Resources for Structure Based Drug Design with Cryo-EM

Resources for drug discovery and rational drug design 

At Thermo Fisher Scientific, we are here to help accelerate your drug discovery pipeline with powerful cryo-electron microscopes. Discover how cryo-EM can help your research with our curated white papers, eBooks, and on-demand webinars below.

Featured webinars

See the potential of cryo-EM in drug discovery and design across a variety of modalities via on-demand webinars. We’ve included a few webinars below that highlight recent developments in industry. Check our webinar library for a full list of informative videos and case studies.

Incorporating cryo-EM into your current workflows

Bringing cryo-EM to your lab can provide detailed, high-resolution insights to revolutionize structure-based drug design. Our fully integrated software automates data acquisition, analysis, and visualization, ensuring the necessary throughput and speed to rapidly transition from structural insights to candidate selection. By streamlining your workflow with Thermo Scientific instruments and software, you can reduce your time to results and accelerate your development timelines.

Accelerating drug discovery with rational design

Resources for preparing cryo-EM samples

Cryo-EM processing at the pace of medicinal chemistry on AWS

Fully integrated electron microscopy software

Automated data acquisition, analysis, and visualization software provides the throughput and speed needed to go from structural insights to candidate selection in the fastest time possible.

GPCRs and membrane proteins

Cryo-EM approaches for active-state and inactive-state GPCRs

Grid preparation for detergent-solubilized GPCR samples

De novo inactive GPCR cryo-EM structure and epitope mapping

Small molecule drug design

Targeted protein degradation as a novel therapeutic approach for undruggable diseases

Analyzing Microparticles for Drug Delivery: the Critical Role of SEM and FIB-SEM Technology

Fighting against antimicrobial resistance with next-generation antibiotics

Finding new ways to treat pain with novel opioid receptor ligands

Decoding tauopathies: how cutting-edge cryo-EM is unraveling tau protein and Alzheimer’s disease

Revolutionizing Small Molecule Drug Discovery Pipelines with Cryo-EM: A Workflow for High-Throughput Screening and High-Resolution Data Collection

Routine high-throughput screening and high-resolution data collection workflow using 200 kV and 300kV TEMs

Epitope mapping

Guiding the Development of an HIV Vaccine with Structure-Based Drug Design

Cryo-EM as a powerful tool for epitope mapping of difficult targets

Leveraging cryo-electron microscopy for innovative vaccine development

Accelerating discovery and rational engineering of antibody modalities using Cryo-EM

Cryo-EM structure of AAV8 and epitope mapping of CaptureSelect AAVX

High-throughput cryo-EM epitope mapping of SARS-CoV-2 spike protein antibodies

Particle Characterization

Advancing lentiviral vector-based gene therapy utilizing cryo-TEM and automated image analysis

Cryo-TEM unlocks the potential of lipid nanoparticles for drug delivery

Explore available courses and additional cryo-EM resources

Getting started in cryo-EM

Learn tips and tricks and hear practical advice to getting started in single particle cryo-EM—from sample preparation to data collection.

Cryo-EM University

Full single particle cryo-EM course alternating theory and practical demonstration videos covering all aspects from sample preparation, microscope design, cameras, to data acquisition. 

Life in Atomic Resolution

Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology

Cryo-EM Service and Support

Whether you are purchasing a new system, or need services for an existing system, we have a variety of support options and plans.

For Research Use Only. Not for use in diagnostic procedures.