{"id":996,"date":"2019-01-15T00:00:00","date_gmt":"2019-01-15T00:00:00","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cancer9\/"},"modified":"2026-06-29T17:46:14","modified_gmt":"2026-06-29T08:46:14","slug":"cancer9","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/learning-at-the-bench\/cancer9\/","title":{"rendered":"\u3010\u3044\u307e\u3055\u3089\u805e\u3051\u306a\u3044\u304c\u3093\u306e\u57fa\u790e 9\u3011Ras\/Raf\/MEK\/ERK (MAPK)\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u306f\uff1f"},"content":{"rendered":"\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-ad2f72ca wp-block-group-is-layout-flex\">\n<p>\u66f4\u65b0\u65e5 :<\/p>\n\n\n<div class=\"wp-block-post-date__modified-date wp-block-post-date\"><time datetime=\"2026-06-29T17:46:14+09:00\">6.29.2026<\/time><\/div><\/div>\n\n\n\n<div 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class=\"wp-block-heading\" id=\"h-\u6982\u8981-mapk\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\">\u6982\u8981\uff1aMAPK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-\u4e3b\u8981\u306amapk\u7d4c\u8def\u306e\u69cb\u7bc9\">\u4e3b\u8981\u306aMAPK\u7d4c\u8def\u306e\u69cb\u7bc9<\/h4>\n\n\n\n<p>\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08MAPK\uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u30ce\u30fc\u30c9\u306f\u3001\u9175\u6bcd\u304b\u3089\u30d2\u30c8\u306b\u3044\u305f\u308b\u771f\u6838\u751f\u7269\u306b\u304a\u3051\u308b\u5897\u6b96\u3001\u7d30\u80de\u5206\u88c2\u3001\u4ee3\u8b1d\u3001\u904b\u52d5\u6027\u3001\u81ea\u7136\u514d\u75ab\u3001\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u304a\u3088\u3073\u751f\u5b58\u6a5f\u80fd\u3092\u542b\u3080\u6975\u3081\u3066\u91cd\u8981\u306a\u7d30\u80de\u6a5f\u80fd\u3092\u5236\u5fa1\u3001\u5fae\u8abf\u6574\u3059\u308b\u305f\u3081\u306e\u7d30\u80de\u5916\u523a\u6fc0\u3092\u4f1d\u9054\u3057\u3001\u8abf\u7bc0\u3057\u307e\u3059\u3002MAPK\u7d4c\u8def\u306b\u306f\u30014\u7a2e\u985e\u306e\u4e3b\u8981\u306a\u5206\u5c90\u7d4c\u8def\u3001\u304a\u3088\u3073\u5341\u6570\u7a2e\u985e\u306eMAPK\u9175\u7d20\u306e\u5b58\u5728\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u5c11\u306a\u304f\u3068\u30827\u7a2e\u985e\u306e\u7570\u306a\u308b\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u985e\u3055\u308c\u307e\u3059\uff08\u56f34.1\uff09<sup>*1\u20133<\/sup>\u3002<br>ERK\u7d4c\u8def\u306f\u5178\u578b\u7684\u306b\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3059\u308b\u5897\u6b96\u56e0\u5b50\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u306e\u306b\u5bfe\u3057\u3001JNK\u3001p38\u3001\u304a\u3088\u3073ERK5\u7d4c\u8def\u306f\u4e3b\u306b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u5897\u6b96\u963b\u5bb3\u3001\u81ea\u7136\u514d\u75ab\u3001\u304a\u3088\u3073\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u95a2\u9023\u306e\u523a\u6fc0\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u305d\u308c\u305e\u308c\u306e\u53e4\u5178\u7684MAPK\u30ab\u30b9\u30b1\u30fc\u30c9\u306f\u3001\u4e8c\u91cd\u7279\u7570\u6027\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff08MAPK\u3001MAPK\u6d3b\u6027\u5316\u56e0\u5b50\uff08MEK\u3001MKK\u3001\u307e\u305f\u306fMAPK \u30ad\u30ca\u30fc\u30bc\uff09\u3001\u306a\u3089\u3073\u306bMEK\u6d3b\u6027\u5316\u56e0\u5b50\uff08MEK\u30ad\u30ca\u30fc\u30bc [MEKK]\u307e\u305f\u306fMAPK\u30ad\u30ca\u30fc\u30bc\u30ad\u30ca\u30fc\u30bc\uff09\u3092\u4ecb\u3059\u308b3\u7a2e\u985e\u306e\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u306b\u3088\u308b\u9023\u7d9a\u7684\u306a\u6d3b\u6027\u5316\u3092\u7279\u5fb4\u3068\u3057\u307e\u3059\u3002\u53e4\u5178\u7684MAPK\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u306f\u7d30\u80de\u819c\u306b\u304a\u3044\u3066\u958b\u59cb\u3055\u308c\u3001\u305d\u3053\u3067\u4f4e\u5206\u5b50\u91cfGTP\u30a2\u30fc\u30bc\u304a\u3088\u3073\u3055\u307e\u3056\u307e\u306a\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u306b\u3088\u3063\u3066MAPKKK\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3053\u3068\u3067\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002\u7d9a\u3044\u3066\u3001MAPKKK\u306b\u3088\u3063\u3066MAPKK\u304c\u76f4\u63a5\u30ea\u30f3\u9178\u5316\u3055\u308c\u3001\u6d3b\u6027\u5316\u3055\u308c\u305fMAPKK\u306fMAPK\u3092\u30ea\u30f3\u9178\u5316\u3057\u307e\u3059\u3002\u6d3b\u6027\u5316\u3055\u308c\u305fMAPK\u306f\u3001\u591a\u6570\u306e\u7d30\u80de\u8cea\u5185\u57fa\u8cea\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u30ea\u30f3\u9178\u5316\u3092\u884c\u3044\u3001\u6700\u7d42\u7684\u306b\u72b6\u6cc1\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u8abf\u7bc0\u3057\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u3001\u6b21\u3005\u306b\u591a\u69d8\u306a\u751f\u7269\u5b66\u7684\u53cd\u5fdc\u3001\u4f8b\u3048\u3070\u3001\u6d78\u900f\u5727\u30b7\u30e7\u30c3\u30af\u3001\u7d30\u80de\u5468\u671f\u9032\u884c\u3001\u3042\u308b\u3044\u306f\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u7523\u751f\u306e\u8a98\u5c0e\u304c\u751f\u3058\u307e\u3059&nbsp;<sup>*3,4<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-85.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-85.jpg\" alt=\"\u54fa\u4e73\u985e\u306eMAPK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\" class=\"wp-image-3090\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-23.