SNP\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u306e\u300c\u75c5\u6c17\u306e\u306a\u308a\u3084\u3059\u3055\u300d\u3084\u4f53\u8cea\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u3068\u3042\u308bSNP\u3092\u5225\u306e\u5869\u57fa\u306b\u7f6e\u304d\u63db\u3048\u308b\u3068\u3069\u3046\u306a\u308b\u306e\u304b\uff1f\u305d\u306e\u8b0e\u306e\u89e3\u660e\u306b\u306f\u3001\u4eca\u307e\u3067\u591a\u5927\u306a\u6642\u9593\u3068\u52b4\u529b\u3092\u8cbb\u3084\u3055\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u306fSNP\u306e1\u5869\u57fa\u3060\u3051\u3092\u5225\u306e\u5869\u57fa\u306b\u5909\u66f4\u3067\u304d\u307e\u3059\u3002\u305d\u3057\u3066\u3001SNP\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306f\u3001\u75c5\u6c17\u306e\u4e88\u9632\u3084\u500b\u5225\u5316\u533b\u7642\u3078\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u533b\u7642\u306e\u5206\u91ce\u3067\u3082\u3001\u5f93\u6765\u306e\u300c\u907a\u4f1d\u5b50\u6cbb\u7642\u300d\u3067\u306f\u3001\u6b63\u5e38\u306a\u907a\u4f1d\u5b50\u3092\u4f53\u5185\u306b\u5165\u308c\u308b\u3053\u3068\u306f\u3067\u304d\u3066\u3082\u3001\u3082\u3068\u3082\u3068\u6301\u3063\u3066\u3044\u308b\u7570\u5e38\u907a\u4f1d\u5b50\u3092\u5207\u308a\u53d6\u3063\u305f\u308a\u3001\u914d\u5217\u3092\u5909\u66f4\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u306f\u3001\u305d\u306e\u540d\u306e\u3068\u304a\u308a\u30b2\u30ce\u30e0\u3092\u76f4\u63a5\u7de8\u96c6\u3067\u304d\u307e\u3059\u306e\u3067\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u767b\u5834\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u624b\u306e\u5c4a\u304f\u7bc4\u56f2\u304c\u5927\u304d\u304f\u62e1\u5927\u3057\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306f\u6642\u4ee3\u304c\u6c42\u3081\u3066\u304d\u305f\u6280\u8853\u3068\u8a00\u3048\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u73fe\u5728\u4e3b\u6d41\u3067\u4f7f\u308f\u308c\u3066\u3044\u308bCIRSPR\/Cas9\u6280\u8853\u306e\u78ba\u7acb\u307e\u3067\u306b\u306f\u3001\u305f\u304f\u3055\u3093\u306e\u8a66\u884c\u932f\u8aa4\u306e\u7a4d\u307f\u91cd\u306d\u304c\u3042\u308a\u307e\u3057\u305f\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-14756\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg\" alt=\"\" width=\"990\" height=\"660\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg 990w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510-300x200.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510-768x512.jpg 768w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510-96x65.jpg 96w\" sizes=\"auto, (max-width: 990px) 100vw, 990px\" \/><br \/>\n\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u7b2c\u4e00\u4e16\u4ee3\u306f1996\u5e74\u306b\u767b\u5834\u3057\u305fZinc Finger Nuclease\uff08ZFN\uff09\u3001\u7b2c\u4e8c\u4e16\u4ee3\u306f2010\u5e74\u306b\u767a\u8868\u3055\u308c\u305fTALEN\u3067\u3059\u3002\u3069\u3061\u3089\u3082\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u3067\u3042\u308bFok I\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u878d\u5408\u3057\u3066\u4eba\u5de5\u7684\u306b\u4f5c\u88fd\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u30b2\u30ce\u30e0DNA\u306b\u7d50\u5408\u3059\u308b\u306e\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u305f\u3081\u3001\u72d9\u3063\u305fDNA\u3092\u5207\u65ad\u3059\u308b\u305f\u3081\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u30c7\u30b6\u30a4\u30f3\u304c\u96e3\u3057\u3044\u3068\u3044\u3046\u70b9\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u5909\u7570\u5c0e\u5165\u306e\u78ba\u8a8d\u306b\u65e5\u6570\u3082\u8981\u3057\u3001\u91d1\u3082\u6642\u9593\u3082\u304b\u304b\u3063\u3066\u3057\u307e\u3046\u305f\u3081\u53d7\u8a17\u306b\u983c\u308b\u3088\u3046\u306a\u72b6\u6cc1\u3082\u591a\u304f\u898b\u3089\u308c\u3001\u5e83\u304f\u5229\u7528\u3055\u308c\u308b\u307e\u3067\u306f\u81f3\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-14757\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-03.jpg\" alt=\"\" width=\"1000\" height=\"794\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-03.jpg 1000w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-03-300x238.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-03-768x610.