Revolutionizing Drug Discovery Pipelines with Cryo-EM

Rational drug design with protein structure determination

Rational drug design that leverages routine, high-resolution protein structure determination is driving the discovery and development of diverse biologic and small molecule therapies. The rapid maturation of cryo-electron microscopy (cryo-EM) over the past decade underpins the dramatic expansion of modalities benefitting from structural information. Cryo-EM delivers rapid, atomic-scale epitope mapping for antibody therapeutics and immune response profiling, supports the elucidation of mechanisms of action, and expands the range of therapeutic targets accessible to structure-based drug design.



 

Explore cryo-EM solutions for drug discovery

Small molecule structure-based drug design

Using protein structure early reduces the time, cost, and risks of clinical development. Cryo-EM expands the range of structurally enabled targets, unlocking conformations and cryptic sites for new modalities.

Antibody discovery and epitope mapping

Effective antibody development requires an understanding of antibody-antigen interactions. Cryo-EM reveals molecular structures, aiding in differentiation, epitope mapping, design, and more.

Vaccine design

Structure-based vaccine design accelerates antigen identification and engineering which, together with novel vaccine-delivery platforms, shortens the development cycle needed to combat emerging infectious diseases.

Cell and gene therapy

Cryo-EM enables rational design of CAR-T binders, capsid engineering for viral vectors, and characterization of gene delivery vehicles.

Drug formulations and characterization

Electron microscopy makes it possible to characterize a variety of attributes in drug formulations to help ensure quality and efficacy.

Drug Discovery Resource Center

Browse our collection of webinars, white papers, eBooks and posters to discover how cryo-EM is accelerating drug discovery pipelines.

Fully integrated electron microscopy software solutions

Automated data acquisition, analysis, and visualization software provide the throughput and speed needed to quickly go from structural insights to candidate selection.