{"id":916,"date":"2019-01-09T00:00:00","date_gmt":"2019-01-09T00:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cancer6\/"},"modified":"2025-02-20T09:09:11","modified_gmt":"2025-02-20T00:09:11","slug":"cancer6","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cancer6\/","title":{"rendered":"\u3010\u3044\u307e\u3055\u3089\u805e\u3051\u306a\u3044\u304c\u3093\u306e\u57fa\u790e 6\u3011NF-kB\u3001 STAT3\u3001HIF-1\u3063\u3066\u77e5\u3063\u3066\u3044\u307e\u3059\u304b\uff1f"},"content":{"rendered":"<p><br \/>\nNuclear factor kappa-light-chain-enhancer of activated B cells\uff08NF-\u03baB\uff09\u3001hypoxia-inducible factor-1 alpha\uff08HIF-1\u03b1\uff09\u3001\u304a\u3088\u3073signal transducer and activator of 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rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<h4>NF-\u03baB\u8abf\u7bc0\u30d7\u30ed\u30bb\u30b9<\/h4>\n<p>\u304c\u3093\u306b\u304a\u3044\u3066\u3001NF-\u03baB\u306f2\u3064\u306e\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u6025\u6027\u708e\u75c7\u53cd\u5fdc\u306b\u304a\u3051\u308b\u3053\u306e\u8ee2\u5199\u56e0\u5b50\u306e\u5b8c\u5168\u6d3b\u6027\u5316\u306f\u3001\u304c\u3093\u7d30\u80de\u306b\u5411\u3051\u3089\u308c\u305f\u7d30\u80de\u50b7\u5bb3\u6027\u514d\u75ab\u7d30\u80de\u306e\u6d3b\u6027\u5897\u52a0\u306b\u95a2\u9023\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001NF-\u03baB\u306f\u3001\u591a\u304f\u306e\u304c\u3093\u306e\u5f62\u614b\u306b\u304a\u3044\u3066\u7d99\u7d9a\u7684\u306b\u6d3b\u6027\u5316\u72b6\u614b\u306b\u3042\u308a\u3001\u5927\u91cf\u306e\u816b\u760d\u5f62\u6210\u53cd\u5fdc\u3092\u8a98\u767a\u3057\u307e\u3059\u3002NF-\u03baB\u6d3b\u6027\u5316\u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u963b\u5bb3\u3059\u308b\u907a\u4f1d\u5b50\u3084\u3001\u7d30\u80de\u751f\u5b58\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8a98\u5c0e\u3057\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u5185\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u62b5\u6297\u3057\u307e\u3059\u3002<br \/>\nNF-\u03baB\u306f\u3001TNF-\u03b1\u3001IL-1\u3001IL-6\u3001\u304a\u3088\u3073IL-8\u306a\u3069\u306e\u591a\u304f\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u767a\u73fe\u306b\u3082\u95a2\u4e0e\u3057\u307e\u3059\uff08\u56f34.2\uff09<sup>*5<\/sup>\u3002 \u816b\u760d\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u591a\u304f\u306e\u4ed6\u306e\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u306f\u3001NF-\u03baB\u306b\u3088\u3063\u3066\u3082\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u3001\u7d30\u80de\u5897\u6b96\u3001\u7d30\u80de\u63a5\u7740\u3001\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\u3001\u7d30\u80de\u6d78\u6f64\u3001\u8ee2\u79fb\u3001\u304a\u3088\u3073\u8840\u7ba1\u65b0\u751f\u3001\u306a\u3089\u3073\u306b\u4ed6\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u542b\u307e\u308c\u307e\u3059 (\u56f34.2)\u3002NF-\u03baB\u306f\u3001\u304c\u3093\u5e79\u7d30\u80de\u306b\u304a\u3044\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u304c\u3093\u7d30\u80de\u306e\u5c11\u6570\u306e\u4e9c\u96c6\u56e3\u304c\u816b\u760d\u6210\u9577\u3092\u5a92\u4ecb\u3057\u3001\u5316\u5b66\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u6301\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059<sup>*6<\/sup>\u3002<a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-26.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2952 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-26.jpg\" alt=\"NF-\u03baB\u306e\u6d3b\u6027\u5316\u304a\u3088\u3073\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\" width=\"385\" height=\"481\" \/><\/a><\/p>\n<h4>\u708e\u75c7\u304a\u3088\u3073STAT3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/h4>\n<p>\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u304a\u3088\u3073IL-6\u306f\u3001\u30e4\u30cc\u30b9\u30ad\u30ca\u30fc\u30bc\uff08JAK\uff09-\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304a\u3088\u3073\u8ee2\u5199\u6d3b\u6027\u5316\u56e0\u5b50\uff08STAT\uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u56e0\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u6700\u521d\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3067\u3059\u3002\u8907\u6570\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304a\u3088\u3073\u6210\u9577\u56e0\u5b50\u304c\u3001\u3053\u306e\u7d4c\u8def\u3092\u4ecb\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff08\u56f34.3\u304a\u3088\u3073\u56f34.5\uff09<sup>*8<\/sup>\u30027\u7a2e\u985e\u306eSTAT\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306e\u3046\u3061\u3001STAT3\u304a\u3088\u3073STAT5\u304c\u6700\u3082\u304c\u3093\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u3044\u304f\u3064\u304b\u306e\u6700\u8fd1\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3001Toll\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u304a\u3088\u3073Nod\u69d8\u53d7\u5bb9\u4f53\uff08NLR\uff09\u306f\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u3088\u3046\u306b\u3001JAK\u2013STAT3\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