What is Gibco AGT dry media format?
Advanced Granulation Technology (AGT) is a well-established and scalable dry media format that combines complex dry and liquid media formulations into a dry, single-component, granulated medium. The technology also simplifies the handling and reconstitution of media and feeds in production while streamlining raw materials quality control. AGT Gibco cell culture products help users overcome challenges associated with dry media preparation, such as multiple hydration steps, pH adjustments, long hydration times, inconsistent batches, and clumping and floating of the medium. The technology was introduced in 2001, bringing speed and consistency to the transition to larger bioreactors through increased stability, scalability, cost, and ease of use.
The shelf life for AGT media is 24 months, as demonstrated by test data from stability studies. Additionally, shipment conditions were tested with the most complex, chemically defined formulations to support international shipment. The product’s form, fit, and function remained unaffected at shipment ranges 2 to 8°C and -10 to -20°C.
The AGT dry media format refers to the unique process used to manufacture highly dissolvable powder granules aimed to simplify the media preparation process and reduce the risk of human error. Additionally, the AGT format has both pH and osmolality pre-adjusted, removing the need for additional workflow steps to further accelerate preparation.
There were no inconsistencies when separate mixing protocols were used to test the hydration of AGT dry media in several mixing studies conducted with Thermo Scientific HyPerforma and imPULSE S.U.M.s. Studies support that the utilization of optimized operating settings for S.U.M. equipment results in further shortening AGT medium preparation time.
AGT reduces the hydration time significantly due to increased solubility and decreased dust generation. Additionally, pre-adjusted pH and osmolality further accelerate preparation. Together, these benefits led to users reporting more than 50% reductions in labor time and costs when using the AGT format. AGT is a one-part solution; growth-factor components can be added into the AGT formulation to reduce risk, cost, and time required for planning, procurement, preparation, and testing of additional raw materials.
What are the four key benefits of AGT?
- AGT dry media are simpler, less expensive, faster, and more consistent to prepare and use than traditional powders.
- The AGT dry media format is an attractive in-house platform for mammalian cell culture media applications.
- AGT dry media show lot-to-lot consistency at multiple lot and batch manufacturing scales.
- Users recognize the high quality of AGT dry media and their robust supply chains.
Learn more at thermofisher.com/agt.