Learning Center

Expand your knowledge of HLA antibodies and molecular typing.

Learn the latest HLA technical and clinical advancements in transplant diagnostics. We have hands-on workshops geared to beginner and advanced HLA technicians who want to learn how to troubleshoot and analyze data results. We also host webinars or symposia at global transplant societies, including ASHI, EFI, and BSHI where you can interact with industry leaders to discuss the latest techniques and procedures.


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Video: Advancements in AllType FASTPlex
Improvements include an optimized primer mix for 11 HLA loci, more robust PCR amplification, greater on-target accuracy, an improved DRB primer design, and better locus balance.
Video: Potential of Imlifidase
Learn how Imlifidase specifically targets IgG and inhibits pathogenic IgG-mediated immune responses in transplant patients and patients with autoimmune disease or cancer.
Video: New Antibody Advances
Discussion on developments and quality improvements of our LABScreen antibody products and a discussion on the future of antibody testing.
UNOS Kidney Allocation: The Evolving Landscape | Cathi Murphey Half
A lab monitored kidney transplant statistics after the March 2021 point-based kidney allocation policy was implemented and used the UNOS kidney simulation model (KPSAM) to assess its predictive value.
Filling in the gaps: A Single-Center Experience with ExPlex | Kelley Hitchman
A laboratory was able to detect HLA reactivity that would have previously gone undetected in Hispanics without having to perform additional tests, saving time and resources.
AllType™ FASTplex™ v2: Our HLA Laboratory Experience | Ahmed Mostafa
Discover how NGS and antibody detection can be combined for broader applications, including virtual crossmatching, to support changes to the kidney allocation system.
Adapting Laboratory Diagnostics to a Changing Landscape | ASHI 2021
Discover how NGS and antibody detection can be combined for broader applications, including virtual crossmatching, to support changes to the kidney allocation system.
Review of AllType FASTplex™ NGS assay & TypeStream Visual NGS Analysis Software v2.1 | Peter Brescia
Login Required | In-depth review of our new AllType™ FASTplex™ NGS assay v2 protocol as well as our updated version of TypeStream™ Visual NGS Analysis Software v2.1
Are Dilutions the Solution? Identifying the True Extent of Patient Sensitization
In this presentation, Drs. Mark Stegall and Anat Tambur discuss how serial dilutions of the LABScreen™ Single Antigen assay aid in the assessment of alloantibody levels.
LATAM Virtual Workshop
This session includes an introduction to the HLA Fusion functionality, a review of challenging LABType and LABScreen case studies, and a discussion about Epitopes and Eplets.
LATAM Taller Virtual - Español
Esta sesión incluye una introducción a la funcionalidad HLA Fusion, una revisión de los estudios de casos de LABType y LABScreen desafiantes, y una discusión sobre Epítopes y Eplets.
Video: LinkSēq™ for both HLA and Transfusion Products (Case Studies)
A high-level product overview of rt PCR products for HLA and Blood Transfusion, with case studies designed to highlight challenging sample analysis and critical points in the LinkSeq assay.
Video: LinkSēq™ for both HLA and Transfusion Products
In this session, we review key software functionality in both the latest SureTyper and SureTyper Blood analysis software applications.
Video: HLA MatchMaker | LABScreen™ Single Antigen Beads in HLA Fusion™ 4.6 (Case Studies)
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: HLA MatchMaker | LABScreen™ Single Antigen Beads in HLA Fusion™ 4.6
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: LABType™ and Specific Case Studies
In this session, case studies cover best practices of assay techniques to the utilization of software functionality for challenging sample analysis.
Video: LABType™ and HLA Fusion™ 4.6
A comprehensive review of the LABType analysis module in HLA Fusion with emphasis placed on new features and functionality implemented in versions 4.0 and above.
Video: AllType™ & AllType FASTplex
Our instructors provide an introduction to our AllType and AllType FASTplex products plus an examination of challenging NGS case studies.
Video: TypeStream™ Visual 2.0.1
Learn data reporting and exporting, comparing results, plus new features like NGS configurations for analysis parameters, customizable health metrics.
Directory: Advanced Virtual Workshop Series
Learn how to process samples using LABType, LABScreen, AllType, and LinkSeq products as well as how to create custom analysis reports using HLA Fusion, TypeStream, and SureTyper software.
Immune Response to COVID-19 and Vaccination in Transplant Patients | Peter Jindra
The COVID-19 pandemic has impacted the transplant community disproportionately and remains an important topic in the field of histocompatibility and immunology.
Basic Immunology and the HLA Complex | Bedrich Prokupek
In the context of transplant medicine, this program will review immunology basics and the structure and function of the HLA complex for both Class I and Class II. 
