{"id":9556,"date":"2021-06-02T09:54:49","date_gmt":"2021-06-02T00:54:49","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/?p=9556"},"modified":"2023-08-16T15:00:16","modified_gmt":"2023-08-16T06:00:16","slug":"proteinstructure_lcms_cmd_mkt","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/proteinstructure_lcms_cmd_mkt\/","title":{"rendered":"Native MS\u3068XL MS\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u89e3\u6790"},"content":{"rendered":"<h1>Native MS\u3068XL MS\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u89e3\u6790<\/h1>\n<p>2017\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u306e\u53d7\u8cde\u30c6\u30fc\u30de\u306f\u3001\u300c\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5\u306e\u958b\u767a\u300d\u3067\u3057\u305f\u3002\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5\u306f\u3001\u5f93\u6765\u306eX\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u3067\u5fc5\u8981\u3067\u3042\u308b\u7d50\u6676\u5316\u304c\u4e0d\u5fc5\u8981\u3067\u3042\u308a\u3001NMR\uff08\u6838\u78c1\u6c17\u5171\u9cf4\u6cd5\uff09\u3067\u306f\u96e3\u3057\u304b\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306a\u3069\u306e\u5de8\u5927\u5206\u5b50\u3092\u5206\u6790\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306a\u305f\u3081\u3001\u69cb\u9020\u751f\u7269\u5b66\u304c\u307e\u3059\u307e\u3059\u767a\u5c55\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2021\/06\/protein20structural20analysis201-1.png\" alt=\"\u6b21\u4e16\u4ee3\u69cb\u9020\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\" width=\"928\" height=\"452\" \/><\/p>\n<p>\u3053\u306e\u30da\u30fc\u30b8\u3067\u306f\u3001\u6b21\u4e16\u4ee3\u306e\u69cb\u9020\u751f\u7269\u5b66\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5206\u6790\u65b9\u6cd5\u3067\u3042\u308b\u300c\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u6cd5\u300d\u3084\u300cX\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u300d\u306e\u89e3\u6790\u7d50\u679c\u3092\u88dc\u5b8c\u3059\u308bNative MS\u3068XL MS\uff08\u30af\u30ed\u30b9\u30ea\u30f3\u30ad\u30f3\u30b0MS\uff09\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<h1>Native MS\u3068\u306f<\/h1>\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u8cea\u91cf\u3092\u3001\u9ad8\u3044\u7cbe\u5ea6\u3067\u89e3\u6790\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u65b9\u6cd5\u306e\u4e00\u3064\u3067\u3059\u3002<br \/>\n\u6c34\u6eb6\u6db2\u4e2d\u3067\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30cd\u30a4\u30c6\u30a3\u30d6\u69cb\u9020\u3092\u3068\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3068\u304d\u3001\u305d\u306e\u6975\u6027\u57fa\u306f\u6c34\u5206\u5b50\u9593\u306e\u6c34\u7d20\u7d50\u5408\u3084\u30a4\u30aa\u30f3\u7d50\u5408\u306b\u3088\u308a\u5b89\u5b9a\u5316\u3057\u3066\u304a\u308a\u3001\u82b3\u9999\u65cf\u5074\u9396\u306f\u6c34\u5206\u5b50\u9593\u306e\u30d5\u30a1\u30f3\u30c7\u30eb\u30ef\u30fc\u30eb\u30b9\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308a\u5b89\u5b9a\u5316\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u5f31\u3044\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u7d50\u5408\u3057\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u3092\u5909\u6027\u3055\u305b\u305a\uff08\u7d50\u5408\u3092\u7834\u58ca\u305b\u305a\u306b\uff09\u3001\u30cd\u30a4\u30c6\u30a3\u30d6\u69