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-23.jpg\" alt=\"Phospho-p44 MAPK\" class=\"wp-image-3091\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-mapk\u7d4c\u8def\u306e\u8907\u96d1\u6027\">MAPK\u7d4c\u8def\u306e\u8907\u96d1\u6027<\/h4>\n\n\n\n<p>MAPK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u306f\u3001\u30b7\u30f3\u30d7\u30eb\u306a\u76f4\u7dda\u7684\u3067\u4e00\u65b9\u5411\u6027\u306e\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u7fa4\u3068\u3057\u3066\u8868\u3055\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u7d4c\u8def\u306f\u975e\u5e38\u306b\u8907\u96d1\u3067\u3059\u3002MAPK\u30ab\u30b9\u30b1\u30fc\u30c9\u304a\u3088\u3073\u4ed6\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u4e2d\u306b\u306f\u3001\u7a0b\u5ea6\u306e\u5927\u304d\u3044\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001MAPK\u3001PI3K\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3001NF\u03baB\u3001\u304a\u3088\u3073JAK-STAT\u7d4c\u8def\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u306f\u5341\u5206\u306b\u7acb\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059<sup>*1,7<\/sup>\u3002<br>\u5f53\u793e\u304c\u63d0\u4f9b\u3057\u3066\u3044\u308bMAPK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u306b\u3064\u3044\u3066\u306e\u5b9f\u9a13\u30c4\u30fc\u30eb\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<br><a href=\"http:\/\/www.thermofisher.com\/jp\/ja\/home\/life-science\/cell-analysis\/signaling-pathways\/mitogen-activated-protein-kinase-mapk\/mitogen-activated-protein-kinase-mapk-overview.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">www.thermofisher.com\/mapk<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-86.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-86.jpg\" alt=\"MAPK\u7d4c\u8def\" class=\"wp-image-3092\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002<br>\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/antibody-cancer-guidebook-form.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-ras-raf-mek-erk\u7d4c\u8def\u306e\u8abf\u7bc0\">Ras\/Raf\/MEK\/ERK\u7d4c\u8def\u306e\u8abf\u7bc0<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-ras\u6d3b\u6027\u5316\">Ras\u6d3b\u6027\u5316<\/h4>\n\n\n\n<p>Ras\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001HRAS\u3001KRAS\u304a\u3088\u3073NRAS\u306e3\u7a2e\u985e\u306e\u30a2\u30a4\u30bd\u30bf\u30a4\u30d7\u304c\u767a\u898b\u3055\u308c\u3066\u304a\u308a\u3001\u7d30\u80de\u5468\u671f\u9032\u884c\u3001\u7d30\u80de\u79fb\u52d5\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3001\u8001\u5316\u3001\u304a\u3088\u3073\u4ed6\u306e\u751f\u4f53\u6a5f\u80fd\u306b\u95a2\u4e0e\u3059\u308b\u591a\u304f\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u95a2\u9023\u3059\u308b\u4f4e\u5206\u5b50\u91cf\u30b0\u30a2\u30ce\u30b7\u30f3\u30c8\u30ea\u30db\u30b9\u30d5\u30a1\u30bf\u30fc\u30bc\uff08GTP\u30a2\u30fc\u30bc\uff09\u3067\u3059\u3002Ras\u6d3b\u6027\u5316\u306e\u7c21\u5358\u306a\u8aac\u660e\u56f3\u3092\u56f34.3\u306b\u793a\u3057\u307e\u3059\u3002<sup>*8,9\u201310<\/sup> SRC\u306f\u6700\u521d\u306e\u304c\u3093\u907a\u4f1d\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001Ras\u306f\u6700\u521d\u306e\u30d2\u30c8\u304c\u3093\u907a\u4f1d\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001Ras\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306b\u304a\u3051\u308b\u5909\u7570\u306f\u30d2\u30c8\u816b\u760d\u306e\u7d0430\uff05\u306b\u304a\u3044\u3066\u691c\u51fa\u3055\u308c\u3066\u3044\u307e\u3059<sup>*11\u201313<\/sup>\u3002<br>\u591a\u6570\u306e\u7d30\u80de\u8868\u9762\u5206\u5b50\u306b\u3088\u308aRas\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001\u304c\u3093\u306b\u304a\u3051\u308b\u5f79\u5272\u304c\u660e\u78ba\u3068\u306a\u3063\u3066\u3044\u308bRas\u306e\u4e3b\u8981\u306a\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u7d4c\u8def\u3067\u3042\u308bRaf\/MEK\/ERK\u306a\u3069\u306eMAPK\u30ab\u30b9\u30b1\u30fc\u30c9\u304c\u6b21\u3005\u306b\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002PI3K\/Akt\/mTOR\u7d4c\u8def\u306f\u3001Ras\u4f9d\u5b58\u6027\u304a\u3088\u3073Ras\u975e\u4f9d\u5b58\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u3001\u5897\u6b96\u56e0\u5b50\u304a\u3088\u3073G\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53\u306eMAPK\u7d4c\u8def\u4e0b\u6d41\u3068\u53ce\u675f\u70b9\u3092\u5171\u6709\u3057\u307e\u3059<sup>*11<\/sup> \u3002\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30a4\u30d9\u30f3\u30c8\u306f\u3001Raf\u3001MEK\u3001\u304a\u3088\u3073ERK1\/2\uff08MAPK1\/3\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u3092\u4ecb\u3057\u3066\u5c0e\u5165\u3055\u308c\u308bRas\u306b\u3088\u3063\u3066\u958b\u59cb\u3055\u308c\u3001\u6838\u307e\u3067\u4f1d\u9054\u3055\u308c\u307e\u3059\u3002\u305d\u3053\u3067\u3001FOS\u3001MYC\u3001ELK\u3001\u304a\u3088\u3073 c-JUN\u306a\u3069\u306e\u8ee2\u5199\u56e0\u5b50\u304c\u5236\u5fa1\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u5897\u6b96\u304a\u3088\u3073\u751f\u5b58\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u8abf\u7bc0\u3055\u308c\u307e\u3059\u3002\uff08\u56f34.2\u304a\u3088\u3073\u56f34.4\uff09<sup>*6,11,14<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-87.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-87.jpg\" alt=\"Ras\u6d3b\u6027\u5316\u304a\u3088\u3073\u4e0d\u6d3b\u6027\u5316\" class=\"wp-image-3093\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-24.