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Tundra Cryo TEM

Bringing cryo-electron microscopy to you

Whether you’re an experienced microscopist, or just starting out, the Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM) is a dedicated structural analysis solution designed to bring cryo-electron microscopy (cryo-EM) to your laboratory at an affordable price point. Simplified data collection and rapid sample loading/unloading make the Tundra Cryo-TEM a powerful tool for answering your most challenging research questions. With the Tundra Cryo-TEM, you can obtain structures at biologically relevant resolutions in-house or reliably prepare high-quality samples for further analysis on Thermo Scientific Krios or Glacios Cryo-TEMs.

Simplified cryo-EM

The Tundra Cryo-TEM allows you to perform structural analyses on challenging proteins and macromolecules with unprecedented ease of use.

Cryo-EM structure determination at biologically relevant resolutions

The Tundra Cryo-TEM is a dedicated structure determination solution, operating at 100 kV, the Tundra Cryo-TEM can generate high-contrast biological images down to 2.1 Å.

Tundra Cryo-TEM resources

Learn more from scientists who are using the Tundra Cryo-TEM in their research and take a closer look with our on-demand product tour. 

Advanced cryo-TEM software with streamlined workflows

The Tunda Cryo-TEM comes with AI-enabled software to make it easier than ever to run and acquire high-resolution data.

Cryo-TEM service and support

To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and workflow validation.

Electron Microscopy Funding Support Center

A wide range of funding proposals and grants were considered when designing the Tundra Cryo-TEM to keep its price within the reach of most instrumentation grants.

Frequently asked questions about the Tundra Cryo-TEM

The Thermo Scientific Tundra Cryo-TEM is a cryo transmission electron microscope optimized for cryo-electron microscopy single particle analysis; it is designed to increase the accessibility of this powerful technique for biochemistry laboratories, pharmaceutical researchers, and more. The integrated Thermo Scientific Falcon C Direct Electron Detector allows the Tundra Cryo-TEM to perform structural analysis on a range of challenging proteins and macromolecules. With the Tundra Cryo-TEM, you can easily load and unload cryo-EM grids in a contamination-free state, discover high-resolution structures that support your biological research, and even examine room-temperature samples such as negative stain grids and plastic sections.

The Tundra Cryo-TEM includes a number of hardware and software features that facilitate cryo-EM workflows, thereby improving productivity. For example, it features an innovative cryo-loading station that uses automation to load the sample grid into a transfer device and then into the microscope, reducing possible user error and manual steps. 

 

The Tundra Cryo-TEM also comes with a complete suite of automation software, including user-friendly Thermo Scientific EPU Software, which allows for high-resolution single-particle-analysis data collection in only a few clicks. The instrument is also integrated with Smart EPU Software, which is an AI-enabled solution for the analysis of intermediate results, which can be used to steer data collection on the fly.

 

The specialized configuration of the Tundra Cryo-TEM makes cryo-electron microscopy more accessible, facilitating the investigation of infectious and neurodegenerative diseases, cancer, and more.

The Tundra Cryo-TEM is designed with new users in mind, even those who are unfamiliar with electron microscopy. It includes a range of automation features that facilitates the entire analytical workflow, including instrument configuration, sample optimization, and data collection. Tundra Cryo-TEM data is compatible with a variety of common analytical software, supporting post-processing and reconstruction.

 

The Tundra Cryo-TEM only takes a few minutes to load a new cryo-sample into the microscope, allowing for rapid, automated optimization of sample conditions. This minimizes the risk of sample damage or vacuum leak from the microscope.

 

The rapid feedback of the Tundra Cryo-TEM significantly shortens the time required for biochemical sample optimization. This design is especially constructed so that new users are capable of doing the procedure without extensive training.

The Tundra Cryo-TEM can resolve protein structures down to 2.1 Å resolution through the creation of high-quality 3D reconstructions. Such high-resolution maps allow for de novo model building; the protein backbone can be clearly traced, side chains can be easily modeled, and water networks in active sites can be visualized. These biologically relevant atomic models can help you understand how proteins function, how to modify genes, and how to optimize drug designs.

Yes, the Tundra Cryo-TEM can be operated at room temperature, supporting a number of common EM techniques. This includes negative-stain electron microscopy, which serves as an easy and cost-effective method for the assessment of purified biological specimens. Additionally, sections of resin-embedded cells and tissues can be readily visualized at room temperature.

For Research Use Only. Not for use in diagnostic procedures.