EMEA Virtual Workshop
Learn key software functionality for HLA Fusion™ 4.4 and TypeStream™ Visual 2.0.1. Includes challenging LABScreen™, AllType™, and LABType™ case studies, and overview of HLA MatchMaker.
Vein to Vein: RBC Alloimmunization, Genotyping & Inventory Management | Drs. Stella Chou and Monica Kalvelage
Hear from industry leaders as they discuss transfusion medicine, challenges of finding donors, managing blood bank inventory, as well as the benefits of preventing alloimmunization.
Increasing Access to Transplantation for the Highly Sensitized Patient: Combining the Latest Innovations in HLA Typing, Antibody Detection and Data Analysis | Taba Kheradmand and Robert Liwski
We explore how the evolution of more efficient NGS workflows and advanced Single Antigen assays with extended allele coverage can improve analysis with Epitope Matching and Virtual Crossmatching.
The Role of Race in Transplant and Transfusion: a Roundtable Discussion | Patient Stories
HLA experts discuss the need for a more diverse donor pool and the impact that the COVID-19 pandemic is having on minority donor recruitment in transplant and transfusion.
Multiplexed SARS CoV2 Platforms: Future Interactions | Steve Woodle
Dr. Woodle reviews the body of evidence that suggests SARS-CoV-2 may circumvent many of the typical rules of immune response and discusses the research applications for a multiplex assay as a tool.
Testing for SARS-CoV-2 Antibodies: How it began | Howard Gebel
Dr. Howard Gebel shares the need for an assay that is comprehensive, specific, and sensitive enough to build a complete antibody profile for patients exposed to the COVID-19 virus.
Cinical Utility of SARS-CoV-2 Antibody Testing | Deepali Kumar
Dr. Deepali Kumar examines how a multi-antigen assay can help characterize vaccine response and clarify how antibodies present in asymptomatic versus symptomatic patients.
What is the LABScreen COVID Plus Assay? | Robert Bray
Dr. Bray explains how the assay will allow labs to examine the heterogeneity of humoral responses between patients as well as the development of the humoral response in a single patient over time.
Virtual crossmatch strategy to facilitate kidney transplantation for highly sensitized candidates | Rajalingam Raja
In this talk, Dr. Raja delves into key considerations for highly sensitized candidates.
Recovering from the COVID-19 Crisis in Transplantation – A Roundtable Discussion | Robert Liwski and Robert
Doctors Robert Liwski and Bob Bray lead a discussion on how centers are managing operations and patient care during the ongoing pandemic.
The Quest to Decipher HLA Immunogenicity: Telling Friend from Foe | Anat Tambur
Dr. Tambur explores a new way to interrogate molecular mismatch load and discusses important concepts in immunogenicity.
The Kinetics of Anti-HLA Antibody in Simultaneous Liver-Kidney Transplantation | Matthew Cusick
Dr. Matthew Cusick will provide an assessment of the impact that DSAs may have on simultaneous liver-kidney transplants and discuss how the liver may play a key role in antibody clearance.
Allele-specific DSA: Lessons from SAB and NGS | Gerald P. Morris
Dr. Morris explores the limitations of solid-organ HLA genotyping methods that may preclude DSA identification and discussed various approaches for monitoring allele-specific anti-HLA antibodies. 
AllType Next Generation Sequencing – Easy Integration and Future Innovation | Elizabeth Wroe
Elizabeth Wroe showcased the NHSBT’s rigorous selection criteria and provided an in-depth look of the lab’s integration of the AllType NGS assay into routine laboratory practice.
New Frontiers in Expanded Single Antigen Testing | Jakob Nilsson
Dr. Jakob Nilsson gives a preliminary summary of his experience using LABScreen Single Antigen ExPlex, and assesses the test’s ability to predict possible binding epitopes through HLAMatchmaker.
The Evolution of Risk Assessment in Solid Organ Transplantation | Kwllwy Hitchman
Dr. Kelley Hitchman gives an overview of advancements in crossmatch testing, examines the practicality and advantages of virtual crossmatching, and reviews requirements that impact labs.
The Usefulness of Epitope Analysis When Interpreting HLA Antibody Test Results | Robert Liwski
Dr. Robert Liwski provides an overview of the HLAMatchmaker approach and explores the key role of epitope analysis in HLA antibody testing through literature review and case studies.
Assessing HLA Antibodies: Can we understand the strength? | Nicole Valenzuela
Learn about HLA antibody testing, interpretation of HLA antibody profiles, and the utility of serum dilution and C1qScreen in this discussion led by Dr. Nicole Valenzuela.
