{"id":17926,"date":"2024-08-30T16:17:36","date_gmt":"2024-08-30T07:17:36","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/?p=17926"},"modified":"2024-09-18T15:57:49","modified_gmt":"2024-09-18T06:57:49","slug":"sanger-seq-ce-gsd-ts-ce-24056","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/sanger-seq-ce-gsd-ts-ce-24056\/","title":{"rendered":"\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u306e\u9032\u6b69 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\/>\n\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u591a\u304f\u306e\u7814\u7a76\u5ba4\u3067\u5b9a\u756a\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3067\u3042\u308b\u3001\u86cd\u5149\u30ad\u30e3\u30d4\u30e9\u30ea\u30fc\u96fb\u6c17\u6cf3\u52d5\uff08CE\uff09\u3092\u7528\u3044\u3066\u3001\u7814\u7a76\u8005\u305f\u3061\u304c\u3069\u306e\u3088\u3046\u306b\u3053\u306e\u5206\u91ce\u3067\u9032\u6b69\u3092\u9042\u3052\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u898b\u3066\u3044\u304d\u307e\u3059\u3002<br \/>\n\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306f\u3001\u4eca\u5f8c10\u5e74\u3067\u91cd\u8981\u306a\u5065\u5eb7\u5206\u91ce\u3067\u306e\u8ab2\u984c\u306b\u306a\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306b\u3088\u308b\u3068\u30013\u4eba\u306b1\u4eba\u304c\u751f\u6daf\u306e\u3069\u3053\u304b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u3001\u795e\u7d4c\u75be\u60a3\uff08\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3092\u542b\u3080\uff09\u3092\u767a\u75c7\u3059\u308b\u3068\u8a00\u308f\u308c\u3066\u304a\u308a\u3001\u795e\u7d4c\u75be\u60a3\u306f\u8eab\u4f53\u969c\u5bb3\u306e\u539f\u56e0\u306e\u7b2c1\u4f4d\u3067\u3042\u308a\u3001\u6b7b\u4ea1\u539f\u56e0\u306e\u7b2c2\u4f4d\u3068\u306a\u3063\u3066\u3044\u307e\u3059<sup>(1)<\/sup>\u3002<\/p>\n<p>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u7814\u7a76\u3092\u3059\u308b\u305f\u3081\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u6cd5\u306e\u4e2d\u3067\u3082\u3001\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u3084\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u89e3\u6790\u306e\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u306b\u4e0d\u53ef\u6b20\u306a\u86cd\u5149\u30ad\u30e3\u30d4\u30e9\u30ea\u30fc\u96fb\u6c17\u6cf3\u52d5\uff08CE\uff09\u306f\u3001\u7c21\u4fbf\u3055\u3068\u9ad8\u5206\u89e3\u80fd\u306b\u512a\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u8fc5\u901f\u306a\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u89e3\u6790\u307e\u3067\u306e\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u5c11\u91cf\u306e\u30b5\u30f3\u30d7\u30eb\u3067\u30821\u5869\u57fa\u306e\u5206\u89e3\u80fd\u3092\u5b9f\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u8a18\u4e8b\u3067\u306f\u3001\u7814\u7a76\u8005\u304c\u3053\u306e\u6280\u8853\u3092\u6d3b\u7528\u3057\u3066\u3001\u795e\u7d4c\u5909\u6027\u306e\u6839\u5e95\u306b\u3042\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u5149\u3092\u5f53\u3066\u305f\u3001\u3044\u304f\u3064\u304b\u306e\u4f8b\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<h2>\u30d2\u30c8\u8133\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u30e2\u30c7\u30eb\u4f5c\u6210\u306b\u304a\u3051\u308b\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u7531\u6765\u306e\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPS\uff09\u306e\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9<\/h2>\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u4e2d\u30672\u756a\u76ee\u306b\u591a\u304f\u3001\u5168\u4e16\u754c\u3067850\u4e07\u4eba\u8d85\u304c\u7f79\u60a3\u3057\u3066\u3044\u307e\u3059<sup>(2