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><br \/>\n\u3053\u306e\u3088\u3046\u306a\u4e2d\u3067\u767b\u5834\u3057\u305f\u306e\u304c\u3001CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002CRISPR\u3068\u306f<u>C<\/u>lustered <u>R<\/u>egularly <u>I<\/u>nterspaced <u>S<\/u>hort <u>P<\/u>alindromic <u>R<\/u>epeats\u306e\u982d\u6587\u5b57\u3092\u53d6\u3063\u3066\u304a\u308a\u3001\u7d30\u83cc\u306b\u5b58\u5728\u3059\u308b\u6570\u5341\u5869\u57fa\u306e\u7e70\u308a\u8fd4\u3057\u914d\u5217\u306e\u3053\u3068\u3092\u6307\u3057\u307e\u3059\u3002ZFN\u3084TALEN\u306e\u3088\u3046\u306b\u30b2\u30ce\u30e0DNA\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7d50\u5408\u3055\u305b\u308b\u306e\u3067\u306f\u306a\u304f\u3001RNA\u3092\u7d50\u5408\u3055\u305b\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30b2\u30ce\u30e0DNA\u306b\u7d50\u5408\u3055\u305b\u308bRNA\uff08\u30ac\u30a4\u30c9RNA\u3068\u547c\u3073\u307e\u3059\uff09\u306e\u30c7\u30b6\u30a4\u30f3\u304cZFN\u3084TALEN\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u7c21\u5358\u3067\u3001\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u8d77\u3053\u3059\u914d\u5217\u306e\u4e88\u6e2c\u3082\u3057\u3084\u3059\u304f\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u3092\u8907\u6570\u8a2d\u5b9a\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u3001\u3055\u3089\u306b\u4fa1\u683c\u3082\u5b89\u4fa1\u3002\u8ab0\u3082\u304c\u5f85\u3061\u671b\u3093\u3067\u3044\u305f\u300c\u7c21\u5358\u306a\u30b2\u30ce\u30e0\u7de8\u96c6\u30b7\u30b9\u30c6\u30e0\u300d\u3067\u3059\u304b\u3089\u3001\u5e83\u304c\u3089\u306a\u3044\u7406\u7531\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306eCRISPR\/Cas9\u306e\u767b\u5834\u3067\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306f\u7814\u7a76\u5ba4\u30ec\u30d9\u30eb\u3067\u8ab0\u3082\u304c\u5b9f\u9a13\u304c\u53ef\u80fd\u306a\u30b7\u30b9\u30c6\u30e0\u3068\u306a\u308a\u3001\u7206\u767a\u7684\u306b\u5e83\u304c\u3063\u305f\u306e\u3067\u3059\u3002\u3053\u306e\u753b\u671f\u7684\u306a\u7c21\u4fbf\u3055\u304c\u3001\u30ce\u30fc\u30d9\u30eb\u8cde\u30922\u4eba\u306e\u5049\u5927\u306a\u6559\u6388\u3078\u4e0e\u3048\u308b\u306b\u81f3\u3063\u305f\u7406\u7531\u3067\u3059\u3002<\/p>\n<p>\u305d\u308c\u3067\u306f\u6b21\u306b\u3001CRISPR\/Cas9\u304c\u3069\u306e\u3088\u3046\u306b\u30b2\u30ce\u30e0\u3092\u5207\u65ad\u3059\u308b\u306e\u304b\u3001\u305d\u306e\u4ed5\u7d44\u307f\u3092\u3072\u3082\u3068\u3044\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u95a2\u9023\u8a18\u4e8b\uff1a<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/communities-social\/NEXT-Forum\/Interview\/interview-vol31.html?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u8ab0\u3082\u304c\u4f7f\u3044\u3053\u306a\u3059\u30b2\u30ce\u30e0\u7de8\u96c6\u6642\u4ee3\u306e\u5e55\u958b\u3051\u3078<\/a><\/p>\n<h2>CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u306e\u539f\u7406<\/h2>\n<p>CRISPR\/Cas9\u306f\u3001\u30bc\u30ed\u304b\u3089\u69cb\u7bc9\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3082\u3068\u3082\u3068\u7d30\u83cc\u3084\u53e4\u7d30\u83cc\u306b\u304a\u3044\u3066\u3001\u5916\u6765\u6027\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u8105\u5a01\u306b\u5bfe\u3059\u308b\u653b\u6483\u624b\u6bb5\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f\u3001\u7372\u5f97\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002\u7d30\u83cc\u306b\u304a\u3051\u308b\u3053\u306e\u30b7\u30b9\u30c6\u30e0\u304c\u3001\u30a8\u30de\u30cb\u30e5\u30a8\u30eb\u30fb\u30b7\u30e3\u30eb\u30d1\u30f3\u30c6\u30a3\u30a8\u6559\u6388\u3068\u30b8\u30a7\u30cb\u30d5\u30a1\u30fc\u30fb\u30c0\u30a6\u30c9\u30ca\u6559\u6388\u306b\u3088\u3063\u3066\u3001\u65b0\u3057\u3044\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3078\u3068\u6607\u83ef\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305a\u306f\u7d30\u83cc\u5185\u3067\u3069\u306e\u3088\u3046\u306bCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u304c\u50cd\u3044\u3066\u3044\u308b\u306e\u304b\u3001\u56f32\u3067\u89e3\u8aac\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<div id=\"attachment_14766\" style=\"width: 908px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-14766\" class=\"size-full wp-image-14766\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-04.jpg\" alt=\"\u7d30\u83cc\u306b\u304a\u3051\u308bCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\uff5e\u521d\u56de \u5916\u6575DNA\u4fb5\u5165\u6642\" width=\"898\" height=\"404\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-04.jpg 898w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-04-300x135.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-04-768x346.jpg 768w\" sizes=\"auto, (max-width: 898px) 100vw, 898px\" \/><p id=\"caption-attachment-14766\" class=\"wp-caption-text\">\u56f32-(1) \u7d30\u83cc\u306b\u304a\u3051\u308bCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\uff5e\u521d\u56de \u5916\u6575DNA\u4fb5\u5165\u6642<\/p><\/div>\n<p>\u56f32-(1) \u306e\u3088\u3046\u306b\u3001\u7d30\u83cc\u5185\u306b\u30a6\u30a4\u30eb\u30b9\u3084\u30d7\u30e9\u30b9\u30df\u30c9\u304c\u4fb5\u5165\u3059\u308b\u3068\u3001Cas9\u306b\u3088\u3063\u3066PAM\u914d\u5217\u304c\u8a8d\u8b58\u3055\u308c\u3001\u5916\u6575DNA\u306e\u4e00\u90e8\u304c\u5207\u308a\u53d6\u3089\u308c\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001\u5bbf\u4e3b\u306e\u30b2\u30ce\u30e0DNA\u5185\u306eCRISPR\u914d\u5217\uff08\u30ea\u30d4\u30fc\u30c8\u914d\u5217\uff09\u306e\u9593\u306b\u3001\u30b9\u30da\u30fc\u30b5\u30fc\u914d\u5217\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u633f\u5165\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u304c\u3001crRNA\uff08\u30bf\u30fc\u30b2\u30c3\u30c8DNA\u306b\u7d50\u5408\u3057\u3066\u5207\u65ad\u3059\u308b\u30ac\u30a4\u30c9RNA\uff09\u3092\u751f\u307f\u51fa\u3059\u92f3\u578b\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u4f5c\u3089\u308c\u305f\u92f3\u578b\u304c\u514d\u75ab\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u69d8\u5b50\u3092\u3001\u56f32-(2)\u306b\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<div