{"id":4696,"date":"2025-07-17T01:16:10","date_gmt":"2025-07-17T01:16:10","guid":{"rendered":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/?p=4696"},"modified":"2025-07-17T01:16:14","modified_gmt":"2025-07-17T01:16:14","slug":"bioprocessing-single-use-equipment-lentiviral-vector-production-scalable","status":"publish","type":"post","link":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/","title":{"rendered":"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production"},"content":{"rendered":"\n
\"Scalable<\/figure>\n\n\n\n

In cell and gene therapy, the production of lentiviral vectors (LVVs) is a critical component. These vectors are essential for delivering genetic material into cells, a process fundamental to many therapeutic applications. However, scaling up the production of LVVs to meet clinical and commercial demands has been a significant challenge. This case study explores how an effective, scalable fed-batch bioreactor process helps to address these challenges, advancing LVV production.<\/p>\n\n\n\n

Scaling up LVV production<\/h2>\n\n\n\n

A research team at the National Research Council of Canada (NRC) encountered a major obstacle in their goal to produce LVVs at a scale required for clinical trials and commercial therapies. Traditional LVV production methods relied on adherent cell cultures, which were not easily scalable. The process required extensive plasticware and complex handling, creating a bottleneck in producing the necessary quantities of LVVs.<\/p>\n\n\n\n

The estimated annual vector requirement for treating just 5,000 pediatric cancer patients was around 3.5\u00d71012<\/sup> transduction units. This meant producing hundreds to thousands of liters of LVVs, a task that seemed nearly insurmountable with existing methods.<\/p>\n\n\n\n

Developing a scalable and efficient production process<\/h2>\n\n\n\n

The research team set out with a clear objective: to develop a scalable, efficient, and cost-effective process for producing high-titer LVVs using a cell suspension line. The solution needed to simplify the scale-up process, reduce production costs, and maintain high product quality.<\/p>\n\n\n\n

Scalable fed-batch bioreactor process<\/h2>\n\n\n\n

Key findings<\/h3>\n\n\n\n
    \n
  1. Enhanced titer and productivity:<\/strong> The fed-batch process demonstrated a significant increase in LVV-GFP titers compared to batch production. Specifically, the fed-batch regimens (FB R1 and FB R2) achieved up to a 2.6-fold increase in titer, highlighting the process’s efficiency in boosting viral vector yields.<\/li>\n\n\n\n
  2. Improved cell density and viability:<\/strong> The study reported higher viable cell concentrations in fed-batch cultures, leading to increased specific productivity. This improvement is attributed to controlled culture conditions in the bioreactor, such as pH and dissolved oxygen levels, which are more challenging to maintain in shake flask cultures.<\/li>\n\n\n\n
  3. Scalability and reproducibility:<\/strong> The process was successfully scaled up from a 4 L bioreactor to a 50 L bioreactor, maintaining consistent metabolite profiles and productivity levels. This scalability is crucial for industrial applications, ensuring that the process can be adapted to larger production volumes without compromising efficiency or product quality.<\/li>\n\n\n\n
  4. Cost-effectiveness:<\/strong> By optimizing feed additions and reducing the overall culture duration, the fed-batch process offers a cost-effective solution for LVV production. The study’s approach minimizes the use of expensive reagents and reduces the timeline for manufacturing, thereby lowering production costs.<\/li>\n<\/ol>\n\n\n\n

    Conclusion<\/h2>\n\n\n\n

    The development of a scalable fed-batch bioreactor process for high-titer LVV production marks an advancement in the field of biotechnology. This study offers a robust framework for producing LVVs at an industrial scale, helping to meet the growing demands of cell and gene therapies. The enhanced titer, improved cell viability, and cost-effectiveness of the process underscore its potential for widespread adoption in clinical research and commercial settings.<\/p>\n\n\n\n

    To read more about this case study, check out the full paper on BioProcessing Journal<\/a>.<\/p>\n\n\n\n

