Increasing Analytical Depth via Native LC-MS Biopharmaceutical Characterization

Native mass spectrometry has emerged as a powerful tool to understand protein assemblies and post-translational modifications (PTMs) in structural biology. The coupling of liquid phase separations such as size exclusion chromatography (SEC-MS), or cation or anion exchange chromatography (IEX-MS) with native MS, facilitates biopharmaceutical characterization for the analysis of aggregates and size variants of monoclonal antibodies (mAbs).

The ability to perform native LC-MS has been driven by advances in high-resolution mass spectrometry (HRMS) and the associated bioinformatics used for post-acquisition spectral processing. In this webinar, Drs. Füssl and Carillo will present an evaluation of the performance of Thermo Scientific hybrid quadrupole-Orbitrap MS instruments, namely the Thermo Scientific Q Exactive Plus mass spectrometer and the Thermo Scientific Orbitrap Exploris 240 mass spectrometer for the characterization of mAbs and other biopharmaceuticals, using native LC-MS.

What you will learn:

• How to increase the analytical depth of your biopharmaceuticals
• The importance of software for confident characterization
• Advances in analytical technologies

Who should attend:

• Mass Spectrometry Practitioners
• Researchers / R&D Managers
• Laboratory Managers / Directors / Supervisors
• Laboratory Technicians / Operators