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ImmunoCAP Rapid 

Delivering reliable results to help clinicians determine the course of care

ImmunoCAPTM Rapid* generates an IgE profile within minutes for adults and children with symptoms of wheezing and rhinitis. The procedure is simple, and results can be obtained within 20 minutes. In clinical studies, more than 95% of allergic patients studied were identified with ImmunoCAP Rapid test.1-3 In addition, there is a good correlation between positive ImmunoCAP Rapid test results and specific IgE results above 1 kUA/L measured with ImmunoCAP tests.

And it is available in Italy, Spain, Sweden, Switzerland, and the United Kingdom.

Principle of the test

ImmunoCAP Rapid is a lateral flow test. The blood sample is applied to the sample well and the separated plasma portion flows onto the test strips. IgE antibodies present in the sample, specific to any of the allergens in the test, bind to the relevant areas on the strip. 

The Developer Solution is then added to the Developer Solution well, releasing the dried gold-anti-IgE-conjugate. The conjugate forms a complex with the already bound IgE antibodies, visible as pink-red lines in the test windows.

The remaining conjugate continues to migrate, forming pink-red lines in the Control windows. The control line will appear regardless of whether the sample is positive or not, indicating that the test has performed correctly.

Assay Device

Allergens in the Assay Device

Cat (e1)

Cat
(e1)

Common silver birch

Common silver birch
(t3)

Timothy (g6)

Timothy
(g6)

Mugwort (w6)

Mugwort
(w6)

Cockroach

Cockroach
(i6)

Dog (e5)

Dog
(e5)

Olive - pollen (t9)

Olive - pollen
(t9)

Wall pellitory

Wall pellitory
(w21)

House dust mite

House dust mite
(d1)

Mold - A. alternate (m6)

Mold - A. alternate
(m6)

 

 

References
  1. Hedlin G, Moreno C, Petersson CJ, et al. Allergy Diagnosis in Children and Adults: Performance of a New Point-of-Care Device, ImmunoCAP Rapid. World Allergy Organ J. 2009;2:146. 
  2. Diaz-Vazquez C, et al. Accuracy of ImmunoCAP Rapid in the diagnosis of allergic sensitization in children between 1 and 14 years with recurrent wheezing: The IReNE study. Pediatr Allergy Immunol 2009;20:601–609.
  3. Eigenmann PA, et al. The ImmunoCAP Rapid Wheeze/Rhinitis Child test is useful in the initial allergy diagnosis of children with respiratory symptoms. Pediatr Allergy Immunol 2009;20:772–779.