    We\u2019re thrilled that our 50 L DynaDrive Single-Use Bioreactor (S.U.B.) was used in this important study. Visit our website to learn more about the DynaDrive S.U.B<\/a>.<\/p>\n\n\n\n

    \u00a9 2025 Thermo Fisher Scientific Inc. All rights reserved. For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.<\/p>\n","protected":false},"excerpt":{"rendered":"

    In cell and gene therapy, the production of lentiviral vectors (LVVs) is a critical component. These vectors are essential for delivering genetic material into cells, a process fundamental to many therapeutic applications. However, scaling up the production of LVVs to meet clinical and commercial demands has been a significant challenge. This case study explores how<\/p>\n","protected":false},"author":537,"featured_media":4707,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[24],"tags":[1283,857,1254,1104,1280,1278,1281,1279,1282,1284],"division":[],"class_list":{"0":"post-4696","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-bioprocessing","8":"tag-bioreactor","9":"tag-cell-therapy","10":"tag-dynadrive","11":"tag-gene-therapy","12":"tag-lentivirus","13":"tag-lvv","14":"tag-national-research-council","15":"tag-nrc","16":"tag-nrc-canada","17":"tag-scalable-fed-batch-bioreactor-process","18":"entry"},"_selected_authors":[],"_selected_reviewers":[],"acf":[],"yoast_head":"\nScalable Fed-Batch Bioreactor Process for Lentiviral Vector Production - Life in the Lab<\/title>\n<meta name=\"description\" content=\"Explore high-titer lentiviral vector production with our fed-batch bioreactors. Help achieve excellent results in your therapeutic applications.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production\" \/>\n<meta property=\"og:description\" content=\"Explore high-titer lentiviral vector production with our fed-batch bioreactors. Help achieve excellent results in your therapeutic applications.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/\" \/>\n<meta property=\"og:site_name\" content=\"Life in the Lab\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/thermofisher\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-17T01:16:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-17T01:16:14+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Life in the Lab Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:site\" content=\"@thermofisher\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Life in the Lab Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/\"},\"author\":{\"name\":\"Life in the Lab Staff\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/#\\\/schema\\\/person\\\/94e6af6a12acc2bfb329e78f34c584db\"},\"headline\":\"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production\",\"datePublished\":\"2025-07-17T01:16:10+00:00\",\"dateModified\":\"2025-07-17T01:16:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/\"},\"wordCount\":552,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/wp-content\\\/uploads\\\/sites\\\/10\\\/2025\\\/06\\\/lentiviral-vector-prod-1.jpg\",\"keywords\":[\"bioreactor\",\"Cell Therapy\",\"DynaDrive\",\"gene therapy\",\"lentivirus\",\"LVV\",\"National Research Council\",\"NRC\",\"NRC Canada\",\"Scalable Fed-Batch Bioreactor Process\"],\"articleSection\":[\"Bioprocessing\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/\",\"url\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/\",\"name\":\"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production - Life in the Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/wp-content\\\/uploads\\\/sites\\\/10\\\/2025\\\/06\\\/lentiviral-vector-prod-1.jpg\",\"datePublished\":\"2025-07-17T01:16:10+00:00\",\"dateModified\":\"2025-07-17T01:16:14+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/#\\\/schema\\\/person\\\/94e6af6a12acc2bfb329e78f34c584db\"},\"description\":\"Explore high-titer lentiviral vector production with our fed-batch bioreactors. Help achieve excellent results in your therapeutic applications.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#primaryimage\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/wp-content\\\/uploads\\\/sites\\\/10\\\/2025\\\/06\\\/lentiviral-vector-prod-1.jpg\",\"contentUrl\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/wp-content\\\/uploads\\\/sites\\\/10\\\/2025\\\/06\\\/lentiviral-vector-prod-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"Case Study: Advancements in Lentiviral Vector Production with a Scalable Fed-Batch Bioreactor Process\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.thermofisher.com\\\/blog\\\/life-in-the-lab\\\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/#website\",\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/\",\"name\":\"Life in the Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/life-in-the-lab\\\/#\\\/schema\\\/person\\\/94e6af6a12acc2bfb329e78f34c584db\",\"name\":\"Life in the Lab Staff\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6e7a7b602b581c067a3cfb9b274d10e69983e39b7d5c0b59d7fae67a14823eaa?