{"id":547,"date":"2020-03-12T00:00:00","date_gmt":"2020-03-11T15:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/"},"modified":"2025-09-17T11:21:28","modified_gmt":"2025-09-17T02:21:28","slug":"rnai-non-coding-rna-research","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/","title":{"rendered":"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58"},"content":{"rendered":"\n

\u306f\u3058\u3081\u306b<\/h2>\n\n\n\n

RNA\u5e72\u6e09\uff08RNAi\uff09<\/a>\u306f\u3001\u5e83\u7bc4\u56f2\u306a\u7d30\u80de\u30bf\u30a4\u30d7\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u624b\u6cd5<\/strong>\u3067\u3001\u7d30\u80de\u306e\u57fa\u790e\u751f\u7269\u5b66\u3092\u7814\u7a76\u3059\u308b\u305f\u3081\u306e\u975e\u5e38\u306b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3059\u3002\u4ee5\u524d\u306f\u9650\u5b9a\u3055\u308c\u305f\u7814\u7a76\u5ba4\u306e\u307f\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u305fRNAi \u6280\u8853\u3067\u3059\u304c\u3001\u73fe\u5728\u3067\u306f\u907a\u4f1d\u5b50\u6a5f\u80fd\u7814\u7a76\u306b\u6b20\u304b\u305b\u306a\u3044\u3082\u306e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u672c\u6280\u8853\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u7814\u7a76\u3001\u8868\u73fe\u578b\u89e3\u6790\u3001\u6a5f\u80fd\u56de\u5fa9\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u3001in vivo\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3001\u304a\u3088\u3073\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u63a2\u7d22\u306e\u305f\u3081\u306e\u5353\u8d8a\u3057\u305f\u30c4\u30fc\u30eb\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4eca\u56de\u306f\u3001RNAi\u3068\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u307e\u3057\u305f\u306e\u3067\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n

RNAi\u306e\u4e00\u822c\u7528\u8a9e\u96c6<\/h2>\n\n\n\n

RNAi<\/a><\/h3>\n\n\n\n

\u30ea\u30dc\u6838\u9178\u5e72\u6e09\uff081998\u5e74\u306bA. Fire and C. Mello\u3089\u304c\u521d\u3081\u3066\u5b9f\u65bd\uff09\u3002<\/p>\n\n\n\n

siRNA<\/a><\/h3>\n\n\n\n

\u77ed\u3044\u5e72\u6e09RNA\u3002siRNA\u306f\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c93’\u30aa\u30fc\u30d0\u30fc\u30cf\u30f3\u30b0\u304c\u4ed8\u3044\u305f21\u201325 bp\u306edsRNA\u3067\u3001RNA\u5e72\u6e09\u7d4c\u8def\u306b\u304a\u3044\u3066\u9577\u9396dsRNA\u304cDicer\u306b\u3088\u308a\u5207\u65ad\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002\u5408\u6210siRNA\u3092\u54fa\u4e73\u985e\u7d30\u80de\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001RNAi\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001siRNA\u306b\u306f\u5185\u5728\u6027\u524d\u99c6\u4f53\u7531\u6765\u306e\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

shRNA<\/h3>\n\n\n\n

\u77ed\u3044\u30d8\u30a2\u30d4\u30f3RNA\uff08\u77ed\u3044\u5e72\u6e09\u30d8\u30a2\u30d4\u30f3\uff09\u3002shRNA\u306f\u3001\u5b89\u5b9a\u3057\u305f\u907a\u4f1d\u5b50\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u306b\u7528\u3044\u3089\u308c\u308bsiRNA\u3092\u4f9b\u7d66\u3059\u308b\u305f\u3081\u306e\u30d9\u30af\u30bf\u30fc\u30d9\u30fc\u30b9\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002\u5f37\u529b\u306aPol III\u7cfb\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306f\u3001\u7d30\u80de\u5185siRNA\u6a5f\u69cb\u306b\u304a\u3044\u3066\u3001\u69d8\u3005\u306a\u9577\u3055\u306e\u30d8\u30a2\u30d4\u30f3\u578b\u304a\u3088\u3073\u30eb\u30fc\u30d7\u578b\u306eRNA\u3092\u5f62\u6210\u3059\u308b\u3088\u3046\u306b\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u30bf\u30fc\u30b2\u30c3\u30c8\u914d\u5217\u306e\u8ee2\u5199\u3092\u958b\u59cb\u3055\u305b\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002shRNA\u304c\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3055\u308c\u308b\u3068\u3001RNAi\u306b\u3088\u3063\u3066\u76f8\u88dc\u914d\u5217\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

