{"id":1480,"date":"2018-10-12T00:00:00","date_gmt":"2018-10-11T15:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cnvs_cytoscan-xon-suite\/"},"modified":"2025-02-28T11:29:55","modified_gmt":"2025-02-28T02:29:55","slug":"cnvs_cytoscan-xon-suite","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cnvs_cytoscan-xon-suite\/","title":{"rendered":"\u30b3\u30d4\u30fc\u6570\u591a\u578b\u30a2\u30c3\u30bb\u30a4\u3092\u30a8\u30af\u30bd\u30f3\u30ec\u30d9\u30eb\u3067\u884c\u3046\u65b9\u6cd5\u3068\u306f\uff1f"},"content":{"rendered":"<p>\u30b3\u30d4\u30fc\u6570\u591a\u578b\uff08CNVs\uff09\u306f\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u6027\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304b\u3089\u3001<br \/>\n\u57fa\u790e\u7814\u7a76\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u5e83\u304f\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306f\u3001\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306e\u6982\u8981\u3068\u3001\u81e8\u5e8a\u7814\u7a76\u3067\u306e\u30cb\u30fc\u30ba\u3001<br \/>\n\u3055\u3089\u306b\u306f\u4fbf\u5229\u306a\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<p>\u25bc\u3053\u3093\u306a\u65b9\u306b\u30aa\u30b9\u30b9\u30e1\u3067\u3059\uff01<br \/>\n\u25a0\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306b\u8208\u5473\u304c\u3042\u308b\u65b9<br \/>\n\u25a0\u907a\u4f1d\u5b50\u75be\u60a3\u5206\u91ce\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3001\u307e\u305f\u306f\u4eca\u5f8c\u884c\u3046\u4e88\u5b9a\u306e\u3042\u308b\u65b9<\/p>\n<h2><strong>\u30b3\u30d4\u30fc\u6570\u591a\u578b<\/strong><strong> (CNVs)<\/strong><strong>\u3068\u306f\uff1f<\/strong><\/h2>\n<p><strong>\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306f\u3001\u907a\u4f1d\u5b50\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u30b2\u30ce\u30e0\u69cb\u9020\u591a\u578b\u3068\u3057\u3066\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n<p>\u67d3\u8272\u4f53\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u89e3\u6790 (CMA) \u3067\u306f\u3001\u9855\u5fae\u93e1\u3067\u306f\u898b\u3048\u306a\u3044\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306e\u691c\u51fa\u304c\u53ef\u80fd\u3067\u3001<br \/>\n2010\u5e74\u4ee5\u964d\u306f\u77e5\u7684\u969c\u5bb3\u3001\u767a\u9054\u9045\u5ef6\u3001\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u3001\u304a\u3088\u3073\u5148\u5929\u6027\u7570\u5e38\u306b\u95a2\u308f\u308b<br \/>\n\u30b3\u30d4\u30fc\u6570\u591a\u578b\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306b First-tier test \u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059 [1]\u3002<\/p>\n<h2><strong>\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u7814\u7a76\u30cb\u30fc\u30ba<\/strong><\/h2>\n<p>CMA \u3067\u4e00\u822c\u7684\u306b\u691c\u51fa\u3055\u308c\u308b\u5168\u30b2\u30ce\u30e0\u9818\u57df\u306b\u542b\u307e\u308c\u308b\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306b\u52a0\u3048\u3066\u3001<br \/>\n\u8907\u6570\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u5358\u4e00\u307e\u305f\u306f\u591a\u6570\u306e\u30a8\u30af\u30bd\u30f3\u306e\u6b20\u5931\u304a\u3088\u3073\u91cd\u8907\u306b\u95a2\u308f\u308b\u30b3\u30d4\u30fc\u6570\u591a\u578b\u3092\u8abf\u3079\u3066<br \/>\n\u304a\u308a\u3001\u7279\u306b\u795e\u7d4c\u767a\u9054\u9045\u6ede [2]\u3001\u5931\u660e [3]\u3001\u96e3\u8074 [4] \u3068\u306e\u76f8\u95a2\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u907a\u4f1d\u5b50\u5185\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306f\u3053\u308c\u307e\u3067\u7591\u308f\u308c\u3066\u3044\u305f\u30e1\u30f3\u30c7\u30eb\u907a\u4f1d\u75c5\u3088\u308a\u3082\u9ad8\u983b\u5ea6\u306b\u898b\u3089\u308c\u308b<br \/>\n\u305f\u3081\u3001\u81e8\u5e8a\u7814\u7a76\u3067\u3053\u308c\u3089\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u89e3\u6790\u3059\u308b\u5834\u5408\u306b\u306f\u691c\u8a0e\u304c\u671b\u307e\u308c\u307e\u3059 [5]\u3002<\/p>\n<p>\u4eca\u65e5\u3067\u306f\u3001<span style=\"text-decoration: underline\">\u907a\u4f1d\u5b50\u5185\u5909\u7570\u306e\u6700\u5927 40% \u304c\u30011\u500b\u304b2\u500b\u306e\u30a8\u30af\u30bd\u30f3\u306e\u307f\u306b\u95a2\u308f\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c<\/span><br \/>\n<span style=\"text-decoration: underline\">\u5206\u304b\u3063\u3066\u3044\u308b\u305f\u3081\u30011\u3064\u306e\u907a\u4f1d\u5b50\u5185\u3092\u6700\u5927\u9650\u306b\u7db2\u7f85\u3059\u308b\u30b2\u30ce\u30e0\u6280\u8853\u304c\u4e0d\u53ef\u6b20<\/span>\u3067\u3059 [6]\u3002<\/p>\n<h2><strong>\u30a8\u30af\u30bd\u30fc\u30e0\u63a2\u7d22\u306b\u9069\u3057\u305f\u7814\u7a76\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u306e\u3054\u7d39\u4ecb<\/strong><\/h2>\n<p>\u30a8\u30af\u30bd\u30f3\u30ec\u30d9\u30eb\u306e\u30b3\u30d4\u30fc\u6570\u30a2\u30c3\u30bb\u30a4\u3067\u3042\u308b <a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/microarray-analysis\/applications\/reproductive-health\/postnatal-genetic-testing\/arrays.html?CID=gsd_mic_gex_r04_jp_cp0000_pjt0000_gsd00000_0so_blg_op_awa_oc_s00_ma4_Social_LAB\" target=\"_blank\" rel=\"noopener\">Applied Biosystems\u2122 CytoScan\u2122 XON Suite<\/a> \u306f\u3001\u81e8\u5e8a\u7814\u7a76\u306b\u304a\u3044\u3066\u3053\u308c\u3089\u306e\u91cd\u8981\u306a\u591a\u578b\u306e\u89e3\u6790\u3092\u6539\u5584\u3001\u88dc\u5b8c\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u3068\u306a\u308b\u611f\u5ea6\u3068\u67d4\u8edf\u6027\u3092\u5b9f\u73fe\u3057\u307e\u3059\u3002\u5168\u30b2\u30ce\u30e0\u3092\u7db2\u7f85\u3059\u308b\u8a2d\u8a08\u3068\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a 7,000\u306e\u907a\u4f1d\u5b50\u306e\u30ab\u30d0\u30ec\u30c3\u30b8\u3092\u5411\u4e0a\u3055\u305b\u305f CytoScan XON Suite\u3067\u306f\u3001NGS\u306e\u5909\u7570\u89e3\u6790\u3092\u5f37\u529b\u306b\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u30b3\u30d4\u30fc\u6570\u591a\u578b\u30c7\u30fc\u30bf\u3092\u5f97\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<h4>CytoScan XON