ABO Blood Subgrouping and Implications in Transplantation | William Lane
Understand ABO genotyping, how it enables ABO minor incompatible (ABOi) transplants and the technologies and resources that are available to help labs perform ABOi transplants.
Non-HLA Antibodies: A New Perspective on Allograft Injury & Rejection | Annette Jackson
Dr. Jackson, provides a detailed introduction to non-HLA antibodies, discusses their potential impact to transplantation, and reviews new developments in their characterization.
Video: Assessment of the Humoral Response to SARS-CoV-2 Infection Via Novel Multiplexed Assays
Discussion on what we currently know about the humoral response to the SARS-CoV-2 virus and explore the clinical and research applications of using a multiplexed assay to test for COVID-19 antibodies.
Video: APAC Virtual Workshop
This session features an overview of SureTyper, TypeStream Visual, HLA Fusion, HLA MatchMaker, and a discussion on the role of HLA Antibodies in transplantation by Dr. Cathi Murphey-Half.
MMDx Heart & Kidney Brochure
MMDx Heart Brochure
MMDx Kidney Brochure
Case Study | A Challenging Diagnosis in Kidney Transplantation: MMDx Kidney
In a case where a highly sensitized patient received abnormal biopsy results after transplantation, gene expression profiling provided the treating clinician with confirmatory results for diagnosis.
Video: Non-HLA Antibodies: Preliminary Experience
A case study of nine patients that had high levels of REG3A, LMNB, PRKCH, GAPDH, HNRNPK, VM, and IFNG autoantibodies; correlated with humoral rejection in kidney and heart transplant recipients.
Video: HLA Typing by Next-Generation Sequencing (NGS) Using the AllType Fastplex Kit and the Relevance of Anti-HLA Antibody Monitoring After Kidney Transplantation
Dr. Andreani shares his laboratory’s evaluation of One Lambda™ AllType™ FASTPlex™ NGS showing 100% concordance on 240 and demonstrates how his lab determines a patient’s eplet load using HLAMatchmaker
Video: An Introduction to and the Evolution of the UK Living Kidney Sharing Scheme
Learn how Imlifidase specifically targets IgG and inhibits pathogenic IgG-mediated immune responses in transplant patients and patients with autoimmune disease or cancer.
PubSummary | Long Term Survival after Kidney Transplantation
Long-term kidney transplant graft and patient survival have improved with time due to a superior understanding of pre-transplant immunological risk.
Clinical Applications for MMDx®: Gene Expression Profiling in Transplant Biopsies | Georg Böhmig
Molecular assessment was applied to diagnose allograft dysfunction and to determine if rejection was due to ABMR, TCMR, or a combination of both.
Cross-organ comparisons: Temporal Gene Expression Changes In Kidney, Heart, Liver, and Lung Transplant Biopsies
ATC2020 Presentation by PF Halloran, J Reeve, and the INTERLIVER, INTERLUNG, INTERCOMEX, INTERHEART Study Groups
PubSummary | A 2020 Banff Antibody Mediated Injury Working Group examination of international practices for diagnosing antibody mediated rejection in kidney transplantation
Biopsy data is accompanied by DSA data in +/- 30% of cases, suggesting urgent action to improve the accessibility of DSA information is needed.
PubSummary | Analysis of RNA Transcripts by the Molecular Microscope Diagnostic System Can Direct Management after Indication Kidney Transplant Biopsy
These two cases describe how MMDx was used to aid the management of two patients with Banff diagnoses of “borderline” and “Banff 1a TCMR.”
PubSummary | Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies
This study demonstrates the reproducibility of MMDx and the lack of significant disagreement between MMDx sign outs.
Innovations in Rejection Surveillance after Heart Transplantation | Jon Kobashigawa
For post-transplant management in heart patients, the endomyocardial biopsy is considered the gold standard to detect acute rejection.
PubSummary | Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection
The study describes the molecular landscape of antibody mediated rejection.
PubSummary | Revisiting the changes in the Banff Classification for antibody‐mediated rejection after kidney transplantation
In the search for potential treatments and personalized prognostication, a clear definition of antibody mediated rejection (ABMR) is an indispensable prerequisite.
MMDx Kidney Report Sample
What information will the MMDx-Kidney Assessment Report provide? This sample will show you how to interpret the report.
Discovering novel injury features in kidney transplant biopsies associated with TCMR and donor aging
We previously characterized the molecular changes in acute kidney injury (AKI) and chronic kidney disease (CKD) in kidney transplant biopsies, but parenchymal changes selective for specific types ...
