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Advanced 120 kV electron microscope built for performance, automation, and flexibility
The Thermo Scientific Talos 12 TEM combines optical stability, integrated detectors, advanced automation, connected software, and flexible configurations within a single platform. From routine TEM imaging to cryo-EM, tomography, STEM analysis, and elemental characterization, the Talos 12 TEM provides the performance and versatility needed to support multidisciplinary research today while enabling future workflow expansion.
Whether used in a research laboratory, shared facility, or core resource center, the Talos 12 TEM helps researchers generate high-quality results through a combination of optical stability, workflow automation, and digital control.
A versatile TEM and STEM platform
The Talos 12 TEM is designed as a flexible electron microscopy platform capable of supporting a wide range of imaging and analytical workflows. Researchers can configure the system for conventional transmission electron microscopy (TEM), scanning transmission electron microscopy (STEM), cryogenic imaging, tomography, and elemental analysis.
The adaptable design supports both biological and materials science applications while allowing laboratories to expand capabilities as research needs evolve.
Platform highlights
- TEM and STEM imaging modes
- Continuously adjustable accelerating voltage from 20–120 kV
- LaB6 thermionic electron source
- Optional tungsten filament configuration
- Cryogenic imaging support
- Tomography workflows
- Optional EDS elemental analysis
- Flexible detector configurations
Proven imaging performance and optical stability
High-quality imaging begins with a stable optical system. The Talos 12 TEM combines advanced electron optics with a robust mechanical design to deliver consistent imaging performance across a wide range of applications.
Constant-power C-TWIN objective lens
The Talos 12 TEM incorporates a constant-power objective lens designed to maintain stable optical conditions during imaging. This architecture minimizes thermal drift associated with lens changes and enables rapid transitions between magnifications.
Benefits include:
- Improved image stability
- Reduced drift during imaging
- Consistent optical performance
- Faster magnification changes
- Enhanced STEM imaging performance
The column for the Talos 12 TEM has an integrated constant-power C-TWIN objective lens for stable optical conditions during imaging.
Robust system stability
The redesigned enclosure helps reduce environmental influences that can affect microscope performance.
Features include:
- Improved thermal stability
- Reduced airflow variability
- Enhanced mechanical rigidity
- Stable operating conditions
- Oil-free vacuum operation
Talos 12 TEM technical performance specifications
| Accelerating voltage | 20–120 kV |
TEM line resolution |
0.204 nm |
TEM point resolution |
<0.37 nm |
STEM HAADF resolution |
<1.0 nm |
TEM magnification range |
25×–650k× (standard) |
Enhanced TEM magnification range |
35×–910k× |
STEM magnification range |
205×–140M× |
Maximum stage tilt |
±90° |
Integrated detectors for multiple research workflows
The Talos 12 TEM offers a comprehensive portfolio of integrated detectors designed to support a wide range of imaging and analytical workflows. From routine TEM imaging and low-dose cryo-EM to diffraction, STEM, and elemental analysis, the detector portfolio provides the flexibility to configure the system for diverse research applications while enabling streamlined operation and automated data acquisition.
Automation designed for every user
The Talos 12 TEM incorporates workflow automation to help users achieve consistent results regardless of their level of electron microscopy experience. The result is a simplified user experience that helps laboratories maximize instrument productivity.
Connected electron microscopy software solutions
The Talos 12 TEM combines microscope hardware with an integrated software ecosystem designed to accelerate acquisition, analysis, visualization, and collaboration.
Amira Software
Thermo Scientific Amira Software completes the imaging workflow by transforming microscopy data into quantitative insights through AI-powered visualization, segmentation, and analysis.
- Multi-modal data support
- AI-powered workflows
- 3D visualization
- Image segmentation
- Quantitative analysis
- Publication-ready outputs
Cryo-tomography image of proteoliposome architecture
Sample courtesy of Dr. Sara García-Linares and Dr. Alvaro Martínez-del-Pozo, Complutense University of Madrid, Spain, and Dr. Jaime Martín-Benito Romero CNB-CSIC, Spain.
Remote operation and collaboration
The Talos 12 TEM was designed for modern research environments where flexibility and collaboration are increasingly important. A high level of automation combined with complete digital control enables remote operation and efficient facility management.