miR RNAi<\/h3>\n\n\n\n

RNAi\u3092\u5f15\u304d\u8d77\u3053\u3059\u305f\u3081\u306emicroRNA\u3092\u767a\u73fe\u3055\u305b\u308b\u305f\u3081\u306e\u30d9\u30af\u30bf\u30fc\u3002miRNA\u306f\u300119\uff5e23 nt\u306e\u4e00\u672c\u9396RNA\u3067\u3001\u4e0d\u5b8c\u5168\u306a\u5869\u57fa\u5bfe\u3067\u5f62\u6210\u3055\u308c\u308b\u30d8\u30a2\u30d4\u30f3\u69cb\u9020\u3092\u7279\u5fb4\u3068\u3059\u308b\u4e00\u672c\u9396\u306e\u524d\u99c6\u4f53\u8ee2\u5199\u7269\u304b\u3089\u751f\u3058\u307e\u3059\u3002miRNA\u306f\u3001RISC\u3068\u540c\u4e00\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u985e\u4f3c\u3057\u305f\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u8907\u5408\u4f53\u4e2d\u3067\u6a5f\u80fd\u3057\u307e\u3059\uff08\u56f31\u53c2\u7167\uff09\u3002<\/p>\n\n\n\n

\u5316\u5b66\u7684\u6539\u5909siRNA<\/h3>\n\n\n\n

\u5316\u5b66\u7684\u306b\u6539\u5909\u3055\u308c\u305fsiRNA\u5206\u5b50\u3002<\/p>\n\n\n\n

RISC<\/h3>\n\n\n\n

RNA\u8a98\u5c0e\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u8907\u5408\u4f53\uff08RISC\uff09\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u3068siRNA\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u8907\u5408\u4f53\u3067\u3001RISC\u8907\u5408\u4f53\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305fsiRNA\u306f\u76f8\u88dc\u7684\u306a\u5185\u5728\u6027mRNA\u3092\u6a19\u7684\u3068\u3057\u3066\u5207\u65ad\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c<\/h3>\n\n\n\n

\u7279\u5b9a\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u907a\u4f1d\u5b50\u4ee5\u5916\u306e1\u500b\u307e\u305f\u306f2\uff5e3\u500b\u306e\u907a\u4f1d\u5b50\u306b\u751f\u3058\u308b\u52b9\u679c\u3067\u3001siRNA\u307e\u305f\u306fd-siRNA\u30d7\u30fc\u30eb\u306e\u5c0e\u5165\u5f8c\u306b\u907a\u4f1d\u5b50\u6a5f\u80fd\u306e\u6291\u5236\u304c\u307f\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u52b9\u679c\u306f\u3001siRNA\u306e\u30bb\u30f3\u30b9\u9396\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u3001\u610f\u56f3\u3057\u306a\u3044\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u55aa\u5931\u3092\u958b\u59cb\u3055\u305b\u307e\u3059\u3002\u6a19\u7684\u3068\u306f\u7121\u95a2\u4fc2\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3055\u308c\u308b\u306e\u306b\u5341\u5206\u306a\u76f8\u540c\u6027\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\u304c\u7279\u5b9a\u306esiRNA\u306e\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u9396\u306e\u4e8c\u6b21\u7684\u52b9\u679c\u3068\u3057\u3066\u751f\u3058\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\u3092\u51fa\u6765\u308b\u3060\u3051\u524a\u6e1b\u3057\u305f\u3044\u4eba\u306f\u3053\u3061\u3089<\/a><\/p>\n\n\n\n

RNAi<\/a>\u306e\u4f5c\u7528\u6a5f\u5e8f<\/h2>\n\n\n\n

RNAi\u306b\u306f\u30012\u30bf\u30a4\u30d7\u306esmall RNA\u5206\u5b50\u304c\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/strong>1\u3064\u306f\u3001\u5408\u6210\u3055\u308c\u305f\u77ed\u3044\u5e72\u6e09RNA\uff08siRNA\uff09\u5206\u5b50<\/strong>\u3067\u3001mRNA\u306e\u5207\u65ad\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u3001\u76ee\u7684\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u52b9\u7387\u7684\u306b\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001microRNA\uff08miRNA\uff09\u5206\u5b50<\/strong>\u306f\u3001\u81ea\u7136\u767a\u751f\u3059\u308b19\uff5e22\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9577\u306e\u4e00\u672c\u9396RNA\u3067\u3001\u6a19\u7684mRNA\u306e3’\u975e\u7ffb\u8a33\u9818\u57df\uff08UTR\uff09\u306b\u7d50\u5408\u3057\u3001\u7ffb\u8a33\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3057\u307e\u3059\uff08Ambros,2004\uff09\u3002<\/p>\n\n\n\n