)<\/sup>\u3002\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u60a3\u8005\u306e\u8133\u306b\u306f\u3001<i>SNCA<\/i>\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u30b3\u30fc\u30c9\u3055\u308c\u308b\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4e3b\u6210\u5206\u3067\u3042\u308b\u3001\u30ec\u30d3\u30fc\u5c0f\u4f53\u3068\u547c\u3070\u308c\u308b\u7570\u5e38\u306a\u7d30\u80de\u542b\u6709\u7269\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059<sup>(3)<\/sup>\u3002\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u75c5\u614b\u3092\u63a2\u308b\u7814\u7a76\u3067\u306f\u3001\u4e8c\u6b21\u5143\u7d30\u80de\u57f9\u990a\u30e2\u30c7\u30eb\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u75be\u60a3\u306e\u8907\u96d1\u3055\u3092\u518d\u73fe\u3067\u304d\u307e\u305b\u3093\u3002\u3053\u306e\u554f\u984c\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u3001Mohamed\u3089\u306f<i>SNCA<\/i>\u907a\u4f1d\u5b50\u306e\u4e09\u91cd\u8907\u907a\u4f1d\u5b50\u3092\u6301\u3064\u60a3\u8005\u7531\u6765\u306e\u30d2\u30c8\u4eba\u5de5\u591a\u80fd\u6027\u5e79\u7d30\u80de\uff08iPS\u3082\u3057\u304f\u306fiPSCs\uff09\u3068\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u3057\u305f\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7d30\u80de\u304b\u3089\u3001\u4e09\u6b21\u5143\u306e\u4e2d\u8133\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f<sup>(4)<\/sup>\u3002<br \/>\niPSC\u682a\u306e\u7d30\u80de\u8a8d\u8a3c\u306e\u305f\u3081\u306b\u3001\u7814\u7a76\u8005\u3089\u306fApplied Biosystems\u2122 SeqStudio\u2122 \u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u30a2\u30ca\u30e9\u30a4\u30b6\u3092\u7528\u3044\u3066<i>SNCA<\/i>\u9818\u57df\u306e\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u884c\u3044\u307e\u3057\u305f<sup>(4)<\/sup>\u3002<br \/>\n\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u306f\u3001\u5869\u57fa\u914d\u5217\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306e\u4e00\u822c\u7684\u306a\u65b9\u6cd5\u3067\u3042\u308a\u3001\u7279\u306b\u8907\u6570\u30b5\u30f3\u30d7\u30eb\u306b\u5bfe\u3059\u308b\u5358\u4e00\u907a\u4f1d\u5b50\u89e3\u6790\u306e\u8cbb\u7528\u5bfe\u52b9\u679c\u304c\u9ad8\u304f\u3001\u5909\u7570\u3084\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u305f\u633f\u5165\u914d\u5217\u306e\u78ba\u8a8d\u3001\u307e\u305f\u9577\u3044\u65ad\u7247\u306e\u89e3\u6790\u306b\u3082\u9069\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u306e\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u306e\u95a2\u9023\u30da\u30fc\u30b8\u306f\u3053\u3061\u3089(<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/sequencing\/sanger-sequencing\/sanger-sequencing-workflow.html?CID=gsd_cdx_r04_jp_cp0000_pjt0000_gsd00000_0so_blg_sanger_seq_ce_gsd_ts_ce_24056_Social_LAB\" rel=\"noopener\" target=\"_blank\">https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/sequencing\/sanger-sequencing\/sanger-sequencing-workflow.html<\/a>)<br \/>\n<div id=\"attachment_17932\" style=\"width: 1296px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-17932\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/f5e043cb34912ea362f224cb85b8dde6.jpg\" alt=\"\u56f31. \u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u6982\u8981\" width=\"1286\" height=\"268\" class=\"size-full wp-image-17932\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/f5e043cb34912ea362f224cb85b8dde6.jpg 1286w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/f5e043cb34912ea362f224cb85b8dde6-300x63.