id=\"attachment_14763\" style=\"width: 907px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-14763\" class=\"size-full wp-image-14763\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-05.jpg\" alt=\"\u7d30\u83cc\u306b\u304a\u3051\u308bCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\uff5e2\u56de\u76ee\u4ee5\u964d \u5916\u6575DNA\u4fb5\u5165\u6642\uff08\u7372\u5f97\u514d\u75ab\u306e\u4f5c\u7528\uff09\" width=\"897\" height=\"646\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-05.jpg 897w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-05-300x216.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-05-768x553.jpg 768w\" sizes=\"auto, (max-width: 897px) 100vw, 897px\" \/><p id=\"caption-attachment-14763\" class=\"wp-caption-text\">\u56f32-(2) \u7d30\u83cc\u306b\u304a\u3051\u308bCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\uff5e2\u56de\u76ee\u4ee5\u964d \u5916\u6575DNA\u4fb5\u5165\u6642\uff08\u7372\u5f97\u514d\u75ab\u306e\u4f5c\u7528\uff09<\/p><\/div>\n<p>2\u56de\u76ee\u4ee5\u964d\u3001\u5916\u6575DNA\u304c\u7d30\u83cc\u306b\u4fb5\u5165\u3057\u305f\u3068\u304d\u3001\u3059\u3067\u306b\u5bbf\u4e3b\u306e\u30b2\u30ce\u30e0DNA\u306b\u306f\u30b9\u30da\u30fc\u30b5\u30fc\u3068\u3057\u3066\u5916\u6575DNA\u306e\u914d\u5217\u304c\u7d44\u307f\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u304c\u8ee2\u5199\u3055\u308c\u3066\u5207\u65ad\u5f8c\u3001\u6210\u719fcrRNA\u306b\u306a\u308a\u3001\u5916\u6575DNA\u306ePAM\u914d\u5217\u4e0a\u6d41\u306b\u7d50\u5408\u3057\u307e\u3059\u3002\u305d\u3053\u306btracrRNA\uff08Trans-activating crRNA\u3001Cas9\u3092\u547c\u3073\u8fbc\u3080RNA\uff09\u304c\u7d50\u5408\u3057\u3001Cas9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306b\u3088\u308b\u5207\u65ad\u304c\u884c\u308f\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u3044\u3064\u5916\u6575DNA\u304c\u4fb5\u5165\u3057\u3066\u304d\u3066\u3082\u826f\u3044\u3088\u3046\u306b\u3001\u7d30\u83cc\u306f\u5916\u6575DNA\u3092\u653b\u6483\u3067\u304d\u308b\u6e96\u5099\u3092\u6574\u3048\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u30a8\u30de\u30cb\u30e5\u30a8\u30eb\u30fb\u30b7\u30e3\u30eb\u30d1\u30f3\u30c6\u30a3\u30a8\u6559\u6388\u3068\u30b8\u30a7\u30cb\u30d5\u30a1\u30fc\u30fb\u30c0\u30a6\u30c9\u30ca\u6559\u6388\u306f\u3001\u7d30\u83cc\u306b\u304a\u3051\u308bCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u306e\u300c\u826f\u3044\u3068\u3053\u53d6\u308a\u300d\u3092\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u6700\u4f4e\u9650\u5fc5\u8981\u306a\u3082\u306e\u3060\u3051\u3092\u53d6\u308a\u51fa\u3057\u3066\u3001\u540c\u3058\u3088\u3046\u306b\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u30b2\u30ce\u30e0DNA\u3092\u5207\u65ad\u3059\u308b\u65b9\u6cd5\u3092\u8003\u3048\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u305d\u3046\u3057\u3066\u5b8c\u6210\u3057\u305f\u306e\u304c\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u304a\u3051\u308bCRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002<\/p>\n<div id=\"attachment_14764\" style=\"width: 971px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-14764\" class=\"size-full wp-image-14764\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-06.jpg\" alt=\"\u30b2\u30ce\u30e0\u7de8\u96c6CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\" width=\"961\" height=\"588\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-06.jpg 961w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-06-300x184.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-06-768x470.jpg 768w\" sizes=\"auto, (max-width: 961px) 100vw, 961px\" \/><p id=\"caption-attachment-14764\" class=\"wp-caption-text\">\u56f33. \u30b2\u30ce\u30e0\u7de8\u96c6CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0<\/p><\/div>\n<p>\u56f33\u3092\u898b\u308b\u3068\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u304a\u3044\u3066Cas9\u306b\u3088\u308a\u5207\u65ad\u304c\u8d77\u3053\u308b\u307e\u3067\u306e\u6d41\u308c\u306f\u3001\u56f32\u306e\u7d30\u83cc\u5185\u306e\u30b7\u30b9\u30c6\u30e0\u3068\u5927\u5909\u3088\u304f\u4f3c\u3066\u3044\u307e\u3059\u3088\u306d\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u3082\u3068\u3082\u3068\u7d30\u83cc\u304c\u6301\u3063\u3066\u3044\u305f\u30b7\u30b9\u30c6\u30e0\u3092\u6d3b\u7528\u3057\u3066\u3001\u30b2\u30ce\u30e0\u7de8\u96c6CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u306f\u78ba\u7acb\u3055\u308c\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u56f32\uff08\u7d30\u83cc\u306e\u7372\u5f97\