u3001\u7d9a\u3044\u3066\u60aa\u6027\u7d30\u80de\u306b\u304a\u3051\u308bTLR\u306e\u767a\u73fe\u3092\u4fc3\u9032\u3057\u3001\u3055\u3089\u306b\u816b\u760d\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6b63\u5e38\u7d30\u80de\u306b\u304a\u3044\u3066\u3001STAT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u4e00\u904e\u6027\u3067\u3059\u304c\u3001\u6210\u9577\u56e0\u5b50\u304a\u3088\u3073\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304b\u3089JAK-STAT3\u7d4c\u8def\u307e\u3067\u306e\u5897\u5f37\u3055\u308c\u305f\u81ea\u5df1\u5206\u6ccc\u578b\u304a\u3088\u3073\u508d\u5206\u6ccc\u578b\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u3001\u907a\u4f1d\u7684\u4e0d\u5b89\u5b9a\u6027\u304a\u3088\u3073\u816b\u760d\u95a2\u9023\u708e\u75c7\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4e0d\u6d3b\u6027\u578b\u306eSTAT\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7d30\u80de\u8cea\u306b\u5b58\u5728\u3057\u307e\u3059\u3002\u819c\u53d7\u5bb9\u4f53\u306e\u523a\u6fc0\u306f\u3001JAK\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u53d7\u5bb9\u4f53\u95a2\u9023\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3057\u3001\u305d\u308c\u306b\u3088\u308aSTAT\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u307e\u3059\u3002JAK1\u306f\u3001STAT3\u306e\u4e3b\u8981\u306a\u6d3b\u6027\u5316\u56e0\u5b50\u3067\u3059\u3002\u30ea\u30f3\u9178\u5316STAT\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001Src\u76f8\u540c\u9818\u57df\uff08SH2\uff09\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u4ecb\u3057\u3066\u3001\u30db\u30e2\u307e\u305f\u306f\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u4e8c\u91cf\u4f53STAT\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u6838\u306b\u5165\u308a\u3001\u907a\u4f1d\u5b50\u8ee2\u5199\u3092\u5236\u5fa1\u3057\u307e\u3059\uff08\u56f34.3\uff09<sup>*6,10<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2953 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-27.jpg\" alt=\"NF-\u03baB\u306f\u3001\u6b63\u5e38\u7d30\u80de\u6a5f\u80fd\u304a\u3088\u3073\u304c\u3093\u3092\u591a\u304f\u306e\u9762\u3067\u8abf\u7bc0\u3059\u308b\u8ee2\u5199\u5236\u5fa1\u56e0\u5b50\u3067\u3059\u3002\" width=\"386\" height=\"239\" \/><\/p>\n<h4>NF-\u03baB\u304a\u3088\u3073STAT3\u30af\u30ed\u30b9\u30c8\u30fc\u30af<\/h4>\n<p>NF-\u03baB\u304a\u3088\u3073STAT3\u306f\u3001\u81a8\u5927\u306a\u6570\u306e\u304c\u3093\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u6a19\u7684\u907a\u4f1d\u5b50\u306b\u304a\u3044\u3066\u3001\u7570\u306a\u308a\u304b\u3064\u91cd\u8907\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002STAT3\u306f\u30013,000\u4ee5\u4e0a\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u7d50\u5408\u3057\u3001NF-\u03baB\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3055\u3089\u306b\u591a\u304f\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u63a8\u6e2c\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u816b\u760d\u5f62\u6210\u304a\u3088\u3073\u304c\u3093\u9032\u884c\u306e\u904e\u7a0b\u3067\u3001\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\/\u7d4c\u8def\u306fNF-\u03baB\u304a\u3088\u3073STAT3\u306e\u4e21\u65b9\u306e\u5171\u901a\u306e\u6a19\u7684\u3068\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u4e21\u65b9\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u3001\u6297\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u30d7\u30ed\u30bb\u30b9\u3001\u8840\u7ba1\u65b0\u751f\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7523\u751f\u3001\u708e\u75c7\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u907a\u4f1d\u5b50\u3001\u7d30\u80de\u5468\u671f\u3001\u304a\u3088\u3073\u4ed6\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u5236\u5fa1\u3059\u308b\u907a\u4f1d\u5b50\u306e\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3067\u3059<sup>*6<\/sup>\u3002<\/p>\n<p>NF-\u03baB\u304a\u3088\u3073STAT\u306f\u3001\u591a\u7a2e\u591a\u69d8\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4ecb\u3057\u3066\u3001\u4e92\u3044\u306b\u5f71\u97ff\u3057\u5408\u3044\u307e\u3059\uff08\u56f34.4\uff09\u30021\u3064\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u76f4\u63a5\u7684\u306a\u7269\u7406\u7684\u7d50\u5408\u3092\u4ecb\u3057\u3066\u751f\u3058\u3001\u8ee2\u5199\u6d3b\u6027\u307e\u305f\u306fDNA\u7d50\u5408\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002STAT3\u306f\u3001p65\u304a\u3088\u3073p50\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u308c\u306b\u3088\u308a\u3001NF-\u03baB\u306eSTAT\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u3078\u306e\u5c40\u5728\u5316\u3084STAT3\u306eNF-\u03baB\u7d50\u5408\u9818\u57df\u3078\u306e\u5c40\u5728\u5316\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002STAT3\u306e\u4ed6\u306b\u3001p53\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u3001ATF3\u3001SMAD3\u3001\u304a\u3088\u3073SMAD4\u306a\u3069\u306e\u4ed6\u306e\u8ee2\u5199\u56e0\u5b50\u3082NF-\u03baB\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-28.