Advance nuclear receptor drug discovery with comprehensive screening services that generate high-quality biochemical and cell-based data to characterize ligand binding, receptor activation, and functional activity. Leveraging validated assay technologies and scientific expertise, we deliver actionable insights that support target validation, lead optimization, and confident candidate selection.

 

Expect and receive high-quality profiling data in days and steamline your lead discovery projects with SelectScreen Nuclear Receptor Profiling Services from Thermo Fisher Scientific.

 

Labs from pharmaceutical, biotech, consumer goods, and academic institutions have utilized SelectScreen Nuclear Receptor Profiling Service since their initiation in 2006.

  • Access your data in real-time as soon as it’s available through our secure online portal
  • Reliable and fast turnaround: projects completed in an average of 7 days
  • Broad panel of 75 nuclear receptor assays available
  • Robust compound management process: helps ensure sample quality and data consistency from project initiation through reporting.
  • Complete lab information management system (LIMS): helps ensure project traceability and consistency

Project options

Customize your nuclear receptor–based profiling project to get the right data for your research.

 

Standard service options include:

  • Targets: 19 cellular nuclear receptors (37 assays) and 23 Biochemical Nuclear receptors (37 assays) available
  • Mode: IC50 and/or EC50 determinations

Technology overview

Currently, biochemical and cell-based nuclear receptor assays are available:

  • Biochemical: LanthaScreen Competitive Binding and Coactivator assays
  • Cellular: GeneBLAzer Nuclear Receptor assays

Overview of available formats

 

LanthaScreen biochemical competitive binding assays

Technology overview Protocol and assay conditions

LanthaScreen biochemical coactivator assays

Technology overview Protocol and assay conditions

GeneBLAzer cellular assays

Technology overview Protocol and assay conditions

 

A stringent verification process helps ensure high-quality data, with each data point performed in duplicate. Strict quality control protocols ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration for each assay on every plate.


SelectScreen nuclear receptor profiling panel

Assay

GeneBLAzer cellular assay

LanthaScreen biochemical assay

Cell line

Agonist

Antagonist

Coactivator agonist

Coactivator inverse agonist

Coactivator antagonist

Competitive binding

CAR

N/A

   

✓

✓

   

ER-alpha

UAS-bla GripTite 293

✓

✓

✓

 

✓

✓

ER-beta

UAS-bla GripTite 293

✓

✓

✓

 

✓

✓

ERR-alpha

UAS-bla HEK 293T

 

✓

 

✓

   

ERR-beta

N/A

     

✓

   

ERR-gamma

N/A

     

✓

   

FXR

UAS-bla HEK 293T

✓

✓

✓

     

GR

UAS-bla HEK 293T

✓

✓

✓

 

✓

✓

LXR-alpha

UAS-bla HEK 293T

✓

✓

✓

     

LXR-beta

UAS-bla HEK 293T

✓

✓

✓

     

MR

UAS-bla H

✓

✓

       

PPAR-alpha

N/A

   

✓

 

✓

✓

PPAR-delta

UAS-bla HEK 293T

✓

✓

✓

   

✓

PPAR-gamma

UAS-bla HEK 293H

✓

✓

✓

 

✓

✓

PR

UAS-bla HEK 293T

✓

✓

✓

 

✓

 

PXR(SXR)

N/A

         

✓

RAR-alpha

UAS-bla HEK 293T

✓

✓

✓

     

RAR-beta

UAS-bla HEK 293T

✓

✓

✓

 

✓

 

RAR-gamma

UAS-bla HEK 293T

✓

✓

✓

     

RXR-alpha

UAS-bla HEK 293T

✓

✓

✓

     

RXR-beta

UAS-bla HEK 293T

✓

✓

✓

     

TR-alpha

UAS-bla HEK 293T

✓

✓

✓

     

TR-beta

UAS-bla HEK 293T

✓

✓

✓

     

VDR

UAS-bla HEK 293T

✓

✓

✓

     

Personalized support

Personalized support is at the core of every SelectScreen project. From project initiation through data delivery, you'll work with a dedicated project manager who serves as your single point of contact, providing proactive communication, coordinating timelines and milestones, and ensuring proficient project execution.

 

Backed by experienced scientists and technical specialists, our team works as an extension of yours to deliver a responsive, collaborative experience and high-quality results tailored to your research goals.

For Research Use Only. Not for use in diagnostic procedures.