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Spatial Biology Resource Center

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Explore the plexibilities of spatial biology

Understanding biology requires context—and spatial imaging enables researchers to study cells, proteins, and gene expression within intact tissue, preserving the relationships that define complex biological systems. By revealing how components are organized and interact in their native environment, spatial approaches offer insights that go beyond what traditional, dissociated methods can support.

 

From characterizing tumor microenvironments to exploring brain organization and treatment response, spatial imaging supports a wide range of applications. As the field evolves, researchers face new decisions around experimental design, data interpretation, and scaling workflows.

 

This resource center is designed to support that journey. Whether you are new to spatial imaging or advancing established workflows, explore curated content, application data, and expert guidance to deepen your understanding and move your research forward with confidence.

Get started with spatial biology

Build a foundational understanding of spatial imaging and how it can help answer your biological questions.

Spatial Imaging Demystified

Spatial Biology Colors Outside the Lines

Nature Symposium: Spatial Biology

Understanding spatial imaging: Methods, technologies, and research applications

Spectral imaging vs cyclic imaging: Choosing the right spatial imaging approach

The rise of mid-plex: Making multiplex imaging more accessible

Meet the bold innovators shaping the future of discovery—one spatial insight at a time

Our quarterly webinar series spotlights pioneering scientists who are redefining what’s possible—integrating spatial context into their research to uncover deeper biological insight and drive discovery forward.

Panel design and optimization in multiplexed immunofluorescence tissue imaging

Juan Garcia Vallejo, MD, PhD, MBA
Amsterdam UMC

Spatial proteomics for translational research

Charlotte Stadler, PhD
Science for Life Laboratory

Multiplex immunofluorescence-based analysis of immune infiltration in colorectal cancer

Matthew Bechard, PhD
Research Scientist, Vanderbilt University

Applications for spatial imaging

Explore how spatial imaging approaches are applied across research areas and select the right strategy for your study.

Choosing the right protein labeling strategy for multiplex immunofluorescence

9 common mistakes in spatial imaging experiments (and how to avoid them)

Organ mapping antibody panels (OMAPs)

A step-by-step guide to help navigate community resources for picking multiple protein markers and antibodies.

Neuroscience

Streamlined spatial analysis of the brain tumor microenvironment

Advancements in multiplexed spatial phenotyping of CNS tissue

An optimized fluorescent 9-plex spatial proteomics approach with spectral unmixing to identify cell types in the brain

Multiplex spatial imaging for brain mapping with mIF, IHC, and ISH

How single cell analysis and spatial imaging work together in neurobiology research

Oncology

High-plex spatial proteomics for enhanced breast cancer research

Learn how enzyme-activated spatial amplification reagents have deepened cancer research.

Investigating the colon adenocarcinoma tumor microenvironment

Advancements in multiplexed spatial phenotyping

Spatial biology in-situ hybridization and multiplexed immunohistochemistry detection

An optimized fluorescent 9-plex spatial proteomics workflow enables single cell quantification within human IDC breast cancer research

Spatial-omics detection of neuroendocrine involvement in cancer tissue

Immunology

Expanded tools for spatial biology applications

Multiplex made practical: A direct-conjugated antibody panel design workflow

Scale and refine spatial biology experiments

Dive deeper into multiplex optimization, advanced techniques, and best practices to refine and scale your experiments.

Multiplex IHC using primary antibodies conjugated with fluorophores

Learn how to stain tissue for IHC with a mixture of multiplexed primary antibodies conjugated to fluorophores. 

Imaging protocol handbook

Access trusted protocols, including 3D staining, and multiplexing ISH in tissue among others.

For Research Use Only. Not for use in diagnostic procedures.

Photo credit, headline image: IBEX image of B cells in the germinal center and medulla of the human lymph node. Image is courtesy of Drs. Andrea J. Radtke and Ronald N. Germain.