LEVERAGING CONSUMER TECHNOLOGY FOR SCIENTIFIC BREAKTHROUGHS

Ion Torrent™ semiconductor sequencing technology 
is as simple as it is fast.

利用Ion Torrent™技术在半导体芯片上直接将化学编码的信息 (A,C,G,T) 转换为数字信息 (0,1)。 此方法将简单的化学试剂与专利半导体技术相结合——就像沃森遇到摩尔。 该测序技术较其它技术更简单、快速、经济高效且扩展性更佳。 半导体已经改变了它所触及的每一个行业。 微处理器实现了台式计算,半导体技术推动了测序大众化,使任何实验室或临床都能够使用。



In nature, when a nucleotide is incorporated into a strand of DNA by a polymerase, a hydrogen ion is released as a byproduct.

 



If there are two identical bases on the DNA strand, the voltage will be double, and the chip will record two identical bases called. Because this is direct detection - no scanning, no cameras, no light - each nucleotide incorporation is recorded in seconds.

The semiconductor will inevitably transform the life sciences, just as it has transformed every other industry it has touched. By creating a direct connection between chemical and digital information, Ion Torrent™ will democratize research, providing a fast, simple, scalable sequencing solution that every lab can afford. Eventually, Ion Torrent Technology™ will also be able to provide diagnostics that are less expensive and more reliable, improving human health around the world.

 



Here’s how the technology is used to call a base: If a nucleotide, for example a C, is added to a DNA template and is then incorporated into a strand of DNA, a hydrogen ion will be released. The charge from that ion will change the pH of the solution, which can be detected by our proprietary ion sensor. Our sequencer - essentially the world's smallest solid-state pH meter - will call the base, going directly from chemical information to digital information.

 



The Ion Personal Genome Machine™ (PGM™) sequencer then sequentially floods the chip with one nucleotide after another. If the next nucleotide that floods the chip is not a match, no voltage change will be recorded and no base will be called.

 



If there are two identical bases on the DNA strand, the voltage will be double, and the chip will record two identical bases called. Because this is direct detection - no scanning, no cameras, no light - each nucleotide incorporation is recorded in seconds.

The semiconductor will inevitably transform the life sciences, just as it has transformed every other industry it has touched. By creating a direct connection between chemical and digital information, Ion Torrent™ will democratize research, providing a fast, simple, scalable sequencing solution that every lab can afford. Eventually, Ion Torrent Technology™ will also be able to provide diagnostics that are less expensive and more reliable, improving human health around the world.

 

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