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\uff09\u3068\u56f33\uff08\u30b2\u30ce\u30e0\u7de8\u96c6\uff09\u3067\u7570\u306a\u308b\u70b9\u306f\u3001\u4e3b\u306b2\u3064\u3002<\/p>\n<p>1\u3064\u3081\u306f\u3001\u30ac\u30a4\u30c9RNA\u3067\u3059\u3002\u7d30\u83cc\u3067\u306fcrRNA\u3068tracrRNA\u306f\u5225\u306eRNA\u3067\u3057\u305f\u304c\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u306f\u3053\u306e2\u3064\u3092\u3064\u306a\u3052\u3066\u30ad\u30e1\u30e9\u306b\u3057\u3066\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306ecrRNA-tracrRNA\u30ad\u30e1\u30e9\u304c\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u304a\u3051\u308b\u30ac\u30a4\u30c9RNA\u3001\u3064\u307e\u308a\u3001\u30bf\u30fc\u30b2\u30c3\u30c8DNA\u306bCas9\u3092\u30ac\u30a4\u30c9\u3057\u3066\u3042\u3052\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002tracrRNA\u306fCas9\u304c\u540c\u4e00\u3067\u3042\u308c\u3070\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3088\u3089\u305a\u540c\u914d\u5217\u3067\u3001crRNA\u306f\u30bf\u30fc\u30b2\u30c3\u30c8DNA\u306b\u5fdc\u3058\u3066\u914d\u5217\u3092\u30c7\u30b6\u30a4\u30f3\u3057\u307e\u3059\u3002<\/p>\n<p>2\u3064\u3081\u306f\u3001Cas9\u3082\u7d30\u80de\u5185\u3078\u5c0e\u5165\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u70b9\u3067\u3059\u3002<\/p>\n<p>\u3055\u3066\u3001\u3053\u3053\u307e\u3067\u306e\u8a71\u306fCas9\u304c\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u3092\u300c\u5207\u308b\u300d\u3068\u3053\u308d\u307e\u3067\u306e\u8aac\u660e\u3067\u3059\u3002\u30b2\u30ce\u30e0\u3092\u300c\u7de8\u96c6\u300d\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002\u3067\u306f\u3069\u306e\u3088\u3046\u306b\u7de8\u96c6\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u56f34\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n<div id=\"attachment_14765\" style=\"width: 990px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-14765\" class=\"size-full wp-image-14765\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-07.jpg\" alt=\"CRISPR\/Cas9\u5207\u65ad\u5f8c\u306b\u5909\u7570\u304c\u5165\u308b\u4ed5\u7d44\u307f\" width=\"980\" height=\"713\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-07.jpg 980w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-07-300x218.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-07-768x559.jpg 768w\" sizes=\"auto, (max-width: 980px) 100vw, 980px\" \/><p id=\"caption-attachment-14765\" class=\"wp-caption-text\">\u56f34\u3000CRISPR\/Cas9\u5207\u65ad\u5f8c\u306b\u5909\u7570\u304c\u5165\u308b\u4ed5\u7d44\u307f<\/p><\/div>\n<p>Cas9\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u306b\u3088\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u30b2\u30ce\u30e0\u5207\u65ad\uff08\u30c0\u30d6\u30eb\u30b9\u30c8\u30e9\u30f3\u30c9\u30d6\u30ec\u30fc\u30af\u3001\u982d\u6587\u5b57\u3092\u53d6\u3063\u3066DSB\u3068\u547c\u3070\u308c\u307e\u3059\uff09\u304c\u8d77\u3053\u3063\u305f\u5f8c\u306e\u6d41\u308c\u3092\u3001\u56f34\u306b\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305a\u306f\u5de6\u5074\u306e\u6d41\u308c\u3001\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u306b\u3064\u3044\u3066\u3067\u3059\u3002\u5207\u65ad\u3055\u308c\u305fDNA\u306f\u3001\u4e00\u822c\u7684\u306b\u3001\u7d30\u80de\u5185\u306e\u4fee\u5fa9\u7d4c\u8def\u3067\u3042\u308b\u975e\u76f8\u540c\u672b\u7aef\u7d50\u5408\uff08NHEJ\uff1anon homologous end joint\uff09\u306b\u3088\u308a\u3001\u3082\u3068\u306e\u914d\u5217\u306b\u623b\u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7d30\u80de\u5185\u306b\u306f\u307e\u3060\u30ac\u30a4\u30c9RNA\u3068Cas9\u306e\u8907\u5408\u4f53\u304c\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u518d\u5ea6\u5207\u65ad\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u5207\u65ad\u30fb\u4fee\u5fa9\u304c\u7e70\u308a\u8fd4\u3055\u308c\u308b\u3046\u3061\u306b\u3001\u4f4e\u3044\u78ba\u7387\u3067\u4fee\u5fa9\u30a8\u30e9\u30fc\u304c\u8d77\u304d\u3001\u5909\u7570\u304c\u5165\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u5909\u7570\u306f\u30e9\u30f3\u30c0\u30e0\u306e\u305f\u3081\u3001\u3069\u306e\u3088\u3046\u306a\u5909\u7570\u304c\u5165\u308b\u306e\u304b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u30b7\u30fc\u30b1\u30f3\u30b9\u3067\u5909\u7570\u306e\u78ba\u8a8d\u304c\u5fc5\u8981\u3067\u3059\u304c\u3001\u5de6\u5074\u306e\u6d41\u308c\u306e\u5834\u5408\u3001\u76ee\u7684\u306f\u300c\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u300d\u3002\u3064\u307e\u308a\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u6b20\u5931\u3055\u308c\u308c\u3070\u3088\u3044\u306e\u3067\u3001\u5909\u7570\u306b\u3088\u3089\u305a\u3001\u30d5\u30ec\u30fc\u30e0\u30b7\u30d5\u30c8\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u304b\u3001\u307e\u305f\u306f\u3001\u5165\u3063\u305f\u5909\u7570\u306b\u3088\u3063\u3066\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u304c\u6b20\u5931\u3057\u3066\u3044\u308c\u3070\u6210\u529f\u3067\u3059\u3002<\/p>\n<p>\u6b21\u306b\u53f3\u5074\u306e\u6d41\u308c\u3001\u30ce\u30c3\u30af\u30a4\u30f3\u306b\u3064\u3044\u3066\u3067\u3059\u3002\u633f\u5165\u3057\u305f\u3044\u914d\u5217\u304c\u6c7a\u307e\u3063\u3066\u3044\u308b\u5834\u5408\u3001\u633f\u5165\u3059\u308b\u914d\u5217\u3092\u542b\u3093\u3060\u30c9\u30ca\u30fc\u3068\u547c\u3070\u308c\u308b\u30d9\u30af\u30bf\u30fc\u3084\u30011\u672c\u9396\u30aa\u30ea\u30b4\u304c\u5fc5\u8981\u3067\u3059\u3002\u3053\u308c\u3089\u304c\u7d30\u80de\u5185\u306b\u3042\u308b\u3068\u3001\u30c0\u30d6\u30eb\u30b9\u30c8\u30e9\u30f3\u30c9\u30d6\u30ec\u30fc\u30af\u306e\u5f8c\u306b\u7d30\u80de\u5185\u306e\u76f8\u540c\u7d44\u307f\u63db\u3048\uff08Homology