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2954 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-28.jpg\" alt=\"NF-\u03baB \u3068 STAT3 \u306e\u9593\u306e\u5206\u5b50\u30af\u30ed\u30b9\u30c8\u30fc\u30af\" width=\"383\" height=\"449\" \/><\/a><\/p>\n<p>NF-\u03baB\u304a\u3088\u3073STAT3\u306a\u3069\u306e\u8ee2\u5199\u56e0\u5b50\u306f\u3001\u305d\u308c\u3089\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u307e\u305f\u306f\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u914d\u5217\u4e0a\u306e\u3082\u3046\u4e00\u65b9\u306b\u8fd1\u63a5\u3059\u308bDNA\u914d\u5217\u306b\u3082\u7d50\u5408\u3057\u3001\u8ee2\u5199\u5236\u5fa1\u6a5f\u69cb\u306e\u5fc5\u8981\u306a\u30b3\u30f3\u30dd\u30fc\u30cd\u30f3\u30c8\u3092\u30ea\u30af\u30eb\u30fc\u30c8\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001STAT3\u306f\u30a2\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bcp300\u3092NF-\u03baB\u306b\u30ea\u30af\u30eb\u30fc\u30c8\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002RelA\u306e\u7ffb\u8a33\u5f8c\u30a2\u30b7\u30eb\u5316\u306b\u3088\u308a\u3001\u6838\u3078\u306e\u5c40\u5728\u5316\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u306f\u6ce8\u76ee\u306b\u5024\u3057\u307e\u3059\u3002STAT\u3092\u4ecb\u3059\u308bNF-\u03baB\u306e\u30a2\u30b7\u30eb\u5316\u304cNF-\u03baB\u6d3b\u6027\u306e\u6301\u7d9a\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u3044\u3046\u30d5\u30a3\u30fc\u30c9\u30d5\u30a9\u30ef\u30fc\u30c9\u6a5f\u69cb\u304c\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306b\u304a\u3051\u308b\u6210\u9577\u56e0\u5b50\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u3088\u308b\u523a\u6fc0\u3068\u540c\u69d8\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u304c\u3093\u306b\u304a\u3051\u308bNF-\u03baB\u306e\u6052\u5e38\u7684\u306a\u6d3b\u6027\u5316\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002NF-\u03baB\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001IL-6\u306a\u3069\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u653e\u51fa\u304c\u751f\u3058\u3001\u305d\u308c\u306b\u3088\u3063\u3066STAT3\u304c\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\uff08\u56f34.5\uff09<sup>*5,6<\/sup>\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-44.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3003 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-44.jpg\" alt=\"STAT3 Mouse Monoclonal Antibody (9D8)\" width=\"384\" height=\"365\" \/><\/a><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-29.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2955 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-29.jpg\" alt=\"NF-\u03baB\u304a\u3088\u3073STAT3\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u4e00\u822c\u7684\u306a\u30a4\u30f3\u30c7\u30e5\u30fc\u30b5\u30fc\" width=\"394\" height=\"316\" \/><\/a><\/p>\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u816b\u760d\u95a2\u9023\u708e\u75c7\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u6297\u4f53\u30d9\u30fc\u30b9\u306e\u30c4\u30fc\u30eb\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002<br \/>\n\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/antibody-inflammation-tumor-guidebook-form.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab11_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<h4>NF-kB\u304a\u3088\u3073STAT3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u30a4\u30f3\u30c7\u30e5\u30fc\u30b5\u30fc<\/h4>\n<p>\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u5185\u3067\u306f\u3001\u9593\u8cea\u7d30\u80de\u3001\u816b\u760d\u6d78\u6f64\u6027\u30ea\u30f3\u30d1\u7403\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u304a\u3088\u3073\u4ed6\u306e\u7d30\u80de\u30bf\u30a4\u30d7\u304c\u7d30\u80de\u8868\u9762\u5206\u5b50\uff08TLR\u304a\u3088\u3073NLR\u306a\u3069\uff09\u3092\u767a\u73fe\u3059\u308b\u304b\u3001NF-\u03baB\u7d4c\u8def\u304a\u3088\u3073STAT3\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3059\u308b\u53ef\u6eb6\u6027\u56e0\u5b50\u3092\u7523\u751f\u3057\u3066\u3044\u307e\u3059\u3002\u5f53\u793e\u306e\u6297\u4f53\u691c\u7d22\u30c4\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3001\u3053\u308c\u3089\u306a\u3089\u3073\u306bNF-\u03baB\u304a\u3088\u3073STAT3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u4ed6\u306e\u30a4\u30f3\u30c7\u30e5\u30fc\u30b5\u30fc\u3092\u8a8d\u8b58\u3059\u308b\u6297\u4f53\u3092\u898b\u3064\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u4e00\u6b21\u6297\u4f53\u304a\u3088\u3073\u4e8c\u6b21\u6297\u4f53\u306e\u81a8\u5927\u306a\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u306b\u52a0\u3048\u3066\u3001\u5f53\u793e\u3067\u306f\u3001\u304a\u5ba2\u69d8\u306e\u7814\u7a76\u76ee\u6a19\u306e\u9054\u6210\u306e\u305f\u3081\u306b\u3001\u5e45\u5e83\u3044\u624b\u52d5\u304a\u3088\u3073\u81ea\u52d5\u306e\u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u88c5\u7f6e\u306a\u3089\u3073\u306b\u8a66\u85ac\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h4>Invitrogen\u30d6\u30e9\u30f3\u30c9\u306eiBind\u2122\u304a\u3088\u3073iBind Flex Western