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They’re misbehavin’ molecules

When mAbs present purification challenges, the right strategies can help tame them

Complex antibody formats require purification approaches and chromatography resins designed to support modern workflows.
 

Explore Thermo Scientific resins that help enable efficient mAb purification across a range of feed streams while helping reduce process steps and improve yield to support purification productivity.

It’s chromatography chaos


See what happens when a group of misbehaving mAbs invades the lab. Then explore Thermo Scientific resins designed to help address purification challenges across a range of mAb molecules.

 

Beyond Protein A: Efficient purification strategies for complex mAbs


As modern antibody formats grow more complex, traditional protein A–based processes can become a limiting step. Explore innovative approaches that leverage subdomain-specific ligands to help address purification challenges.
 

Improve mAb purification productivity


Explore Thermo Scientific affinity chromatography resins that help enable efficient capture of therapeutic mAbs across a range of feed streams, while helping reduce process steps and improve yield to support purification productivity.
 

Address 5 key purification challenges in complex mAbs


The added structural complexity of novel mAbs can introduce purification challenges that conventional chromatography strategies may not fully address. Explore approaches to help overcome key purification challenges.
 

Discover solutions for today’s purification challenges

Improve mAb manufacturing with Protein A resin

Thermo Scientific MabCaptureC ProA resin supports high binding capacity and stability to help enable consistent purification performance and improved cost efficiency.

Improve selectivity with subdomain-specific affinity chromatography

Thermo Scientific CaptureSelect affinity resins help enable earlier selectivity and reduce reliance on polishing steps.

Refine polishing steps with POROS resins

Help address mAb polishing challenges with Thermo Scientific POROS chromatography resins, supporting targeted removal of aggregates, charge variants, HCPs, and residual DNA.

Not sure which resins are right for you?


Selecting the right resin depends on your molecule type, process stage, and purification goals. Compare chemistries, binding capacities, and scalability data in one place.
 

mAbs have gone mAd - contact us to explore solutions for your purification workflow

For research and development use only in support of FDA-regulated end uses. Not for diagnostic use or direct administration to humans or animals.