siRNA\u89e3\u6790<\/a><\/h2>\n\n\n\n

RNAi\u3092\u8a98\u5c0e\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u5408\u6210\u5206\u5b50\u3001RNAi\u30d9\u30af\u30bf\u30fc\u3001\u304a\u3088\u3073in vitro dicing\u3092\u7528\u3044\u308b\u8907\u6570\u306e\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059<\/strong>\uff08\u56f31\u53c2\u7167\uff09\u3002\u54fa\u4e73\u985e\u7d30\u80de\u3067\u306f\u3001dsRNA\u306e\u77ed\u3044\u65ad\u7247–\u77ed\u3044\u5e72\u6e09RNA–\u304c\u30bf\u30fc\u30b2\u30c3\u30c8\u7d30\u80de\u5185mRNA\u306e\u7279\u7570\u7684\u5206\u89e3\u3092\u958b\u59cb\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3044\u3066\u3001siRNA\u306e\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u9396\u306f\u591a\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u307e\u305f\u306fRNA\u8a98\u5c0e\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u8907\u5408\u4f53\uff08RISC\uff09\u306e\u4e00\u90e8\u3068\u306a\u308a\u3001\u305d\u306e\u5f8c\u3001\u5bfe\u5fdc\u3059\u308bmRNA\u3092\u540c\u5b9a\u3057\u3001\u7279\u7570\u7684\u90e8\u4f4d\u3067\u5207\u65ad\u3057\u307e\u3059\u3002\u6b21\u306b\u3001\u3053\u306e\u5207\u65ad\u304c\u7e70\u308a\u8fd4\u3055\u308c\u308b\u3053\u3068\u3067mRNA\u304c\u5206\u89e3\u3055\u308c\u3001\u6700\u7d42\u7684\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u6291\u5236\u304c\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\"rnai-non-coding-rna-research-fig1\"<\/a>
\u56f31 \u54fa\u4e73\u985e\u7d30\u80de\u306b\u304a\u3051\u308bRNAi\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u6cd5<\/figcaption><\/figure>\n\n\n\n

miRNA\u89e3\u6790<\/a><\/h2>\n\n\n\n

RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bcII\u304a\u3088\u3073III\u306f\u3068\u3082\u306bmiRNA\u304c\u542b\u307e\u308c\u308b\u907a\u4f1d\u5b50\u3092\u8ee2\u5199\u3057\u3066\u3001\u9577\u3044\u4e00\u6b21\u8ee2\u5199\u7523\u7269\uff08primiRNA\uff09\u3092\u751f\u6210\u3057\u3001\u3053\u308c\u304cRNase III\u578b\u9175\u7d20\u306eDrosha\u306b\u3088\u3063\u3066\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3055\u308c70\uff5e90 bp\u306e\u30d8\u30a2\u30d4\u30f3\u69cb\u9020\uff08pre miRNA\uff09\u304c\u751f\u3058\u307e\u3059\u3002Pre miRNA\u30d8\u30a2\u30d4\u30f3\u306f\u7d30\u80de\u8cea\u306b\u8f38\u9001\u3055\u308c\u3001RNase III\u30bf\u30f3\u30d1\u30af\u8cea\u306eDicer\u306b\u3088\u3063\u306619\uff5e22\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u9577\u306e\u77ed\u3044miRNA\u4e8c\u672c\u9396\u307e\u3067\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3055\u308c\u307e\u3059\u3002miRNA\u4e8c\u672c\u9396\u306fRNA\u8a98\u5c0e\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u8907\u5408\u4f53\uff08RISC\uff09\u3068\u547c\u3070\u308c\u308b \u591a\u91cd\u30bf\u30f3\u30d1\u30af\u8cea\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u8907\u5408\u4f53\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u6642\u3001\u4e8c\u672c\u9396\u306e\u3046\u3061\u4e00\u65b9\u306e\u9396\u3067\u3042\u308b\u30ac\u30a4\u30c9\u9396\u304c\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u304c\u76f8\u88dc\u7684\u306amRNA\u8ee2\u5199\u7523\u7269\u3092\u8a8d\u8b58\u3059\u308b\u3088\u3046\u306b\u5c0e\u304d\u307e\u3059\u3002RISC-miRNA\u8907\u5408\u4f53\u306f\u3001\u3057\u3070\u3057\u3070\u4e0d\u5b8c\u5168\u306a\u914d\u5217\u76f8\u540c\u6027\u3092\u793a\u3059\u9818\u57df\u3067\u6a19\u7684mRNA\u306e3’UTR\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001\u3044\u307e\u3060\u306b\u5341\u5206\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308a\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3092\u963b\u5bb3\u3057\u307e\u3059\uff08\u56f32\uff09\u3002<\/p>\n\n\n\n

\"rnai-non-coding-rna-research-fig2\"<\/a>
\u56f32 miRNA\u306e\u751f\u5408\u6210\u3068\u6a5f\u80fd\u3002RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bcII\u304a\u3088\u3073III\u306b\u3088\u3063\u3066\u751f\u6210\u3057\u305fmicroRNA\u8ee2\u5199\u7523\u7269\u306f\u3001RNaseIII\u9175\u7d20\u306eDrosha\uff08\u6838\u5185\uff09\u3068Dicer\uff08\u7d30\u80de\u8cea\u5185\uff09\u306b\u3088\u3063\u3066\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3055\u308c\u306619\uff5e22\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306emiRNA2\u672c\u9396\u3092\u751f\u3058\u308b\u3002\u3053\u306e\u4e8c\u672c\u9396\u306e\u3046\u3061\u306e\u4e00\u65b9\u306e\u9396\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308bRISC\u8907\u5408\u4f53\u306b\u7d44\u307f\u8fbc\u307e\u308c\u308b\u3002<\/figcaption><\/figure>\n\n\n\n