Device\u306f\u3001\u30a6\u30a7\u30b9\u30bf\u30f3\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u306b\u304a\u3051\u308b\u514d\u75ab\u691c\u51fa\u5de5\u7a0b\u3092\u81ea\u52d5\u5316\u3059\u308b\u305f\u3081\u306eSequential Lateral Flow\uff08SLF\uff09\u6280\u8853\u3092\u63a1\u7528<\/h4>\n<p>\u5f93\u6765\u306e\u30de\u30cb\u30e5\u30a2\u30eb\u51e6\u7406\u6cd5\u3067\u306f\u3001\u8907\u6570\u306e\u6297\u4f53\u3092\u6e96\u5099\u30fb\u4ea4\u63db\u3057\u3001\u3055\u3089\u306b\u76ee\u7684\u30d6\u30ed\u30c3\u30c8\u3092\u542b\u3080\u30c8\u30ec\u30a4\u4e2d\u3067\u6570\u6642\u9593\u304b\u3051\u3066\u53cd\u5fdc\u3057\u307e\u3059\u3002Invitrogen\u2122iBind\u2122 Western System\u306f\u3001\u514d\u75ab\u691c\u51fa\u5de5\u7a0b\u3092\u81ea\u52d5\u3067\u884c\u3046\u96fb\u6e90\u30fb\u96fb\u6c60\u4e0d\u8981\u306e\u88c5\u7f6e\u3067\u3059\u3002\u6297\u4f53\u3092\u5145\u586b\u3059\u308b\u3060\u3051\u3067\u30013\u6642\u9593\u5f8c\u306b\u6297\u4f53\u6297\u539f\u53cd\u5fdc\u306f\u7d42\u308f\u308a\u691c\u51fa\u306e\u6e96\u5099\u304c\u6574\u3044\u307e\u3059\u3002\u30de\u30cb\u30e5\u30a2\u30eb\u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c6\u30a3\u30f3\u30b0\u306e\u6539\u826f\u306b\u3088\u308a\u8a95\u751f\u3057\u305fiBind Western System\u306f\u3001\u30cf\u30f3\u30ba\u30aa\u30f3\u30bf\u30a4\u30e0\u306e\u77ed\u7e2e\u304a\u3088\u3073\u3088\u308a\u4e00\u8cab\u6027\u306e\u3042\u308b\u7d50\u679c\u3092\u53ef\u80fd\u3068\u3057\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u67d4\u8edf\u6027\u0336\u540c\u6761\u4ef6\u3067\u3082\u3001\u7570\u306a\u308b\u6761\u4ef6\u4e0b\u3067\u3082\u3001\u4e00\u5ea6\u306b\u6700\u59271\u679a\u306eMidi Gel\u30012\u679a\u306eMini \u30b2\u30eb\u3001\u307e\u305f\u306f6\u679a\u306e\u30ab\u30c3\u30c8\u3057\u305f\u30b2\u30eb\u306e\u51e6\u7406\u304c\u53ef\u80fd<\/li>\n<li>\u9069\u5408\u6027\u0336\u30cb\u30c8\u30ed\u30bb\u30eb\u30ed\u30fc\u30b9\u819c\u307e\u305f\u306fPVDF\u819c\u3092\u4f7f\u7528\u3057\u3066\u3001\u76f4\u63a5\u6a19\u8b58\u3067\u4e00\u6b21\/\u4e8c\u6b21\u6297\u4f53\u3092\u691c\u51fa\uff08AP\u3001HRP\u3001\u307e\u305f\u306f\u86cd\u5149\u6a19\u8b58\uff09<\/li>\n<\/ul>\n<p>\u7d30\u80de\u8868\u9762\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u691c\u51fa\u306b\u306f\u3001\u518d\u73fe\u6027\u306b\u512a\u308c\u3001\u5168\u3066\u306e\u30a6\u30a7\u30b9\u30bf\u30f3\u691c\u51fa\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u9069\u5408\u3059\u308b\u3001\u5f53\u793e\u306e\u81ea\u52d5\u5316\u3055\u308c\u305f\u30a6\u30a7\u30b9\u30bf\u30f3\u51e6\u7406\u30b7\u30b9\u30c6\u30e0\u3092\u3054\u4f7f\u7528\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/protein-biology\/protein-assays-analysis\/western-blotting\/detect-proteins-western-blot\/ibind-western-system.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab11_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u512a\u308c\u305f\u30a6\u30a7\u30b9\u30bf\u30f3\u6027\u80fd\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u3061\u3089\u3092\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p>\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff08IL-6\uff09\u306f\u3001\u5f37\u529b\u306a\u708e\u75c7\u8a98\u5c0e\u56e0\u5b50\u3067\u3001\u3055\u307e\u3056\u307e\u306aT\u7d30\u80de\u30b5\u30d6\u30bb\u30c3\u30c8\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u597d\u4e2d\u7403\u3001\u4e0a\u76ae\u7d30\u80de\u3001\u816b\u760d\u7d30\u80de\u3001\u304a\u3088\u3073\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u5185\u306e\u4ed6\u306e\u7d30\u80de\u30bf\u30a4\u30d7\u306b\u3088\u3063\u3066\u5206\u6ccc\u3055\u308c\u307e\u3059\u3002<a href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies\/immunoassays\/elisa-kits.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab11_Social_LAB\" target=\"_blank\" rel=\"noopener\">IL-6\u304a\u3088\u3073\u4ed6\u306eSTAT3\u8a98\u5c0e\u56e0\u5b50\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306eELISA\u306f\u3001\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2956 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-30.jpg\" alt=\"\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306b\u5b58\u5728\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u4ee3\u8868\u7684\u306aELISA\u30ad\u30c3\u30c8\" width=\"807\" height=\"593\" \/><a href=\"http:\/\/thermofisher.com\/findelisa?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab11_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u3053\u308c\u3089\u304a\u3088\u3073\u4ed6\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u3053\u306e\u4ed6\u306e\u30d2\u30c8\u7528\u30ad\u30c3\u30c8\u306a\u3089\u3073\u306b\u8907\u6570\u306e\u3055\u307e\u3056\u307e\u306a\u751f\u7269\u7a2e\u7531\u6765\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u30ad\u30c3\u30c8\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<h4>\u304c\u3093\u6a19\u7684\u6cbb\u7642<\/h4>\n<p>\u816b\u760d\u9032\u884c\u306e\u767a\u5c55\u306b\u304a\u3044\u3066NF-\u03baB\u304a\u3088\u3073STAT3\u306e\u8ee2\u5199\u56e0\u5b50\u7d4c\u8def\u304c\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u60f3\u5b9a\u3057\u3001NF-\u03baB\u304a\u3088\u3073STAT3\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306a\u3089\u3073\u306b\u3053\u308c\u3089\u306e\u7d4c\u8def\u306b\u95a2\u9023\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u6570\u591a\u304f\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u304a\u3088\u3073\u9032\u884c\u4e2d\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059<sup>*11,12<\/sup>\u3002 