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Powering results in mAb bioprocessing workflows

Driving performance across your monoclonal antibody bioprocessing workflow to enhance throughput, efficiency, and cost control

From upstream development to downstream purification, Thermo Fisher Scientific helps improve process performance, reduce variability, and support confident scale-up. By aligning technologies, process insights, and experience across the workflow, our integrated solutions help enable greater throughput, more efficient use of resources, and consistent, high-quality outcomes—supporting more predictable and cost-efficient manufacturing across the lifecycle.

Monoclonal Antibody Bioprocessing Workflow

Workflow diagram describing upstream and downstream steps

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Sustained productivity gains come from optimizing the full workflow

Implementing upstream intensification strategies—such as high-density cell banking, N-1 perfusion, and intensified fed-batch processing—can increase titers and overall process productivity. In parallel, advanced purification techniques, including high-capacity chromatography resins, inline dilution, and practical buffer strategies, support productivity through improved efficiency, cost-effectiveness, and sustainability. Together, these approaches help reduce resource consumption, lower operational burden, and improve cost efficiency—supporting more economical mAb manufacturing at scale.

Infographic describing benefits and advantages for upstream and downstream workflows with these solutions

*The data shown here represent an illustrative example of how an intensified mAb process differs from a standard mAb process. The process data, modeled using BioSolve Process™ software, show how Thermo Fisher Scientific’s bioprocessing technologies can help demonstrate the value of process intensification in both upstream and downstream workflows. Economic modeling is based on representative industry assumptions, including production scale (e.g., 6 × 2,000 L bioreactors), facility utilization (~80%), and standard cost inputs (e.g., labor, capital, and pricing), unless otherwise noted. Results are based on lab-generated data (up to 500 L scale) and modeled case studies, and are provided for illustrative purposes only. Actual customer results may vary depending on process design, scale, and site-specific conditions. The information provided is for illustrative purposes only and does not relieve customers or users of their responsibility for determining the suitability of our products for the customer or user's intended use.

Advance mAb workflow performance across upstream and downstream operations

Enhancing performance across the mAb workflow begins with upstream intensification and extends through downstream purification. By aligning these strategies, manufacturers can support higher productivity, improved efficiency, and more predictable scale-up.

Turn upstream strategy into production performance

Explore how upstream process intensification strategies can help improve cell growth, increase production performance, and support more efficient scale-up. This white paper* outlines how approaches such as high-density cell banking, N-1 perfusion, and intensified fed-batch culture can work together to streamline the seed train, reduce process complexity, and enable higher throughput. By aligning cell line, media, and bioreactor strategies, manufacturers can improve consistency and resource efficiency while supporting more productive upstream operations.

Simplify purification while improving downstream efficiency

Learn how downstream process optimization can help improve purification efficiency while supporting consistent product quality. This white paper* highlights how high-capacity chromatography resins, inline dilution, and flow-through polishing approaches can help simplify workflows, reduce resource requirements, and enhance throughput. By improving recovery and reducing processing burden, these strategies support more efficient downstream operations and contribute to more cost-efficient manufacturing across the mAb workflow.
 

Explore the full mAb bioprocessing workflow in an interactive experience

Navigate our interactive mAb Bioprocessing Workflow Experience to explore how technologies across upstream and downstream manufacturing connect to support yield, efficiency and scalability. This interactive digital experience highlights workflow considerations from development through manufacturing, helping teams evaluate process strategies, review technology applications, and identify opportunities to improve throughput and operational efficiency across mAb manufacturing.
 

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Advance your mAb workflow with confidence

From early process development through commercial manufacturing, aligning upstream and downstream strategies can support consistent performance, efficient scale-up, and improved cost control. By taking a workflow-based approach, manufacturers can reduce variability, improve throughput, and make more informed decisions across the lifecycle.

Explore more on how our approaches can be applied to your process to help improve performance across your mAb workflow.
 

For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.