RNAi<\/a>\u5b9f\u9a13\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u9078\u629e<\/h2>\n\n\n\n

RNAi \uff08RNA\u5e72\u6e09\uff09\u306e\u30d7\u30ed\u30bb\u30b9\u306fsiRNA\u307e\u305f\u306fmiRNA\u306b\u3088\u3063\u3066\u7de9\u548c\u3067\u304d\u307e\u3059\u3002<\/strong>\u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082Dicer\u3068\u547c\u3070\u308c\u308b\u9175\u7d20\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u3067\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3055\u308c\u3001RISC\uff08RNA\u8a98\u5c0e\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u8907\u5408\u4f53\uff09\u3068\u547c\u3070\u308c\u308b\u8907\u5408\u4f53\u306b\u7d44\u307f\u8fbc\u307e\u308c\u307e\u3059\u3002\u3057\u304c\u3057\u306a\u304c\u3089\u3001\u3053\u306e2\u3064\u306b\u306f\u308f\u305a\u304b\u306a\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

siRNA<\/strong>\u306f\u3001\u5916\u6765\u4e8c\u672c\u9396RNA\u3067\u3001\u5316\u5b66\u5408\u6210\u3055\u308c\u3001\u7d30\u80de\u306b\u76f4\u63a5\u5c0e\u5165\u3055\u308c\u308b\u304b\u3001siRNA\u306e\u524d\u99c6\u4f53\u3067\u3042\u308b\u77ed\u3044\u30d8\u30a2\u30d4\u30f3RNA\uff08shRNA\uff09\u3092\u767a\u73fe\u3059\u308b\u30d9\u30af\u30bf\u30fc\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u3067\u7523\u751f\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001miRNA<\/strong>\u306f\u4e00\u672c\u9396RNA\u3067\u3001\u3088\u308a\u5927\u304d\u3044RNA\u5206\u5b50\u306e\u30a4\u30f3\u30c8\u30ed\u30f3\u5185\u306b\u5b58\u5728\u3059\u308b\u5185\u5728\u6027\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u3067\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001shRNA\u304b\u3089\u6a5f\u80fd\u6027siRNA\u3078\u306e\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u306f\u3001mRNA\u306e\u5b89\u5b9a\u6027\u3001\u7ffb\u8a33\u3001\u304a\u3088\u3073\u30af\u30ed\u30de\u30c1\u30f3\u69cb\u9020\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u7d30\u80de\u5185\u8abf\u7bc0\u306e\u5f79\u5272\u3092\u6301\u3064\u3001\u30b2\u30ce\u30e0\u306b\u30b3\u30fc\u30c9\u3055\u308c\u305fmiRNA\u304c\u81ea\u7136\u306b\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u3055\u308c\u308b\u306e\u3068\u540c\u3058\u7d30\u80de\u5185RNAi\u6a5f\u69cb\u3092\u4ecb\u3057\u3066\u884c\u308f\u308c\u307e\u3059\uff08Hutvagner and Zamore, 2002\uff09\u3002<\/p>\n\n\n\n

siRNA\u3068miRNA\u306e\u4ed6\u306e\u9055\u3044<\/strong>\u3068\u3057\u3066\u306f\u3001siRNA\u306f\u4e00\u822c\u7684\u306b\u52d5\u7269\u306b\u304a\u3051\u308bmRNA\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u5b8c\u5168\u304b\u3064\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001miRNA \u306f\u305d\u306e\u30da\u30a2\u30ea\u30f3\u30b0\u304c\u4e0d\u5b8c\u5168\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u591a\u304f\u306e\u7570\u306a\u308bmRNA\u914d\u5217\u306e\u7ffb\u8a33\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u690d\u7269\u306b\u304a\u3044\u3066\u3001miRNA\u306f\u3088\u308a\u5b8c\u5168\u306b\u76f8\u88dc\u7684\u306a\u914d\u5217\u3092\u6301\u3064\u50be\u5411\u304c\u3042\u308a\u3001\u5358\u306b\u7ffb\u8a33\u3092\u963b\u6b62\u3059\u308b\u306e\u3068\u306f\u5bfe\u7167\u7684\u306bmRNA\u958b\u88c2\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

siRNA\u3068miRNA\u306f\u3044\u305a\u308c\u3082RNA\u8a98\u5c0e\u8ee2\u5199\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\uff08RITS\uff09\u3068\u547c\u3070\u308c\u308b\u30d7\u30ed\u30bb\u30b9\u3092\u4ecb\u3057\u3066\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3059\u308b\u5f79\u5272\u3092\u62c5\u3046\u305f\u3081\u3001\u6cbb\u7642\u7528\u9014\u306e\u91cd\u8981\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3059\u3002<\/p>\n\n\n\n