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/f5e043cb34912ea362f224cb85b8dde6-1024x213.jpg 1024w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/f5e043cb34912ea362f224cb85b8dde6-768x160.jpg 768w\" sizes=\"auto, (max-width: 1286px) 100vw, 1286px\" \/><p id=\"caption-attachment-17932\" class=\"wp-caption-text\">\u56f31. \u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u6982\u8981<\/p><\/div><\/p>\n<h2>\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306b\u304a\u3051\u308bCAG\u30ea\u30d4\u30fc\u30c8\u306e\u6b63\u78ba\u306a\u30b5\u30a4\u30b8\u30f3\u30b0<\/h2>\n<p>\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u6bd4\u3079\u308b\u3068\u7f79\u60a3\u7387\u306f\u4f4e\u3044\u3082\u306e\u306e\u3001\u8870\u5f31\u3092\u3082\u305f\u3089\u3059\u75be\u60a3\u3067\u3059\u3002\u307b\u3068\u3093\u3069\u304c\u907a\u4f1d\u6027\u3067\u3001\u30cf\u30f3\u30c1\u30f3\u30c1\u30f3\uff08<i>HTT<\/i>\uff09\u907a\u4f1d\u5b50\u306eCAG\u30ea\u30d4\u30fc\u30c8\u304c\u4f38\u9577\u3057\u3001\u30dd\u30ea\u30b0\u30eb\u30bf\u30df\u30f3\u53cd\u5fa9\u914d\u5217\u306b\u7ffb\u8a33\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u767a\u75c7\u3057\u307e\u3059\u3002<i>HTT<\/i>\u306eCAG\u30ea\u30d4\u30fc\u30c8\u306e\u9577\u3055\u306f\u3001\u767a\u75c7\u5e74\u9f62\u3068\u9006\u306e\u76f8\u95a2\u95a2\u4fc2\u304c\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30b2\u30ce\u30e0\u306e\u4ed6\u306e\u90e8\u5206\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u5909\u5316\u3082\u3001\u767a\u75c7\u5e74\u9f62\u306b\u5f71\u97ff\u3057\u307e\u3059\u3002Goold\u3089\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u4fee\u98fe\u56e0\u5b50\u306e\u4e00\u3064\u3067\u3042\u308bFAN1\uff08DNA\u9396\u9593\u306e\u67b6\u6a4b\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308b\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\uff09\u304c\u3001\u3069\u306e\u3088\u3046\u306b\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306e\u9032\u884c\u3092\u5909\u5316\u3055\u305b\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u5f7c\u3089\u306f\u3001\u3053\u306e\u4fee\u98fe\u56e0\u5b50\u306e\u767a\u73fe\u304c\u9ad8\u3044\u307b\u3069\u767a\u75c7\u304c\u9045\u308c\u3001\u75c5\u6c17\u306e\u9032\u884c\u304c\u9045\u308c\u308b\u3053\u3068\u3092\u89e3\u660e\u3057\u307e\u3057\u305f<sup>(5)<\/sup>\u3002<\/p>\n<p>\u7814\u7a76\u30c1\u30fc\u30e0\u304c\u958b\u767a\u3057\u305f\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u682a\u306b\u304a\u3051\u308bCAG\u30ea\u30d4\u30fc\u30c8\u306e\u30b5\u30a4\u30ba\u3092\u6b63\u78ba\u306b\u6e2c\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001Applied Biosystems\u2122 3730 DNA \u30a2\u30ca\u30e9\u30a4\u30b6\u3068GeneMapper\u2122\u30bd\u30d5\u30c8\u30a6\u30a8\u30a2\u3092\u7528\u3044\u3066\u3001PCR\u7523\u7269\u306e\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u56f32\u3067\u306f\u3001\u4ee3\u8868\u7684\u306a\u30d4\u30fc\u30af\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u3082\u9ad8\u3044\u30d4\u30fc\u30af\uff08\u8d64\u77e2\u5370\uff09\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u5185\u306e\u5909\u52d5\u306a\u3069\u3092\u8003\u616e\u3057\u306a\u304c\u3089\u3082\u3001\u6700\u3082\u4e00\u822c\u7684\u306a\u5024\u3068\u3057\u3066\u3001\u305d\u306e\u30b5\u30f3\u30d7\u30eb\u306eCAG\u30ea\u30d4\u30fc\u30c8\u30b5\u30a4\u30ba\u3068\u3055\u308c\u308b\u3082\u306e\u3067\u3059<sup>(5)<\/sup>\u3002<br \/>\n<div id=\"attachment_17933\" style=\"width: 404px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-17933\" src=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/4398e79a5ad23c3fbe7f4305f60625f4.jpg\" alt=\"\u56f32. CE\u3092\u7528\u3044\u305f\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u7d30\u80de\u682a\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308bCAG\u30ea\u30d4\u30fc\u30c8\u306e\u30b5\u30a4\u30b8\u30f3\u30b0\" width=\"394\" height=\"348\" class=\"size-full