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-24.jpg\" alt=\"GTPase Activating Protein Mouse Monoclonal Antibody (B4F8)\u3000\" class=\"wp-image-3094\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002<br>\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/antibody-cancer-guidebook-form.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-\u304c\u3093\u306b\u304a\u3051\u308bras-raf-mek-erk\u7d4c\u8def\u306e\u5f79\u5272\">\u304c\u3093\u306b\u304a\u3051\u308bRas\/Raf\/MEK\/ERK\u7d4c\u8def\u306e\u5f79\u5272<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-ras\u6d3b\u6027\u5316\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\">Ras\u6d3b\u6027\u5316\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc<\/h4>\n\n\n\n<p>Ras\u5909\u7570\u306f\u3001\u8840\u6db2\u816b\u760d\u304a\u3088\u3073\u56fa\u5f62\u816b\u760d\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002NRAS\u306f\u3001\u8840\u6db2\u816b\u760d\u304a\u3088\u3073\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u304a\u3044\u3066\u6700\u3082\u9ad8\u983b\u5ea6\u3067\u5909\u7570\u304c\u898b\u3089\u308c\u308b\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3001KRAS\u306f\u3001\u7d50\u8178\u304c\u3093\u304a\u3088\u3073\u80ba\u304c\u3093\u306b\u304a\u3044\u3066\u9ad8\u983b\u5ea6\u3067\u5909\u7570\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u5b8c\u5168\u306b\u306f\u7db2\u7f85\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001Ras\u5909\u7570\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u30d2\u30c8\u304c\u3093\u306e\u30ea\u30b9\u30c8\u3092\u88684.1\u306b\u793a\u3057\u307e\u3059\u3002\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u7279\u7570\u7684\u306aRas\u5909\u7570\u306e\u983b\u5ea6\u304a\u3088\u3073\u4ed6\u306eMAPK\u7d4c\u8def\u306e\u907a\u4f1d\u5b50\u3092\u56f34.5\u306b\u793a\u3057\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306bRas\u963b\u5bb3\u5264\u306f\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u4e0b\u6d41\u306eRas\/Raf\/MEK\/ERK\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306b\u3064\u3044\u3066\u306f\u3044\u304f\u3064\u304b\u306e\u963b\u5bb3\u5264\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u3059&nbsp;<sup>*15\u201317&nbsp;<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-88.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-88.jpg\" alt=\"Ras\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u30ab\u30b9\u30b1\u30fc\u30c9\" class=\"wp-image-3095\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-25.jpg\" alt=\"\u9078\u629e\u3055\u308c\u305f\u30d2\u30c8\u304c\u3093\u306b\u304a\u3051\u308bRas\u5909\u7570\" class=\"wp-image-3096\" \/><\/figure>\n\n\n\n<p> \u5f53\u793e\u306f\u3001Ras\u304a\u3088\u3073\u4ed6\u306e\u304c\u3093\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u30b3\u30fc\u30c9\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5e45\u5e83\u3044\u6297\u4f53\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u5e83\u7bc4\u306a\u88fd\u54c1\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<a href=\"http:\/\/www.thermofisher.com\/ras?cid=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">www.thermofisher.com\/ras<\/a><br><strong>KRAS Rabbit Polyclonal Antibody<\/strong><br>\u88fd\u54c1\u756a\u53f7 PA5-27234<br>\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\uff1aWB\u3001IF\u3001ICC\u3001IHC (P)\u3001IP\u3001ELISA<br>Ras\u304c\u3093\u907a\u4f1d\u5b50\u30d5\u30a1\u30df\u30ea\u30fc\uff08\u305d\u306e\u30e1\u30f3\u30d0\u30fc\u306f\u54fa\u4e73\u985e\u8089\u816b\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u306e\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30df\u30f3\u30b0\u907a\u4f1d\u5b50\u306b\u95a2\u4fc2\uff09\u306f\u3001\u8180\u80f1\u304c\u3093\u3001\u6ffe\u80de\u6027\u7532\u72b6\u817a\u304c\u3093\u3001\u304a\u3088\u3073\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u306a\u3069\u306e\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002Ras\u5909\u7570\u306f\u3001\u30b3\u30b9\u30c6\u30ed\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u3067\u3082\u3042\u308a\u307e\u3059\u3002<br><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-89.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-89.jpg\" alt=\"KRAS Rabbit Polyclonal Antibody\" class=\"wp-image-3097\" \/><\/a><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-ras-raf-mek-erk\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u963b\u5bb3\u5264\">Ras\/Raf\/MEK\/ERK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u963b\u5bb3\u5264<\/h4>\n\n\n\n<p>Ras\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u4e0b\u6d41\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u304c\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u73fe\u5728\u30013\u7a2e\u985e\u306eRas\/Raf\/MEK\/ERK\u7d4c\u8def\u963b\u5bb3\u5264\u304c\u533b\u85ac\u54c1\u898f\u5236\u6a5f\u95a2\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u30022\u7a2e\u985e\u306fBRAF\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\u304c\u3001\u3053\u306eMAPKKK\u306f\u6d3b\u6027\u578bRas\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u76f4\u63a5\u7684\u306a\u57fa\u8cea\u3068\u3057\u3066\u50cd\u304d\u307e\u3059\u30023\u756a\u76ee\u306e\u963b\u5bb3\u5264\u306f\u3001BRAF\u306e\u4e0b\u6d41\u3067\u6a5f\u80fd\u3059\u308bMEK\u3092\u6a19\u7684\u3068\u3057\u307e\u3059\uff08\u56f34.6\u304a\u3088\u3073\u56f34.7\uff09\u3002<br>BRAF\u304c\u3093\u539f\u907a\u4f1d\u5b50\u306f\u3001ARAF\u3001BRAF\u3001\u304a\u3088\u3073CRAF\uff08RAF1\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u306e3\u7a2e\u985e\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u77e5\u3089\u308c\u308bRaf\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u3092\u30b3\u30fc\u30c9\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u9ad8\u5ea6\u306b\u4fdd\u5b58\u3055\u308c\u305f\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u306f\u3001MAPK [Ras\/Raf\/MEK\/ERK] \u7d4c\u8def\u306e\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3067\u3059\u3002Raf\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u4e0a\u6d41\u30ad\u30ca\u30fc\u30bcRas\u306e\u57fa\u8cea\u3001\u304a\u3088\u3073MEK\u306e\u76f4\u63a5\u7684\u306a\u6d3b\u6027\u5316\u56e0\u5b50\u3068\u3057\u3066\u50cd\u304d\u307e\u3059\u3002Raf\u306e\u904e\u5270\u6d3b\u6027\u5316\u306f\u5897\u6b96\u3001\u5206\u5316\u3001\u304a\u3088\u3073\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8abf\u7bc0\u4e0d\u5168\u306b\u3064\u306a\u304c\u308a\u3001\u767a\u304c\u3093\u6027Ras\u5909\u7570\u306f\u7a2e\u3005\u306e\u30d2\u30c8\u304c\u3093\u306b\u304a\u3044\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002BRAF\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306e\u5909\u7570\u306f\u3001\u60aa\u6027\u816b\u760d\u0336\u7279\u306b\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u306a\u3089\u3073\u306b\u7532\u72b6\u817a\u304c\u3093\u304a\u3088\u3073\u7d50\u8178\u304c\u3093\u306b\u304a\u3044\u3066\u6700\u3082\u9ad8\u983b\u5ea6\u306b\u8a8d\u3081\u3089\u308c\u307e\u3059\u304c\u3001ARAF\u3084CRAS\u306b\u3082\u767a\u304c\u3093\u6027\u5909\u7570\u306f\u751f\u3058\u307e\u3059&nbsp;<sup>*18<\/sup>\u3002<br>2002\u5e74\u3001\u4e00\u5869\u57fa\u306e\u30df\u30b9\u30bb\u30f3\u30b9\u7f6e\u63db\uff081,799\u4f4d\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306b\u304a\u3051\u308bT\u2192A\uff09\u306b\u3088\u3063\u3066\u3001BRAF\u306e\u30b3\u30c9\u30f3600\u306b\u304a\u3044\u3066\u30d0\u30ea\u30f3\u304c\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u306b\u7f6e\u63db\u3055\u308c\u308b\uff08V600E\uff09\u3053\u3068\u304c\u7814\u7a76\u8005\u306b\u3088\u308a\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u5168BRAF\u5909\u7570\u306e80\uff05\u306f\u9ad8\u3044\u767a\u304c\u3093\u6027\u3092\u793a\u3057\u307e\u3059\u3002BRAF\u5909\u7570\u306e\u6b8b\u308a\u306e20\uff05\u306f\u3001V600\u306e\u8fd1\u304f\u306b\u4f4d\u7f6e\u3059\u308b\u30a8\u30ad\u30bd\u30f3\u306b\u304a\u3044\u3066\u30df\u30b9\u30bb\u30f3\u30b9\u5909\u7570\u304c\u751f\u3058\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306eBRAF\u5909\u7570\u306f\u3001BRAF\u30ad\u30ca\u30fc\u30bc\u6d3b\u6027\u3092\u640d\u306a\u308f\u305b\u308b\u3001MAPK\u7d4c\u8def\u306e\u6301\u7d9a\u7684\u306a\u6d3b\u6027\u5316\u56e0\u5b50\u3067\u3059\uff08\u56f34.5\uff09<sup>*18,19<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-90.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-90.jpg\" alt=\"BRAF\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u56f3\u89e3\" class=\"wp-image-3098\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-braf\u963b\u5bb3\u5264\">BRAF\u963b\u5bb3\u5264<\/h4>\n\n\n\n<p>Ras\u304a\u3088\u3073BRAF\u306e\u5909\u7570\u306f\u3044\u305a\u308c\u3082\u5f37\u3044\u767a\u304c\u3093\u6027\u3092\u793a\u3057\u3001\u6b63\u5e38\u7d30\u80de\u306b\u304a\u3051\u308b\u60aa\u6027\u5f62\u8cea\u8ee2\u63db\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002Ras\u306e\u4f4e\u5206\u5b50\u963b\u5bb3\u5264\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u9032\u5c55\u304c\u307f\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u30012\u7a2e\u985e\u306eBRAF\u963b\u5bb3\u5264\u2015\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u304a\u3088\u3073\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u2015\u306b\u3064\u3044\u3066\u306f\u3001\u73fe\u5728\u3001\u7279\u5b9a\u306e\u578b\u306e\u30e1\u30e9\u30ce\u30fc\u30de\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4f7f\u7528\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\uff08\u56f34.6\uff09\u3002<br>\u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u306f2011\u5e74\u306b\u3001\u7d9a\u3044\u3066\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\u306f2013\u5e74\u306b\u3001V600E\u5909\u7570\u3092\u6709\u3059\u308b\u5207\u9664\u4e0d\u80fd\u307e\u305f\u306f\u8ee2\u79fb\u6027\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3044\u305a\u308c\u306eBRAF\u963b\u5bb3\u5264\u3082\u3001\u91ce\u751f\u578bBRAF\u3092\u6709\u3059\u308b\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u6cbb\u7642\u306b\u306f\u4f7f\u7528\u3055\u308c\u307e\u305b\u3093&nbsp;<sup>*20\u201323<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-91.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-91.jpg\" alt=\"BRAF\u963b\u5bb3\u5264\uff1a \u30d9\u30e0\u30e9\u30d5\u30a7\u30cb\u30d6\u304a\u3088\u3073\u30c0\u30d6\u30e9\u30d5\u30a7\u30cb\u30d6\" class=\"wp-image-3099\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>BRAF Rabbit Polyclonal Antibody<\/strong><br>\u88fd\u54c1\u756a\u53f7 PA5-14926<br>\u5f53\u793e\u306f\u3001BRAF\u304a\u3088\u3073\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u306eRaf\u30b5\u30d6\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4ed6\u306e\u30e1\u30f3\u30d0\u30fc\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5e45\u5e83\u3044\u6297\u4f53\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u88fd\u54c1\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<a href=\"http:\/\/www.thermofisher.com\/raf?cid=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">www.thermofisher.com\/raf<\/a><br>BRAF\u306f\u3001\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u306eRaf\u30b5\u30d6\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3042\u308a\u3001\u7d30\u80de\u819c\u304b\u3089\u6838\u307e\u3067\u306e\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002BRAF\u306e\u7570\u5e38\u306f\u3001\u80ba\u304c\u3093\u304a\u3088\u3073\u975e\u30db\u30b8\u30ad\u30f3\u30ea\u30f3\u30d1\u816b\uff08NHK\uff09\u306a\u3069\u306e\u5e83\u7bc4\u56f2\u306e\u304c\u3093\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-92.