NF-\u03baB\u3092\u76f4\u63a5\u7684\u306b\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u306f\u73fe\u5728\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001NF-\u03baB\u3092\u9593\u63a5\u7684\u306b\u6a19\u7684\u3068\u3059\u308bFDA\u627f\u8a8d\u85ac\u3084\u524d\u81e8\u5e8a\u8a66\u9a13\u4e2d\u306e\u5316\u5408\u7269\u306f\u5b58\u5728\u3057\u307e\u3059\u3002Bortezomib\u2015I\u03baB\u03b1\u306e\u5206\u89e3\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066NF-\u03baB\u3092\u4e0d\u6d3b\u6027\u5316\u3059\u308b\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u5264\u2015\u306f\u3001\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u304a\u3088\u3073\u30de\u30f3\u30c8\u30eb\u7d30\u80de\u30ea\u30f3\u30d1\u816b\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066FDA\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u4ed6\u3001\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u524d\u7acb\u817a\u304c\u3093\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059<sup>*13,14<\/sup>\u3002<\/p>\n<h4>NF-\u03baB\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6a19\u7684\u3068\u3059\u308b\u6226\u7565\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u958b\u767a\u304c\u542b\u307e\u308c\u307e\u3059<\/h4>\n<ul>\n<li>\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u5264\u306f\u3001I\u03baB\u03b1\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u304a\u3088\u3073\u5206\u89e3\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u963b\u5bb3\u5264\u306f\u3001I\u03baB\u03b1\u306e\u534a\u6e1b\u671f\u3092\u5ef6\u3070\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n<li>NF-\u03baB\uff08RelA\uff09\u306e\u7ffb\u8a33\u5f8c\u4fee\u98fe\u3092\u963b\u5bb3\u3059\u308b\u30a2\u30bb\u30c1\u30eb\u5316\u963b\u5bb3\u5264\u306f\u3001\u305d\u306e\u6838\u5c40\u5728\u5316\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002<\/li>\n<li>\u907a\u4f1d\u5b50\u5c0e\u5165\u3001\u7d30\u80de\u900f\u904e\u6027\u30da\u30d7\u30c1\u30c9\u3001\u304a\u3088\u3073siRNA\u306f\u3001\u304c\u3093\u306b\u304a\u3051\u308bNF-\u03baB\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u963b\u5bb3\u306b\u3064\u3044\u3066\u7814\u7a76\u3059\u308b\u305f\u3081\u306e\u3055\u3089\u306a\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059<sup>*15<\/sup>\u3002<\/li>\n<\/ul>\n<h4>STAT3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6a19\u7684\u3068\u3059\u308b\u6226\u7565\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u958b\u767a\u304c\u542b\u307e\u308c\u307e\u3059<\/h4>\n<p>STAT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u963b\u5bb3\u306b\u306f\u3001\u6570\u591a\u304f\u306e\u6226\u7565\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u306f\u3001\u5e45\u5e83\u304f\u85ac\u7406\u7642\u6cd5\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002STAT\u306e\u963b\u5bb3\u3067\u306f\u3001STAT\u306e\u30ea\u30f3\u9178\u5316\u306b\u95a2\u4e0e\u3059\u308b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u304c\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3055\u308c\u307e\u3059\u3002STAT\u306f\u3001\u30ea\u30f3\u9178\u5316\u306b\u7d9a\u3044\u3066\u3001\u4e8c\u91cf\u5316\u304a\u3088\u3073\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002\u4e73\u304c\u3093\u7d30\u80de\u306b\u304a\u3051\u308b\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u306f\u3001\u57f9\u990a\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u6210\u9577\u3092\u963b\u5bb3\u3057\u3001\u6052\u5e38\u7684\u306aSTAT3\u6d3b\u6027\u5316\u306e\u963b\u5bb3\u3068\u95a2\u4fc2\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8131\u30ea\u30f3\u9178\u5316\u3082\u91cd\u8981\u306a\u8abf\u7bc0\u30b7\u30b0\u30ca\u30eb\u3067\u3001\u30b7\u30b0\u30ca\u30eb\u3092\u30aa\u30d5\u306b\u5207\u308a\u66ff\u3048\u305f\u308a\u30aa\u30f3\u306b\u623b\u3057\u305f\u308a\u3057\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u30c1\u30ed\u30b7\u30f3\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\u306e\u8abf\u7bc0\u306f\u3001STAT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u963b\u5bb3\u3059\u308b\u305f\u3081\u306e\u3082\u3046\u4e00\u3064\u306e\u6709\u671b\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u63d0\u6848\u3055\u308c\u3066\u3044\u307e\u3059\u3002STAT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u751f\u7406\u5b66\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u963b\u5bb3\u5264\u306b\u306f\u3001STAT\u6d3b\u6027\u5316\u3092\u76f4\u63a5\u7684\u307e\u305f\u306f\u9593\u63a5\u7684\u306b\u5236\u5fa1\u3059\u308b\u5185\u5728\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4f8b\u3068\u3057\u3066\u3001SH2\u30c9\u30e1\u30a4\u30f3\u542b\u6709\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6291\u5236\u56e0\u5b50\uff1bSOCS\uff09\u3001JAK\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\uff08JAB\uff09\u3001\u304a\u3088\u3073STAT\u8a98\u5c0eSTAT\u963b\u5bb3\u5264\uff08SSI\uff09\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4ed6\u306eSTAT\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u963b\u5bb3\u306b\u3064\u3044\u3066\u306f\u3001\u4e8c\u91cf\u5316\u306e\u963b\u5bb3\u7269\u8cea\u3001STAT