directed repair\uff1aHDR\uff09\u6d3b\u6027\u306b\u3088\u308a\u3001\u30c9\u30ca\u30fc\u914d\u5217\u307e\u305f\u306f1\u672c\u9396\u30aa\u30ea\u30b4\u306e\u914d\u5217\u304c\u30b2\u30ce\u30e0\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u30ce\u30c3\u30af\u30a4\u30f3\u304c\u884c\u308f\u308c\u307e\u3059\u3002<\/p>\n<h2>CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3067\u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\u3092\u884c\u3046\u306b\u306f\uff1f<\/h2>\n<p>\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u6b74\u53f2\u3001CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u306e\u539f\u7406\u3001\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3084\u30ce\u30c3\u30af\u30a4\u30f3\u306e\u6d41\u308c\u3092\u7406\u89e3\u3057\u305f\u3068\u3053\u308d\u3067\u3001\u300c\u3058\u3083\u3042\u3001\u3069\u3046\u3084\u3063\u3066\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u5b9f\u9a13\u3092\u3059\u308c\u3070\u3088\u3044\u306e\u304b\uff1f\u300d\u306b\u8a71\u3092\u79fb\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u3053\u306e\u30d6\u30ed\u30b0\u3067\u3059\u3079\u3066\u3092\u8aac\u660e\u3057\u3066\u3057\u307e\u3046\u3068\u304b\u306a\u308a\u9577\u304f\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3001\u9023\u8f09\u5f62\u5f0f\u3067\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\u306e\u6d41\u308c\u3092\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li><a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/gene-editing_bid_ts_1\/?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b ! \u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\uff08CRISPR\/Cas9\uff09\uff5e\u7b2c1\u56de CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u306e\u539f\u7406\uff5e<\/a><\/li>\n<li><a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/gene-editing_bid_ts_2\/?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b ! \u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\uff08CRISPR\/Cas9\uff09\uff5e\u7b2c2\u56de \u30ac\u30a4\u30c9RNA\u306e\u30c7\u30b6\u30a4\u30f3\uff5e<\/a><\/li>\n<li><a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/gene-editing_bid_ts_3\/?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b ! \u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\uff08CRISPR\/Cas9\uff09\uff5e\u7b2c3\u56de 3\u3064\u306eCRIPSR\/Cas9\u5b9f\u9a13\u7cfb\uff5e<\/a><\/li>\n<li><a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/gene-editing_bid_ts_4\/?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b ! \u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\uff08CRISPR\/Cas9\uff09\uff5e\u7b2c4\u56de \u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30af\u30b7\u30e7\u30f3\uff5e<\/a><\/li>\n<li><a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/gene-editing_bid_ts_5\/?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b\uff01 \u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\uff08CRISPR\/Cas9\uff09\uff5e\u7b2c5\u56de\u3000\u5909\u7570\u306e\u78ba\u8a8d\u65b9\u6cd5\uff5e<\/a><\/li>\n<li><a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/gene-editing_bid_ts_6\/?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b\uff01 \u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\uff08CRISPR\/Cas9\uff09\uff5e\u7b2c6\u56de\u3000\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\uff5e<\/a><\/li>\n<li><a href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/gene-editing_bid_ts_7\/?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b\uff01 \u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\uff08CRISPR\/Cas9\uff09\uff5e\u7b2c7\u56de\u3000\u30ce\u30c3\u30af\u30a4\u30f3\u5b9f\u9a13\u306e\u6d41\u308c\uff5e<\/a><\/li>\n<\/ul>\n<p>\u300c\u305d\u3046\u3044\u3046\u3053\u3068\u3060\u3063\u305f\u306e\u304b\uff01\u300d\u30b7\u30ea\u30fc\u30ba\u3067\u306f\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u521d\u3081\u3066\u884c\u3046A\u3055\u3093\u304c\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u7cbe\u901a\u3057\u3066\u3044\u308b\u5148\u8f29\u306b\u76f8\u8ac7\u30fb\u4f1a\u8a71\u3057\u306a\u304c\u3089\u5b9f\u9a13\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002\u5b9f\u306f\u3001\u5f53\u793e\u5185\u3067\u5b9f\u969b\u306b\u4ea4\u308f\u3055\u308c\u305f\u521d\u5fc3\u8005\u