 <\/td>siRNA<\/a><\/strong><\/td>miRNA<\/a><\/strong><\/td><\/tr>
\u767a\u751f<\/strong><\/td>\u690d\u7269\u304a\u3088\u3073\u4e0b\u7b49\u52d5\u7269\u3067\u81ea\u7136\u767a\u751f\u3057\u307e\u3059\u3002\u54fa\u4e73\u985e\u3067\u81ea\u7136\u767a\u751f\u3059\u308b\u304b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/td>\u690d\u7269\u304a\u3088\u3073\u52d5\u7269\u3067\u81ea\u7136\u767a\u751f\u3057\u307e\u3059\u3002<\/td><\/tr>
\u69cb\u9020<\/strong><\/td>\u4e8c\u672c\u9396<\/td>\u4e00\u672c\u9396<\/td><\/tr>
\u9396\u9577<\/strong><\/td>21\uff5e22 nt<\/td>19\uff5e25 nt<\/td><\/tr>
\u6a19\u7684miRNA\u306b\u5bfe\u3059\u308b\u76f8\u88dc\u6027<\/strong><\/td>100%\u5b8c\u5168\u306b\u4e00\u81f4\u3059\u308b\u305f\u3081\u3001siRNA\u306f\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3057\u3001\u30de\u30a4\u30ca\u30fc\u306a\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u4f8b\u5916\u304c\u751f\u3058\u307e\u3059\u3002<\/td>\u6b63\u78ba\u3067\u306f\u306a\u3044\u305f\u3081\u30011\u3064\u306emiRNA\u306f\u6700\u5927\u6570\u767e\u306emRNA\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u307e\u3059\u3002<\/td><\/tr>
\u751f\u5408\u6210<\/strong><\/td>siRNA\u3092\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u3068\u540c\u3058\u907a\u4f1d\u5b50\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002<\/td>miRNA\u3092\u4f5c\u88fd\u3059\u308b\u76ee\u7684\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u767a\u73fe\u3055\u308c\u307e\u3059\u304c\u3001miRNA\u3092\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u4ee5\u5916\u306e\u907a\u4f1d\u5b50\uff08mRNA\uff09\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002<\/td><\/tr>
\u4f5c\u7528<\/strong><\/td>mRNA\u306e\u5207\u65ad<\/td>mRNA\u306e\u7ffb\u8a33\u963b\u5bb3<\/td><\/tr>
\u6a5f\u80fd<\/strong><\/td>\u6297\u4f53\u3084\u7d30\u80de\u5a92\u4ecb\u6027\u514d\u75ab\u3092\u6301\u305f\u306a\u3044\u690d\u7269\u304a\u3088\u3073\u52d5\u7269\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u306e\u76e3\u67fb\u5f79\u3068\u3057\u3066\u6a5f\u80fd<\/td>\u907a\u4f1d\u5b50\uff08mRNA\uff09\u306e\u8abf\u7bc0\u56e0\u5b50\uff08\u963b\u5bb3\u5264\uff09<\/td><\/tr>
\u7528\u9014<\/strong><\/td>siRNA\u306f\u3001\u307b\u307c\u5168\u3066\u306e\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u5ba4\u3067\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3001\u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u305f\u3081\u306e\u6709\u7528\u306a\u5b9f\u9a13\u5ba4\u30c4\u30fc\u30eb\u3067\u3059\u3002\u3044\u304f\u3064\u304b\u306esiRNA\u304c\u6709\u671b\u306a\u6cbb\u7642\u85ac\u3068\u3057\u3066\u81e8\u5e8a\u8a66\u9a13\u4e2d\u3067\u3059\u3002<\/td>\u85ac\u5264\u30bf\u30fc\u30b2\u30c3\u30c8\u307e\u305f\u306f\u85ac\u5264\u81ea\u4f53\u3068\u3057\u3066\u306e\u6cbb\u7642\u7528\u9014\u304c\u6709\u671b\u3067\u3059\u3002miRNA\u306e\u767a\u73fe\u30ec\u30d9\u30eb\u304b\u3089\u3001\u8a3a\u65ad\u30c4\u30fc\u30eb\u304a\u3088\u3073\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306e\u4f7f\u7528\u304c\u6709\u671b\u8996\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011RNAi\u30cf\u30f3\u30c9\u30d6\u30c3\u30af<\/h2>\n\n\n\n

\u6a5f\u80fd\u55aa\u5931\u7814\u7a76\u306e\u305f\u3081\u306esiRNA\u3084miRNA\u7528\u306e\u30c4\u30fc\u30eb\u3001\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3001\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u304c\u308f\u304b\u308b\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3067\u3059\u3002PDF\u30d5\u30a1\u30a4\u30eb\u306e\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u3054\u5e0c\u671b\u306e\u65b9\u306f\u3001\u4e0b\u8a18\u30dc\u30bf\u30f3\u3088\u308a\u304a\u7533\u3057\u8fbc\u307f\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><\/p>\n\n\n\n

 <\/p>\n\n\n\n

\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u7528\u306b\u306f\u4f7f\u7528\u3044\u305f\u3060\u3051\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

