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Human FGF-basic ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human FGF-basic in a sandwich ELISA format. Using the ELISA protocol, the recommended microplates, reagents and solutions, the components supplied in this kit are sufficient to assay human FGF-basic in approximately 200 ELISA plate wells.
This PeproTech ABTS ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant proteins in a sandwich ELISA format. This ABTS ELISA Development Kit contains enough material to assay the target cytokine in at least 200 ELISA plate wells. The ABTS ELISA Buffer Kit (Product # 900-K00), sold separately, is recommended to be used in conjunction with this ABTS ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.
FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : BFGF, FGF-2, FGF2, FGFB, HBGF-2
Gene ID : (Human) 2247
Gene symbol : FGF2
Protein Aliases : Basic fibroblast growth factor, basic fibroblast growth factor bFGF, bFGF, FGF-2, Fibroblast growth factor 2, fibroblast growth factor 2 (basic), HBGF-2, Heparin-binding growth factor 2, prostatropin
UniProt ID (Human) P09038
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