PEGylation Reagents (PEG Labeling)

We offer activated linear and branched derivatives of polyethylene glycol (PEG) for pegylation and the PEG-modification of peptides and proteins via primary amines and sulfhydryl groups. These reagents are typically used to increase solubility, prolong stability, and reduce immunogenicity. Certain experimental systems and assay platforms depend on the ability to alter the mass, solubility or other properties of proteins, immunogens, reaction vessels and other materials.

Learn more about PEG labeling chemistries

Choose the right PEGylation reagent for your experiment

Reactive Chemistry/ Group Products Spacer Arm (Å) Pegylation application
Amine-reactive (NHS) MS(PEG)4 16.4Å Protein or surface, terminating with a methyl group
MS(PEG)8   30.8Å
MS(PEG)12 44.9Å
MS(PEG)24 88.2Å
TMS(PEG)12 77.5Å
Sulfhydryl-reactive (Maleimide) MM(PEG)12 51.9Å Protein or surface (branched), terminating with a methyl group
MM(PEG)24 95.3Å
Carboxy-PEG-amine (Amine or carboxylic acid) CA(PEG)4 18.1Å Protein or surface, terminating with a carboxylic acid or primary amine
CA(PEG)8 33.6Å
CA(PEG)12 46.8Å
CA(PEG)24 89.8Å
Carboxy-PEG-lipoamide (Bidentate thiol) CL(PEG)12 56Å Gold or metal surface, terminating with a methyl group
Carboxy-PEG-thiol (Carboxylic acid or thiol) CT(PEG)12 47.8Å Gold or metal surface, terminating with a carboxylic acid
Methyl-PEG-amine (Amine) MA(PEG)4 15.5Å Protein, oxidized carbohydrate or surface, terminating with a methyl group
MA(PEG)8 29.7Å
MA(PEG)12 43.9Å
MA(PEG)24 86.1Å
Methyl-PEG-lipoamide (Bidentate thiol) ML(PEG)4 23.6Å Gold or metal surface, terminating with a methyl group
Methyl-PEG-thiol (Thiol) MT(PEG)4 15.8Å Protein or inert material surface, terminating with a methyl group

Bulk or custom product request

Need larger quantities of our protein labeling, crosslinking or modification reagents? We offer bulk and custom fill sizes.

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