DNA-\u7d50\u5408\u304a\u3088\u3073\u8ee2\u5199\u6d3b\u6027\u306e\u963b\u5bb3\u5264\u3001\u306a\u3089\u3073\u306bSTAT\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u300216 NF-\u03baB\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304a\u3088\u3073\u304c\u3093\u306e\u9032\u884c\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u7d4c\u8def\u306b\u3064\u3044\u3066\u7406\u89e3\u3092\u6df1\u3081\u308b\u3053\u3068\u306f\u3001\u5c06\u6765\u306e\u65b0\u3057\u3044\u6a19\u7684\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u306e\u62e1\u5927\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-45.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3004 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-45.jpg\" alt=\"STAT3 ABfinity\u2122 Recombinant Rabbit Oligoclonal Antibody (3HCLC)\" width=\"386\" height=\"316\" \/><\/a><\/p>\n<h4>\u4f4e\u9178\u7d20\u3001\u708e\u75c7\u3001\u304a\u3088\u3073\u304c\u3093<\/h4>\n<p>\u6b63\u5e38\u306a\u751f\u7406\u7684\u6761\u4ef6\u4e0b\u306e\u4f4e\u9178\u7d20\u2015\u3059\u306a\u308f\u3061\u3001\u4f4e\u3044\u9178\u7d20\u6fc3\u5ea6\u30ec\u30d9\u30eb\u2015\u306e\u72b6\u614b\u306f\u3001\u5275\u50b7\u6cbb\u7652\u304a\u3088\u3073\u767a\u751f\u904e\u7a0b\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u7121\u5236\u5fa1\u306a\u4f4e\u9178\u7d20\u72b6\u614b\u306f\u3001\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3001\u708e\u75c7\u6027\u8178\u75be\u60a3\u3001\u304c\u3093\u304a\u3088\u3073\u4ed6\u306e\u75c7\u72b6\u306a\u3069\u8907\u6570\u306e\u7570\u306a\u308b\u533b\u5b66\u7684\u75c7\u72b6\u306b\u95a2\u9023\u3057\u307e\u3059\u3002\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u5185\u306b\u304a\u3044\u3066\u3001\u4f4e\u9178\u7d20\u306f\u901a\u5e38\u306e\u72b6\u614b\u3067\u3042\u308a\u3001\u816b\u760d\u5f62\u6210\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u8ee2\u5199\u5236\u5fa1\u306f\u3001\u7d30\u80de\u306e\u9806\u5fdc\u3092\u53ef\u80fd\u306b\u3059\u308b\u591a\u69d8\u306a\u4e00\u9023\u306e\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5927\u90e8\u5206\u304c\u5a92\u4ecb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f4e\u9178\u7d20\u306b\u5bfe\u3059\u308b\u7d30\u80de\u5fdc\u7b54\u306f\u3001\u4f4e\u9178\u7d20\u8a98\u5c0e\u56e0\u5b50\uff08HIF\uff09\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u4e00\u7fa4\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u307e\u3059\u3002HIF \u306f\u3001HIF-1\u03b1\u3001-2\u03b1\u3001\u304a\u3088\u3073-3\u03b1\u306e3\u3064\u306e\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u304b\u3089\u306a\u308a\u3001HIF-1\u304c\u304c\u3093\u9032\u884c\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059<sup>*17,18<\/sup>\u3002 \u4f4e\u9178\u7d20\u9818\u57df\u306e\u5f62\u6210\u306b\u5bc4\u4e0e\u3059\u308b\u3044\u304f\u3064\u304b\u306e\u8981\u56e0\u306f\u3001\u6162\u6027\u708e\u75c7\u7d44\u7e54\u306b\u95a2\u9023\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001\u904e\u5ea6\u306e\u708e\u75c7\u304a\u3088\u3073\u7dda\u7dad\u75c7\u306b\u3088\u308b\u5fae\u5c0f\u8840\u7ba1\u7cfb\u5185\u9178\u7d20\u6d41\u306e\u65ad\u7d76\u3001\u708e\u75c7\u304c\u5b58\u5728\u3059\u308b\u7d44\u7e54\u7d30\u80de\u304a\u3088\u3073\u4ee3\u8b1d\u7684\u306b\u6d3b\u6027\u306a\u6d78\u6f64\u6027\u514d\u75ab\u7d30\u80de\u306b\u3088\u308b\u9178\u7d20\u6d88\u8cbb\u91cf\u306e\u5897\u52a0\u306a\u3069\u304c\u542b\u307e\u308c\u307e\u3059<sup>*19<\/sup>\u3002<\/p>\n<p>HIF-1 \u306e\u6d3b\u6027\u306f\u3001\u4ee5\u4e0b\u306e\u89b3\u5bdf\u304b\u3089\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u708e\u75c7\u3068\u8840\u7ba1\u65b0\u751f\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u660e\u78ba\u306b\u3055\u308c\u3066\u3044\u307e\u3059\uff1a\u7d50\u8178\u76f4\u8178\u816b\u760d\u306b\u304a\u3044\u3066\u3001COX-2\u306fHIF-1\u306b\u3088\u308b\u4f4e\u9178\u7d20\u306b\u3088\u308a\u8ee2\u5199\u8a98\u5c0e\u3055\u308c\u3001\u816b\u760d\u751f\u5b58\u304a\u3088\u3073\u8840\u7ba1\u65b0\u751f\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002\u6025\u901f\u306b\u6210\u9577\u3059\u308b\u816b\u760d\u306b\u304a\u3044\u3066\u3001HIF-1 \u306f\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u62b5\u6297\u6027\u3001\u8840\u7ba1\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306a\u3069\u306e\u6570\u591a\u304f\u306e\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u306e\u6d3b\u6027\u5316\u306b\u95a2\u4e0e\u3057\u3001\u816b\u760d\u9032\u884c\u306e\u5f37\u529b\u306a\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3067\u3042\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50\uff08VEGF\uff09\u306a\u3069\u306e\u8840\u7ba1\u65b0\u751f\u306b\u4e0d\u53ef\u6b20\u306a\u6570\u591a\u304f\u306e\u907a\u4f1d\u5b50\u3092\u8a98\u5c0e\u3057\u307e\u3059<sup>*20<\/sup>\u3002 