EM Life Science Newsletter

Our Cryo-EM Consortia and Drug Discovery Centers support pharmaceutical and biotechnology companies by providing access to advanced cryo-electron microscopy (cryo-EM) technology, deep scientific expertise, and collaborative research environments. The initiative began in 2016 with the U.K. Pharmaceutical Cryo-EM Consortium, which brought together Thermo Fisher and leading pharma companies to expand industry use of high-resolution structural biology tools for therapeutic research.

Discover how Thermo Fisher’s Cryo-EM Drug Discovery Center in South San Francisco helps biotech and pharma teams accelerate structure-based drug discovery. Through advanced cryo-EM technology, streamlined workflows, expert scientific support, and deeper molecular insights, researchers can move more efficiently from discovery to preclinical development and potential therapies. Watch the video to see cryo-EM in action.

Modern neuroscience imaging delivers extraordinary detail across scales, but turning complex, high-resolution data into meaningful insight remains a major challenge. Accurate segmentation, 3D reconstruction, quantitative analysis, and multimodal integration all demand advanced, reliable workflows.

This eBook features five neuroscience studies demonstrating how Thermo Scientific Amira Software helps researchers:

• Analyze complex neural structures across multiple spatial scales
• Build accurate, high-quality 3D reconstructions from advanced imaging data
• Extract reliable quantitative measurements from multidimensional datasets

Cryo-electron microscopy (cryo-EM) is helping researchers accelerate rational drug design by delivering near-atomic-resolution structural insights into complex biological targets. In this eBook, we highlight how cryo-EM supports structure-based drug discovery workflows by enabling scientists to visualize protein-drug interactions, optimize lead candidates, and better understand mechanisms of action earlier in development.

This eBook also explores how integrated cryo-EM workflows can help researchers tackle challenging targets such as membrane proteins, GPCRs, and large protein complexes. From sample preparation and imaging to automated data collection and analysis, we provide end-to-end solutions designed to support faster, more informed therapeutic development across biologics and small molecule discovery.

Read this eBook to discover how our cryo-EM solutions can support faster and more precise therapeutic development.

Room-temperature electron microscopy (RT-EM) has long been a cornerstone of biological imaging, enabling the visualization of cells, tissues, and organelles in their natural state under standard laboratory conditions.

RT-EM bridges the gap between functional techniques (such as light microscopy, genetic analysis, and behavioral studies) and high-resolution approaches like cryo-EM. It enables researchers to correlate functional and morphological data across spatial and resolution scales, contributing to a comprehensive understanding of biological systems. Such a versatile toolkit provides both high precision and flexibility as needed, meeting the diverse demands of modern life sciences.

Read our application note to learn how RT-EM can serve as a valuable tool for the investigation of biological systems in a broader experimental context.

Our latest white paper explores how high-quality sample preparation is fundamental to achieving accurate and reliable results in electron microscopy (EM) for life sciences. It highlights how key steps, such as fixation, dehydration, staining, and embedding, directly impact ultrastructural preservation, contrast, and imaging performance across both TEM and SEM modalities. This paper also outlines how preparation strategies vary depending on imaging goals, including 2D analysis and advanced 3D reconstruction, enabling researchers to better correlate cellular structure with function. Through real-world application examples, it demonstrates how room-temperature EM can deliver high-contrast, structurally preserved datasets across diverse specimen types.

Read the full white paper to learn how to optimize your EM workflows and unlock deeper biological insights.

Some of the most difficult drug targets require entirely new ways of thinking. Molecular glue degraders (MGDs) are emerging as a promising therapeutic strategy by harnessing the ubiquitin-proteasome system to selectively degrade challenging targets once considered out of reach.

In this on-demand webinar, experts from Monte Rosa Therapeutics explore how their proprietary drug discovery platform, combined with advanced cryo-electron microscopy (cryo-EM) workflows, is helping expand the possibilities of rational MGD discovery. Attendees will gain insight into novel binding mode discovery, ternary complex interface analysis, and strategies for addressing conformational heterogeneity within cryo-EM pipelines.

Key topics

• Why MGDs represent a compelling therapeutic approach for difficult drug targets
• How integrated discovery approaches enable rational identification of novel binding modes
• Practical examples from Monte Rosa Therapeutics’ cryo-EM pipeline and structural biology workflows

Watch this webinar to learn how structural biology and targeted protein degradation are converging to accelerate next-generation therapeutic discovery.