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CD4+ T\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8<\/h4>\n

\u56fa\u5f62\u816b\u760d\u306e\u4e2d\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u30bf\u30a4\u30d7\u306eT\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u304c\u5b58\u5728\u3057\u307e\u3059\uff08\u56f33.3\uff09\u3002Th1\u304a\u3088\u3073Th2\u30b5\u30d6\u30bb\u30c3\u30c8\u306f\u3001\u6700\u521d\u306b\u540c\u5b9a\u3055\u308c\u3001\u5e83\u304f\u7279\u6027\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002Th1\u7d30\u80de\u7cfb\u7d71\u306f\u8ee2\u5199\u56e0\u5b50T-bet\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3001Th2\u7d30\u80de\u5206\u5316\u306b\u306fGATA-3\u304c\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002CD4+ T\u30d8\u30eb\u30d1\u30fc1\uff08Th1\uff09\u7d30\u80de\u306f\u3001\u816b\u760d\u8840\u7ba1\u65b0\u751f\u3092\u6291\u5236\u3057\u3001\u6297\u539f\u63d0\u793a\u7d30\u80de\uff08APC\uff09\u304a\u3088\u3073NK\u7d30\u80de\u306e\u52d5\u54e1\u3092\u4ecb\u3059\u308b\u6297\u816b\u760d\u7279\u6027\u3092\u6301\u3061\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-2\uff08IL-2\uff09\u3084\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u03b3\uff08IFN-\u03b3\uff09\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066CD8+\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002\u4e00\u822c\u7684\u306b\u3001Th2\u7d30\u80de\u306f\u6bba\u816b\u760d\u6027\u597d\u9178\u7403\u3092\u52d5\u54e1\u3059\u308bIL-4\u304a\u3088\u3073IL-13\u0336\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u7523\u751f\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6297\u816b\u760d\u53cd\u5fdc\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u9006\u306b\u3001Th2\u306f\u3001IL-5\u306e\u5206\u6ccc\u3092\u4ecb\u3057\u3066\u816b\u760d\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b\u3068\u3055\u308c\u307e\u3059\u3002Th17\u7d30\u80de\u306f\u3001\u6297\u83cc\u6027\u7d44\u7e54\u708e\u75c7\u306b\u95a2\u4e0e\u3059\u308bIL-17\u3001IL-21\u304a\u3088\u3073IL-22\u3092\u7523\u751f\u3057\u3001\u591a\u304f\u306e\u304c\u3093\u306b\u304a\u3051\u308b\u816b\u760d\u306e\u6210\u9577\u304a\u3088\u3073\u8840\u7ba1\u65b0\u751f\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3068\u4e00\u822c\u7684\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002FOXP3+ CD4+ Treg\u306f\u3001FOXP3\u8ee2\u5199\u56e0\u5b50\u3092\u767a\u73fe\u3057\u3001\u514d\u75ab\u5b66\u7684\u6052\u5e38\u6027\u304a\u3088\u3073\u81ea\u5df1\u5bdb\u5bb9\u306e\u7dad\u6301\u306b\u91cd\u8981\u3068\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u5236\u5fa1\u6027T\u7d30\u80de\uff08Treg\uff09\u306f\u3001\u4ed6\u306eT\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u3092\u963b\u5bb3\u3057\u3001\u816b\u760d\u9032\u884c\u306b\u5bdb\u5927\u306a\u95a2\u4e0e\u3092\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002FOXP3\u3092\u4ecb\u3059\u308bT\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d30\u80de\u306eTreg\u3078\u306e\u5206\u5316\u8a98\u5c0e\u306f\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u5185\u306bTreg\u304c\u591a\u6570\u5b58\u5728\u3059\u308b\u6f5c\u5728\u7684\u306a\u8981\u56e0\u3068\u3057\u3066\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002Treg\u306f\u3001\u4ed6\u306e\u816b\u760d\u304c\u30ea\u30f3\u30d1\u7403\u306b\u6d78\u6f64\u3059\u308b\u6a5f\u80fd\u3092\u6291\u5236\u3057\u307e\u3059\u304c\u3001\u901a\u5e38\u3001\u816b\u760d\u9032\u884c\u306b\u5bdb\u5bb9\u306a\u74b0\u5883\u3092\u4f9b\u7d66\u3057\u3066\u3044\u308b\u3068\u8aac\u660e\u3055\u308c\u307e\u3059\u3002Treg\u306f\u3001IL-10\u3001\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30df\u30f3\u30b0\u5897\u6b96\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\u306e\u7523\u751f\u3001\u304a\u3088\u3073\u7d30\u80de\u50b7\u5bb3\u6027T\u30ea\u30f3\u30d1\u7403\u6297\u539f4\uff08CTLA4\uff09\u306e\u95a2\u4e0e\u3092\u4ecb\u3057\u3066\u514d\u75ab\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u816b\u760d\u7d30\u80de\u3092\u76f4\u63a5\u6bba\u50b7\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308bCD8+T\u7d30\u80de\uff08\u7d30\u80de\u50b7\u5bb3\u6027T\u30ea\u30f3\u30d1\u7403 [CTL]\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u306a\u3069\u306e\u6bba\u816b\u760d\u7d30\u80de\u306b\u3088\u308b\u6297\u539f\u8a8d\u8b58\u304a\u3088\u3073\u816b\u760d\u7d30\u80de\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u6291\u5236\u3057\u307e\u3059*8,9<\/sup>\u3002<\/p>\n