VEGF \u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306f\u3001\u8840\u7ba1\u900f\u904e\u6027\u3092\u5897\u52a0\u3055\u305b\u3001\u5185\u76ae\u7d30\u80de\u306e\u5897\u6b96\u3092\u8a98\u5c0e\u3057\u3001\u767d\u8840\u7403\u7c98\u7740\u80fd\u3092\u4ea2\u9032\u3057\u3001\u65b0\u751f\u8840\u7ba1\u306e\u8840\u7ba1\u5f84\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002VEGF \u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u540c\u65cf\u53d7\u5bb9\u4f53\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001PI3K\/ Akt\u3001Ras\/Raf-MEK\/ Erk\u3001eNOS\/NO\u306a\u3069\u306e\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u30fb\u751f\u5b58\u306b\u304a\u3051\u308b\u5168\u3066\u306e\u91cd\u8981\u56e0\u5b50\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002HIF-1\u306f\u3001VEGF \u8abf\u7bc0\u306e\u4ed6\u3001STAT3\u3001NF-\u03baB\u3001mTOR\u3001TGF-\u03b2\u306a\u3069\u306e\u3044\u304f\u3064\u304b\u306e\u3055\u307e\u3056\u307e\u306a\u8ee2\u5199\u56e0\u5b50\u306e\u95a2\u4e0e\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4ecb\u3057\u3066\u767a\u304c\u3093\u4fc3\u9032\u6d3b\u6027\u3092\u767a\u63ee\u3057\u307e\u3059\u3002HIF-1\u304c\u816b\u760d\u5f62\u6210\u306b\u95a2\u9023\u3059\u308b\u5236\u5fa1\u907a\u4f1d\u5b50\u306b\u4e2d\u5fc3\u7684\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u4eee\u5b9a\u306e\u3082\u3068\u3001HIF-1 \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3059\u308b\u7279\u5b9a\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u304a\u3088\u3073\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u306e\u958b\u767a\u306b\u591a\u304f\u306e\u529b\u304c\u6ce8\u304c\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u8ee2\u5199\u56e0\u5b50\u306e NF-\u03baB\u304a\u3088\u3073STAT3\u306f\u708e\u75c7\u53cd\u5fdc\u306e\u91cd\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3001\u304c\u3093\u306e\u767a\u751f\u3092\u4fc3\u9032\u3057\u3001HIF-1\u03b1\u3068\u9023\u643a\u3057\u3066\u816b\u760d\u9032\u884c\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u5927\u90e8\u5206\u306e\u65b0\u751f\u7d44\u7e54\u306e\u5fae\u5c0f\u74b0\u5883\u306b\u304a\u3051\u308b\u708e\u75c7\u6027\u6210\u5206\u306e\u5b58\u5728\u306f\u3001\u8840\u7ba1\u65b0\u751f\u3001\u30db\u30eb\u30e2\u30f3\u306b\u5bfe\u3059\u308b\u62b5\u6297\u6027\uff08\u30db\u30eb\u30e2\u30f3\u4f9d\u5b58\u6027\u816b\u760d\u306b\u304a\u3051\u308b\uff09\u304a\u3088\u3073\u6297\u816b\u760d\u514d\u75ab\u3092\u9ad8\u983b\u5ea6\u3067\u5897\u5f37\u3059\u308b\u7d50\u679c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u816b\u760d\u7d30\u80de\u306e\u751f\u5b58\u3001\u5897\u6b96\u3001\u305d\u3057\u3066\u6700\u7d42\u7684\u306a\u6d78\u6f64\u304a\u3088\u3073\u8ee2\u79fb\u306f\u3001\u5168\u3066\u816b\u760d\u90e8\u4f4d\u306b\u5b58\u5728\u3059\u308b\u708e\u75c7\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059<sup>*1,21<\/sup>\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-3005 aligncenter\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-46.jpg\" alt=\"HIF-1 alpha Mouse Monoclonal Antibody (H1alpha67)\" width=\"386\" height=\"577\" \/><a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/antibodies.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab11_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u8a73\u7d30\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/a><\/p>\n<h2>\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011\u816b\u760d\u95a2\u9023\u708e\u75c7\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u6297\u4f53\u30d9\u30fc\u30b9\u306e\u30c4\u30fc\u30eb<\/h2>\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u816b\u760d\u95a2\u9023\u708e\u75c7\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u6297\u4f53\u30d9\u30fc\u30b9\u306e\u30c4\u30fc\u30eb\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u5185\u5bb9\u3092\u542b\u3080PDF\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n<ol>\n<li>\u6162\u6027\u708e\u75c7\u304a\u3088\u3073\u304c\u3093<\/li>\n<li>\u304c\u3093\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u304a\u3088\u3073\u708e\u75c7<\/li>\n<li>\u816b\u760d\u5fae\u5c0f\u74b0\u5883<\/li>\n<li>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304a\u3088\u3073\u816b\u760d\u95a2\u9023\u708e\u75c7<\/li>\n<li>\u8981\u7d04\u304a\u3088\u3073\u4ed8\u9332<\/li>\n<\/ol>\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/antibody-inflammation-tumor-guidebook-form.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab11_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n<h2>\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011\u304c\u3093\u7814\u7a76\u3092\u4fc3\u9032\u3055\u305b\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u30cf\u30f3\u30c9\u30d6\u30c3\u30af<\/h2>\n<p>\u307e\u305f\u3001\u8907\u6570\u306e\u304c\u3093\u7814\u7a76\u9818\u57df\u306b\u304a\u3051\u308b\u8208\u5473\u6df1\u3044\u6700\u65b0\u306e\u767a\u898b\u3092\u53ef\u80fd\u306b\u3059\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3092\u7d39\u4ecb\u3059\u308b\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3082\u914d\u5e03\u3057\u3066\u3044\u307e\u3059\u3002\u4f75\u305b\u3066\u3054\u3089\u3093\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/cancer-genetic-tech-ebook-download.