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-92.jpg\" alt=\"BRAF Rabbit Polyclonal Antibody\" class=\"wp-image-3100\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-mek\u963b\u5bb3\">MEK\u963b\u5bb3<\/h4>\n\n\n\n<p>MAPKKs\u3001MEK1\u304a\u3088\u3073MEK2\u306f\u3001ERK1\u304a\u3088\u3073ERK2\u4e0a\u306e\u30bb\u30ea\u30f3\u6b8b\u57fa\u304a\u3088\u3073\u30b9\u30ec\u30aa\u30cb\u30f3\u6b8b\u57fa\u3092\u9078\u629e\u7684\u306b\u30ea\u30f3\u9178\u5316\u3059\u308b\u30ad\u30ca\u30fc\u30bc\u3067\u3042\u308a\u3001Ras\/Raf\/MEK\/ERK\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u672b\u7aef\u30ad\u30ca\u30fc\u30bc\u3067\u3059\u3002\u3044\u3063\u305f\u3093\u6d3b\u6027\u5316\u3055\u308c\u308b\u3068\u3001ERK1\u304a\u3088\u3073ERK2\u306f\u3001\u7d30\u80de\u5468\u671f\u9032\u884c\u3001\u5206\u5316\u3001\u904b\u52d5\u6027\u3001\u4ee3\u8b1d\u3001\u304a\u3088\u3073\u8840\u7ba1\u65b0\u751f\u306a\u3069\u306e\u5e45\u5e83\u3044\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u8907\u6570\u306e\u57fa\u8cea\u2015\u6838\u304a\u3088\u3073\u7d30\u80de\u8cea\u306e\u30ea\u30f3\u9178\u5316\u3092\u89e6\u5a92\u3057\u307e\u3059\u3002MEK1\u304a\u3088\u3073MEK2\u30ad\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\u306b\u907a\u4f1d\u5b50\u5909\u7570\u304c\u751f\u3058\u308b\u3053\u3068\u306f\u7a00\u3067\u3059\u304c\u3001\u539f\u767a\u30d2\u30c8\u816b\u760d\u306e\u89e3\u6790\u306b\u304a\u3044\u3066MEK\u6d3b\u6027\u306e\u4e0a\u65b9\u5236\u5fa1\u304c\u983b\u7e41\u306b\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30c8\u30e9\u30e1\u30c1\u30cb\u30d6\u306f\u3001V600E\u307e\u305f\u306fV600K BRAF\u5909\u7570\u967d\u6027\u306e\u30e1\u30e9\u30ce\u30fc\u30de\u306b\u5bfe\u3059\u308b\u963b\u5bb3\u6d3b\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u308bMEK\u963b\u5bb3\u5264\u3067\u3059\uff08\u56f34.7\uff09<sup>*16,24\u201325<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-93.jpg\" alt=\"MEK1\u304a\u3088\u3073MEK2\u306e\u4f4e\u5206\u5b50\u306b\u3088\u308b\u963b\u5bb3\u306e\u63d0\u5531\u3055\u308c\u3066\u3044\u308b\u4f5c\u7528\u6a5f\u5e8f\" class=\"wp-image-3101\" \/><\/figure>\n\n\n\n<p>\u5f53\u793e\u306f\u3001MEK1\/2\u304a\u3088\u3073\u4e8c\u91cd\u7279\u7570\u6027\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4ed6\u306e\u30e1\u30f3\u30d0\u30fc\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5e45\u5e83\u3044\u6297\u4f53\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u5e83\u7bc4\u306a\u88fd\u54c1\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<a href=\"https:\/\/www.thermofisher.com\/search\/results?query=MEK&amp;persona=Catalog&amp;category=Primary+Antibodies&amp;CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">www.thermofisher.com\/mek<\/a><br><strong>MEK1 + MEK2 Mouse Monoclonal Antibody&nbsp;(J.653.9)<\/strong><br>\u88fd\u54c1\u756a\u53f7 MA5-15135<br>MEK1\/2\u306f\u3001\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\uff08MAP\uff09\u30ad\u30ca\u30fc\u30bc\u30ad\u30ca\u30fc\u30bc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u4e8c\u91cd\u7279\u7570\u6027\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3059\u3002MAP\u30ad\u30ca\u30fc\u30bc\u306f\u3001\u7d30\u80de\u5916\u30b7\u30b0\u30ca\u30eb\u5236\u5fa1\u30ad\u30ca\u30fc\u30bc\uff08ERK\uff09\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3001\u8907\u6570\u306e\u751f\u5316\u5b66\u7684\u30b7\u30b0\u30ca\u30eb\u306e\u7d71\u5408\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30ad\u30ca\u30fc\u30bc\u306f\u3001MAP\u30ad\u30ca\u30fc\u30bc\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u5fc5\u8981\u4e0d\u53ef\u6b20\u306a\u8981\u7d20\u3068\u3057\u3066\u3001\u5897\u6b96\u3001\u5206\u5316\u3001\u8ee2\u5199\u8abf\u7bc0\u3001\u304a\u3088\u3073\u767a\u751f\u306a\u3069\u306e\u591a\u304f\u306e\u7d30\u80de\u30d7\u30ed\u30bb\u30b9\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-94.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-94.jpg\" alt=\"MEK1 + MEK2 Mouse Monoclonal Antibody\" class=\"wp-image-3102\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-erk\u963b\u5bb3\">ERK\u963b\u5bb3<\/h4>\n\n\n\n<p>MAPK ERK1\u304a\u3088\u3073ERK 2\uff08MAPK3\u304a\u3088\u3073MAPK1\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u306f\u3001G0\/G1\u671f\u304b\u3089S\u671f\u307e\u3067\u306e\u7d30\u80de\u5468\u671f\u9032\u884c\u3092\u8a98\u5c0e\u3059\u308b\u30bb\u30ea\u30f3\u304a\u3088\u3073\u30b9\u30ec\u30aa\u30cb\u30f3\u30ad\u30ca\u30fc\u30bc\u3067\u3059\uff08\u56f34.8\uff09\u3002ERK1\u304a\u3088\u3073ERK2\uff08ERK1\/2\uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306f\u3001\u6b63\u306e\u7d30\u80de\u5468\u671f\u5236\u5fa1\u56e0\u5b50\u3067\u3042\u308b\u30b5\u30a4\u30af\u30ea\u30f3D1\u304a\u3088\u3073c-MYC\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001Tob1\u3001FOXO3a\u3001\u304a\u3088\u3073p21\u306a\u3069\u306e\u8ca0\u306e\u5236\u5fa1\u56e0\u5b50\u3092\u4e0b\u65b9\u5236\u5fa1\u3057\u307e\u3059\u3002ERK1\/2 