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表1. 使用赛默飞抗体进行神经退行性疾病研究的文献举例

疾病 基因 靶点 抗体货号 引用文献
AD BACE β- 分泌酶 (BACE-1) β- 分泌酶 (BACE-1) 多克隆抗 体
Walker KR, Kang EL, Whalen MJ et al. (2012) Depletion of GGA1 and GGA3 mediates
postinjury elevation of BACE1. J Neurosci 32(30):10423–37.
MAPT 微管相关蛋白tau Tau 单克隆抗体 (HT7)
Baglietto-Vargas D1, Kitazawa M2, Le EJ1, et al. (2014) Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis 62:407-15.
MAPT 微管相关蛋白tau Phospho-PHF-tau
pSer202+Thr205 单克隆抗体(AT8)
Jiang T,Yu JT,Zhu XC, et al.(2014) Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance. Neuropharmacology 85:121-30.
APP beta A4 淀粉样蛋白 beta- 淀粉样蛋白单克隆抗体(MABP2 1)
Steinhilb, M.L. et al. (2001) The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-secretase. J. Biol. Chem. 276, 4476-4484.
PD PARK2 Parkin Parkin 多克隆抗体
Chung KK,Zhang Y,Lim KL, et al.(2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nature medicine 7(10):1144-50.
HD DLG4 突触后密度蛋白95 PSD95 单克隆抗体(6G6-1C9)
Dau A,Gladding CM,Sepers MD et al.. (2014) Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice. Neurobiol Dis 62:533-42.

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