3068\u30d9\u30c6\u30e9\u30f32\u4eba\u306e\u4f1a\u8a71\u3082\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u521d\u5fc3\u8005\u306e\u65b9\u304c\u3076\u3064\u304b\u308a\u305d\u3046\u306a\u7591\u554f\u3068\u305d\u306e\u89e3\u7b54\u3001\u305d\u3057\u3066\u521d\u3081\u3066\u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\u3092\u884c\u3046\u3068\u304d\u306e\u30dd\u30a4\u30f3\u30c8\u304c\u8a70\u3081\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u3053\u308c\u304b\u3089\u59cb\u3081\u308b\u65b9\u306f\u305c\u3072\u306e\u305e\u3044\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2>\u307e\u3068\u3081\uff1aCRISPR\/Cas9\u3067\u3001\u8ab0\u3067\u3082\u7c21\u5358\u306b\u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\u304c\u3067\u304d\u308b\u3088\u3046\u306b<\/h2>\n<p>CRISPR\/Cas9\u306f\u7d30\u83cc\u304c\u3082\u3068\u3082\u3068\u6301\u3063\u3066\u3044\u305f\u30b7\u30b9\u30c6\u30e0\u3092\u5229\u7528\u3057\u305f\u3082\u306e\u3067\u3059\u304c\u3001\u30ac\u30a4\u30c9RNA\u306e\u30c7\u30b6\u30a4\u30f3\u304c\u7c21\u5358\u3067\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\u306e\u4e88\u6e2c\u3082\u3057\u3084\u3059\u3044\u306a\u3069\u306e\u7406\u7531\u304b\u3089\u3001\u5206\u5b50\u751f\u7269\u5b66\u306e\u57fa\u790e\u3092\u5b66\u3093\u3067\u3044\u308b\u7814\u7a76\u8005\u306a\u3089\u3001\u3069\u306a\u305f\u3067\u3082\u53d6\u308a\u639b\u304b\u308c\u308b\u6280\u8853\u306b\u306a\u308a\u3001\u7206\u767a\u7684\u306b\u5e83\u304c\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u79d1\u5b66\u306e\u9032\u6b69\u306f\u3081\u3056\u307e\u3057\u304f\u3001\u300c\u30b2\u30ce\u30e0\u3092\u7de8\u96c6\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u300d\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u9769\u65b0\u7684\u3059\u304e\u3066\u3001\u304d\u3063\u3068\u30e1\u30f3\u30c7\u30eb\u3084\u30af\u30ea\u30c3\u30af\u304c\u751f\u304d\u3066\u3044\u305f\u3089\u3001\u9a5a\u304d\u306a\u304c\u3089\u3082\u62cd\u624b\u3092\u9001\u3063\u3066\u304f\u308c\u305f\u306b\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u3002\u533b\u7642\u3078\u306e\u767a\u5c55\u3001\u8fb2\u696d\u3078\u306e\u5c55\u958b\u3001\u305d\u3057\u3066\u57fa\u790e\u5b9f\u9a13\u3078\u306e\u5fdc\u7528\u306a\u3069\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306f\u3053\u308c\u304b\u3089\u3082\u591a\u5206\u91ce\u3067\u6d3b\u8e8d\u3057\u3001\u3055\u3089\u306b\u767a\u5c55\u3092\u7d9a\u3051\u3066\u3044\u304f\u3067\u3057\u3087\u3046\u3002<\/p>\n<h3>\u5b9f\u969b\u306bCRISPR\/Cas9\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u59cb\u3081\u308b\u65b9\u306b\u304a\u3059\u3059\u3081\uff01<\/h3>\n<p>\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u8a66\u85ac\u304c\u30bb\u30c3\u30c8\u306b\u306a\u3063\u305f\u30b2\u30ce\u30e0\u7de8\u96c6\u5b9f\u9a13\u30b9\u30bf\u30fc\u30bf\u30fc\u30d1\u30c3\u30af<\/p>\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/products-and-services\/services\/technical-services\/starter-pack.html?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u8a73\u3057\u304f\u306f\u3053\u3061\u3089<\/a><\/p>\n<h3>\uff3b\u7121\u6599\u516c\u958b\u4e2d\uff3dCRISPR\u30b2\u30ce\u30e0\u7de8\u96c6\u30ea\u30bd\u30fc\u30b9\u30ac\u30a4\u30c9<\/h3>\n<p>\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u57fa\u790e\u306e\u5fa9\u7fd2\u3001\u3088\u308a\u6df1\u3044\u77e5\u8b58\u306e\u7372\u5f97\u3001\u307e\u305f\u306f\u6700\u65b0\u306e\u7814\u7a76\u30c4\u30fc\u30eb\u306e\u691c\u7d22\u304c\u3067\u304d\u307e\u3059\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u4e2d\u6838\u3068\u3057\u3066\u3001\u521d\u5fc3\u8005\u304b\u3089\u7d4c\u9a13\u8005\u307e\u3067\u3001\u8c4a\u5bcc\u3067\u4fe1\u983c\u3067\u304d\u308b\u6280\u8853\u7684\u306a\u5185\u5bb9\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/genome-editing-resource-guide-form-download.html?CID=bid_syn_gns_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_lgn_kt_s00_crispr_cas9_basic_bid_ts_1_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u7528\u306b\u306f\u4f7f\u7528\u3044\u305f\u3060\u3051\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u306f\u3058\u3081\u306b 2020\u5e74\u306b\u30b2\u30ce\u30e0\u7de8\u96c6\u306eCRISPR\/Cas9\uff08\u30af\u30ea\u30b9\u30d1\u30fc\u30fb\u30ad\u30e3\u30b99\uff09\u3092\u958b\u767a\u3057\u305f\u5973\u6027\u7814\u7a76\u80052\u540d\u304c\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u305f\u306e\u306f\u8a18\u61b6\u306b\u65b0\u3057\u3044\u3068\u3053\u308d\u3067\u3059\u3002\u5b9f\u306f\u3053\u306e\u53d7\u8cde\u3001\u7814\u7a76\u8005\u305f\u3061\u306e\u9593\u3067\u306f\u78ba\u5b9f\u8996\u3055\u308c\u3066\u3044\u305f\u6804\u8a89\u3067\u3001201<\/p>\n","protected":false},"author":975,"featured_media":14756,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[156],"tags":[190,175],"division":[],"class_list":{"0":"post-14750","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-mol-bio","8":"tag-crispr-cas9","9":"tag-genome-editing","10":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.8 (Yoast SEO v27.8) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f - Learning at the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f\" \/>\n<meta property=\"og:description\" content=\"\u306f\u3058\u3081\u306b 2020\u5e74\u306b\u30b2\u30ce\u30e0\u7de8\u96c6\u306eCRISPR\/Cas9\uff08\u30af\u30ea\u30b9\u30d1\u30fc\u30fb\u30ad\u30e3\u30b99\uff09\u3092\u958b\u767a\u3057\u305f\u5973\u6027\u7814\u7a76\u80052\u540d\u304c\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u305f\u306e\u306f\u8a18\u61b6\u306b\u65b0\u3057\u3044\u3068\u3053\u308d\u3067\u3059\u3002\u5b9f\u306f\u3053\u306e\u53d7\u8cde\u3001\u7814\u7a76\u8005\u305f\u3061\u306e\u9593\u3067\u306f\u78ba\u5b9f\u8996\u3055\u308c\u3066\u3044\u305f\u6804\u8a89\u3067\u3001201\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/\" \/>\n<meta property=\"og:site_name\" content=\"Learning at the Bench\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ThermoFisherJapan\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-14T02:55:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-18T05:09:02+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"990\" \/>\n\t<meta property=\"og:image:height\" content=\"660\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"LatB Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ThermoFisherJP\" \/>\n<meta name=\"twitter:site\" content=\"@ThermoFisherJP\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"LatB Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"17\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/\"},\"author\":{\"name\":\"LatB Staff\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/bdbe319a2001f279ddce6ab8eaad1253\"},\"headline\":\"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\\\/Cas9\u3068\u306f\uff1f\",\"datePublished\":\"2023-07-14T02:55:25+00:00\",\"dateModified\":\"2024-09-18T05:09:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/\"},\"wordCount\":190,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2023\\\/07\\\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg\",\"keywords\":[\"CRISPR\\\/CAS9\",\"\u30b2\u30ce\u30e0\u7de8\u96c6\"],\"articleSection\":[\"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023\"],\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/\",\"name\":\"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\\\/Cas9\u3068\u306f\uff1f - Learning at the Bench\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2023\\\/07\\\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg\",\"datePublished\":\"2023-07-14T02:55:25+00:00\",\"dateModified\":\"2024-09-18T05:09:02+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/bdbe319a2001f279ddce6ab8eaad1253\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2023\\\/07\\\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2023\\\/07\\\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg\",\"width\":990,\"height\":660},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/crispr-cas9_basic_bid_ts_1\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\\\/Cas9\u3068\u306f\uff1f\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/\",\"name\":\"Learning at the Bench\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/bdbe319a2001f279ddce6ab8eaad1253\",\"name\":\"LatB Staff\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2b3fdaccc53ad9dae08baccbcf9e8774350bd5682b89e353a9b7a999834e9306?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2b3fdaccc53ad9dae08baccbcf9e8774350bd5682b89e353a9b7a999834e9306?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2b3fdaccc53ad9dae08baccbcf9e8774350bd5682b89e353a9b7a999834e9306?s=96&d=mm&r=g\",\"caption\":\"LatB Staff\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/lgbadmin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f - Learning at the Bench","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/","og_locale":"ja_JP","og_type":"article","og_title":"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f","og_description":"\u306f\u3058\u3081\u306b 2020\u5e74\u306b\u30b2\u30ce\u30e0\u7de8\u96c6\u306eCRISPR\/Cas9\uff08\u30af\u30ea\u30b9\u30d1\u30fc\u30fb\u30ad\u30e3\u30b99\uff09\u3092\u958b\u767a\u3057\u305f\u5973\u6027\u7814\u7a76\u80052\u540d\u304c\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u305f\u306e\u306f\u8a18\u61b6\u306b\u65b0\u3057\u3044\u3068\u3053\u308d\u3067\u3059\u3002\u5b9f\u306f\u3053\u306e\u53d7\u8cde\u3001\u7814\u7a76\u8005\u305f\u3061\u306e\u9593\u3067\u306f\u78ba\u5b9f\u8996\u3055\u308c\u3066\u3044\u305f\u6804\u8a89\u3067\u3001201","og_url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/","og_site_name":"Learning at the Bench","article_publisher":"https:\/\/www.facebook.com\/ThermoFisherJapan","article_published_time":"2023-07-14T02:55:25+00:00","article_modified_time":"2024-09-18T05:09:02+00:00","og_image":[{"width":990,"height":660,"url":"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg","type":"image\/jpeg"}],"author":"LatB