Helping you get the most from your cell culture

Gibco BioProduction Services offer a full suite of media specific analyses globally. These services can provide powerful and insightful data that can help you to save time and money throughout your workflow. Shorten your time to market today by allowing our experienced team of analytical scientists to help you understand how to get the most from your cell culture. 

Our team of experienced scientists can help you optimize your unique cell culture environment by providing you crucial answers regarding the utilization profiles of amino acids, water-soluble vitamin components, metabolites, and trace elements over a period of time. Understanding this data will enable you to make informed decisions regarding your culture in order to obtain increased titers and/or productivity and cell growth. We offer a short turnaround time in addition to giving you the freedom to choose only those components that you need.

  • 10 business day turnaround for amino acids and water-soluble vitamins analyses
  • Analyses require only small sample sizes
  • Access to experienced consultation


Table 1. List of common cell culture components analyzed in spent media

Amino acid components

Water-soluble vitamin components

Advanced water-soluble vitamin components

Ammonia
L-Alanine
L-Arginine
L-Aspartic Acid
L-Cystine/L-Cysteine
Ethanolamine HCl
L-Glutamic Acid
L-Glutamine
Glycine
L-Histidine
L-Hydroxyproline
L-Isoleucine
L-Leucine
L-Lysine HCl
L-Methionine
L-Phenylalanine
L-Proline
L-Serine
L-Threonine
L-Tryptophan
L-Tyosine
L-Valine

Cyancobalamin (B-12)
Folic Acid
Niacinamide
Riboflavin
Thiamine HCl

Additional components

Phenol red
L-Tryptophan

Biotin
Cyancobalamin (B-12)
Folic Acid
Niacinamide
Pantothenate
Pyridoxal
Pyridoxine
Riboflavin
Thiamine HCl

Additional components

Phenol red
L-Tryptophan

Trace elements
Antimony
Arsenic
Barium
Beryllium
Boron
Cadmium
Calcium
Chromium
CobaltCopper
Gallium
Germanium
Gold
Hafnium
Iron
Lead
Lithium
Magnesium
Manganese
MolybdenumNickel
Palladium
Potassium
Rhenium
Ruthenium
Selenium
Silicon
Silver
Sodium
Strontium
Tantalum
Thallium
Tin
Titanium
Tungsten
Uranium
Vanadium
Zinc

In addition to the components and elements listed above, we also provide testing for Glucose/Lactate, Insulin, Cholesterol, Glutamax, IgG and Ortho-Phosphate in spent media. We also provide testing for Pluronic which requires fresh media samples.

Understanding the glycosylation profile of your antibody is one of the most important attributes when defining product quality. Our scientists can provide you with your unique Glycan Profile. If so desired, upon completion of your N-Glycan Profile Analysis, our scientists can then further assist you with how to modulate your glycosylation profile to match your specific targeted protein of interest. For more information on this process please visit our GlycanTune Total Feeds page.

  • Expedited process development
  • Improved pharmacokinetics of molecule
  • Analyses require only small sample sizes
  • Access to experienced consultation

Charge heterogeneity can change throughout the biopharmaceutical production process as well as during purification and storage. These changes can impact your molecule’s yield, structure, stability, and biological function. The Gibco BioProduction Analytical Team can help you to understand changes to your charge variants for your antibody at different points of time in your process by performing charge variant analysis. Maintaining consistency of balanced positive and negative charges of your molecule is essential for your molecule to perform optimally.

  • Helps to increase downstream yields
  • Provides important information regarding product quality
  • Helps to simplify downstream processes
  • Access to experienced consultation

Gibco BioProduction Services offers real time stability testing of your Gibco catalog and custom products in their packaged form, under certain conditions and specific time points as determined by you. We have performed testing for industry, government and academia, and possess the capability to perform a variety of quality tests dependent upon the stability indicating factors for your unique formulation. Understanding the stability of your Gibco custom formulation over time is important for setting expiration dates for materials in your bioproduction process.

  • As the manufacturer of your medium we have expert knowledge to apply to your formulation
  • Save time and money by eliminating the need to transfer samples from multiple lots