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Join us for an exclusive series of end-of-year tech talks. Our product experts will delve into the latest advancements and data, providing valuable insights to help you stay ahead of the curve. Whether you have years of experience with electron microscopy technology or are new to cryo-electron microscopy, this webinar series will equip you with new ideas and tools to take your research to the next level. Don’t miss out on this opportunity to connect with our technical experts to get your questions answered.
Learn about the latest advancements in automating sample screening for the single particle analysis (SPA) data acquisition workflow using Thermo Scientific Smart EPU Software. This session will demonstrate the functionality of three key plugins for automatic screening, highlighting their advantages over manual settings. We will discuss how these tools enhance efficiency and simplify operation, enabling better use of high-throughput cryo-electron microscopes in both industrial and entry-level laboratory environments.
Speaker
Fanis Grollios, Sr. Software Product Manager, Thermo Fisher Scientific
Fanis holds a master’s degree in electrical engineering and a post-master’s degree in software engineering. He has more than 10 years of experience in building software for cryo-EM applications as an engineer, architect, and product manager. Fanis focuses on TEM microscope automation as well as bringing ease of use to single particle analysis and cryo-tomography workflows.
Explore how Thermo Scientific Tomography Software and Tomo Live Software can significantly enhance your cryo-EM workflow, from data acquisition to real-time analysis. This session is designed for professionals in cryo-EM and cryo-electron tomography who want to enhance their data acquisition and processing workflows.
Speaker
Julio Ortiz, Sr. Software Product Marketing Manager, Thermo Fisher Scientific
Julio began his career in electron microscopy at the Venezuelan Institute for Scientific Research (IVIC) and specialized in tomography at the Max Planck Institute of Biochemistry during his post-doctoral studies. His expertise spans various cryo-EM techniques, including single particle analysis and focused ion beam micromachinery. Prior to joining Thermo Fisher Scientific, Julio served as a cryo-EM facility manager at the Netherlands Centre for Electron Nanoscopy (NeCEN), the Institute of Genetics and Molecular and Cellular Biology (IGBMC), and the Forschungszentrum Jülich.
Discover how you can help drive innovation in sample preparation for cryo-EM by joining The Open Plunge Initiative, our first open science program. In this session, we’ll uncover vitrification challenges and provide an overview of our open science vitrification platform, the Vitrobox. Together with our industrialized cryo-EM screening pipeline, the modular Vitrobox platform was built for comprehensive assessments of grid quality for a wide variety of vitrification techniques through direct interaction with the EM community. By embracing open science, we believe we can help drive progress and innovation in cryo-EM sample preparation.
Speaker
Albert Konijnenberg, Product Manager, Cryo-EM Sample Preparation, Thermo Fisher Scientific
Albert obtained his PhD from the University of Antwerp in Belgium in 2016. His thesis research focused on developing methods to apply native mass spectrometry techniques for studying protein structure in the gas phase, with a strong focus on intrinsically disordered and integral membrane proteins. After postdocs at the Flemish Institute for Biotechnology and the University of Antwerp, he joined Thermo Fisher Scientific in 2017, where he champions initiatives supporting cryo-EM sample preparation and integrative structural biology techniques.
Achievements in cryo-EM at atomic resolutions were accomplished using non-identical approaches and technologies based in high-end and costly 300 kV instrumentation. To expand availability to a broader range of researchers, recent efforts have focused on identifying which combination of technology could provide high-resolution, structure determination using straightforward and economical solutions below 200 kV. Optimized 100 kV systems like the Thermo Scientific Tundra Cryo-TEM can reduce cost of ownership and provide more accessibility through automation, while maintaining the data quality necessary for high-resolution structure determination. Furthermore, recent advancements in detectors optimized at 100 kV can deliver improved resolutions on the Tundra Cryo-TEM as well as widely available and low cost LaB6 120 kV systems, like the Thermo Scientific Talos L120C TEM. This session will review the technological advances that are lowering the barrier to accessing cryo-EM.
Speaker
Tim Booth, Product Marketing Manager, Thermo Fisher Scientific
With 23 years of experience in cryo-EM, Tim’s expertise encompasses structural biology, workflow strategy, and core facility management. In his current role, he is responsible for promoting and supporting accessible solutions that lower barriers for those new to TEM and cryo-EM and provide the most straightforward and economical approach to reaching higher data quality and structural resolutions.
The Thermo Scientific Glacios 2 Cryo-TEM is a revolution in both productivity and resolution. Join this session to learn about the hardware advances that are improving both data quantity and quality. We’ll discuss the low energy-spread cold field emission gun (E-CFEG), Selectris Imaging Filter, Falcon 4i Direct Electron Detector, and optical improvements. We’ll also share examples of high-throughput drug screening with EPU Multigrid Software and high-resolution cryo-EM for drug design.
Speaker
Lingbo Yu, Product Marketing Manager, Thermo Fisher Scientific
Lingbo received her PhD from the University of Vermont working on algorithms specifically designed for low-dose cryo-EM images of biological samples in the lab of Michael Radermacher. She worked on the NIH-FEI living lab project as a software developer to optimize automated single particle data collection. Later, she moved to the Netherlands and joined the Thermo Fisher Scientific team.