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Molecular Allergology

Offer Advanced Diagnostics by Quantifying Specific IgE Antibodies to Single, Pure Allergen Molecules

Molecular allergology allows your laboratory to measure sensitization to specific allergen components, which helps to identify, on a molecular level, which component proteins your clinician’s patients are sensitized to.

Molecular allergology helps to:1,2

risk of reaction

1. Assess the clinical risk for reaction

Sensitization to allergen components that are stable may elicit both systemic and local reactions, while sensitization to labile components is mainly associated with local reactions.3-8 This information can help a clinician narrow the patient’s diagnosis.

cross reaction

2. Explain symptoms due to cross-reactivity

Symptoms elicited by cross-reacting antibodies can be distinguished from those caused by genuine sensitization, which can help a clinician refine the patient’s treatment plan. In addition, in cases where only cross-reactive sensitization is identified, your laboratory may be able to assist with further testing to find the primary sensitizer.

Identifying allergens

3. Identify appropriate allergens for improved allergy immunotherapy outcomes

By helping clinicians match patients who have a genuine sensitization with an extract from the relevant source, your laboratory can play a role in improving patients’ treatment outcomes.

improve recommendations

4. Can help you decrease the need for provocation testing and improve recommendations for allergen avoidance

Detecting “low-risk” versus “high-risk” molecules could reduce the use of potentially harmful diagnostic procedures such as challenge tests.

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Is your laboratory ready to make ImmunoCAP Whole Allergen and Allergen Components available to your clinicians?

References
 
  1. Canonica GW, Ansotegui IJ, Pawankar R, et al. A WAO - ARIA - GA² LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J.  2013;6(1):17.
  2. Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, et al. EAACI Molecular Allergology User’s Guide Pediatr Allergy Immunol. 2016;27 Suppl 23:1-250.