Introduction to the Molecular Microscope Diagnostic System (MMDx)
What is MMDx and how does it work? Dr. Christopher Lawrence gives a brief overview of the biopsy service.
Specimen Collection Procedure for the Molecular Microscope Diagnostics System (MMDx)
Thinking of ordering an MMDx specimen collection kit? See what's in the kit and how to collect the specimen and ship it to the lab for assessment.
Molecular phenotypes of liver transplant injury: the INTERLIVER study
ATC2020 Presentation by KS Madill-Thomsen, PF Halloran, and the INTERLIVER Study Group
The Molecular Microscope Diagnostic System: Precision and Accuracy in Transplant Diagnostics | Philip Halloran
Dr. Phil Halloran discusses the unmet need for precision and accuracy in pathological biopsy assessment and reviews the applications of the actionable data generated in MMDx reports.
PubSummary | US payer budget impact of a microarray assay with machine learning to evaluate kidney transplant rejection in for-cause biopsies
Dr. Chris Lawrence explores how a US payer budget model demonstrates that MMDx® Kidney is a cost-effective intervention despite the cost of the assay and the higher treatment costs associated with identifying more rejection.
MMDx Kidney Patient FAQ
Using Molecular Diagnostics for Kidney Transplants: Getting There! | Gaurav Gupta
Explore how molecular diagnostics can be used in clinical practice, including how the test can complement traditional histology as well as how the results can be incorporated into patient management.
MMDx Kidney, Heart & Lung Brochure
MMDx Heart Patient FAQs
Type Stream Visual 2.0: Establishing Assignment Settings
In this tutorial, learn how to establish your default final assignment settings in TypeStream Visual 2.0
PubSummary | Intensity of de novo DSA detected by Immucor Lifecodes assay and C3d fixing antibodies are not predictive of subclinical ABMR after kidney transplantation
Bertrand et al. demonstrate that there are significant differences between HLA antibody test vendors in the ability to detect dnDSA in cases of biopsy-proven sABMR.
White Paper | Research suggests HLA & HNA may play a critical role in COVID-19 Susceptibility, Immune Protection and Success of Novel Treatments during a Global Pandemic Crisis
We have the requisite HLA and HNA antibody screening products to protect patients from an adverse transfusion-related lung injury during upcoming convalescent plasma therapy trials.
PubSummary | Incidence and impact of allele-specific anti-HLA antibodies and high-resolution HLA genotyping on assessing immunologic compatibility
Allele specific anti-HLA reactivity was shown to occur in around 15% of patients awaiting transplantation.
Analyze LinkSeq HLA Typing Kits using SureTyper Software v6.0
Learn how to analyze LinkSēq HLA Typing Kits using the SureTyper Software version 6.0.
White Paper | COVID Plus: A New Diagnostic Tool to Protect Transplant Patients in the Fight Against COVID-19
Identifying multiple distinct antibodies to COVID-19 will be vitally important as some have demonstrated neutralizing capabilities
Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates
This study used serial dilution analysis to determine the point at which cPRA could be reduced below 98%, a value previously shown to significantly increase probability of transplant.
PubSummary | Amplifying the Patient Voice: Key Priorities and Opportunities for Improved Transplant and Living Donor Advocacy and Outcomes During COVID-19 and Beyond
When defining patient advocacy and engagement for modern transplant and living donation care, particularly in light of the COVID-19 pandemic, the authors describe the patient experience when ...
Development and Validation of a Multiplex, Bead-Based Assay to Detect Antibodies Directed Against SARS-CoV-2 Proteins
A new diagnostic tool to determine SARS-CoV-2 antibody status in transplant patients
Import A LABScreen Session In HLA Fusion Software
Follow the step-by-step process in order to import your LABScreen raw data into the HLA Fusion software.
Upload Reference Files in TypeStream Visual 2.0
This is a simple tutorial on where to locate and how to download files for TSV analysis.
Update Reference Files in HLA Fusion Software
Follow the step-by-step process to ensure you have the most up-to-date reference files to accomplish your analysis within the software.
Introduction to the AllType FASTplex Protocol | Peter Brescia
Learn about the streamlined Illumina workflow and kit configuration of the newest AllType FASTplex NGS protocol, and discover how your run step will be simplified with our new Calculator Tool.
Analyzing the AllType™ NGS Assay using TypeStream™ Visual Software - Version 1.2
The course introduces the TypeStream Visual Software and guides you through the analysis of various samples including one "Typical Case" and several "Special Cases".
Validation of HLA Typing by NGS
Includes a summary of NGS validation procedures, in-depth analysis of quality control measures, as well as pre-implementation cost analysis and preparation of the ASHI submission packet.