New Approach Methodologies (NAMs)

Understand. Implement. Innovate. Align with the latest NAMs guidance.

Thermo Fisher Scientific offers a wide suite of products that enable development and multi-omics analysis of innovative NAM systems. Explore resources for 3D cell culture, organoids, labware and analysis systems for NAMs.

Advancing your research with NAMs

In April 2025, the FDA and NIH released updated guidance on New Approach Methodologies (NAMs), signaling a clear move toward human-relevant, non-animal testing models in drug development. The aim is to make research more predictive, efficient, and better aligned with today’s safety standards. These updates also support the long-standing “3Rs” of research: Replace, Reduce, and Refine.

 

Thermo Fisher Scientific offers a broad portfolio of tools, media, and protocols to support your shift toward NAMs. Our technical teams and product solutions are designed to support the integration of new models into your workstreams, help generate high-quality data, and facilitate alignment with changing regulatory expectations.

 

This page will be updated regularly as new guidance, technologies, and resources become available.

Resources

5 Steps to Creating 3D Cell Culture Models

Learn the essential steps to develop 3D cell culture models, including sourcing cells, choosing support materials, selecting media, monitoring growth, and characterizing your models.

Fluorescent microscopic image of a cell culture, showing blue and green cellular 3D structures.

3D Cell Culture Protocols and Organoid Culture Methods

Explore comprehensive protocols for generating spheroids and 3D cell cultures using low attachment plates and matrix systems. Learn how to utilize Invitrogen and Gibco products for effective 3D cell culture and analysis.

Fluorescent microscopic image of organoid structures, showing detailed cellular formations with bright blue highlights

3D Cell Culture Applications and Resources

Discover a variety of resources for 3D cell culture, including application notes, scientific posters, and eLearning courses. Enhance your research with advanced techniques for creating and analyzing 3D cell models, organoids, and spheroids.

Microscopic image of an organoid stained for 3D analysis, showing detailed cellular structures with vibrant red and purple colors

3D Cell Culture Product Selection Guide for Organoids and Spheroids

This selection guide is intended to give researchers a helpful starting point to facilitate the transition from 2D monolayer cultures to 3D cell models.

Neural organoid cultured on a Thermo Scientific Nunclon Sphera 6-Well Plate, which allows cells to grow with virtually no attachment.

Cell Culture, Tissue Culture, and Transfection Solutions

Discover comprehensive cell culture solutions, including media, reagents, plastics, and equipment, many of which are built or qualified to support the shift to human-relevant models, to advance your research and streamline your workflows.

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