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6e7a7b602b581c067a3cfb9b274d10e69983e39b7d5c0b59d7fae67a14823eaa?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6e7a7b602b581c067a3cfb9b274d10e69983e39b7d5c0b59d7fae67a14823eaa?s=96&d=mm&r=g\",\"caption\":\"Life in the Lab Staff\"},\"url\":\"https:\\\/\\\/admin.acceleratingscience.com\\\/author\\\/lifeinthelabstaff\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production - Life in the Lab","description":"Explore high-titer lentiviral vector production with our fed-batch bioreactors. Help achieve excellent results in your therapeutic applications.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/","og_locale":"en_US","og_type":"article","og_title":"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production","og_description":"Explore high-titer lentiviral vector production with our fed-batch bioreactors. Help achieve excellent results in your therapeutic applications.","og_url":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/","og_site_name":"Life in the Lab","article_publisher":"https:\/\/www.facebook.com\/thermofisher","article_published_time":"2025-07-17T01:16:10+00:00","article_modified_time":"2025-07-17T01:16:14+00:00","og_image":[{"width":1200,"height":630,"url":"http:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1.jpg","type":"image\/jpeg"}],"author":"Life in the Lab Staff","twitter_card":"summary_large_image","twitter_creator":"@thermofisher","twitter_site":"@thermofisher","twitter_misc":{"Written by":"Life in the Lab Staff","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#article","isPartOf":{"@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/"},"author":{"name":"Life in the Lab Staff","@id":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/#\/schema\/person\/94e6af6a12acc2bfb329e78f34c584db"},"headline":"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production","datePublished":"2025-07-17T01:16:10+00:00","dateModified":"2025-07-17T01:16:14+00:00","mainEntityOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/"},"wordCount":552,"commentCount":0,"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1.jpg","keywords":["bioreactor","Cell Therapy","DynaDrive","gene therapy","lentivirus","LVV","National Research Council","NRC","NRC Canada","Scalable Fed-Batch Bioreactor Process"],"articleSection":["Bioprocessing"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/","url":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/","name":"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production - Life in the Lab","isPartOf":{"@id":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#primaryimage"},"image":{"@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#primaryimage"},"thumbnailUrl":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1.jpg","datePublished":"2025-07-17T01:16:10+00:00","dateModified":"2025-07-17T01:16:14+00:00","author":{"@id":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/#\/schema\/person\/94e6af6a12acc2bfb329e78f34c584db"},"description":"Explore high-titer lentiviral vector production with our fed-batch bioreactors. Help achieve excellent results in your therapeutic applications.","breadcrumb":{"@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#primaryimage","url":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1.jpg","contentUrl":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1.jpg","width":1200,"height":630,"caption":"Case Study: Advancements in Lentiviral Vector Production with a Scalable Fed-Batch Bioreactor Process"},{"@type":"BreadcrumbList","@id":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/bioprocessing-single-use-equipment-lentiviral-vector-production-scalable\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/"},{"@type":"ListItem","position":2,"name":"Scalable Fed-Batch Bioreactor Process for Lentiviral Vector Production"}]},{"@type":"WebSite","@id":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/#website","url":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/","name":"Life in the Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/#\/schema\/person\/94e6af6a12acc2bfb329e78f34c584db","name":"Life in the Lab Staff","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/6e7a7b602b581c067a3cfb9b274d10e69983e39b7d5c0b59d7fae67a14823eaa?