Suite\u306e4\u3064\u306e\u30e1\u30ea\u30c3\u30c8<\/h4>\n<ul>\n<li>\u8cbb\u7528\u5bfe\u52b9\u679c\u306e\u9ad8\u3044\u65b9\u6cd5\u3067\u5358\u4e00\u30a8\u30af\u30bd\u30f3\u306e\u6b20\u5931\u304a\u3088\u3073\u91cd\u8907\u3092\u5305\u62ec\u7684\u306b\u691c\u51fa<\/li>\n<li>\u30a8\u30af\u30bd\u30f3\u30ec\u30d9\u30eb\u306e\u6b20\u5931\u304a\u3088\u3073\u91cd\u8907\u306e\u78ba\u5b9f\u306a\u691c\u51fa\u306b\u3088\u308aNGS\u5909\u7570\u89e3\u6790\u3092\u88dc\u5b8c<\/li>\n<li>\u4ee3\u66ff\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306b\u3088\u308b\u30b3\u30d4\u30fc\u6570\u591a\u578b\u7d50\u679c\u306e\u88cf\u4ed8\u3051<\/li>\n<li>\u7c21\u5358\u3067\u52b9\u7387\u7684\u306a\u5869\u57fa\u914d\u5217\u591a\u578b\u89e3\u6790<\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/CytoScan-XON-e1539319134836.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4776 alignleft\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/CytoScan-XON-e1539319134836.jpg\" alt=\"CytoScan XON\" width=\"272\" height=\"250\" \/><\/a><\/p>\n<h4><strong>\u9ad8\u6027\u80fd\u8a2d\u8a08\u3067\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u5206\u89e3\u80fd\u3092\u5411\u4e0a<\/strong><\/h4>\n<p><a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/microarray-analysis\/applications\/reproductive-health\/postnatal-genetic-testing\/arrays.html?CID=gsd_mic_gex_r04_jp_cp0000_pjt0000_gsd00000_0so_blg_op_awa_oc_s00_ma4_Social_LAB\" target=\"_blank\" rel=\"noopener\">CytoScan XON Suite<\/a> \u306f\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u3092\u30ab\u30d0\u30fc\u3059\u308b4,900\u4e07\u4ee5\u4e0a\u306e\u30b3\u30d4\u30fc\u6570\u89e3\u6790\u7528\u30d7\u30ed\u30fc\u30d6\u30d7\u30fc\u30eb\u304b\u3089\u7d4c\u9a13\u306b\u57fa\u3065\u3044\u3066\u9078\u629e\u3057\u3001 \u8a2d\u8a08\u3055\u308c\u307e\u3057\u305f\u3002\u6700\u9ad8\u6027\u80fd\u306e\u30d7\u30ed\u30fc\u30d6\u304c\u9078\u629e\u3055\u308c\u3066\u304a\u308a\u3001\u91cd\u8981\u306a\u76ee\u7684\u907a\u4f1d\u5b50\u3068\u305d\u306e\u4e2d\u306b\u3042\u308b\u30a8\u30af\u30bd\u30f3\u3092\u7db2\u7f85\u3067\u304d\u307e\u3059\u3002\u30bf\u30fc\u30b2\u30c3 \u30c8\u9818\u57df\u304b\u3089500 bp \u96e2\u308c\u305f\u9818\u57df\u307e\u3067\u8ffd\u52a0\u30d7\u30ed\u30fc\u30d6\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u3067\u3001\u5404\u30a8\u30af\u30bd\u30f3\u306b\u5bfe\u5fdc\u3059\u308b\u5341\u5206\u306a\u30d7\u30ed\u30fc\u30d6\u6570\u306b\u3088\u308a\u30b3\u30fc\u30eb\u306e\u4fe1\u983c\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059 (\u56f31)\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/CNVS-figure-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-4787\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/CNVS-figure-1.jpg\" alt=\"CNVS-figure-1\" width=\"687\" height=\"302\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u89e3\u6790<\/strong><\/h4>\n<p>\u76f4\u611f\u7684\u306b\u4f7f\u7528\u3067\u304d\u308bChromosome Analysis Suite (ChAS)\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\u3001\u9078\u629e\u3057\u305f\u907a\u4f1d\u5b50\u30ea\u30b9\u30c8\u3084\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u3092\u5229\u7528\u3057\u3066\u7c21\u5358\u306b\u7d50\u679c\u306e\u30ec\u30dd\u30fc\u30c8\u3092\u4f5c\u6210\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u89e3\u6790\u6a5f\u80fd\u306b\u3088\u308a\u3001\u3054\u81ea\u8eab\u3067\u30a2\u30c3\u30d7\u30ed\u30fc\u30c9\u3057\u305f\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u306b\u9650\u5b9a\u3057\u305f\u30a8\u30af\u30bd\u30f3\u30ec\u30d9\u30eb\u306e\u30b3\u30d4\u30fc\u6570\u591a\u578b\u7d50\u679c\u3092\u5f97\u308b\u3053\u3068\u3084\u3001\u5236\u9650\u30e2\u30fc\u30c9\u3092\u6709\u52b9\u306b\u3057\u3066\u76ee\u7684\u306e\u907a\u4f1d\u5b50\u306e\u307f\u3092\u8868\u793a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059 (\u56f32)\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/CNVS-figure-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-4788\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/CNVS-figure-2.jpg\" alt=\"CNVS-figure-2\" width=\"692\" height=\"460\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h4><strong>\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e tier analysis <\/strong><\/h4>\n<p>\u30e6\u30fc\u30b6\u30fc\u30d5\u30ec\u30f3\u30c9\u30ea\u30fc\u306a ChAS\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u306b\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e tier analysis \u3092\u7d44\u307f\u8fbc\u3080\u3053\u3068\u3067\u3001\u67d4\u8edf\u304b\u3064\u65b0\u3057\u3044\u624b\u6cd5\u304c\u5b9f\u73fe\u3057\u307e\u3059\u3002\u81e8\u5e8a\u7814\u7a76\u306e\u95a2\u9023\u6027\u306b\u57fa\u3065\u304d\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e \u968e\u5c64\u3054\u3068\u306b\u7d50\u679c\u3092\u8868\u793a\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u72ec\u81ea\u306e\u6a5f\u80fd\u306b\u3088\u308a\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u907a\u4f1d\u5b50 (\u30ec\u30d9 \u30eb1) \u306b\u7d5e\u308a\u8fbc\u3093\u3067\u30b3\u30d4\u30fc\u6570\u591a\u578b\u3092\u8868\u793a\u3059\u308b\u3053\u3068\u3084\u3001\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e\u968e\u5c64\u3092\u5168\u30b2\u30ce\u30e0\u306b\u5e83\u3052\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059 (\u88681)\u3002\u305d\u306e\u305f\u3081\u3001\u76ee\u7684\u3068\u3059\u308b\u907a\u4f1d\u5b50\u30ec\u30d9\u30eb\u306e\u968e\u5c64\u3092\u6c7a\u5b9a\u3057\u3001\u89e3\u6790\u304a\u3088\u3073\u30ec\u30dd\u30fc\u30c8\u4f5c\u6210\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/0161352a3d2ab457dfa6640c52a8eb52.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4774\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/0161352a3d2ab457dfa6640c52a8eb52.jpg\" alt=\"\" width=\"711\" height=\"186\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<h2><strong>\u307e\u3068\u3081<\/strong><\/h2>\n<ul>\n<li><span class=\"mk-pink\">\u30a8\u30af\u30bd\u30f3\u306e\u6b20\u5931\u304a\u3088\u3073\u91cd\u8907\u306b\u95a2\u308f\u308b\u30b3\u30d4\u30fc\u6570\u591a\u578b\u304c\u7a2e\u3005\u306e\u75be\u60a3\u306b\u76f8\u95a2\u3059\u308b<\/span><\/li>\n<li><span class=\"mk-pink\">\u5358\u4e00\u907a\u4f1d\u5b50\u5185\u3092\u6700\u5927\u9650\u7db2\u7f85\u3059\u308b\u30a8\u30af\u30bd\u30fc\u30e0\u63a2\u7d22\u6280\u8853\u306e\u30cb\u30fc\u30ba\u304c\u3042\u308b<\/span><\/li>\n<li><span class=\"mk-pink\">CytoScan