MAP\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def\u306f\u3001\u7d30\u80de\u5206\u88c2\u5468\u671f\u306b\u304a\u3051\u308b\u76f4\u63a5\u7684\u306a\u5f79\u5272\u306e\u4ed6\u306b\u3001\u3055\u307e\u3056\u307e\u306a\u6a5f\u69cb\u306b\u3088\u3063\u3066\u7d30\u80de\u6210\u9577\u304a\u3088\u3073\u5897\u6b96\u3092\u5236\u5fa1\u3057\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001ERK1\/2\u306f\u3001\u7d30\u80de\u5468\u671f\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3092\u76f4\u63a5\u8abf\u7bc0\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u304a\u3088\u3073\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u5408\u6210\u3092\u4fc3\u9032\u3057\u3001TSC2\uff08\u30c4\u30d9\u30eb\u30f3\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u4ecb\u3057\u3066mTOR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4e0a\u65b9\u5236\u5fa1\u3057\u307e\u3059&nbsp;<sup>*26<\/sup>\u3002<br>\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u7d30\u80de\u682a\u306b\u304a\u3051\u308bERK1\/2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u4f4e\u5206\u5b50\u306b\u3088\u308b\u963b\u5bb3\u306f\u3001ERK1\/2\u306e\u5c01\u9396\u304c\u7d30\u80de\u5468\u671f\u505c\u6b62\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002\u30de\u30a6\u30b9\u7570\u7a2e\u79fb\u690d\u7247\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305fIn vivo\u85ac\u7406\u8a66\u9a13\u306b\u304a\u3044\u3066\u3082\u3001MEK1\/2\u4f4e\u5206\u5b50\u963b\u5bb3\u5264\u304c\u816b\u760d\u6210\u9577\u306e\u963b\u5bb3\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002ERK1\/2\u304cRas\/Raf\/MEK\/ERK\u7d4c\u8def\u306e\u8abf\u7bc0\u304a\u3088\u3073\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u7740\u5b9f\u306a\u524d\u81e8\u5e8a\u8a66\u9a13\u7d50\u679c\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3059\u308b\u3068\u3001ERK1\/2\u30ad\u30ca\u30fc\u30bc\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u306e\u958b\u767a\u3092\u8ffd\u6c42\u3059\u308b\u305f\u3081\u306e\u5f37\u3044\u7406\u8ad6\u7684\u6839\u62e0\u304c\u5b58\u5728\u3059\u308b\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-95.jpg\" alt=\"ERK1\u304a\u3088\u3073ERK2 (ERK1\/2) \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\" class=\"wp-image-3103\" \/><\/figure>\n\n\n\n<p>ERK\u963b\u5bb3\u5264\u306b\u3064\u3044\u3066\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u306b\u5bfe\u3059\u308b\u5358\u72ec\u304a\u3088\u3073\u4f75\u7528\u7642\u6cd5\u306b\u3064\u3044\u3066\u81e8\u5e8a\u8a66\u9a13\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059&nbsp;<sup>*27\u201329<\/sup>\u3002<br>\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\u306f\u3001\u533b\u85ac\u54c1\u898f\u5236\u6a5f\u95a2\u306b\u3088\u308b\u627f\u8a8d\u6e08\u307f\u306eERK1\/2\u30ad\u30ca\u30fc\u30bc\u306b\u5bfe\u3059\u308b\u6d3b\u6027\u3092\u793a\u3059RAF\u963b\u5bb3\u5264\u3067\u3001\u814e\u81d3\u3084\u809d\u81d3\u306e\u304c\u3093\u6cbb\u7642\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\u306f\u3001\u8907\u6570\u6a19\u7684\u306e\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u3067\u3042\u308b\u305f\u3081\u3001ERK1\/2\u6d3b\u6027\u3092\u4e0b\u65b9\u5236\u5fa1\u3059\u308b\u4ed6\u306b\u3001\u4ee5\u4e0b\u306e\u53d7\u5bb9\u4f53\u0336VEGFR\u3001PDGFR\u3001FLT3\u3001RET\u3001\u304a\u3088\u3073c-Kit\u3082\u6a19\u7684\u3068\u3057\u307e\u3059\uff08\u56f34.9\uff09<sup>*30<\/sup> \u3002\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\u306f\u6570\u7a2e\u306e\u7570\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3059\u308b\u305f\u3081\u3001\u3044\u305a\u308c\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3057\u305fERK1\/2\u963b\u5bb3\u304c\u3069\u306e\u7a0b\u5ea6\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\u306e\u6709\u52b9\u6027\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u304b\u306f\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u9078\u629e\u7684ERK\u963b\u5bb3\u5264\u306f\u958b\u767a\u52aa\u529b\u304c\u7d9a\u3051\u3089\u308c\u3066\u3044\u307e\u3059&nbsp;<sup>*31,32<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/2-26.jpg\" alt=\"Ras\/Raf\/MEK\/ERK\u304a\u3088\u3073\u4ed6\u306e\u7d4c\u8def\u306e\u963b\u5bb3\u5264\u3068\u3057\u3066\u5341\u5206\u306b\u7279 \u6027\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u308b\u8907\u6570\u6a19\u7684\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u5264\u3067\u3042\u308b\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\u306b \u3088\u3063\u3066\u6a19\u7684\u3068\u3055\u308c\u308b\u4e3b\u8981\u306a\u7d4c\u8def\u306e\u6a21\u5f0f\u56f3\" class=\"wp-image-3104\" \/><\/figure>\n\n\n\n<p>\u5f53\u793e\u306f\u3001ERK1\/2\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u5e45\u5e83\u3044\u6297\u4f53\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u5e83\u7bc4\u306a\u88fd\u54c1\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306b\u3064\u3044\u3066\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<a href=\"http:\/\/www.thermofisher.com\/erk?cid=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">www.thermofisher.com\/erk<\/a><br><strong>Phospho-p44 MAPK + p42 MAPK pThr185 + pTyr187 (15H10L7), ABfinity\u2122 Rabbit Monoclonal Antibody<\/strong><br>\u88fd\u54c1\u756a\u53f7 