Search

  • Contact Us
  • Quick Order

Talos 12 TEM Features

Proven 120 kV TEM performance

The Thermo Scientific Talos 12 Transmission Electron Microscope (TEM) is an accessible 120 kV instrument with exceptional performance and user-friendliness, designed for a diverse range of scientific imaging and experimentation needs.

 

The Talos 12 TEM features a reduced footprint (compared to previous generations of Talos TEM) with a robust enclosure and systems to improve accessibility, bringing industry-leading performance and automation to more researchers and laboratories.

A TEM designed with high stability and enhanced user interaction features

Trusted performance designed for you

A robust enclosure delivers high stability, with a widened sample loading area and transfer deck to support tools and holder loading stations during user interactions with the TEM. Color LEDs convey system status and provide a working light for sample exchanges in dark rooms. Light animations direct users to insert holders properly and provide alerts for low liquid nitrogen levels or other system issues.

 

Reduced footprint

Smaller than previous generations, the Talos 12 TEM is now suitable for a wider range of researchers in more core labs and imaging facilities.

Frequently asked questions about the Talos 12 TEM

  • What is the Thermo Scientific Talos 12 TEM?
    The Talos 12 TEM is a 120 kV transmission electron microscope designed for versatile use across the life sciences, including in pathology research, drug development, and more. It features a reduced instrument footprint, robust enclosure, and enhanced automation to support users of all experience levels in a wide range of imaging and characterization. 

  • What scientific applications is the Talos 12 TEM used for?
    The Talos 12 TEM features a modular design that allows it to meet the diverse needs of both research labs and core facilities. It can be configured as a conventional TEM for high-resolution imaging in pathology, cell, tissue, and plant biology, or as an advanced system for sample characterization with scanning transmission electron microscopy (STEM) and energy-dispersive X-ray spectroscopy (EDS). It can also be used as an entry-level cryo-electron microscopy (cryo-EM) platform for structural biology research. 

  • What types of samples can be imaged with the Talos 12 TEM? 
    The Talos 12 TEM is capable of imaging a broad range of materials and biological samples in both 2D and 3D. It has been leveraged to analyze resin-embedded cells and tissues, negatively stained proteins and macromolecules, vitrified protein complexes and assemblies, thin-sectioned cells, and lipid nanoparticles. 

  • How does the Talos 12 TEM support pathology research?
    The Talos 12 TEM delivers high-contrast, multi-scale imaging that help researchers and pathologists observe structural details associated with disease states, including infections and tissue abnormalities. Streamlined workflows make it easier to capture these high-quality images routinely, supported by integrated annotation and contextual navigation for post-processing and analysis. 

  • Can the Talos 12 TEM be used for structural biology and single particle analysis? 
    Yes. The Talos 12 TEM can be used directly to perform a number of structural analysis and cryo-EM techniques including negative stain imaging, single particle analysis, and cryo-electron tomography. It can also assess and optimize samples for further analysis on higher resolution cryo-TEMs, supporting faster and more efficient characterization. 

  • What 3D imaging capabilities does the Talos 12 TEM offer? 
    The Talos 12 TEM supports conventional and cryo-electron tomography, allowing for the collection of tilt series and the reconstruction of resin-embedded or vitreous cellular structures and complexes in 3D. Automated acquisition capability, together with specialized software, facilitate detailed spatial analysis at the nanometer scale. 

  • Can the Talos 12 TEM be used for correlative light and electron microscopy (CLEM)? 
    Yes. The Talos 12 TEM supports correlative light and electron microscopy workflows that combine fluorescent imaging with high-resolution electron microscopy, providing complementary biological information in a single comprehensive study. 

  • Does the Talos 12 TEM support elemental analysis? 
    The addition of an optional energy-dispersive X-ray spectroscopy (EDS) detector allows the Talos 12 TEM to perform elemental mapping and compositional analysis. This information can support a number of materials science applications, and can also elucidate the elemental distribution in cells, tissues, and biominerals. 

  • What software and automation features are available for the Talos 12 TEM? 
    Talos 12 TEM software supports automated workflows including large-area imaging, batch acquisition, single particle analysis, and electron tomography. These workflows help make operation more efficient and accessible for both novice and experienced users. 

  • Where can I find additional technical resources and support for the Talos 12 TEM? 
    Thermo Fisher Scientific provides a range of resources including webinars, product documents, application notes, and researcher spotlights that explain system capabilities, workflows, and real-world use cases to help you get the most out of your Talos 12 TEM. 

Fully integrated TEM solution for automated and easy high-resolution imaging

Ceta CMOS cameras deliver high contrast and fast speeds

Fully integrated and embedded into the design of the Talos 12 TEM, Thermo Scientific Ceta Cameras provide stability alongside optimized detector performance. These cameras offer a sensitive and robust fiber-optic-coupled scintillator as well as a large field of view and high speed. This provides the speed and high-contrast visualization necessary to quickly scan and find regions of interest.

User-friendly software with easy and intuitive large-area imaging

The Talos 12 TEM is equipped with Thermo Scientific Velox Software, a workflow-based user interface ideal for both novice and expert TEM and STEM users alike. 

 

Thermo Scientific Maps 3 Software is an add-on for the Talos 12 TEM that facilitates automated data collection for large-area imaging. Navigating the sample is easy and intuitive, even for new users.

Remote operation and powerful system management

The Talos 12 TEM’s digitally controlled hardware components allow remote operation. Integrated cameras and software provide flexible operation and collaboration, regardless of location. 

 

Automated batch acquisition workflows and a long-duration dewar for long imaging sessions allow extended, unattended data collection sessions.

Streamline data collection with Talos 12 TEM and integrated Maps 3 Software

Fully integrated and embedded into the design of the Talos 12 TEM, Ceta CMOS Cameras provide the speed and high-contrast visualization necessary for seamless, live visualization during sample navigation. 

 

Once a region of interest is identified, adjust magnification as needed to easily capture structures of interest. Maps 3 Software can be used for unattended batch acquisition of multiple tile sets, generating high-resolution, multi-scale imaging of intracellular organelles and structures. Navigation and batch acquisition of samples is easy and intuitive, even for new users.

Talos 12 TEM software powers accelerated imaging workflows

The Talos 12 TEM integrates with a range of Thermo Scientific software to support your work and operates via a Microsoft Windows 11 workstation.

 

Velox Software: Routine imaging, STEM, and elemental mapping and analysis for EDS

 

Maps 3 Software: Large area, multi-scale, automated, unattended batch acquisition and offline viewers

 

EPU Software: Easy, automated data acquisition software for single particle analysis

 

Tomography 5 Software: Automated data acquisition and analysis for 3D tomography

 

Amira Software: AI-driven segmentation, reconstruction, and analysis

Integrated software solutions to support data acquisition and analysis workflows.

Built-in sustainability with the ACT Ecolabel

As part of Thermo Fisher Scientific’s commitment to sustainability, the Talos 12 TEM has received an ACT Ecolabel from My Green Lab. This label transparently documents the instrument’s environmental footprint, including manufacturing, energy and water use, and end-of-life disposal. 

For Research Use Only. Not for use in diagnostic procedures.