wp-image-17933\" srcset=\"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/4398e79a5ad23c3fbe7f4305f60625f4.jpg 705w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/4398e79a5ad23c3fbe7f4305f60625f4-300x264.jpg 300w, https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2024\/08\/4398e79a5ad23c3fbe7f4305f60625f4-310x274.jpg 310w\" sizes=\"auto, (max-width: 394px) 100vw, 394px\" \/><p id=\"caption-attachment-17933\" class=\"wp-caption-text\">\u56f32. CE\u3092\u7528\u3044\u305f\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u7d30\u80de\u682a\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308bCAG\u30ea\u30d4\u30fc\u30c8\u306e\u30b5\u30a4\u30b8\u30f3\u30b0<\/p><\/div> 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DNA\u30a2\u30ca\u30e9\u30a4\u30b6\u3068GeneMapper\u30bd\u30d5\u30c8\u30a6\u30a8\u30a2\u3092\u7528\u3044\u305f\u30ad\u30e3\u30d4\u30e9\u30ea\u30fc\u96fb\u6c17\u6cf3\u52d5\u306b\u3088\u308a\u3001\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u9577\u3055\u3092\u6b63\u78ba\u306b\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u3001\u6a19\u6e96\u5316\u3055\u308c\u305f\u300c523\u300d\u30b8\u30a7\u30ce\u30bf\u30a4\u30d4\u30f3\u30b0\u30a2\u30c3\u30bb\u30a4\u3092\u958b\u767a\u3057\u307e\u3057\u305f<sup>(8)<\/sup>\u3002<\/p>\n<h2>\u307e\u3068\u3081<\/h2>\n<p>Applied Biosystems\u2122\u6280\u8853\u304c\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7814\u7a76\u306b\u3069\u306e\u3088\u3046\u306b\u5f79\u7acb\u3063\u3066\u3044\u308b\u306e\u304b\u3001\u30ea\u30f3\u30af\u5148\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<br \/>\n<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/brands\/applied-biosystems\/complex-disease-research.html?CID=gsd_cdx_r04_jp_cp0000_pjt0000_gsd00000_0so_blg_sanger_seq_ce_gsd_ts_ce_24056_Social_LAB\" rel=\"noopener\" target=\"_blank\">thermofisher.com\/abcomplexdisease.<\/a><\/p>\n<h3>\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3000\u30cf\u30f3\u30c9\u30d6\u30c3\u30af<\/h3>\n<p>\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u304b\u3089\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u307e\u3067\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u306e\u57fa\u672c\u539f\u5247\u3092\u5b66\u3079\u307e\u3059\u3002<\/p>\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/sanger-sequencing-guide-download.html?CID=gsd_cdx_r04_jp_cp0000_pjt0000_gsd00000_0so_blg_sanger_seq_ce_gsd_ts_ce_24056_Social_LAB\" target=\"_blank\" rel=\"noopener noreferrer\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u306f\u3053\u3061\u3089<\/a><\/p>\n<h3>\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u89e3\u6790\u30e6\u30fc\u30b6\u30fc\u30ac\u30a4\u30c9<\/h3>\n<p>\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u89e3\u6790\u306e\u57fa\u790e\u304b\u3089\u3001\u5b9f\u9a13\u306e\u30bb\u30c3\u30c8\u30a2\u30c3\u30d7\u306e\u30b3\u30c4\u3084\u30c8\u30e9\u30d6\u30eb\u30b7\u30e5\u30fc\u30c6\u30a3\u30f3\u30b0\u307e\u3067\u69d8\u3005\u306a\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u30ab\u30d0\u30fc\u3057\u3066\u3044\u308b\u30e6\u30fc\u30b6\u30ac\u30a4\u30c9\u3067\u3059\u3002<\/p>\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/fragment-analysis-guide-registration-form.html?CID=gsd_cdx_r04_jp_cp0000_pjt0000_gsd00000_0so_blg_sanger_seq_ce_gsd_ts_ce_24056_Social_LAB\" target=\"_blank\" rel=\"noopener noreferrer\">\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u306f\u3053\u3061\u3089<\/a><\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<ol>\n<li>WHO: <a href=\"https:\/\/www.who.int\/news\/item\/09-08-2022-launch-of-first-who-position-paper-on-optimizing-brain-health-across-life\" rel=\"noopener\" target=\"_blank\">https:\/\/www.who.int\/news\/item\/09-08-2022-launch-of-first-who-position-paper-on-optimizing-brain-health-across-life<\/a>  Accessed November 30, 2022.