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\nWhat is amorphous quartz?<\/h2>\n
Amorphous quartz, by its definition, is non-crystalline form of silica. The Greek root of the word, morph\u0113 means “form,” and a- means “lacking or without.” Called quartz glass or fused quartz, it is beneficial to a number of applications. Silica gel is an amorphous and porous form of silicon dioxide, consisting of an irregular tri-dimensional framework of alternating silicon and oxygen atoms with nanometer-scale voids and pores. The voids may contain water or some other liquids or may be filled by gas or vacuum. In the latter case, the material is properly called Silica xerogel.<\/p>\n
Silica xerogels<\/h2>\n
Silica xerogels are used as matrix materials for the extended and controlled release of different kinds of biologically active agents administered by various routes, as are therefore of interest to the pharmaceutical industry. Sol-gel derived silica xerogels are nontoxic and biocompatible in vivo. These materials cause no adverse tissue reactions and degrade in the body to silicic acid, i.e., Si(OH)4<\/sub>, which is eliminated through the kidneys.<\/p>\n The sol\u2013gel process is a method for producing solid materials from small molecules. The method is used for the fabrication of metal oxides, especially oxides of silicon (Si) and titanium (Ti). The process involves conversion of monomers into a colloidal solution (sol) that acts as a precursor for an integrated network (or gel) of either discrete particles or network polymers.<\/p>\n Highly porous silica xerogels are suitable for a variety of applications in the drug delivery systems. These materials exhibit unique characteristics that make them ideal nanocarriers to host, protect and transport drugs to the target site. It is feasible to incorporate targeting agents in the external surface of mesoporous silica xerogels to direct them to the unhealthy tissues aimed at increasing specificity and therefore diminishing undesired side effects.<\/p>\n Conventional metallic materials have a crystalline structure made up of single crystal grains of varying sizes arranged in a microstructure and are produced by the nucleation and growth of crystalline phases from the molten alloy during solidification. By contrast, certain oxide mixtures such as silicate glasses have such slower crystal nucleation and growth kinetics so that the liquid material can be undercooled far below the melting point of a quartz crystal. These oxide melts, known as bulk metallic glass (BMG), undergo a “glass transition” and freeze as vitreous solids.<\/p>\n BMGs have unusual properties. Typically much stronger than crystalline metal counterparts and even much tougher than ceramics, they have very high strain limits for Hookean elasticity. A new class of engineering materials, BMGs offer an opportunity to revolutionize the field of structural materials with combinations of strength, ductility, toughness, and processability outside the envelope achievable using current technology. BMGs are investigated for uses such as high efficiency transformers, passive ID tags, flow meters, pressure sensors, nanomaterial composites, and biomaterials such as bone replacements.<\/p>\n In various industrial applications, the amorphous content of a mixture of compounds significantly influences the properties. In pharmaceutical preparations the crystallinity is crucial for the bioavailability of an agent and therefore it is important to know the amorphous content of such mixtures. The amorphous content of bulk metallic glasses (BMG) is a measure for the physical properties of the compound and therefore for the quality of the product, comparable to cements and slags. One easy-to-use method for the determination of the amorphous content is X-ray diffraction (XRD)<\/a>. Scientists at Thermo Fisher Scientific used a benchtop X-ray diffractometer to evaluate the amorphous content in glass and quartz mixtures applying a standard-less deconvolution approach with precision down to approximately 25% amorphous content.<\/p>\nSilica xerogels in drug delivery<\/h2>\n
Bulk metallic glass<\/h2>\n
XRD of amorphous quartz<\/h2>\n
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