RNA\u5e72\u6e09\uff08RNAi\uff09\u306f\u3001\u5e83\u7bc4\u56f2\u306a\u7d30\u80de\u30bf\u30a4\u30d7\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u624b\u6cd5\u3067\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u7814\u7a76\u3001\u8868\u73fe\u578b\u89e3\u6790\u3001\u6a5f\u80fd\u56de\u5fa9\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u3001in vivo\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3001\u304a\u3088\u3073\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u63a2\u7d22\u306e\u305f\u3081\u306e\u975e\u5e38\u306b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3059\u3002RNAi\u3068\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u307e\u3057\u305f\u306e\u3067\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"author":988,"featured_media":2871,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[159],"tags":[178],"division":[],"class_list":{"0":"post-547","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cell","8":"tag-rna","9":"entry"},"_selected_authors":[],"_selected_reviewers":[],"acf":[],"yoast_head":"\nsiRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58 - Learning at the Bench<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58\" \/>\n<meta property=\"og:description\" content=\"RNA\u5e72\u6e09\uff08RNAi\uff09\u306f\u3001\u5e83\u7bc4\u56f2\u306a\u7d30\u80de\u30bf\u30a4\u30d7\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u624b\u6cd5\u3067\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u7814\u7a76\u3001\u8868\u73fe\u578b\u89e3\u6790\u3001\u6a5f\u80fd\u56de\u5fa9\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u3001in vivo\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3001\u304a\u3088\u3073\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u63a2\u7d22\u306e\u305f\u3081\u306e\u975e\u5e38\u306b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3059\u3002RNAi\u3068\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u307e\u3057\u305f\u306e\u3067\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Learning at the Bench\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ThermoFisherJapan\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-11T15:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-17T02:21:28+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"631\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"LATB Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ThermoFisherJP\" \/>\n<meta name=\"twitter:site\" content=\"@ThermoFisherJP\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"LATB Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"11\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/\"},\"author\":{\"name\":\"LATB Staff\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/00a095a01d54afcdf9457465feb04f7d\"},\"headline\":\"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58\",\"datePublished\":\"2020-03-11T15:00:00+00:00\",\"dateModified\":\"2025-09-17T02:21:28+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/\"},\"wordCount\":186,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/rnai-non-coding-rna-research-title.jpg\",\"keywords\":[\"RNA\"],\"articleSection\":[\"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\"],\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/\",\"name\":\"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58 - Learning at the Bench\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/rnai-non-coding-rna-research-title.jpg\",\"datePublished\":\"2020-03-11T15:00:00+00:00\",\"dateModified\":\"2025-09-17T02:21:28+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/00a095a01d54afcdf9457465feb04f7d\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/rnai-non-coding-rna-research-title.jpg\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/wp-content\\\/uploads\\\/sites\\\/13\\\/2019\\\/07\\\/rnai-non-coding-rna-research-title.jpg\",\"width\":1200,\"height\":631,\"caption\":\"rnai-non-coding-rna-research-title\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/learning-at-the-bench\\\/rnai-non-coding-rna-research\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/\",\"name\":\"Learning at the Bench\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/learning-at-the-bench\\\/#\\\/schema\\\/person\\\/00a095a01d54afcdf9457465feb04f7d\",\"name\":\"LATB Staff\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ja\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g\",\"caption\":\"LATB Staff\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/latbstaff\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58 - Learning at the Bench","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/","og_locale":"ja_JP","og_type":"article","og_title":"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58","og_description":"RNA\u5e72\u6e09\uff08RNAi\uff09\u306f\u3001\u5e83\u7bc4\u56f2\u306a\u7d30\u80de\u30bf\u30a4\u30d7\u306b\u304a\u3051\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u6a5f\u80fd\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u624b\u6cd5\u3067\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u7814\u7a76\u3001\u8868\u73fe\u578b\u89e3\u6790\u3001\u6a5f\u80fd\u56de\u5fa9\u3001\u30d1\u30b9\u30a6\u30a7\u30a4\u89e3\u6790\u3001in vivo\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3001\u304a\u3088\u3073\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u63a2\u7d22\u306e\u305f\u3081\u306e\u975e\u5e38\u306b\u5f37\u529b\u306a\u30c4\u30fc\u30eb\u3067\u3059\u3002RNAi\u3068\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u307e\u3057\u305f\u306e\u3067\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002","og_url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/","og_site_name":"Learning at the Bench","article_publisher":"https:\/\/www.facebook.com\/ThermoFisherJapan","article_published_time":"2020-03-11T15:00:00+00:00","article_modified_time":"2025-09-17T02:21:28+00:00","og_image":[{"width":1200,"height":631,"url":"http:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title.jpg","type":"image\/jpeg"}],"author":"LATB Staff","twitter_card":"summary_large_image","twitter_creator":"@ThermoFisherJP","twitter_site":"@ThermoFisherJP","twitter_misc":{"\u57f7\u7b46\u8005":"LATB