700012<br>ERK\uff08\u7d30\u80de\u5916\u30b7\u30b0\u30ca\u30eb\u5236\u5fa1\u30ad\u30ca\u30fc\u30bc\uff09\u306f\u3001MAPK\uff08\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u6d3b\u6027\u5316\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bc\uff09\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3001\u5bc6\u63a5\u306b\u95a2\u9023\u3059\u308b44 kDa\u304a\u3088\u307342 kDa\u306e2\u3064\u306e\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30ad\u30ca\u30fc\u30bc\u306f\u3001\u30bb\u30ea\u30f3\/\u30b9\u30ec\u30aa\u30cb\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\u3001\u30de\u30a4\u30c8\u30b8\u30a7\u30f3\u3001\u30db\u30eb\u30e2\u30f3\u3001\u5897\u6b96\u56e0\u5b50\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u304a\u3088\u3073\u751f\u7406\u6d3b\u6027\u30da\u30d7\u30c1\u30c9\u306a\u3069\u306e\u591a\u7a2e\u591a\u69d8\u306e\u523a\u6fc0\u3067\u7d30\u80de\u3092\u51e6\u7406\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3057\u307e\u3059\u3002\u7d30\u80de\u523a\u6fc0\u306f\u3001\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u30ab\u30b9\u30b1\u30fc\u30c9\u306e\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3057\u3001\u305d\u306e\u4e0b\u6d41\u3078\u306e\u5f71\u97ff\u306f\u7d30\u80de\u6210\u9577\u3001\u5206\u5316\u3001\u304a\u3088\u3073\u7d30\u80de\u9aa8\u683c\u306b\u95a2\u4fc2\u3057\u307e\u3059\u3002ERK1\u304a\u3088\u3073ERK2\u306f\u3001MEKs\uff08MAPK\u307e\u305f\u306fERK\u30ad\u30ca\u30fc\u30bc\uff09\u306b\u3088\u308a\u30b9\u30ec\u30aa\u30cb\u30f3\u6b8b\u57fa\u304a\u3088\u3073\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u4e0a\u306e\u6d3b\u6027\u5316\u30eb\u30fc\u30d7\u306eThr-Glu-Tyr\u30e2\u30c1\u30fc\u30d5\u5185\u306e\u30ea\u30f3\u9178\u5316\u306b\u3088\u3063\u3066\u5b8c\u5168\u306b\u6d3b\u6027\u5316\u3055\u308c\u3001\u305d\u308c\u306b\u3088\u308a\u3001ERK1\/2\u9175\u7d20\u6d3b\u6027\u304c\u5927\u5e45\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter\"><a href=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-96.jpg\"><img decoding=\"async\" src=\"https:\/\/www.thermofisher.com\/blog\/wp-content\/uploads\/sites\/13\/2019\/07\/1-96.jpg\" alt=\"Antibody to Phospho-p44 MAPK + p42 MAPK pThr202 + pTyr204\u3092\u4f7f \u7528\u3057\u305f\u4f8b\" class=\"wp-image-3105\" \/><\/a><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9-\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\">\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af<\/h3>\n\n\n\n<p>\u5f53\u8a18\u4e8b\u306f\u3001\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u63a2\u7d22\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u304b\u3089\u306e\u629c\u7c8b\u3067\u3059\u3002\u4e0b\u8a18\u306e\u5185\u5bb9\u3092\u542b\u3080PDF\u306f\u4e0b\u8a18\u304b\u3089\u7121\u6599\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u9802\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<p>\uff5e\u4e3b\u306a\u5185\u5bb9\uff5e<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u304c\u3093\u6982\u8ad6<\/li>\n\n\n\n<li>\u304c\u3093\u5897\u6b96\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054<\/li>\n\n\n\n<li>PI3K\/Akt\/mTOR\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/li>\n\n\n\n<li>Ras\/Raf\/MEK\/ERK(MAPK)\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/li>\n\n\n\n<li>Wnt\/\u03b2-\u30ab\u30c6\u30cb\u30f3 \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/li>\n\n\n\n<li>\u6297\u4f53\uff1a\u304c\u3093\u7814\u7a76\u306e\u305f\u3081\u306e\u5354\u529b\u306a\u30c4\u30fc\u30eb<\/li>\n<\/ol>\n\n\n\n<p><strong><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/antibody-cancer-guidebook-form.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30ac\u30a4\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9-\u304c\u3093\u7814\u7a76\u3092\u4fc3\u9032\u3055\u305b\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\">\u3010\u7121\u6599\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3011\u304c\u3093\u7814\u7a76\u3092\u4fc3\u9032\u3055\u305b\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u30cf\u30f3\u30c9\u30d6\u30c3\u30af<\/h3>\n\n\n\n<p>\u307e\u305f\u3001\u8907\u6570\u306e\u304c\u3093\u7814\u7a76\u9818\u57df\u306b\u304a\u3051\u308b\u8208\u5473\u6df1\u3044\u6700\u65b0\u306e\u767a\u898b\u3092\u53ef\u80fd\u306b\u3059\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u6280\u8853\u3092\u7d39\u4ecb\u3059\u308b\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3082\u914d\u5e03\u3057\u3066\u3044\u307e\u3059\u3002\u4f75\u305b\u3066\u3054\u3089\u3093\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><a class=\"btn btn-red\" href=\"https:\/\/www.thermofisher.com\/jp\/ja\/home\/global\/forms\/cancer-genetic-tech-ebook-download.html?CID=bid_pca_aup_r04_jp_cp0000_pjt0000_bid00000_0so_blg_op_awa_oc_s00_ab14_Social_LAB\" target=\"_blank\" rel=\"noopener\">\u7121\u6599\u30cf\u30f3\u30c9\u30d6\u30c3\u30af\u3092\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3059\u308b<\/a><\/p>\n\n\n\n<p><span style=\"font-size: 8pt\">\u53c2\u8003\u6587\u732e\uff1a<br>1. Roberts PJ, Der CJ (2007) Targeting the Raf-MEK-ERK-mitogen-activated protein kinase cascade for&nbsp;treatment of cancer. Oncogene 26(22):3291\u20133310.<br>2. Morrison DK (2012) MAP kinase pathways. Cold Spring Harb Perspect Biol 4(11). pii:a011254.<br>3. Cargnello M, Roux PP (2011) Activation and function of the MAPKs and their substrates, the MAPK-activated&nbsp;protein kinases. Microbiol Mol Biol Rev 75(1):50\u201383.