Testing for ERBB2/HER2 has paved the way for precision oncology in breast cancer. However, the complexity of HER2 biology is evident in other solid tumor cancers, including non-small cell lung cancer. All three types of HER2 alterations could appear in NSCLC, including mutations, amplifications, and overexpression. HER2 mutations represent distinct oncogenic drivers, and next-generation sequencing is an ideal method for detecting them due to its heterogeneity.
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