Antibodies for Stem Cell Research
Stem cells are unspecialized cells that are able to give rise to somatic and differentiated cells. Embryonic stem cells are pluripotent and can become virtually any tissue in the body; adult stem reside in the tissues, are multi-potent, and have more limited differentiation potential. Adult stem cells are able to self-renew, often after a long period of quiescence, and differentiate through symmetrical or asymmetrical divisions. The ability of stem cells to originate a wide variety of tissue types under the physiological or experimental conditions has made them a subject of great interest to researchers studying various types of diseases.
Induced pluripotent stem cells (iPSC) are somatic cells that have been genetically reprogrammed to an embryonic stem cell-like state.
Hematopoietic stem cells
Hematopoietic stem cells (HSC) are multi-potent cells that give rise to all of the cells in the blood, including B and T lymphocytes, natural killer cells, dendritic cells, monocytes, platelets, and erythrocytes. HSCs are very small and are non-adherent cells that are very difficult to purify or visualize by microscopy. In their quiescent state, HSCs can be found in the red bone marrow. Typically, HSC are identified by flow cytometry using 10-14 antibody panels targeting various cell surface antigens.
Mesenchymal stem cells
Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into many cell types including bone, fat, cartilage, muscle, and skin. MSCs were initially isolated from bone marrow samples, but more recently they have been found in many other types of tissue resulting in a heterogeneous and abundant population of cells with high differentiation potential. The possible use of MSC in treating various diseases such as cardiovascular disease and Crohn’s disease is a popular stem cell research topic.
Endothelial stem cells
Endothelial stem cells (ESC) are multipotent cells that reside in bone marrow and differentiate into endothelial cells (EC) which eventually become the endothelium that lines the walls of blood and lymphatic vessels. ESC have been found to play a critical role in cardiovascular diseases.
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Cell analysis resources
- Cell Imaging Reagent Guide & Protocol App
- Fluorescence and Flow Cytometry Tutorials
- Antibodies for Flow Cytometry
- Antibodies for Western Blotting
- The Molecular Probes Handbook
- Cell Analysis Protocols
- The Cell Culture Basics Handbook
- Cell Analysis Technical Resources
- Labeling Chemistry Selection Tool
- Newsletters & Journals
For Research Use Only. Not for use in diagnostic procedures.