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 ImmunoCAP Assays

Bring the most widely used specific IgE blood test to your laboratory1

Whether your laboratory is in a small local clinic, or large commercial facility, meeting the demand locally rather than as a send-out can help increase operational efficiency and shorten lead times for returning results to clinicians.

Documented in more than 4,000 peer-reviewed publications, ImmunoCAP assays run on Phadia™ Laboratory Systems, and are designed to deliver value to your laboratory through accurate and reproducible results, as they have for over 130 clinical trials and 60,000 patients**

**Internal data as of March 2017, Thermo Fisher Scientific 

ImmunoCAP assays include several categories, including:

  • Grass, weed and tree pollens
  • Microorganisms
  • Mites
  • Food allergens
  • Cats, dogs and other furry animals
  • Insects
  • Venoms
  • Allergen components
  • Atopy screens
  • Cellular markers for asthma and inflammation
  • Tryptase, a mast cell marker

ImmunoCAP Whole Allergen Tests – Fully Quantitative Results from Your Lab

With ImmunoCAP Whole Allergen assays, your laboratory can offer clinicians valuable information to help guide their initial diagnosis. Our whole allergen portfolio can reveal IgE sensitization for more than 600 single allergens and allergen mixes.

ImmunoCAP Whole Allergen results can help clinicians: 


Confirm a suspicion of allergic sensitization


Identify the offending



Rule out allergic



Observe sIgE levels of
antibodies over time



Determine patients that are appropriate for further testing

ImmunoCAP Allergen Components identify and quantify sensitivity to specific allergen proteins

Beyond whole allergens, a focus on individual allergen components allows clinicians to take the next step in identifying the possible source of their patients’ allergies. Assays using allergen components allow your laboratory to provide clinical value to clinicians who need to pinpoint specific proteins that may trigger allergic reactions, especially in the case of food allergies.

Characteristics of Protein Families

Cross reactivity


Profilin PR-10 LTP Storage Proteins
Sensitization is usually asymptomatic2
Labile to heat and digestion2 Stable to heat and digestion4 Stable to heat and digestion6,7
Abundent in nature2
Mainly local reactions2
Associated with local and systemic reactions5
Associated with systemic reactions4
Associated with birch pollen allergy (cross-reactivity)3
Associated with allergy to stone fruits (cross-reactivity)5
Indicates primary sensitization5

With assays utilizing allergen components, your laboratory can measure sensitization to these individual proteins, helping to pinpoint on an exact molecular level which component your clinician’s patients are sensitized to. 

Testing with allergen components can help clinicians:

  • Refine their diagnosis

  • Help determine which patients might pass a supervised oral food challenge
  • Differentiate sensitization due to cross-reactivity from primary sensitization

ImmunoCAP Allergen mixes Offer Qualitative Data on a Range of Allergens

ImmunoCAP Allergen mixes generally test for sensitization to 3 to 6 allergens, and include the most common categories:

Grass, trees and weed

Grass, trees, weed

Food allergy count







Animal Epithelium




When clinicians lack a complete patient history or have no clear suspicion of which allergen may be causing symptoms, they may request testing for a group of related allergens. For situations like these, offering ImmunoCAP Allergen mixes provides qualitative measurement of circulating IgE antibodies, which can be followed up with specific allergen testing to individual whole allergens or components.


  1. Johansson SGO. ImmunoCAP® Specific IgE test: an objective tool for research and routine allergy diagnosis. Expert Rev Mol Diagn. 2004;4:273-279.
  2. Katelaris CH: Food allergy and oral allergy or pollen-food syndrome. Curr Opin Allergy Clin Immunol. 2010, 10:246–251.20.
  3. Mittag D. Akkedaas J, Ballmer-Weber BK, et al. Ara h8, a bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy. J Allergy Clin Immunol. 2004;114(6):1410-1417.
  4. Sastre J: Molecular diagnosis in allergy. Clin Exp Allergy. 2010, 40:1442–1460.
  5. Lauer I, Dueringer N, Pokoj S, et al. The non-specic lipid transfer protein, Ara h 9, is an important allergen in peanut. Clin Exp. Allergy. 2009;39(9):1427-1437.
  6. Peeters KA, Koppelman SJ, van Hoffen E, et al. Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy? Clin Exp Allergy. 2007; 37(1): 108-115.
  7. Asarnoj, A., Glaumann, S. et al. (2013). IgE antibodies to allergen components [Leaflet]. Stockholm: Sachs’ Children and Youth Hospital Karolinska University Hospital.