XON Suite\u306f\u30a8\u30af\u30bd\u30f3\u30ec\u30d9\u30eb\u306e\u30b3\u30d4\u30fc\u6570\u591a\u578b\u3092\u9ad8\u3044\u8cbb\u7528\u5bfe\u52b9\u679c\u3067\u52b9\u7387\u7684\u306b\u89e3\u6790\u3059\u308b<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul style=\"list-style-type: square\">\n<li>CytoScan XON Suite\u306e\u8a73\u7d30\u60c5\u5831\u304c\u6c17\u306b\u306a\u308b\u65b9\u21d2<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/microarray-analysis\/applications\/reproductive-health\/postnatal-genetic-testing\/arrays.html?CID=gsd_mic_gex_r04_jp_cp0000_pjt0000_gsd00000_0so_blg_op_awa_oc_s00_ma4_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u5f0a\u793e\u95a2\u9023\u30da\u30fc\u30b8<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/li>\n<li>CytoScan XON Suite\u306b\u8208\u5473\u304c\u3042\u308b\u65b9\u21d2\u672c\u8a18\u4e8b\u672b\u5c3e\u306e\u304a\u554f\u3044\u5408\u308f\u305b\u30d5\u30a9\u30fc\u30e0\u304b\u3089\u3054\u9023\u7d61\u304f\u3060\u3055\u3044\u3002<\/li>\n<\/ul>\n<h2><strong>\u53c2\u8003\u6587\u732e<\/strong><\/h2>\n<ol>\n<li>Miller DT, Adam MP, Aradhya S et al. (2010) Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet 86:749-764.<\/li>\n<li>Zahir F et al. (2016) Intragenic CNVS for epigenetic regulatory genes in intellectual disability: survey identifies pathogenic and benign single exon changes. Am J Med Genet Part A 170A:2916-2926.<\/li>\n<li>Neuhaus C, Eisenberger T et al. (2017) Next-generation sequencing reveals the mutational landscape of clinically diagnosed Usher syndrome: copy number variations, phenocopies, a predominant target for translational read-through, and PEX26 mutated in Heimler syndrome. Mon Genet Genomics 5:531-552.<\/li>\n<li>Ji H et al. (2014) Combined examination of sequence and copy number variations in human deafness genes improves diagnosis for cases of genetic deafness. BMC Ear Nose Throat Disord 14:9.<\/li>\n<li>Aradhya S, Lewis R, Tahrra B et al. (2012) Exon-level array CGH in a large clinical cohort demonstrates increased sensitivity of diagnostic testing for Mendelian disorders. Genet Med 14:594-603.<\/li>\n<li>Retterer K, Scuffins J et al. (2015) Assessing copy number from exome sequencing and exome array C<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u76ee\u7684\u304a\u3088\u3073\u305d\u306e\u624b\u7d9a\u304d\u4e0a\u3067\u306e\u4f7f\u7528\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30b3\u30d4\u30fc\u6570\u591a\u578b\uff08CNVs\uff09\u306f\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u6027\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u304b\u3089\u3001 \u57fa\u790e\u7814\u7a76\u304b\u3089\u81e8\u5e8a\u7814\u7a76\u307e\u3067\u5e83\u304f\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u4eca\u56de\u306f\u3001\u30b3\u30d4\u30fc\u6570\u591a\u578b\u306e\u6982\u8981\u3068\u3001\u81e8\u5e8a\u7814\u7a76\u3067\u306e\u30cb\u30fc\u30ba\u3001 \u3055\u3089\u306b\u306f\u4fbf\u5229\u306a\u30bd\u30ea\u30e5\u30fc\u30b7\u30e7\u30f3\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002 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