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Urticaria (Hives)

Urticaria, commonly known as hives, is actually the name for a diverse group of diseases with many subtypes. While the symptoms of urticaria—raised patches of skin surrounded by a red area of skin (wheals) and/or swelling of the skin (angioedema)—may be easily identified, further classifying the disease can be challenging.1

Urticaria occurs when mast cells and basophils in the superficial dermis release histamine and other vasoactive substances.1 This can be either an immune- or nonimmune-mediated response.1

Urticaria Classification1

Acute (<6 weeks)

  • Lifetime prevalence: 8.0–20.0% of adults globally2,3

Chronic (>6 weeks)

  • Lifetime prevalence: 0.6-1.8% of adults globally2,3

  Immune-mediated mast cell activation   Nonimmune-mediated mast cell activation 

• Allergic reactions

• Autoimmune disorders

 

• Certain drugs

• Drug-induced cyclooxygenase inhibition

• Physical or emotional stimuli

Understanding the instigating factor involved in your patient’s urticaria is one piece of the puzzle. Discovering whether it is acute or chronic and if it happens alone or in association with other conditions is also important. These clues can be obtained through a physical exam, detailed patient history, and possibly even the results of specific IgE blood testing. The more information you have, the better you may be able to put together a comprehensive management plan to address your patient’s symptoms.1

Diagnosing Urticaria: Using All Your Tools

Diagnosing urticaria will rely on information from a variety of sources, including a physical exam, patient history, and possibly test results.

In the case of acute urticaria, your diagnostic efforts will largely be focused on identifying the possible triggers and allergies. You can acquire these insights through a thorough history, which should cover medications (e.g., non-steroidal analgesic drugs) and foods.4 Your patient history should also cover infections (e.g., acute viral upper respiratory infections), as they are one of the most frequent causes of acute urticaria. Taking blood samples, though, to determine antiviral antibodies is not recommended due to low specificity.4

If your allergy-focused patient history finds strong symptoms or a history of sensitizations, you may wish to follow the current guidelines and conduct diagnostic tests.1 Skin prick testing and specific IgE measurements can help you rule in or rule out allergen sensitization, which may give you the ability to correctly diagnose and improve clinical management.5,6

 

Learn more about how testing can help you diagnose allergic diseases >

Specific IgE testing improves accuracy of results vs. patient history alone7

Identifying the Triggers of Urticaria

The triggers for acute urticaria are well documented. It is possible for there to be no immune involvement in acute urticaria, as the symptoms may result from:1,7

  • Adverse medication reactions (ie, penicillin, sulfa, opiates, ACE inhibitors, NSAIDS)
  • Contact urticaria (ie, plant, animal)
  • Contact dermatitis (ie, poison ivy, nickel)
  • Exacerbation of physical urticaria (ie, dermographism, cholinergic urticaria)
  • Physical stimuli (ie, pressure, cold, heat, exercise, sun exposure)
  • Bacterial or viral infections (ie, Parvo virus B19, Epstein-Barr virus)

Common allergens that trigger an immune-mediated response include:


Allergy-related acute urticaria can be difficult to identify and manage as poly-sensitization is common. Up to 80% of patients are sensitized to more than one allergen.8 Furthermore, identifying the obvious allergen is not always enough. Allergic responses can develop to previously tolerated substances, and sensitization to seasonal and perennial allergens often add up to trigger symptoms.

Chronic urticaria is most often idiopathic. It is known that urticaria can be an immune-mediated response to certain chronic disorders.9 For example, chronic urticaria, is sometimes associated with connective tissue disorders, particularly systemic lupus erythematosus (SLE) or Sjögren’s Syndrome and thyroid disorders.10 Urticaria can also be a presenting symptom of an underlying disorder such as rheumatoid arthritis or celiac disease.10 Urticaria pigmentosa is a subvariant of cutaneous mastocytosis and mastocytosis should be evaluated.1,11

Learn more about mastocytosis>

Symptoms of Urticaria

The hallmarks of urticaria are itchy, red skin plaques that can occur alone or in groups on any part of the skin.1 Urticaria may also present as wheals that vary in size, change shape, and appear and fade repeatedly as the reaction runs its course.1 Patients with urticaria may also have swelling under the skin (angioedema), which results from mast cell and basophil activation deep in the dermis and subcutaneous tissues.1 This symptom may present on the lips, eyelids, and inside the throat.1

Patients with chronic urticaria may have periods of exacerbation and remission that may persist for years.1

Understanding the underlying triggers of these symptoms is critical.1 Especially when autoimmune diseases are at the root of the disease, shortening the time from initial presentation to autoimmune diagnosis could mean you and your patients are spared years of visits, ineffective treatments, and frustration.

Allergy Testing
References
  1. Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy. 2014;69(7):868-887. 
  2. Sanchez-Borges M, Asero R, Ansotegui IJ, et al. Diagnosis and treatment of urticaria and angioedema: a worldwide perspective. World Allergy Organ J. 2012;5(11):125-147.  
  3. Gaig P, Olona M, Muñoz Lejarazu D, et al. Epidemiology of urticaria in Spain. J Invest Allergol Clin Immunol. 2004;14(3):214-220.  
  4. Schoepke N, Doumoulakis G, Maurer M. Diagnosis of urticaria. Indian J Derm. 2013;58:211-218. 
  5. Duran-Tauleria E, Vignati G, Guedan MJ, et al. The utility of specific immunoglobulin E measurements in primary care. Allergy. 2004;59 (Suppl 78):35-41.  
  6. Niggemann B, Nilsson M, Friedrichs F. Paediatric allergy diagnosis in primary care is improved by invitro allergen specific IgE testing. Pediatr Allergy Immunol. 2008;19:325-331.  
  7. Deacock SJ. An approach to the patient with urticaria. Clinical and Experimental Immunology. 2008;153(2):151-161. doi:10.1111/j.1365-2249.2008.03693.x.
  8. Ciprandi G, Alesina R, Ariano R, et al. Characteristics of patients with allergic polysensitization: the POLISMAIL study. Eur Ann Allergy Clin Immunol. 2008;40(3):77-83.  
  9. Wai YC, Sussman GL. Evaluating chronic urticaria patients for allergies, infections, or autoimmune disorders. Clin Rev Allergy Immunol. 2002;23(2):185-193. 
  10. Confino-Cohen R, Chodick G, Shalev V, et al. Chronic urticaria and autoimmunity: associations found in a large population study. J Allergy Clin Immunol. 2012;129(5):1307-1313. 
  11. Valent P, Akin C, Metcalffe DD. Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts. Blood. 2017 Mar 16;129(11):1420-1427