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6e7a7b602b581c067a3cfb9b274d10e69983e39b7d5c0b59d7fae67a14823eaa?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6e7a7b602b581c067a3cfb9b274d10e69983e39b7d5c0b59d7fae67a14823eaa?s=96&d=mm&r=g","caption":"Life in the Lab Staff"},"url":"https:\/\/admin.acceleratingscience.com\/author\/lifeinthelabstaff\/"}]}},"taxonomy_info":{"category":[{"value":24,"label":"Bioprocessing"}],"post_tag":[{"value":1283,"label":"bioreactor"},{"value":857,"label":"Cell Therapy"},{"value":1254,"label":"DynaDrive"},{"value":1104,"label":"gene therapy"},{"value":1280,"label":"lentivirus"},{"value":1278,"label":"LVV"},{"value":1281,"label":"National Research Council"},{"value":1279,"label":"NRC"},{"value":1282,"label":"NRC Canada"},{"value":1284,"label":"Scalable Fed-Batch Bioreactor Process"}]},"featured_image_src_large":["https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1-1024x538.jpg",760,399,true],"author_info":{"display_name":"Life in the Lab Staff","author_link":"https:\/\/admin.acceleratingscience.com\/author\/lifeinthelabstaff\/"},"comment_info":1,"category_info":[{"term_id":24,"name":"Bioprocessing","slug":"bioprocessing","term_group":0,"term_taxonomy_id":24,"taxonomy":"category","description":"","parent":0,"count":77,"filter":"raw","meta":[],"cat_ID":24,"category_count":77,"category_description":"","cat_name":"Bioprocessing","category_nicename":"bioprocessing","category_parent":0}],"tag_info":[{"term_id":1283,"name":"bioreactor","slug":"bioreactor","term_group":0,"term_taxonomy_id":1283,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]},{"term_id":857,"name":"Cell Therapy","slug":"cell-therapy","term_group":0,"term_taxonomy_id":857,"taxonomy":"post_tag","description":"","parent":0,"count":8,"filter":"raw","meta":[]},{"term_id":1254,"name":"DynaDrive","slug":"dynadrive","term_group":0,"term_taxonomy_id":1254,"taxonomy":"post_tag","description":"","parent":0,"count":2,"filter":"raw","meta":[]},{"term_id":1104,"name":"gene therapy","slug":"gene-therapy","term_group":0,"term_taxonomy_id":1104,"taxonomy":"post_tag","description":"","parent":0,"count":2,"filter":"raw","meta":[]},{"term_id":1280,"name":"lentivirus","slug":"lentivirus","term_group":0,"term_taxonomy_id":1280,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]},{"term_id":1278,"name":"LVV","slug":"lvv","term_group":0,"term_taxonomy_id":1278,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]},{"term_id":1281,"name":"National Research Council","slug":"national-research-council","term_group":0,"term_taxonomy_id":1281,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]},{"term_id":1279,"name":"NRC","slug":"nrc","term_group":0,"term_taxonomy_id":1279,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]},{"term_id":1282,"name":"NRC Canada","slug":"nrc-canada","term_group":0,"term_taxonomy_id":1282,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]},{"term_id":1284,"name":"Scalable Fed-Batch Bioreactor Process","slug":"scalable-fed-batch-bioreactor-process","term_group":0,"term_taxonomy_id":1284,"taxonomy":"post_tag","description":"","parent":0,"count":1,"filter":"raw","meta":[]}],"jetpack-related-posts":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/admin.acceleratingscience.com\/life-in-the-lab\/wp-content\/uploads\/sites\/10\/2025\/06\/lentiviral-vector-prod-1.jpg","_links":{"self":[{"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/posts\/4696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/users\/537"}],"replies":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/comments?post=4696"}],"version-history":[{"count":0,"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/posts\/4696\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/media\/4707"}],"wp:attachment":[{"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/media?parent=4696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/categories?post=4696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/tags?post=4696"},{"taxonomy":"division","embeddable":true,"href":"https:\/\/www.thermofisher.com\/blog\/life-in-the-lab\/wp-json\/wp\/v2\/division?post=4696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}