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab11_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/p>\n<p><span style=\"font-size: 8pt\">\u53c2\u8003\u6587\u732e\uff1a<\/span><br \/>\n<span style=\"font-size: 8pt\">1. Porta C, Larghi P, Rimoldi M et al. (2009) Cellular and molecular pathways linking inflammation and cancer. Immunobiology 214(9\u201310):761\u2013777.<\/span><br \/>\n<span style=\"font-size: 8pt\">2. Medzhitov R (2010) Inflammation 2010: new adventures of an old flame. Cell\u00a0140(6): 771\u2013776.<\/span><br \/>\n<span style=\"font-size: 8pt\">3. Scholz CC, Taylor CT (2013) Targeting the HIF pathway in inflammation and\u00a0immunity. Curr Opin Pharmacol 13(4):646\u2013653.<\/span><br \/>\n<span style=\"font-size: 8pt\">4. Kaplan MH (2013) STAT signaling in inflammation. JAKSTAT 2(1):e24198.<\/span><br \/>\n<span style=\"font-size: 8pt\">5. Hoesel B, Schmid JA (2013) The complexity of NF-kB signaling in\u00a0inflammation and cancer. Mol Cancer 12:86.<\/span><br \/>\n<span style=\"font-size: 8pt\">6. Grivennikov S, Karin M (2010) Dangerous liaisons: STAT3 and NF-kB\u00a0collaboration and crosstalk in cancer. Cytokine Growth Factor Rev 21(1):11\u201319.<\/span><br \/>\n<span style=\"font-size: 8pt\">7. Isra\u00ebl A (2010) The IKK complex, a central regulator of NF-\u03baB activation. Cold\u00a0Spring Harb Perspect Biol 2(3):a000158.<\/span><br \/>\n<span style=\"font-size: 8pt\">8. Yu H, Lee H, Herrmann A, et al. (2014) Revisiting STAT3 signalling in cancer:new and unexpected biological function. Nat Rev Cancer 14(11):736\u2013746.<\/span><br \/>\n<span style=\"font-size: 8pt\">9. Khiong K, Adhika OA, Chakravitha M (2010) Inflammation, immunity, and\u00a0cancer: the role of transcription factors NF-kB and STAT3. Maj Kedokt Indon\u00a060(8):369\u2013373.<\/span><br \/>\n<span style=\"font-size: 8pt\">10. Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a\u00a0leading role for STAT3. Nat Rev Cancer 9(11):798\u2013809.<\/span><br \/>\n<span style=\"font-size: 8pt\">11. Furgan M, Akinleye A, Mukhi N et al. (2013) STAT inhibitors for cancer therapy.\u00a0J Hematol Oncol. 6:90.<\/span><br \/>\n<span style=\"font-size: 8pt\">12. Miller SC, Huang R, Srilatha S et al. (2010) Identification of known drugs that\u00a0act as inhibitors of NF-\u03baB signaling and their mechanisms of action. Biochem\u00a0Pharmacol 79(9):1272\u20131280.<\/span><br \/>\n<span style=\"font-size: 8pt\">13. Li C, Chen S, Yue P et al. (2010). Proteasome inhibitor PS-341 (Bortezomib)\u00a0induces calpain-dependent IkBa degradation. J Biol Chem 285(21):16096\u201316104.<\/span><br \/>\n<span style=\"font-size: 8pt\">14. National Cancer Institute. FDA approval for Bortezomab. http:\/\/www.cancer.gov\/about-cancer\/treatment\/drugs\/fda-bortezomib. Accessed December 2, 2015.<\/span><br \/>\n<span style=\"font-size: 8pt\">15. de Lartigue J (2013) The inflammation link: NF-\u03bab remains a difficult but\u00a0intriguing target. OncLive http:\/\/www.onclive.com\/publications\/oncologylive\/2013\/june-2013\/the-inflammation-link-nf-b-remains-a-difficult-butintriguing-target\/2. Accessed April 2015.<\/span><br \/>\n<span style=\"font-size: 8pt\">16. Turkson J, Jove R (2000) STAT proteins: novel molecular targets for cancer\u00a0drug discovery. Oncogene 19(56):6613\u20136626.<\/span><br \/>\n<span style=\"font-size: 8pt\">17. Ke Q, Costa M (2006) Hyoxia-inducible factor-1 (HIF-1). Mol Pharmacol\u00a070(5):1469\u20131480.<\/span><br \/>\n<span style=\"font-size: 8pt\">18. Semenza GL (2014) Oxygen sensing, hypoxia-inducible factors, and disease\u00a0pathophysiology. Annu Rev Pathol. 9:47\u201371.<\/span><br \/>\n<span style=\"font-size: 8pt\">19. Vaupel P, Mayer A (2014) Hypoxia in tumors: pathogenesis-related\u00a0classification, characterization of hypoxia subtypes, and associated biological\u00a0and clinical implications. Adv Exp Med Biol 812:19\u201324.<\/span><br \/>\n<span style=\"font-size: 8pt\">20. Peng XH, Karna P, Cao Z et al. (2006) Cross-talk between epidermal growth\u00a0factor receptor and hypoxia-inducible factor-1alpha signal pathways increases\u00a0resistance to apoptosis by up-regulating survivin gene expression. J Biol\u00a0Chem 281(36):25903\u201325914.<\/span><br \/>\n<span style=\"font-size: 8pt\">21. Balamurugan K (2015) HIF-1 at the crossroads of hypoxia, inflammation and\u00a0cancer. Int J Cancer DOI:10.1002\/ijc.29519.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u76ee\u7684\u304a\u3088\u3073\u305d\u306e\u624b\u7d9a\u304d\u4e0a\u3067\u306e\u4f7f\u7528\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nuclear factor kappa-light-chain-enhancer of activated B cells\uff08NF-\u03baB\uff09\u3001hypoxia-inducible factor-1 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