Find the best crosslinker for your bioconjugation experiments

This Crosslinker Selection Tool provides quick access to customized lists of Thermo Scientific Pierce Crosslinkers that meet specific criteria, including target functional group, solubility, and cell membrane permeability.

Select the desired features to view results. Choose "No specific requirement" to see all items. Search results include a list of products in order of crosslinking distance (spacer arm length) with links to individual product pages. Alternatively, view the Crosslinker Selection Guide page or simply browse our entire line of crosslinking reagents.

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Crosslinker name Catalog no. Spacer arm length Crosslinks Cleavable by Water soluble Membrane permeable
BS3 21580 11.4 Amines to Amines non Yes No
BMH 22330 13 Sulfhydryls to Sulfhydryls non No Yes
BSOCOES 21600 13 Amines to Amines Base No Yes
DFDNB 21525 3 Amines to Amines non No Yes
DMA 20660 8.6 Amines to Amines non Yes Yes
DMP 21666 9.2 Amines to Amines non Yes Yes
DMS 20700 11 Amines to Amines non Yes Yes
DSG 20593 7.7 Amines to Amines non No Yes
DSP 22585 12 Amines to Amines Thiols No Yes
DSS 21555 11.4 Amines to Amines non No Yes
DST 20589 6.4 Amines to Amines Periodate Yes Yes
DTBP 20665 11.9 Amines to Amines Thiols Yes Yes
DTSSP 21578 12 Amines to Amines Thiols Yes No
EDC 22980 0 Amines to Carboxyls non Yes No
EGS 21565 16.1 Amines to Amines Hydroxylamine No Yes
GMBS 22309 7.3 Amines to Sulfhydryls non No Yes
LC-SPDP 21651 15.7 Amines to Sulfhydryls Thiols No Yes
MBS 22311 7.3 Amines to Sulfhydryls non No Yes
MPBH 22305 17.9 Sulfhydryls to Carbohydrates non No Yes
PDPH 22301 9.2 Sulfhydryls to Carbohydrates Thiols Yes Yes
SIAB 22329 10.6 Amines to Sulfhydryls non No Yes
SMCC 22360 8.3 Amines to Sulfhydryls non No Yes
SMPB 22416 11.6 Amines to Sulfhydryls non No Yes
SMPT 21558 11.2 Amines to Sulfhydryls Thiols No Yes
SPDP 21857 6.8 Amines to Sulfhydryls Thiols No Yes
Sulfo-EGS 21566 16.1 Amines to Amines Hydroxylamine Yes No
Sulfo-GMBS 22324 7.3 Amines to Sulfhydryls non Yes No
Sulfo-LC-SPDP 21650 15.6 Amines to Sulfhydryls Thiols Yes No
Sulfo-MBS 22312 7.3 Amines to Sulfhydryls non Yes No
Sulfo-SANPAH 22589 18.2 Amines to Nonselective non Yes No
Sulfo-SIAB 22327 10.6 Amines to Sulfhydryls non Yes No
Sulfo-SMCC 22322 8.3 Amines to Sulfhydryls non Yes No
Sulfo-SMPB 22317 11.6 Amines to Sulfhydryls non Yes No
Sulfo-SBED 33033 14.3 Amines to Nonselective Thiols Yes No
AMAS 22295 4.4 Amines to Sulfhydryls non No Yes
BMPS 22298 5.9 Amines to Sulfhydryls non No Yes
EMCS 22308 9.4 Amines to Sulfhydryls non No Yes
LC-SMCC 22362 16.2 Amines to Sulfhydryls non No Yes
SBAP 22339 6.2 Amines to Sulfhydryls non No Yes
SIA 22349 1.5 Amines to Sulfhydryls non No Yes
SMPH 22363 14.2 Amines to Sulfhydryls non No Yes
Sulfo-EMCS 22307 9.4 Amines to Sulfhydryls non Yes No
Sulfo-KMUS 21111 16.3 Amines to Sulfhydryls non Yes No
BMPH 22297 8.1 Sulfhydryls to Carbohydrates non Yes Yes
EMCH 22106 11.8 Sulfhydryls to Carbohydrates non Yes Yes
KMUH 22111 19 Sulfhydryls to Carbohydrates non No Yes
BMB 22331 10.9 Sulfhydryls to Sulfhydryls non No Yes
BMOE 22323 8 Sulfhydryls to Sulfhydryls non No Yes
BM(PEG)2 22336 14.7 Sulfhydryls to Sulfhydryls non Yes No
BM(PEG)3 22337 17.8 Sulfhydryls to Sulfhydryls non Yes No
DTME 22335 13.3 Sulfhydryls to Sulfhydryls Thiols No Yes
Mts-Atf-Biotin 33093 11.1 Sulfhydryls to Nonselective Thiols No Yes
Mts-Atf-LC-Biotin 33083 21.8 Sulfhydryls to Nonselective Thiols No Yes
SM(PEG)2 22102 17.6 Amines to Sulfhydryls non Yes No
SM(PEG)4 22104 24.6 Amines to Sulfhydryls non Yes No
SM(PEG)8 22108 39.2 Amines to Sulfhydryls non Yes No
SM(PEG)12 22112 53.4 Amines to Sulfhydryls non Yes No
BS(PEG)5 21581 21.7 Amines to Amines non Yes No
BS(PEG)9 21582 35.8 Amines to Amines non Yes No
DCC 20320 0 Amines to Carboxyls non No Yes
SM(PEG)6 22105 32.5 Amines to Sulfhydryls non Yes No
SM(PEG)24 22114 95.2 Amines to Sulfhydryls non Yes No
SDA(Diazirine) 26167 3.9 Amines to Nonselective non No Yes
LC-SDA(Diazirine) 26168 12.5 Amines to Nonselective non No Yes
SDAD(Diazirine) 26169 13.5 Amines to Nonselective Thiols No Yes
Sulfo-SDA(Diazirine) 26173 3.9 Amines to Nonselective non Yes No
Sulfo-LC-SDA(Diazirine) 26174 12.5 Amines to Nonselective non Yes No
Sulfo-SDAD(Diazirine) 26175 13.5 Amines to Nonselective Thiols Yes No
PEG12-SPDP 26129 54.1 Amines to Sulfhydryls Thiols Yes No
PEG4-SPDP 26128 25.7 Amines to Sulfhydryls Thiols Yes No
TSAT 33063 4.2 Amines to Amines non No Yes
TMEA 33043 10.3 Sulfhydryls to Sulfhydryls non No Yes

What is our definition of water soluble?

With very few exceptions, all crosslinkers are soluble in miscible organic solvents such as DMSO, DMF, or acetonitrile. Typical protocols involve first dissolving the reagent at 10X the working concentration and then adding it to an aqueous reaction mixture. Organic solvents are not compatible with certain applications, and directly aqueous-soluble crosslinkers are preferable in these situations. We classify crosslinkers as water-soluble if they can be dissolved directly in water or aqueous buffers at greater than 1 to 5X the concentration needed for typical procedures.

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