Remote capabilities
- Remote microscope operation
- Remote troubleshooting
- Digital detector control
- Motorized aperture control
- Remote collaboration workflows
- Offline data review
Integrated software and remote collaboration tools help researchers acquire, review, and share data efficiently across teams and locations.
Designed for modern research facilities
The Talos 12 TEM combines advanced performance with a compact footprint that helps bring transmission electron microscopy to more laboratories.
Frequently asked questions
The Talos 12 TEM delivers a TEM line resolution of 0.204 nm, a TEM point resolution of less than 0.37 nm, and STEM HAADF resolution of less than 1.0 nm with a LaB₆ source. The microscope supports TEM magnifications from 25× to 650,000× (up to 910,000× in enhanced mode) and STEM magnifications up to 140 million×.
The constant-power C-TWIN objective lens maintains stable optical conditions during magnification changes, minimizing thermal drift while enabling rapid transitions between imaging conditions. This design helps deliver consistent image quality, improved stability, and more efficient workflows across a range of TEM and STEM applications.
The Talos 12 TEM combines a constant-power objective lens, robust enclosure, improved mechanical support, and digitally controlled optics to minimize thermal drift, airflow variability, and environmental influences that can affect image quality. Together, these features help deliver stable, reproducible imaging over extended acquisition sessions.
The Talos 12 TEM supports multiple integrated detector options, including the Ceta 16M CMOS Camera, Ceta-S, Ceta-F, and Ceta-D Cameras, the optional Falcon C Direct Electron Detector for cryo-EM, optional STEM detectors for BF, DF, and HAADF imaging, and optional EDS detectors for elemental analysis. This flexible detector portfolio enables researchers to configure the instrument for a wide range of applications.
The Ceta 16M CMOS Camera provides a large field of view, high dynamic range, and fast readout speeds for efficient sample navigation and high-quality image acquisition. Its integrated design supports automated workflows while delivering reliable performance across routine TEM imaging, pathology, and materials science applications.
The Talos 12 TEM combines automated alignments, guided workflows, motorized hardware, intuitive software, and application-specific workflows to reduce the learning curve for new microscopists. Routine imaging tasks are simplified while still providing advanced controls for experienced users.
The Talos 12 TEM includes automated microscope alignments, autofocus, automated acquisition workflows, batch imaging, motorized apertures, automated mapping, and unattended data collection. Together, these features improve productivity, reduce operator variability, and maximize instrument utilization.
The Talos 12 TEM supports unattended imaging through automated acquisition workflows, batch imaging capabilities, integrated detector control, optional long-duration dewar cooling, and workflow software such as Thermo Scientific Maps 3 Software, EPU Software, and Tomography 5 Software. These capabilities allow researchers to collect large datasets with minimal user intervention.
The Talos 12 TEM is built on Thermo Scientific software solutions, including Velox Software for microscope control and image acquisition, Maps 3 Software for automated large-area imaging and correlative microscopy, EPU Software for cryo-EM data collection, Tomography 5 Software for three-dimensional reconstruction, and Amira Software for AI-powered visualization and analysis.
Maps 3 Software enables automated large-area imaging, multi-scale navigation, unattended tile acquisition, correlative microscopy workflows, and integrated annotation. Researchers can quickly move from whole-sample overviews to high-resolution regions of interest while maintaining spatial context throughout the experiment.
Complete digital control of the microscope, including the electron gun, optics, stage, vacuum system, motorized apertures, and detectors, allows the Talos 12 TEM to support remote operation, remote troubleshooting, and collaborative imaging workflows. Offline viewing capabilities further enable distributed data review and project collaboration.
The Talos 12 TEM features a reduced footprint, simplified installation pathway, improved accessibility for sample loading and liquid nitrogen filling, LED status indicators, an oil-free vacuum system, and an optional long-duration dewar for extended imaging sessions. These design enhancements help laboratories maximize productivity while reducing infrastructure requirements.
The Talos 12 TEM is a modular platform that can be configured for conventional TEM imaging, STEM, cryogenic imaging, tomography, and elemental analysis. Multiple detector options, integrated software packages, and optional analytical capabilities allow laboratories to tailor the system to current applications while supporting future research directions.
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For Research Use Only. Not for use in diagnostic procedures.