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Tim, a 6-year-old with a presumed history of peanut allergy, goes to see his healthcare professional because he’s never been tested for allergic sensitization.
Tim’s healthcare professional conducts a full clinical history and physical examination and decides to test using whole peanut allergen sIgE with reflex to components.
These results, together with this patient's case history and symptoms, help confirm the diagnosis.
|ImmunoCAPTM results (kUA /l)|
|Ara h 1||Allergen Component||<0.1|
|Ara h 2||Allergen Component||<0.1|
|Ara h 3||Allergen Component||<0.1|
|Ara h 8||Allergen Component||2.79|
|Ara h 9||Allergen Component||<0.1|
Tim's sensitization to Ara h 8 is associated with localized reactions, like itching and tingling of the mouth and lips, but low risk of systemic reaction. Tim may actually be sensitized to birch pollen, which is cross-reactive and responds similar to Ara h 8. Tim shows no detectable sensitization to three nut storage proteins associated with severe reactions.1-4
Healthcare professional's management plan
Tim has had no further issues and is doing well.
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Asarnoj A, Nilsson C, Lidholm J, et al. Peanut component Ara h 8 sensitization and tolerance to peanut. J Allergy Clin Immunol. 2012;130(2):468-472
Peeters KA, Koppelman SJ, van Hoffen E, et al. Does skin prick test reactivity to purifed allergens correlate with clinical severity of peanut allergy? Clin Exp Allergy. 2007;37(1):108-115.
Asarnoj A, Movérare R, Östblom E, et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy. 2010;65(9):1189-1195.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, et al. EAACI Molecular Allergology User’s Guide. Pediatr Allergy Immunol. 2016;27 Suppl 23:1-250.