cb\u9020\u3092\u4fdd\u3063\u305f\u307e\u307e\u30a4\u30aa\u30f3\u5316\u3055\u305b\u3066\u89e3\u6790\u3059\u308b\u306e\u304c\u30cd\u30a4\u30c6\u30a3\u30d6MS\u306e\u7279\u9577\u3067\u3042\u308a\u3001\u89b3\u6e2c\u3055\u308c\u305f\u8cea\u91cf\u304b\u3089\u3001\u8907\u5408\u4f53\u7d44\u6210\u3001\u591a\u91cf\u4f53\u69cb\u9020\u3001\u30b9\u30c8\u30a4\u30ad\u30aa\u30e1\u30c8\u30ea\u30fc\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306e\u76f8\u4e92\u4f5c\u7528\u56e0\u5b50\u3092\u78ba\u8a8d\u3067\u304d\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2021\/06\/protein20structural20analysis202-1.png\" alt=\"\u30cd\u30a4\u30c6\u30a3\u30d6\u69cb\u9020\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5909\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9055\u3044\" width=\"782\" height=\"572\" \/><\/p>\n<p style=\"padding-left: 30px\">Native MS\u306e\u7279\u9577<\/p>\n<ul>\n<li>\u7cbe\u88fd\u5ea6\u304c\u4e0d\u5341\u5206\u306a\u30b5\u30f3\u30d7\u30eb\u3067\u3042\u3063\u3066\u3082\u89e3\u6790\u304c\u53ef\u80fd<\/li>\n<\/ul>\n<p style=\"padding-left: 30px\">\u89e3\u6790\u53ef\u80fd\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u60c5\u5831\u4f8b<\/p>\n<ul>\n<li>\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u54c1\u8cea<\/li>\n<li>\u8907\u5408\u4f53\u7d44\u6210<\/li>\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u7d44\u6210\u306e\u5747\u4e00\u6027<\/li>\n<li>\u30b9\u30c8\u30a4\u30ad\u30aa\u30e1\u30c8\u30ea\u30fc<\/li>\n<li>\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528<\/li>\n<\/ul>\n<h1>XL MS\uff08\u30af\u30ed\u30b9\u30ea\u30f3\u30ad\u30f3\u30b0MS\uff09\u3068\u306f<\/h1>\n<p>XL MS\uff08\u30af\u30ed\u30b9\u30ea\u30f3\u30ad\u30f3\u30b0MS\uff09\u3068\u306f\u3001\u300c\u4f4d\u7f6e\u304c\u56fa\u5b9a\u3055\u308c\u3066\u3044\u308b\u300d\u30bf\u30f3\u30d1\u30af\u8cea\u2010\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528\u3092\u5206\u6790\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u3084\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\uff08ATP\uff09\u7523\u751f\u306a\u3069\u306e\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u304b\u3092\u3088\u308a\u6df1\u304f\u7406\u89e3\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u30b5\u30f3\u30d7\u30eb\u3092\u8cea\u91cf\u5206\u6790\u7528\u306e\u5316\u5b66\u7684\u30af\u30ed\u30b9\u30ea\u30f3\u30ab\u30fc\u3067\u67b6\u6a4b\u3057\u3066\u3001\u5f97\u3089\u308c\u305f\u30af\u30ed\u30b9\u30ea\u30f3\u30af\u3055\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30c8\u30ea\u30d7\u30b7\u30f3\u6d88\u5316\u3057\u307e\u3059\u3002\u305d\u3053\u3067\u5f97\u3089\u308c\u305f\u30da\u30d7\u30c1\u30c9\u6df7\u5408\u6db2\u3092\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3068\u540c\u69d8\u306b\u3001\u6db2\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\uff08LC\uff09\u3067\u5206\u96e2\u3057\u3001\u8cea\u91cf\u5206\u6790\uff08MS\uff09\u306b\u3088\u308a\u540c\u5b9a\u3057\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/wp-content\/uploads\/sites\/13\/2021\/06\/protein20structural20analysis203-1.png\" alt=\"XL MS\uff08\u30af\u30ed\u30b9\u30ea\u30f3\u30ad\u30f3\u30b0MS\uff09\u306e\u539f\u7406\u30a4\u30e1\u30fc\u30b8\" width=\"512\" height=\"600\" \/><\/p>\n<p style=\"padding-left: 30px\">XL