Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Push the limits of complex large and small molecule analysis

Thermo Scientific Orbitrap Tribrid mass spectrometers combine versatility, selectivity, sensitivity and speed to extend the limits of detection, characterization, and quantitation. They're equipped with a linear ion tap, a Thermo Scientific Orbitrap mass analyzer, and quadrupole mass analyzers to uniquely enable multiple sophisticated modes of analysis and experimental flexibility, every day.

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Which Orbitrap Tribrid mass spectrometer is best suited for your lab?

Thermo Scientific Tribrid Orbitrap mass spectrometers enable high throughput screening and characterization of challenging samples including low-abundance peptides in complex matrices, determination of positional and posttranslational isoforms of intact proteins, resolution of isobaric metabolites, and protein structure characterization using chemical crosslinking. The tribrid mass spectrometers excel at a broad range of experimental applications from discovery to profiling and quantification, expediting scientific advancements on a single instrument.

Our Orbitrap Tribrid systems vary in terms of mass resolution and analysis modes. To find the system best suited to your laboratory’s specific needs, refer to the chart below to see how our Orbitrap Tribrid mass spectrometers compare.

The Orbitrap Tribrid mass spectrometers offer the following features:

  Orbitrap ID-X
Tribrid MS
Orbitrap Fusion
Tribrid MS
Orbitrap Fusion Lumos
Tribrid MS
Resolution (FWHM) @ m/z 200 7,500-500,000 15,000-500,000 7,500-500,000
Optional 1M Resolution No Yes
Mass accuracy (internal calibration) <3 ppm (<1 ppm)
Mass range m/z 50-2,000 m/z 50-6,000
EASY-IC Optional
Ion source/transfer tube OptaMax NG
Ion optics S-lens HCTT/EDIF
Scan rates (under defined conditions) 30 Hz (OT) 40 Hz (IT)
Polarity Switching One full cycle in 1.1 sec (positive and negative full scan with resolution of 30,000)
Minimum quadrupole mass filter 0.4 amu
Linear ion trap isolation 0.2 to 600 amu
CID/HCD Yes
MSn level Up to 10
ETD No EASY-ETD
UVPD No Yes
Synchronous precursor selection No Yes
Acquisition tool Yes; requires Thermo Scientific Orbitrap Tribrid Series X.X SP1QF1
Primary application Small molecule characterization and elucidation research for applications such as Metabolomics, Drug development Met ID, Extactables and Leachables, Industrial Environmental Health and more Multi-omics, TMT, intact/top-down proteomics Multi-omics, intact/top-down proteomics

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The Orbitrap ID-X Tribrid mass spectrometer in combination with Compound Discoverer software, AcquireX and mzLogic offers a compelling solution for the pharmaceutical industry. Learn how to address your metabolite ID challenges.

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