Staff","\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"11\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#article","isPartOf":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/"},"author":{"name":"LATB Staff","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/00a095a01d54afcdf9457465feb04f7d"},"headline":"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58","datePublished":"2020-03-11T15:00:00+00:00","dateModified":"2025-09-17T02:21:28+00:00","mainEntityOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/"},"wordCount":186,"commentCount":0,"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title.jpg","keywords":["RNA"],"articleSection":["\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0"],"inLanguage":"ja","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/","url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/","name":"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58 - Learning at the Bench","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#primaryimage"},"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title.jpg","datePublished":"2020-03-11T15:00:00+00:00","dateModified":"2025-09-17T02:21:28+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/00a095a01d54afcdf9457465feb04f7d"},"breadcrumb":{"@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/"]}]},{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title.jpg","contentUrl":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title.jpg","width":1200,"height":631,"caption":"rnai-non-coding-rna-research-title"},{"@type":"BreadcrumbList","@id":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/rnai-non-coding-rna-research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/"},{"@type":"ListItem","position":2,"name":"siRNA\u3068miRNA\u306e\u9055\u3044\u306f\u4f55\uff1fRNA\u5e72\u6e09(RNAi)\u306b\u95a2\u3059\u308b\u57fa\u790e\u77e5\u8b58"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#website","url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/","name":"Learning at the Bench","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/#\/schema\/person\/00a095a01d54afcdf9457465feb04f7d","name":"LATB Staff","image":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/secure.gravatar.com\/avatar\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8803277856c8b753feb4217dff0f9953327452df1a615c3c88b2f9864efb2ddd?s=96&d=mm&r=g","caption":"LATB Staff"},"url":"https:\/\/admin.acceleratingscience.com\/author\/latbstaff\/"}]}},"taxonomy_info":{"category":[{"value":159,"label":"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0"}],"post_tag":[{"value":178,"label":"RNA"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title-1024x538.jpg",760,399,true],"author_info":{"display_name":"LATB Staff","author_link":"https:\/\/admin.acceleratingscience.com\/author\/latbstaff\/"},"comment_info":0,"category_info":[{"term_id":159,"name":"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0","slug":"cell","term_group":0,"term_taxonomy_id":159,"taxonomy":"category","description":"","parent":0,"count":102,"filter":"raw","meta":[],"cat_ID":159,"category_count":102,"category_description":"","cat_name":"\u7d30\u80de\u57f9\u990a\u30fb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0","category_nicename":"cell","category_parent":0}],"tag_info":[{"term_id":178,"name":"RNA","slug":"rna","term_group":0,"term_taxonomy_id":178,"taxonomy":"post_tag","description":"","parent":0,"count":10,"filter":"raw","meta":[]}],"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2019\/07\/rnai-non-coding-rna-research-title.jpg","jetpack-related-posts":[{"id":20124,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/exosome-gene-therapy-ts-r-25015\/","url_meta":{"origin":547,"position":0},"title":"\u3010\u7b2c1\u56de\u3011Exosome\uff08\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff0f\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\uff09\u3068\u306f\uff1f","author":"LatB Staff","date":"2026\u5e744\u670815\u65e5","format":false,"excerpt":"Exosome\uff08\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff0f\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\uff09\u306e\u7814\u7a76\u304c\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u8208\u5473\u306f\u3042\u3063\u3066\u3082\u3001\u3069\u306e\u3088\u3046\u306b\u7814\u2026","rel":"","context":"\u305d\u306e\u4ed6","block_context":{"text":"\u305d\u306e\u4ed6","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/else\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/03\/6fae859c8c1eacdaa39f3ae843ae1bda-scaled.png?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":23239,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/ngs-gene-expression-csd-ts-bfx-25060\/","url_meta":{"origin":547,"position":1},"title":"\u98df\u54c1\u958b\u767a\u306b\u304a\u3051\u308b\u83cc\u53e2\u89e3\u6790\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u306e\u6d3b\u7528","author":"LatB Staff","date":"2025\u5e7410\u67088\u65e5","format":false,"excerpt":"\u907a\u4f1d\u5b50\u95a2\u9023\u306e\u89e3\u6790\u6280\u8853\u304c\u7814\u7a76\u306e\u307f\u306a\u3089\u305a\u7523\u696d\u5206\u91ce\u3067\u6d3b\u7528\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u5e74\u6708\u304c\u7d4c\u904e\u3059\u308b\u306b\u3064\u308c\u3066\u5fdc\u7528\u7bc4\u56f2\u3082\u2026","rel":"","context":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","block_context":{"text":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/mol-bio\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/09\/ngs-gene-expression-gsd-ts-tr-25060_eyecatch.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/09\/ngs-gene-expression-gsd-ts-tr-25060_eyecatch.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/09\/ngs-gene-expression-gsd-ts-tr-25060_eyecatch.jpg?