MS\uff08\u30af\u30ed\u30b9\u30ea\u30f3\u30ad\u30f3\u30b0MS\uff09\u306e\u7279\u9577<\/p>\n<ul>\n<li>\u76f8\u4e92\u4f5c\u7528\u56e0\u5b50\u306e\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u691c\u51fa\u304c\u53ef\u80fd<\/li>\n<\/ul>\n<p style=\"padding-left: 30px\"><strong>\u89e3\u6790\u53ef\u80fd\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u60c5\u5831\u4f8b<\/strong><\/p>\n<ul>\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528<\/li>\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020<\/li>\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u30c0\u30a4\u30ca\u30df\u30af\u30b9<\/li>\n<\/ul>\n<h1>\u307e\u3068\u3081<\/h1>\n<p>MS\u306f\u69cb\u9020\u751f\u7269\u5b66\u306b\u304a\u3051\u308b\u9ad8\u5206\u89e3\u80fd\u69cb\u9020\u89e3\u6790\u3092\u88dc\u5b8c\u3059\u308b\u6280\u8853\u3067\u3059\u3002<\/p>\n<p>\u4eca\u56de\u3054\u7d39\u4ecb\u3057\u305fNative MS\u306f\u3001\u7cbe\u88fd\u5ea6\u304c\u4e0d\u5341\u5206\u306a\u30b5\u30f3\u30d7\u30eb\u3067\u3042\u3063\u3066\u3082\u89e3\u6790\u53ef\u80fd\u3067\u3042\u308a\u3001\u30b5\u30f3\u30d7\u30eb\u306e\u72b6\u614b\u3092\u8fc5\u901f\u306b\u30e2\u30cb\u30bf\u30fc\u3067\u304d\u308b\u306e\u304c\u7279\u9577\u3067\u3059\u3002\u7cbe\u88fd\u5ea6\u30fb\u7cbe\u88fd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u54c1\u8cea\u3001\u8907\u5408\u4f53\u7d44\u6210\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u7d44\u6210\u306e\u5747\u4e00\u6027\u3001\u30b9\u30c8\u30a4\u30ad\u30aa\u30e1\u30c8\u30ea\u30fc\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306a\u3069\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306b\u5229\u7528\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u30af\u30ed\u30b9\u30ea\u30f3\u30ad\u30f3\u30b0MS\u306f\u8cea\u91cf\u5206\u6790\u3092\u7528\u3044\u3066\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u5316\u3055\u308c\u305f\u89e3\u6790\u624b\u6cd5\u3067\u3059\u3002\u76f8\u4e92\u4f5c\u7528\u56e0\u5b50\u306e\u60c5\u5831\u3092\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3068\u540c\u69d8\u306e\u5206\u6790\u624b\u6cd5\u3067\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528\u89e3\u6790\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u306e\u60c5\u5831\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u6280\u8853\u306b\u95a2\u5fc3\u306e\u3042\u308b\u304b\u305f\u3001\u307e\u305f\u65e2\u5b58\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u89e3\u6790\u6cd5\u306b\u8ab2\u984c\u3092\u304a\u6301\u3061\u306e\u65b9\u306f\u305c\u3072\u3053\u3061\u3089\u306e\u8cc7\u6599\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3066\u3001\u8a73\u3057\u3044\u6d3b\u7528\u4f8b\u3084\u89e3\u6790\u7d50\u679c\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/industrial\/032421-protein-structure-analysis-blog.html?ICID=cmd_icp_ms_r04_jp_proteinstructure_lcms_cmd_mkt_Social_LAB\" target=\"_blank\" rel=\"noopener\">PDF\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u7528\u306b\u306f\u4f7f\u7528\u3044\u305f\u3060\u3051\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u5f8c\u307e\u3059\u307e\u3059\u306e\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u308b\u69cb\u9020\u751f\u7269\u5b66\u306b\u304a\u3044\u3066\u3001\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u69cb\u9020\u89e3\u6790\u306b\u3054\u6d3b\u7528\u3044\u305f\u3060\u3051\u308bNative MS\u3068XL 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