NIRS: A practical alternative to traditional wet lab testing methods

Near-Infrared spectroscopy (NIRS) has been widely deployed in the pharmaceutical industry as a practical alternative to time-consuming, solvent intensive, wet-testing methods and liquid chromatography techniques. The ability of NIRS to test materials quickly as-received or in their production state allows routine analyses to be carried out at the line, rather than in the lab.

Use NIRS to monitor biopharma or solid-dose pharma production in real-time to help control product quality and  your continuous process.

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NIRS offers the following advantages over traditional techniques:

  • No sample preparation - sampling can be done through glass and other packaging materials
  • Non-destructive measurement
  • Accurate, reliable analysis
  • Reduced cost
  • Increased sample throughput
  • Remote sampling with low-cost fiber optics

See answers to NIRS frequently asked questions ›

Featured NIR analyzers for pharmaceutical applications

Streamline your analysis with these NIR products

The Thermo Scientific™ Antaris™ II FT-NIR Analyzer sets an industry standard, providing laboratory-based FT-NIR performance in a ready-for-plant package. No matter what the sample, the Antaris II NIR analyzer provides robust, reliable data collection for at-line, on-line and in-line analysis. Customize an Antaris II for specific applications or choose the Antaris II MDS Method Development Sampling System, which includes transmission, fiber-optic and integrating sphere diffuse reflection analysis all in one turnkey system.

The Antaris II analyzer provides:

  • High performance combined with rugged design
  • Reproducible regardless of configuration, maintenance, user or environment
  • System-to-systems repeatability for method transfer
  • Easy software set up via dedicated validation and application programs
  • A regulatory and validation-ready instrument
  • Complete worldwide support programs
  • Low cost of ownership.

The Thermo Scientific™ Antaris™ MX FT-NIR process analyzer offers optimized QC testing and remote process monitoring using fiber optic simultaneous multiplexing technology and integrated communication for real-time feedback. The Antaris MX is a complete, fit-for-purpose solution for point-of-use materials analysis and online process monitoring applications. The Antaris MX is the only near-infrared analyzer featuring truly simultaneous measurements of up to four points. The analyzer is also simultaneously self-referenced at every data collection, so stability is unequalled and background collection or qualification does not require removing the probe from the process stream.

Developed in partnership with pharmaceutical industry leaders, the Thermo Scientific™ Antaris™ Target blend analyzer provides continuity and scalability between product development and operations, and facilitates the implementation of control strategies. The Antaris Target is the most complete, reliable analytical package for monitoring solids blending, including traceable design modeled from quality system requirements in the highly-regulated medical device industry.

Near-Infrared Webinars for Pharmaceutical Analysis