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":24187,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/ngs-gene-expression-csd-ts-ion-25073\/","url_meta":{"origin":547,"position":2},"title":"\u3010\u3084\u3063\u3066\u307f\u305f\u3011\u5fae\u91cf\u30fb\u5206\u89e3RNA\u306b\u3088\u308b\u767a\u73fe\u89e3\u6790\u306e\u6700\u9069\u89e3\u306f\uff1fRNA-Seq\u3068Ion AmpliSeq Transcriptome\u3092\u6bd4\u3079\u3066\u307f\u305f","author":"LatB Staff","date":"2025\u5e7411\u670828\u65e5","format":false,"excerpt":"\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b5\u3067\u306e\u767a\u73fe\u89e3\u6790\u306b\u53d6\u308a\u7d44\u3080\u969b\u3001RNA\u30b5\u30f3\u30d7\u30eb\u304c\u300c\u5c11\u306a\u3059\u304e\u308b\u300d\u300c\u5206\u89e3\u3057\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u72b6\u6cc1\u306f\u2026","rel":"","context":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","block_context":{"text":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/mol-bio\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/ngs-gene-expression-csd-ts-ion-25073_eyecatch-scaled.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/ngs-gene-expression-csd-ts-ion-25073_eyecatch-scaled.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/ngs-gene-expression-csd-ts-ion-25073_eyecatch-scaled.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/ngs-gene-expression-csd-ts-ion-25073_eyecatch-scaled.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/ngs-gene-expression-csd-ts-ion-25073_eyecatch-scaled.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2025\/11\/ngs-gene-expression-csd-ts-ion-25073_eyecatch-scaled.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":24606,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/transfection-antibody-bid-ts-mbr-26004\/","url_meta":{"origin":547,"position":3},"title":"\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u9664\u53bb\u30b7\u30b9\u30c6\u30e0\uff08Trim-Away\u6cd5\uff09\u306e\u7d39\u4ecb\uff5e\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u6a5f\u5668\u3092\u4f7f\u7528\u3057\u3066\uff5e","author":"LatB Staff","date":"2026\u5e742\u67084\u65e5","format":false,"excerpt":"2018\u5e74\u306e\u6587\u732e(1)\u3067\u7d30\u80de\u5185\u306e\u5185\u5728\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u76f4\u63a5\u5206\u89e3\u3059\u308b\u3001Trim-Away\u6cd5\u304c\u7d39\u4ecb\u3055\u308c\u307e\u3057\u305f\u2026","rel":"","context":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","block_context":{"text":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/mol-bio\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/01\/transfection-antibody-bid-ts-mbr-26004_eyecatch.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/01\/transfection-antibody-bid-ts-mbr-26004_eyecatch.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/01\/transfection-antibody-bid-ts-mbr-26004_eyecatch.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/01\/transfection-antibody-bid-ts-mbr-26004_eyecatch.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":20152,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/exosome-nucleic-acid-purification-ts-r-25017\/","url_meta":{"origin":547,"position":4},"title":"\u3010\u7b2c3\u56de\u3011\u201cRNA cargo\u201d\u306e\u7cbe\u88fd\u3068\u5b9a\u91cf\u89e3\u6790","author":"LatB Staff","date":"2026\u5e745\u670813\u65e5","format":false,"excerpt":"\u7b2c2\u56de\u3067\u306f\u3001\u57f9\u990a\u4e0a\u6e05\u3084\u3055\u307e\u3056\u307e\u306a\u4f53\u6db2\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u6fc3\u7e2e\u30fb\u56de\u53ce\u65b9\u6cd5\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3057\u307e\u3057\u305f\u304c\u2026","rel":"","context":"\u305d\u306e\u4ed6","block_context":{"text":"\u305d\u306e\u4ed6","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/else\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/f17931341a23d82235760ed66ded9c41.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/f17931341a23d82235760ed66ded9c41.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/f17931341a23d82235760ed66ded9c41.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/f17931341a23d82235760ed66ded9c41.jpg?resize=700%2C400&ssl=1 2x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/f17931341a23d82235760ed66ded9c41.jpg?resize=1050%2C600&ssl=1 3x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/f17931341a23d82235760ed66ded9c41.jpg?resize=1400%2C800&ssl=1 4x"},"classes":[]},{"id":25325,"url":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/exosome-gene-expression-ts-r-25019\/","url_meta":{"origin":547,"position":5},"title":"\u3010\u7b2c5\u56de\u3011 “RNA cargo”\u306e\u7cbe\u88fd\u3068\u5b9a\u91cf\u89e3\u6790\u300d\uff5emRNA\u306e\u5b9a\u91cf\u89e3\u6790\uff5e","author":"LatB Staff","date":"2026\u5e746\u670811\u65e5","format":false,"excerpt":"\u4eca\u56de\u306f\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff08\u30a8\u30ad\u30bd\u30bd\u30fc\u30e0\uff09\u4e2d\u306emRNA\u306e\u5b9a\u91cf\u89e3\u6790\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002\u7b2c3\u56de\u3067\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u304b\u2026","rel":"","context":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","block_context":{"text":"\u5206\u5b50\u751f\u7269\u5b66\u5b9f\u9a13\u95a2\u9023","link":"https:\/\/admin.acceleratingscience.com\/learning-at-the-bench\/mol-bio\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25018_eyecatch-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25018_eyecatch-1.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25018_eyecatch-1.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/admin.acceleratingscience.com\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2026\/05\/exosome-gene-expression-ts-r-25018_eyecatch-1.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts\/547","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/users\/988"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/comments?post=547"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/posts\/547\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/media\/2871"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/media?parent=547"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/categories?post=547"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/tags?post=547"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-json\/wp\/v2\/division?post=547"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}