Staff","twitter_card":"summary_large_image","twitter_creator":"@ThermoFisherJP","twitter_site":"@ThermoFisherJP","twitter_misc":{"\u57f7\u7b46\u8005":"LatB Staff","\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"17\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#article","isPartOf":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/"},"author":{"name":"LatB Staff","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/bdbe319a2001f279ddce6ab8eaad1253"},"headline":"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f","datePublished":"2023-07-14T02:55:25+00:00","dateModified":"2024-09-18T05:09:02+00:00","mainEntityOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/"},"wordCount":190,"commentCount":0,"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg","keywords":["CRISPR\/CAS9","\u30b2\u30ce\u30e0\u7de8\u96c6"],"articleSection":["\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023"],"inLanguage":"ja","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/","url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/","name":"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f - Learning at the Bench","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#primaryimage"},"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg","datePublished":"2023-07-14T02:55:25+00:00","dateModified":"2024-09-18T05:09:02+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/bdbe319a2001f279ddce6ab8eaad1253"},"breadcrumb":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/"]}]},{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg","contentUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg","width":990,"height":660},{"@type":"BreadcrumbList","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/crispr-cas9_basic_bid_ts_1\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/"},{"@type":"ListItem","position":2,"name":"\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u539f\u7406\u3068\u624b\u5f15\u304d\uff5eCRISPR\/Cas9\u3068\u306f\uff1f"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#website","url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/","name":"Learning at the Bench","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/bdbe319a2001f279ddce6ab8eaad1253","name":"LatB Staff","image":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/secure.gravatar.com\/avatar\/2b3fdaccc53ad9dae08baccbcf9e8774350bd5682b89e353a9b7a999834e9306?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/2b3fdaccc53ad9dae08baccbcf9e8774350bd5682b89e353a9b7a999834e9306?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2b3fdaccc53ad9dae08baccbcf9e8774350bd5682b89e353a9b7a999834e9306?s=96&d=mm&r=g","caption":"LatB Staff"},"url":"https:\/\/admin.acceleratingscience.com\/author\/lgbadmin\/"}]}},"taxonomy_info":{"category":[{"value":156,"label":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023"}],"post_tag":[{"value":190,"label":"CRISPR\/CAS9"},{"value":175,"label":"\u30b2\u30ce\u30e0\u7de8\u96c6"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg",760,507,false],"author_info":{"display_name":"LatB Staff","author_link":"https:\/\/admin.acceleratingscience.com\/author\/lgbadmin\/"},"comment_info":3,"category_info":[{"term_id":156,"name":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","slug":"mol-bio","term_group":0,"term_taxonomy_id":156,"taxonomy":"category","description":"","parent":0,"count":536,"filter":"raw","meta":[],"cat_ID":156,"category_count":536,"category_description":"","cat_name":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","category_nicename":"mol-bio","category_parent":0}],"tag_info":[{"term_id":190,"name":"CRISPR\/CAS9","slug":"crispr-cas9","term_group":0,"term_taxonomy_id":190,"taxonomy":"post_tag","description":"","parent":0,"count":9,"filter":"raw","meta":[]},{"term_id":175,"name":"\u30b2\u30ce\u30e0\u7de8\u96c6","slug":"genome-editing","term_group":0,"term_taxonomy_id":175,"taxonomy":"post_tag","description":"","parent":0,"count":14,"filter":"raw","meta":[]}],"jetpack-related-posts":[],"jetpack_sharing_enabled":true,"amp_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2023\/07\/crispr-cas9_basic_bid_ts_1-02-e1689300175510.jpg","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts\/14750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/users\/975"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/comments?post=14750"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts\/14750\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/media\/14756"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/media?parent=14750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/categories?post=14750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/tags?post=14750"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/division?post=14750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}