<br>4. Schaeffer HJ, Weber MJ (1999) Mitogen-activated protein kinases: specific messages from ubiquitous&nbsp;messengers. Mol Cell Biol 19(4):2435\u20132444.<br>5. Keshet Y, Seger R (2010) The Map kinase signaling cascades: a system of hundreds of components&nbsp;regulates a diverse array of physiological functions. Methods Mol Biol 661:3\u201338.<br>6. Keyse SM (2000) Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.&nbsp;Curr Opin Cell Biol 12(2):186\u2013192.<br>7. Carracedo P, Pandolfi PP (2008) The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene&nbsp;27(41):5527\u20135541.<br>8. Kolch W (2000) Meaningful relationships: the regulation of the Ras\/Raf\/MEK\/ERK pathway by protein&nbsp;interactions. Biochem J 351 Pt 2:289\u2013305.<br>9. Santarpia L, Lippman SM, El-Naggar AK (2012) Targeting the MAPK-RAS-RAF signaling pathway in cancer&nbsp;therapy. Expert Opin Ther Targets 16(1):103\u2013119.<br>10. McArthur, GA (2014) The RAS\/RAF\/MEK\/ERK pathway in cancer: combination therapies and overcoming&nbsp;feedback. ASCO Daily News, June 2, 2014. p 38B.<br>11. Castellano E., Downward J (2011) Ras Interaction with PI3K: more than just another effector pathway.&nbsp;Genes Cancer 2(3):261\u2013274.<br>12. Martin GS (2004) The road to Src. Oncogene 23(48):7910\u20137917.<br>13. Goymer P (2006) (1979) First human oncogene: an important difference. Nature Milestones: Cancer&nbsp;website. http:\/\/www.nature.com\/milestones\/milecancer\/full\/milecancer17.html<br>14. Giltnane JM, Balko JM (2014) Rationale for targeting the Ras\/MAPK pathway in triple-negative breast&nbsp;cancer. Discov Med 17(95):275\u2013283.<br>15. National Cancer Institute (US) website (2013) MEK: a single drug target shows promise in multiple cancers.&nbsp;http:\/\/www.cancer.gov\/cancertopics\/research-updates\/2013\/MEK<br>16. Cheng Y, Zhang G, Li G (2013) Targeting MAPK pathway in melanoma therapy. Cancer Metastasis Rev&nbsp;32(3\u20134):567\u2013584.<br>17. Der C (2014) Are All RAS Proteins Created Equal in Cancer? National Cancer Institute website.&nbsp;http:\/\/www.cancer.gov\/researchandfunding\/priorities\/ras\/advance-research\/ras-blogs\/ras-proteins-createdequal<br>18. Davies H, Bignell GR, Cox C et al. (2002) Mutations of the BRAF gene in human cancer. Nature&nbsp;417(6892):949\u2013954.<br>19. Domingo E, Schwartz S Jr (2004) BRAF (v-raf murine sarcoma viral oncogene homolog B1). Atlas Genet&nbsp;Cytogenet Oncol Haematol 8(4):294\u2013298. http:\/\/atlasgeneticsoncology.org\/Genes\/BRAFID828.html<br>20. Flaherty KT (2012) Vemurafenib: a first in class serine-threonine protein kinase inhibitor for the treatment of&nbsp;malignant melanoma with activating BRAF mutations. AccessMedicine, McGraw-Hill. http:\/\/www.medscape.com\/viewarticle\/771620<br>21. Genentech (2014) Zelboraf (vemurafenib) prescribing information. http:\/\/www.gene.com\/download\/pdf\/zelboraf_prescribing.pdf<br>22. GlaxoSmithKline (2013) Tafinlar (dabrafenib) prescribing information. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2013\/202806s000lbl.pdf<br>23. Menzies AM, Long GV, Murali R (2012) Dabrafenib and its potential for the treatment of metastatic&nbsp;melanoma. Drug Des Devel Ther 6:391\u2013405.<br>24. GlaxoSmithKline (2014) Mekinist (trametinib) prescribing information. https:\/\/www.gsksource.com\/gskprm\/htdocs\/documents\/MEKINIST-PI-PIL.pdf<br>25. Hilal-Dandan R (2014) Trametinib: a first in class oral MEK inhibitor approved for treatment of metastaticmelanoma with BRAF V600 mutations. AccessMedicine, McGraw-Hill. http:\/\/www.medscape.com\/viewarticle\/822974<br>26. Fr\u00e9min C, Meloche S (2010) From basic research to clinical development of MEK1\/2 inhibitors for cancer&nbsp;therapy. J Hematol Oncol 3:8.<br>27. Davies BR, Logie A, McKay JS et al. (2007) AZD6244 (ARRY-142886), a potent inhibitor of mitogenactivated&nbsp;protein kinase\/extracellular signal-regulated kinase kinase 1\/2 kinases: mechanism of action in&nbsp;vivo, pharmacokinetic\/pharmacodynamic relationship, and potential for combination in preclinical models.&nbsp;Mol Cancer Ther 6(8):2209\u20132219.<br>28. Wong DJ, Robert L, Atefi MS et al. (2014) Antitumor activity of the ERK inhibitor SCH722984 against&nbsp;BRAF mutant, NRAS mutant and wild-type melanoma. Mol Cancer 13:194.<br>29. ClinicalTrials.gov website (2015) Selumetinib. https:\/\/clinicaltrials.gov\/ct2\/results?term=Selumetinib<br>30. Wilhelm S, Carter C Lynch M, et al. (2006) Discovery and development of sorafenib: a multikinase inhibitor&nbsp;for treating cancer. Nat Rev Drug Discov 5(10):835\u2013844.<br>31. Liu L, Cao Y, Chen C et al. (2006) Sorafenib blocks the RAF\/MEK\/ERK pathway, inhibits tumor&nbsp;angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC\/PRF\/5. Cancer Res&nbsp;66(24):11851\u201311858.<br>32. Morris EJ, Jha S, Restaino CR et al. (2013) Discovery of a novel ERK inhibitor with activity in models of&nbsp;acquired resistance to BRAF and MEK inhibitors. Cancer Discov 3(7):742\u2013750.<br><\/span><\/p>\n\n\n\n<p>&nbsp;<\/p>\n\n\n\n<p>\u7814\u7a76\u7528\u306b\u306e\u307f\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002\u8a3a\u65ad\u76ee\u7684\u304a\u3088\u3073\u305d\u306e\u624b\u7d9a\u304d\u4e0a\u3067\u306e\u4f7f\u7528\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u66f4\u65b0\u65e5 : 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