Large Molecule Bioanalysis DMPK

Sensitive, selective, peptide and protein bioanalysis

The rise in large molecule biotherapeutics, which are more complex and challenging to analyze, has increased the demand for peptide bioanalysis using mass spectrometry. High resolution accurate mass orbitrap technology provides ultimate selectivity for the analysis of biotheraputic peptide based products. A unique combination of innovative technologies provides a workflow with superior quantitative accuracy and sensitivity.

Popular large molecule bioanalysis products

Featured large molecule bioanalysis categories

The InsuQuant Mass Spectrometric Kit is an affinity purification clean-up kit used to extract endogenous insulin and exogenous insulin analogues from plasma for further analysis in LC-MS. Porous microcolumns are coated with an insulin-specific affinity ligand, targeted to capture insulin and its exogenous analogues. Through repeated pipetting of the matrix, the analyte of interest is put into contact with the antibody-coated surface on the microcolumn.

Obtain high quality analytical results from protein digests by using Thermo Scientific SMART Digest Kits. A significant advance in sample preparation for biopharmaceutical and protein research, the kits provide fast and simple protein digestion with high reproducibility, high sensitivity, and high levels of data quality in a format that is compatible with automation. SMART Digest kits result in less autolysis than from traditional in-solution trypsin digestion, and usually results in no unspecific cleavage. The digestion enzyme can be use in excess so there’s no need for careful measurement. This means vastly accelerated proteolysis and no enzyme to substrate adjustment.

Thermo Scientific Vanquish Flex UHPLC system is a new biocompatible chromatography system with state-of-the-art quaternary solvent blending. The Vanquish Flex system delivers new benchmarks in accuracy, precision, and sensitivity with a state of the art quaternary pump. The Vanquish Flex system shares all Vanquish portfolio values; such as robustness and reliability. Multiple detection options as well as Thermo Scientific Viper Fingertight Fitting connections throughout the system will give you the performance you need with the ease of use you want. Vanquish Flex UHPLC is engineered for extremely reproducible peptide separations and exceptionally small retention time deviations.


Featured video

Troy Voelker of Covance discusses why they chose the Q Exactive systems for HRAM MS bioanalysis of oligonucleotides and other novel therapeutics.