Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is well known for its role in glycolysis. GAPDH catalyzes the phosphorylation of glyceraldehyde-3-phosphate. In addition to this metabolic function, GAPDH is involved in many nonmetabolic cellular processes, including membrane fusion, transcription, RNA transport, DNA replication, and apoptosis.
GAPDH has been associated with various cancers and may also play a part in neurodegenerative diseases like Alzheimer’s and Huntington’s diseases. While it is expressed differentially from tissue to tissue, GAPDH is often stably and constitutively expressed, making it useful as a loading control.
Quality Invitrogen GAPDH antibodies are available for a variety of research needs. We also offer fluorescent and enzyme-conjugated versions for your added convenience.