\"T\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\"<\/a>\"CD8<\/a><\/p>\n

\u30a4\u30e0\u30ce\u30a2\u30c3\u30bb\u30a4\u3092\u4f7f\u7528\u3059\u308bTh1\/Th2\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u75d5\u8de1\u306e\u691c\u51fa<\/h4>\n

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\n\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n

\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n

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    \n
  1. \u6162\u6027\u708e\u75c7\u304a\u3088\u3073\u304c\u3093<\/li>\n
  2. \u304c\u3093\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u304a\u3088\u3073\u708e\u75c7<\/li>\n
  3. \u816b\u760d\u5fae\u5c0f\u74b0\u5883<\/li>\n
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  5. \u8981\u7d04\u304a\u3088\u3073\u4ed8\u9332<\/li>\n<\/ol>\n

    \u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n

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    \u7121\u6599\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/p>\n

    \u53c2\u8003\u6587\u732e\uff1a
    \n1. Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539\u2013545.
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    \n3. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860\u2013867.
    \n4. Shiao SL, Ganesan AP, Rugo HS et al. (2011) Immune microenvironments in\u00a0solid tumors: new targets for therapy. Genes Dev 25(24):2559\u20132572.
    \n5. Gajewski TF, Schreiber H, Fu YX (2013) Innate and adaptive immune cells in the\u00a0tumor microenvironment. Nature Immunol 10:1014\u20131022.
    \n6. DeNardo DG, Brennan DJ, Rexhepaj E et al. (2011) Leukocyte complexity\u00a0predicts breast cancer survival and functionally regulates response to\u00a0chemotherapy. Cancer Discov 1(1):54\u201367.
    \n7. Yang L, Karin M (2014) Roles of tumor suppressors in regulating tumorassociated\u00a0inflammation. Cell Death Differ 21(11):1677\u20131686.
    \n8. Kim HJ, Cantor H (2014) CD4 T-Cell Subsets and Tumor Immunity: The Helpful\u00a0and the not-so-helpful. Cancer Immunol Res 2(2):91\u201398.
    \n9. Anestakis D, Petanidis S, Kalyvas S et al. (2015) Mechanisms and applications\u00a0of interleukins in cancer immunotherapy. Int J Mol Sci 16(1):1691\u20131710.
    \n10. Spranger S, Koblish HK, Horton B et al. (2014) Mechanism of tumor rejection\u00a0with doublets of CTLA-4, PD-1\/PD-L1, or IDO blockade involves restored\u00a0IL-2 production and proliferation of CD8(+) T cells directly within the tumor\u00a0microenvironment. Immuno Ther Cancer 2:3.
    \n11. Platten M, Wick W, Van den Eynde BJ (2012) Tryptophan catabolism in cancer:\u00a0beyond IDO and tryptophan depletion. Cancer Res 72(21):5435\u20135440.
    \n12. Joyce JA, Fearon DT (2015) T cell exclusion, immune privilege, and the tumormicroenvironment. Science 348(6230): 74\u201380.
    \n13. Molon B, Ugel S, Del Pozzo F et al. (2011) Chemokine nitration prevents\u00a0intratumoral infiltration of antigen-specific T cell. JEM 208(10):1949\u201362.
    \n14. Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators\u00a0of the immune system. Nat Rev Immunol 9(3):162\u2013174.
    \n15. Sharda DR, Yu S, Ray M et al. (2011) Regulation of macrophage arginase\u00a0expression and tumor growth by the Ron receptor tyrosine kinase. J Immunol\u00a0187(5):2181\u20132192.
    \n16. Allavena P, Sica A, Solinas G, et al. (2008) The inflammatory micro-environment\u00a0in tumor progression: the role of the tumor-associated macrophages. Crit Rev\u00a0Oncol Hematol 66(1):1\u20139.
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    \n24. FDA News Release. FDA approves Keytruda for advanced non-small cell lungcancer. http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm465444.htm. Accessed October 2015.<\/span><\/p>\n

     <\/p>\n

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19\u4e16\u7d00\u306b\u3001\u708e\u75c7\u30a4\u30d9\u30f3\u30c8\u3068\u304c\u3093\u9032\u884c\u3068\u306e\u95a2\u9023\u6027\u306b\u95a2\u3059\u308b\u6700\u521d\u306e\u77e5\u898b\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5148\u306e\u77e5\u898b\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u75ab\u5b66\u7684\u3001\u5b9f\u9a13\u7684\u3001\u304a\u3088\u3073\u81e8\u5e8a\u7684\u8a3c\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u6570\u591a\u304f\u306e\u5831\u544a\u304c\u5287\u7684\u306b\u5897\u52a0\u3057\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u304c\u3093\u306e\u767a\u751f\u306b\u304a\u3051\u308b\u30ea\u30b9<\/p>\n","protected":false},"author":988,"featured_media":3757,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[156],"tags":[83,32],"division":[],"class_list":{"0":"post-900","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-mol-bio","8":"tag-cancer","9":"tag-antibody","10":"entry"},"_selected_authors":"","_selected_reviewers":"","acf":[],"yoast_head":"\n\u3010\u3044\u307e\u3055\u3089\u805e\u3051\u306a\u3044\u304c\u3093\u306e\u57fa\u790e 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