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Atopic Dermatitis

Eczema is a complex inflammatory skin disease that presents clinically with a wide spectrum of symptoms.1 Eczema is a nonspecific term synonymous with dermatitis that is often used to refer to atopic dermatitis (AD), the most common type of eczema. Also known as allergic eczema or atopic eczema, it affects about 20 percent of children worldwide.2

AD usually starts in early childhood and is often the initial step in the atopic march'.3 Skin barrier dysfunction in eczema may lead to both food and aeroallergens entering through the impaired barrier, initiating immunological reactions and inflammation.1,3 Children with early-onset eczema are three times more likely to develop allergen sensitization by the age of two.3 And only up to 60% of children outgrow eczema when they reach adulthood.4 As the ‘march’ continues, children are at increased risk to develop allergic rhinitis or asthma later in life.3-6

Atopic dermatitis poses not only a significant burden on healthcare resources, but on the quality of life of your patients and their caregivers.1

AD

Children with AD have a worse quality of life than children with asthma, diabetes, or epilepsy8

School Absents

Eczema may result in school absenteeism, activity avoidance, and social isolation

Eczema

Children suffering from eczema, and their parents, can lose up to 2 hours of sleep per night10


The majority of infants and young children with eczema have an underlying allergy that contributes to disease severity.3,11

Specific IgE blood testing can help you identify these allergens and provide a personalized management plan >

Testing

Atopic dermatitis is a complex disease which often develops in connection with other conditions, like asthma and rhinitis. Guidelines advise that diagnosing AD starts with a physical examination. During that evaluation, it may help to employ an allergy-focused patient history.1

The findings of this allergy-focused patient history may also suggest that the next best step is to order specific IgE tests. Specific IgE measurements and skin prick testing (SPT) can help you rule in or rule out allergen sensitization, which may give you the ability to correctly diagnose and improve clinical management.11,12 Specific IgE blood testing can be performed irrespective of skin condition, whereas SPT may not be applicable due to the skin condition of an AD patient.

 

Learn more about how testing can help you diagnose allergies that may be contributing to your patient’s AD. >

Specific IgE testing improves accuracy of results vs. patient history alone14

References
  1. Pawankar R, Holgate S, Canonica G, at el. World Allergy Organization. White Book on Allergy (WAO). 2011. http://www.worldallergy.org/UserFiles/file/WAO-White-Book-on-Allergy_web.pdf. Accessed December 2017. 
  2. Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG. The prevalence of childhood atopic eczema in a general population. J Am Acad Dermatol. 1994;30(1):35-39.  
  3. Bantz SK, Zhu Z1, Zheng T. The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. J Clin Cell Immunol. 2014;5(2):202.  
  4. Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am. 2010;30:269-80. 
  5. Van Der Hulst AE, Klip H, Brand PL. Risk of developing asthma in young children with atopic eczema: a systematic review. J Allergy Clin Immunol. 2007;120(3):565-569.  
  6. Gustafsson D, Sjöberg O, Foucard Tet al. Development of allergies and asthma in infants and young children with atopic dermatitis--a prospective follow-up to 7 years of age. Allergy. 2000;55(3):240-245.  
  7. Beattie PE, Lewis-Jones MS.A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol. 2006;155(1):145-151
  8. Lewis-Jones S: Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract. 2006;60:984-992. 
  9. Reid P, Lewis-Jones MS. Sleep difficulties and their management in preschoolers with atopic eczema. Clin Exp Dermatol. 1995;20(1):38-41.  
  10. European Academy of Allergy and Clinical Immunology; Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis, 2015. http://www.eaaci.org/globalatlas/ENT_Atlas_web.pdf. Accessed January 2018. 
  11. Duran-Tauleria E, Vignati G, Guedan MJ, et al. The utility of specific immunoglobulin E measurements in primary care. Allergy. 2004;59 (Suppl 78):35-41.  
  12. Niggemann B, Nilsson M, Friedrichs F. Paediatric allergy diagnosis in primary care is improved by invitro allergen specific IgE testing. Pediatr Allergy Immunol. 2008;19:325-331.