The S is for Simplicity

The new Ion S5 Systems

Adopting next-generation sequencing (NGS) in your lab is now simpler than ever. With the Ion S5™ and Ion S5™ XL next-generation sequencing systems, you get the simplest DNA-to-data* workflow for targeted sequencing with industry-leading speed and affordability. Get a quote ›


  • <15 minutes of sequencer hands-on time
  • <45 minutes of hands-on time for a DNA-to-data* targeted sequencing workflow

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  • Go from DNA to data* in as little as 24 hours
  • 2.5 to 4 hours per sequencing run

Small sample input

  • 10 ng of low-quality DNA or RNA needed to generate mutational or gene expression profiles


  • All you need is one sequencer - for cancer, inherited disease, infectious disease or reproductive genomics research.

*Automated data analysis to aligned BAM files.

“I need to be able to vary the number and type of samples I put onto a run in any given week, but not compromise on cost per sample. If we have a lower number of samples we can run them on the smaller throughput chips. The Ion S5 XL offers this flexibility.”

- Dr. Jean François Laes, Chief Technology Officer, OncoDNA, Belgium

Watch how the Ion S5 System works

Whether using the Ion S5 System for small-scale studies and lower weekly throughput or the Ion S5 XL System for faster analysis and higher weekly throughput, you can benefit from a simple and scalable sequencer that can match your unique project needs.

Watch the demo to see the simple load-and-go workflow of the Ion S5 System.

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Ion S5 Systems

Learn more about the Ion S5 Systems

View system specifications, download application notes, and much more.
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“We found the Ion S5 XL system reduced the run time from 4.5 hours to 2.5 hours, and halved the data analysis time. We ran different panels on the same chip and obtained 100% variant concordance with previously tested platforms. The different chips also allowed us to run both smaller panels and larger panels on the same instrument.”

- Dr. Dzifa Yawa Duose, Department of Translational Molecular Pathology,
The University of Texas MD Anderson Cancer Center, USA*

*Dr. Meenakshi Mehrotra and Dr. Dzifa Yawa Duose at the Molecular Testing Developmental Laboratory in the Department of Translational Molecular Pathology at The University of Texas MD Anderson Cancer Center, headed by Dr. Raja Luthra and Dr. Ignacio Wistuba, compared the Ion S5 XL system with the Ion PGM System and the Ion Proton System.