<\/li>\n<li>WHO: <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/parkinson-disease\" rel=\"noopener\" target=\"_blank\">https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/parkinson-disease<\/a> Accessed November 30, 2022.<\/li>\n<li>Lee A, Gilbert RM. Epidemiology of Parkinson Disease. Neurol Clin. 2016 Nov;34(4):955-965. doi: 10.1016\/j.ncl.2016.06.012. Epub 2016 Aug 18.<\/li>\n<li>Mohamed NV, Sirois J, Ramamurthy J, et al. Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy. Brain Commun. 2021;3(4):fcab223. Published 2021 Sep 25. doi:10.1093\/braincomms\/fcab223<\/li>\n<li>Goold R, Flower M, Moss DH, Medway C, Wood-Kaczmar A, Andre R, Farshim P, Bates GP, Holmans P, Jones L, Tabrizi SJ. FAN1 modifies Huntington\u2019s disease progression by stabilizing the expanded HTT CAG repeat. Hum Mol Genet. 2019 Feb 15;28(4):650-661. doi: 10.1093\/hmg\/ddy375.<\/li>\n<li>Christopher H. van Dyck, M.D., Chad J. Swanson, Ph.D., Paul Aisen, M.D., Randall J. Bateman, M.D., Christopher Chen, B.M., B.Ch., Michelle Gee, Ph.D., Michio Kanekiyo, M.S., David Li, Ph.D., Larisa Reyderman, Ph.D., Sharon Cohen, M.D., Lutz Froelich, M.D., Ph.D., Sadao Katayama, M.D., Marwan Sabbagh, M.D., Bruno Vellas, M.D., David Watson, Psy.D., Shobha Dhadda, Ph.D., Michael Irizarry, M.D., Lynn D. Kramer, M.D., and Takeshi Iwatsubo, M.D. Lecanemab in Early Alzheimer\u2019s Disease N Engl J Med 2023;388:9-21 DOI: 10.1056\/NEJMoa2212948<br \/>\n<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2212948\" rel=\"noopener\" target=\"_blank\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2212948<\/a><\/li>\n<li>Guerreiro RJ, Hardy J. TOMM40 association with Alzheimer disease: tales of APOE and linkage disequilibrium. Arch Neurol. 2012 Oct;69(10):1243-4. doi: 10.1001\/archneurol.2012.1935.<\/li>\n<li>Linnertz C, Saunders AM, Lutz MW, Crenshaw DM, Grossman I, Burns DK, Whitfield KE, Hauser MA, McCarthy JJ, Ulmer M, Allingham R, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. Characterization of the poly-T variant in the TOMM40 gene in diverse populations. PLoS One. 2012;7(2):e30994. doi: 10.1371\/journal.pone.0030994. Epub 2012 Feb 16.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u7528\u306b\u306f\u4f7f\u7528\u3044\u305f\u3060\u3051\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u6cbb\u7642\u306b\u306f\u3001\u75be\u60a3\u304c\u3069\u306e\u3088\u3046\u306b\u9032\u884c\u3059\u308b\u306e\u304b\u3001\u3088\u308a\u6df1\u304f\u7406\u89e3\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u6b8b\u5ff5\u306a\u3053\u3068\u306b\u3001\u3053\u308c\u3089\u591a\u304f\u306e\u8eab\u4f53\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u72b6\u614b\u306e\u88cf\u306b\u96a0\u3055\u308c\u305f\u8b0e\u306f\u3001\u4f9d\u7136\u3068\u3057\u3066\u89e3\u660e\u3055\u308c\u3066<\/p>\n","protected":false},"author":975,"featured_media":17927,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[156],"tags":[172,183],"division":[],"class_list":{"0":"post-17926","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-mol-bio","8":"tag-ce","9":"tag-sanger-seq","10":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"<!-- 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